AIM: To review imaging characteristics and surgical outcomes of orbital neurilemmoma. METHODS: Retrospective review of 21 patients with orbital neurilemmoma managed at the Zhongshan Ophthalmic Center of Sun Yat-sen Un...AIM: To review imaging characteristics and surgical outcomes of orbital neurilemmoma. METHODS: Retrospective review of 21 patients with orbital neurilemmoma managed at the Zhongshan Ophthalmic Center of Sun Yat-sen University from June 2005 to December 2016. All patients underwent surgical excision following preoperative imaging including ultrasonography, computed tomography(CT) and magnetic resonance imaging(MRI).RESULTS: Among these patients, 11 were male and 10 were female, with age ranging from 12 to 75y(average, 40.3 y). Ultrasound of the orbit showed a roundish well-demarcated orbital mass with low or middle internal reflectivity in each case. Dark inner liquid fields were detected in 28.6% of these cases. Doppler ultrasound demonstrated blood flow signals in these masses. CT showed that the tumors were either homogeneous or heterogeneous. MRI of T1 WI revealed isointense or hypointense tumors, while the T2 WI indicated heterogeneous hyperintense lesions. Gd contrast MRI demonstrated heterogenous or homogeneous enhancement initiating from the wide area of the lesion. Six patients underwent lateral orbitotomy and 15 anterior orbitotomy. All tumors were completely removed. After a mean followup of 1.8 y, 3 patients experienced reduced vision while the remaining 10 patients showed improved vision after surgery. One patient experienced a mild limitation of upward motility. No recurrence occurred. CONCLUSION: Orbital neurilemmoma is a relatively rare, benign orbital tumor. Effective diagnosis requires a combination of ultrasonography, CT and/or MRI. These imaging techniques are also vital to differentiate neurilemmomas from other orbital masses like that of cavernous hemangiomas and meningiomas.Successful treatment requires complete resection of the neurilemmomas as performed either by lateral or anterior orbitotomy. Recurrence is rare after complete removal.展开更多
BACKGROUND Tracheal tumors are relatively rare in adults and uncommon in children.Tracheal neurilemmoma is a rare condition in adults that usually affects middle-aged people,but it can also occur in children.Because t...BACKGROUND Tracheal tumors are relatively rare in adults and uncommon in children.Tracheal neurilemmoma is a rare condition in adults that usually affects middle-aged people,but it can also occur in children.Because the clinical presentation is nonspecific and insidious,diagnosis is often delayed.The most common symptoms in these patients are stridor or wheezing(especially positional)and cough.A few patients are misdiagnosed and mistakenly treated for asthma.CASE SUMMARY A 10-year-old girl was admitted to our unit with a 2-mo history of recurrent cough,dyspnea,and tachypnea.Her condition was more severe after exercise.Her symptoms progressed despite treatment with inhaled fluticasone/salmeterol.Flexible electronic laryngoscopy showed a red,smooth,and round mushroomshaped mass in the trachea,about 1 cm below the vocal cords.The surface of the mass was covered with several small and discontinuous blood vessels.About 90%of the tracheal lumen was occupied by the mass.A multidisciplinary operation was performed.The surgically resected mass was diagnosed as benign neurilemmoma by immunohistochemical analysis.CONCLUSION Intratracheal neurilemmoma is fairly rare in children.The main symptoms include coughing,wheezing,and dyspnea.The tumor’s size,location,and degree of intratracheal and extratracheal invasion can be measured by chest computed tomography.The main treatment strategies used for tracheal neurilemmoma are surgical resection and endoscopic excision.Long-term follow-up is warranted for the evaluation of outcomes and complications.展开更多
Objective To explore surgical techniques and curative effects of microsurgical treatment for neuriemmoma in upper cervical spinal canal. Methods Form Jan. 2004 to Nov. 2007. 59 cases of schwannoma was resected through...Objective To explore surgical techniques and curative effects of microsurgical treatment for neuriemmoma in upper cervical spinal canal. Methods Form Jan. 2004 to Nov. 2007. 59 cases of schwannoma was resected through microoperation, the operation was conducted through a posteromedial approach,using German Laika microscope resection展开更多
