BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract...BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract either as a sole agent or as an adjunct in depression therapy.METHODS Adult mice were assigned into three main groups based on the neurobehavioural models;and each main group had ten treatment groups of 10 mice each.Treatment groups were:Vehicle control group,oral sertraline(SERT)group,two groups fed SILY)-supplemented diet(SILY at 140 and 280 mg/kg of feed,respectively),dexamethasone(DEX;i.p.)group,DEX/SERT group,two groups of DEX/SILY(SILY at 140 and 280 mg/kg of feed,respectively),and another two groups of(SERT/DEX/SILY)(SILY at 140 and 280 mg/kg of feed,respectively,plus i.p.DEX plus SERT).Duration of the study was 7 wk,and treatments were administered daily.RESULTS SILY(alone)increased body weight,open field locomotor activity,rearing,and grooming;it also enhanced spatial working memory while decreasing anxietyrelated behaviours and behavioural despair.SILY also improved antioxidant status while decreasing lipid peroxidation,acetylcholinesterase activity,and inflammatory markers.Neuronal integrity of the cerebral cortex and hippocampus was preserved.Overall,when administered alone or with SERT,SILY counteracted DEX-induced behavioural and biochemical changes while preserving neuromorphological integrity.CONCLUSION In conclusion,SILY is beneficial in mitigating DEX-induced central nervous system and other related changes in mice.展开更多
目的:探讨高原军人睡眠质量与神经行为之间的关系。方法:对108名驻高原地区的士兵进行部分神经行为功能测试,测验有数字译码、数字跨度、视觉记忆和目标追踪。睡眠质量评估采用匹兹堡量表。结果:41.7%(45/108)的士兵存在睡眠质量降低,...目的:探讨高原军人睡眠质量与神经行为之间的关系。方法:对108名驻高原地区的士兵进行部分神经行为功能测试,测验有数字译码、数字跨度、视觉记忆和目标追踪。睡眠质量评估采用匹兹堡量表。结果:41.7%(45/108)的士兵存在睡眠质量降低,下降组匹兹堡量表各成分平均得分高于对照组,除药物因子外,其余因子组间有显著统计差异。两组间神经行为测验和训练成绩比较,下降组成绩明显低于对照组(数字译码:47.69 vs 53.41,t=2.21,P<0.05;数字跨度:15.80 vs17.63,t=2.96,P<0.01;视觉记忆:7.02 vs 7.86,t=2.98,P<0.01;目标追踪:165.0 vs 179.6,t=2.53,P<0.05;训练成绩:35.2 vs 39.7,t=2.61,P<0.01)。结论:高原军人的睡眠质量对认知功能和军事训练有不同程度的影响,睡眠质量的改善将有助于军事训练水平的提高。展开更多
文摘BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract either as a sole agent or as an adjunct in depression therapy.METHODS Adult mice were assigned into three main groups based on the neurobehavioural models;and each main group had ten treatment groups of 10 mice each.Treatment groups were:Vehicle control group,oral sertraline(SERT)group,two groups fed SILY)-supplemented diet(SILY at 140 and 280 mg/kg of feed,respectively),dexamethasone(DEX;i.p.)group,DEX/SERT group,two groups of DEX/SILY(SILY at 140 and 280 mg/kg of feed,respectively),and another two groups of(SERT/DEX/SILY)(SILY at 140 and 280 mg/kg of feed,respectively,plus i.p.DEX plus SERT).Duration of the study was 7 wk,and treatments were administered daily.RESULTS SILY(alone)increased body weight,open field locomotor activity,rearing,and grooming;it also enhanced spatial working memory while decreasing anxietyrelated behaviours and behavioural despair.SILY also improved antioxidant status while decreasing lipid peroxidation,acetylcholinesterase activity,and inflammatory markers.Neuronal integrity of the cerebral cortex and hippocampus was preserved.Overall,when administered alone or with SERT,SILY counteracted DEX-induced behavioural and biochemical changes while preserving neuromorphological integrity.CONCLUSION In conclusion,SILY is beneficial in mitigating DEX-induced central nervous system and other related changes in mice.
文摘目的:探讨高原军人睡眠质量与神经行为之间的关系。方法:对108名驻高原地区的士兵进行部分神经行为功能测试,测验有数字译码、数字跨度、视觉记忆和目标追踪。睡眠质量评估采用匹兹堡量表。结果:41.7%(45/108)的士兵存在睡眠质量降低,下降组匹兹堡量表各成分平均得分高于对照组,除药物因子外,其余因子组间有显著统计差异。两组间神经行为测验和训练成绩比较,下降组成绩明显低于对照组(数字译码:47.69 vs 53.41,t=2.21,P<0.05;数字跨度:15.80 vs17.63,t=2.96,P<0.01;视觉记忆:7.02 vs 7.86,t=2.98,P<0.01;目标追踪:165.0 vs 179.6,t=2.53,P<0.05;训练成绩:35.2 vs 39.7,t=2.61,P<0.01)。结论:高原军人的睡眠质量对认知功能和军事训练有不同程度的影响,睡眠质量的改善将有助于军事训练水平的提高。
