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Oligodendrocytes in neurodegenerative diseases 被引量:1
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作者 Yingjun LIU Jiawei ZHOU 《Frontiers in Biology》 CAS CSCD 2013年第2期127-133,共7页
Oligodendrocyte is a highly specialized glial cell type in the vertebrate central nervous system, which guarantees the long-distance transmission of action potential by producing myelin sheath wrapping adjacent axons.... Oligodendrocyte is a highly specialized glial cell type in the vertebrate central nervous system, which guarantees the long-distance transmission of action potential by producing myelin sheath wrapping adjacent axons. Disrupted myelin and oligodendrocytes are hallmarks of some devastating neurological diseases, such as multiple sclerosis, although their contribution to neurodegeneration in a given disease is still controversial. However, accumulating evidence from clinical studies and genetic animal models implicates oligodendrocyte dysfunction as one of major events in the processes of initiation and progression of neurodegeneration. In this article, we will review recent progress in understanding non-traditional function of oligodendrocytes in neuronal support and protection independent of myelin sheath and its possible contribution to neurodegeneration. Oligodendrocytes play a pivotal role in neurodegenerative diseases among which special emphasis is given to multiple system atrophy and Alzheimer's disease in this review. 展开更多
关键词 GLIA OLIGODENDROCYTE neurodegenemtive disease myelin sheath multiple sclerosis multiple system atrophy Alzheimer's disease Parkinson's disease
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