Background: Neurilemmoma (Schwannomas) are the most common peripheral nerve tumors and usually do not undergo malignant transformation, except in some atypical cases. Additionally, the imaging appearance of schwannoma...Background: Neurilemmoma (Schwannomas) are the most common peripheral nerve tumors and usually do not undergo malignant transformation, except in some atypical cases. Additionally, the imaging appearance of schwannomas resembles that of neurofibromas, making it difficult to distinguish between the two. Therefore, the clinical diagnosis and treatment of schwannomas may face certain challenges. The management and prognosis of neurilemmomas differ from their malignant counterparts, making correct diagnosis important. Objective: This study evaluates the clinical and histopathological characteristics of 45 cases of neurilemmoma. Methods: This retrospective study involves 45 cases diagnosed with cutaneous neurilemmoma at the Seventh Affiliated Hospital of Sun Yat-sen University between April 2020 and September 2024. All cases were retrieved from medical records. Results: The age range of the 45 patients was 23 to 73 years, with a male to female ratio of 1.6:1. Over half the cases occurred in individuals aged 30 to 59, with most lesions found in the extremities, predominantly in the lower limbs. Disease duration varied from 7 days to 20 years. All tumors were solitary, with diameters ranging from 0.8 cm to 8 cm. Most tumors (33/45, 73.33%) were asymptomatic, though some patients experienced symptoms like pain and numbness. Mass was the most common clinical diagnosis (33/45, 73.33%). Five patients had suspected neurilemmomas prior to surgery. Immunohistochemical staining revealed all positive results for S-100 and SOX-10 markers, while EMA staining showed a negative rate of 93.33%. Most Ki-67 values (19/23, 82.6%) were less than or equal to 5%. Conclusion: The diversity of clinical features, pathological manifestations, and immunohistochemical results of schwannoma poses a challenge to accurate diagnosis. A comprehensive understanding of its clinical and pathological characteristics is essential for accurate diagnosis, and when combined with immunohistochemical analysis, it helps avoid misdiagnosis.展开更多
Neurilemmoma, also named Schwannoma, is usually a benign tumour composed of Schwann cells. It is commonly located in the retroperitoneum, mediastinum, head and neck, and is rarely seen in the genitourinary organs. Onl...Neurilemmoma, also named Schwannoma, is usually a benign tumour composed of Schwann cells. It is commonly located in the retroperitoneum, mediastinum, head and neck, and is rarely seen in the genitourinary organs. Only cases of neurilemmoma originating from the seminal vesicle have been reported. Here we present the third case.展开更多
Neurilemmomas is usually a benign neoplasm which is composed of Schwann cells, alsonamed schwannomas and originates from the peripheral nerve sheath. It most frequently （25%- 45%） occurs in the head and neck, but ra...Neurilemmomas is usually a benign neoplasm which is composed of Schwann cells, alsonamed schwannomas and originates from the peripheral nerve sheath. It most frequently （25%- 45%） occurs in the head and neck, but rarely （4%） in the nasal cavity and paranasal sinuses, especially rare in nasal vestibule. In English literature, only Alessandrinis reported one case with the tumor originating from the nasal vestibule. Here we report two cases.展开更多
基金Supported by the National Natural Science Foundation of China(No.81670885)the Science and Technology Program of Guangdong Province,China(No.2013B020400003)Science and Technology Program of Guangzhou,China(No.15570001)
文摘AIM: To review imaging characteristics and surgical outcomes of orbital neurilemmoma. METHODS: Retrospective review of 21 patients with orbital neurilemmoma managed at the Zhongshan Ophthalmic Center of Sun Yat-sen University from June 2005 to December 2016. All patients underwent surgical excision following preoperative imaging including ultrasonography, computed tomography(CT) and magnetic resonance imaging(MRI).RESULTS: Among these patients, 11 were male and 10 were female, with age ranging from 12 to 75y(average, 40.3 y). Ultrasound of the orbit showed a roundish well-demarcated orbital mass with low or middle internal reflectivity in each case. Dark inner liquid fields were detected in 28.6% of these cases. Doppler ultrasound demonstrated blood flow signals in these masses. CT showed that the tumors were either homogeneous or heterogeneous. MRI of T1 WI revealed isointense or hypointense tumors, while the T2 WI indicated heterogeneous hyperintense lesions. Gd contrast MRI demonstrated heterogenous or homogeneous enhancement initiating from the wide area of the lesion. Six patients underwent lateral orbitotomy and 15 anterior orbitotomy. All tumors were completely removed. After a mean followup of 1.8 y, 3 patients experienced reduced vision while the remaining 10 patients showed improved vision after surgery. One patient experienced a mild limitation of upward motility. No recurrence occurred. CONCLUSION: Orbital neurilemmoma is a relatively rare, benign orbital tumor. Effective diagnosis requires a combination of ultrasonography, CT and/or MRI. These imaging techniques are also vital to differentiate neurilemmomas from other orbital masses like that of cavernous hemangiomas and meningiomas.Successful treatment requires complete resection of the neurilemmomas as performed either by lateral or anterior orbitotomy. Recurrence is rare after complete removal.
文摘BACKGROUND Tracheal tumors are relatively rare in adults and uncommon in children.Tracheal neurilemmoma is a rare condition in adults that usually affects middle-aged people,but it can also occur in children.Because the clinical presentation is nonspecific and insidious,diagnosis is often delayed.The most common symptoms in these patients are stridor or wheezing(especially positional)and cough.A few patients are misdiagnosed and mistakenly treated for asthma.CASE SUMMARY A 10-year-old girl was admitted to our unit with a 2-mo history of recurrent cough,dyspnea,and tachypnea.Her condition was more severe after exercise.Her symptoms progressed despite treatment with inhaled fluticasone/salmeterol.Flexible electronic laryngoscopy showed a red,smooth,and round mushroomshaped mass in the trachea,about 1 cm below the vocal cords.The surface of the mass was covered with several small and discontinuous blood vessels.About 90%of the tracheal lumen was occupied by the mass.A multidisciplinary operation was performed.The surgically resected mass was diagnosed as benign neurilemmoma by immunohistochemical analysis.CONCLUSION Intratracheal neurilemmoma is fairly rare in children.The main symptoms include coughing,wheezing,and dyspnea.The tumor’s size,location,and degree of intratracheal and extratracheal invasion can be measured by chest computed tomography.The main treatment strategies used for tracheal neurilemmoma are surgical resection and endoscopic excision.Long-term follow-up is warranted for the evaluation of outcomes and complications.
文摘Objective To explore surgical techniques and curative effects of microsurgical treatment for neuriemmoma in upper cervical spinal canal. Methods Form Jan. 2004 to Nov. 2007. 59 cases of schwannoma was resected through microoperation, the operation was conducted through a posteromedial approach,using German Laika microscope resection
文摘Background: Neurilemmoma (Schwannomas) are the most common peripheral nerve tumors and usually do not undergo malignant transformation, except in some atypical cases. Additionally, the imaging appearance of schwannomas resembles that of neurofibromas, making it difficult to distinguish between the two. Therefore, the clinical diagnosis and treatment of schwannomas may face certain challenges. The management and prognosis of neurilemmomas differ from their malignant counterparts, making correct diagnosis important. Objective: This study evaluates the clinical and histopathological characteristics of 45 cases of neurilemmoma. Methods: This retrospective study involves 45 cases diagnosed with cutaneous neurilemmoma at the Seventh Affiliated Hospital of Sun Yat-sen University between April 2020 and September 2024. All cases were retrieved from medical records. Results: The age range of the 45 patients was 23 to 73 years, with a male to female ratio of 1.6:1. Over half the cases occurred in individuals aged 30 to 59, with most lesions found in the extremities, predominantly in the lower limbs. Disease duration varied from 7 days to 20 years. All tumors were solitary, with diameters ranging from 0.8 cm to 8 cm. Most tumors (33/45, 73.33%) were asymptomatic, though some patients experienced symptoms like pain and numbness. Mass was the most common clinical diagnosis (33/45, 73.33%). Five patients had suspected neurilemmomas prior to surgery. Immunohistochemical staining revealed all positive results for S-100 and SOX-10 markers, while EMA staining showed a negative rate of 93.33%. Most Ki-67 values (19/23, 82.6%) were less than or equal to 5%. Conclusion: The diversity of clinical features, pathological manifestations, and immunohistochemical results of schwannoma poses a challenge to accurate diagnosis. A comprehensive understanding of its clinical and pathological characteristics is essential for accurate diagnosis, and when combined with immunohistochemical analysis, it helps avoid misdiagnosis.
文摘Neurilemmoma, also named Schwannoma, is usually a benign tumour composed of Schwann cells. It is commonly located in the retroperitoneum, mediastinum, head and neck, and is rarely seen in the genitourinary organs. Only cases of neurilemmoma originating from the seminal vesicle have been reported. Here we present the third case.
文摘Neurilemmomas is usually a benign neoplasm which is composed of Schwann cells, alsonamed schwannomas and originates from the peripheral nerve sheath. It most frequently （25%- 45%） occurs in the head and neck, but rarely （4%） in the nasal cavity and paranasal sinuses, especially rare in nasal vestibule. In English literature, only Alessandrinis reported one case with the tumor originating from the nasal vestibule. Here we report two cases.
