Small cell carcinoma of cervix (SCCC) is a rare disease with highly aggressive behaviour and is pathologically hard to diagnose.In this study, the clinicopathological features, diagnosis, treatment and prognosis of th...Small cell carcinoma of cervix (SCCC) is a rare disease with highly aggressive behaviour and is pathologically hard to diagnose.In this study, the clinicopathological features, diagnosis, treatment and prognosis of the condition were examined.Clinical records and follow-up data of 7 cases of SCCC were retrospectively studied.Our results showed that five non-recurrent cases initially presented irregular vaginal bleeding or increased apocenosis of varying degrees.Pathological examination revealed that the stroma was diffusely infiltrated with small monomorphous cells ranging from round to oval shape.Three cases were immunohistochemically confirmed.One case was accompanied with squamous cell cancer.Of the 7 cases, one case was classified as stage Ⅰb 1, two stageⅠ b2, one stage Ⅱ a, one stage Ⅱb , and one stage Ⅲ b.On the basis of their stages of condition, one subject with stage III b underwent chemotherapy, and one with stage Ib2 received extensive hysterectomy plus pelvic lymphadenectomy, while the other 5 cases were treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.Of the 7 patients, 4 had relapse-free survival of 14, 14, 16 and 28 months respectively.It is concluded that SCCC is an aggressive tumor with propensity for early pelvis lymph node metastases.Early-stage patients should be treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.展开更多
宫颈小细胞神经内分泌癌(small cell neuroendocrine carcinoma of the cervix,SCNCC)早期易发生淋巴转移,病理表现独特,易复发,预后差。报告1例SCNCCⅢC1r期病例资料,患者因间断性阴道出血伴下腹痛1个月余就诊,结合盆腔磁共振成像、全...宫颈小细胞神经内分泌癌(small cell neuroendocrine carcinoma of the cervix,SCNCC)早期易发生淋巴转移,病理表现独特,易复发,预后差。报告1例SCNCCⅢC1r期病例资料,患者因间断性阴道出血伴下腹痛1个月余就诊,结合盆腔磁共振成像、全腹CT及宫腔镜活检结果诊断为SCNCCⅢC1r期,根据2022年美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)指南,结合该患者病情,给予患者3个周期的卡铂+依托泊苷新辅助化疗,后行腹腔镜下广泛性子宫切除术+双侧卵巢切除术+双侧输卵管切除术+盆腔淋巴结清扫术+腹主动脉旁淋巴结切除术+抗肿瘤药物腹腔灌注治疗(奈达铂冲洗腹腔)+双侧输尿管支架植入术,术后继续化疗3个周期,术后随访13个月未见复发。展开更多
目的:通过文献复习探讨宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理特点、生物学行为、治疗及预后情况。方法:应用检索Meta Med及CHKD期刊全文数据库检索系统,以"宫颈恶性肿瘤、小细胞癌和神经内分泌癌"...目的:通过文献复习探讨宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理特点、生物学行为、治疗及预后情况。方法:应用检索Meta Med及CHKD期刊全文数据库检索系统,以"宫颈恶性肿瘤、小细胞癌和神经内分泌癌"为关键词,分别或联合检索1998-01-2008-06的相关文献80篇。纳入标准:1)组织发生;2)临床病理特点;3)化疗、放疗和综合治疗疗效;4)预后分析。根据纳入标准,精选59篇文献,最后纳入分析28篇文献。结果:SCCC是一种罕见的宫颈原发恶性肿瘤,与普通的子宫颈癌相比,SCCC具有高度侵袭性,常早期发生远处转移和局部复发,预后差。正确的临床诊断需联合光镜、电镜和免疫组化检查。因发病率低和各中心累积的病例数有限,目前尚无规范的治疗方法。手术是治疗早期SCCC的重要手段,同步放化疗可用于治疗晚期SCCC患者,联合化疗和放疗可能改善预后。临床期别是决定预后的重要因素。结论:SCCC预后差,强调早期诊断和综合治疗,由于SCCC罕见,需长时间才能积累一定数量的患者资料,建议通过多中心协作以探求最佳的治疗方案。展开更多
目的探讨子宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理学特征、免疫表型、与人乳头瘤病毒(human papilloma virus,HPV)的关系及预后。方法采用免疫组化En Vision法对35例SCCC进行检测及PCR法进行HPV检测并分型...目的探讨子宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理学特征、免疫表型、与人乳头瘤病毒(human papilloma virus,HPV)的关系及预后。方法采用免疫组化En Vision法对35例SCCC进行检测及PCR法进行HPV检测并分型。结果患者年龄29~76岁,中位年龄47岁。临床表现主要为不规则阴道出血。组织学上28例为单纯型小细胞癌,7例合并其他类型癌或癌前病变。镜下见小而深染的圆形或短梭形肿瘤细胞,呈巢状或条索状排列,胞质稀少,核仁不明显,坏死及核分裂象多见。免疫表型:神经内分泌标志物NSE(30/35)、CD56(27/35)、Syn(28/35)、CgA(20/35)阳性;其他标志物p16(29/35)、PAX-8(3/35)、TTF-1(15/35)及p63(12/35)阳性;Ki-67增殖指数均>50%。27例HPV检测结果为阳性,8例为阴性。29例随访时间3个月~6年,4例复发或转移,8例死亡。结论 SCCC组织学形态与其他部位小细胞癌类似,其发病与高危型HPV感染相关;常表达p16及TTF-1,PAX-8多呈阴性;预后差。展开更多
基金supported by a grant from the Program of Scientific Innovation of Huazhong University of Science and Technology (No.HF-05-035-07-540)
文摘Small cell carcinoma of cervix (SCCC) is a rare disease with highly aggressive behaviour and is pathologically hard to diagnose.In this study, the clinicopathological features, diagnosis, treatment and prognosis of the condition were examined.Clinical records and follow-up data of 7 cases of SCCC were retrospectively studied.Our results showed that five non-recurrent cases initially presented irregular vaginal bleeding or increased apocenosis of varying degrees.Pathological examination revealed that the stroma was diffusely infiltrated with small monomorphous cells ranging from round to oval shape.Three cases were immunohistochemically confirmed.One case was accompanied with squamous cell cancer.Of the 7 cases, one case was classified as stage Ⅰb 1, two stageⅠ b2, one stage Ⅱ a, one stage Ⅱb , and one stage Ⅲ b.On the basis of their stages of condition, one subject with stage III b underwent chemotherapy, and one with stage Ib2 received extensive hysterectomy plus pelvic lymphadenectomy, while the other 5 cases were treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.Of the 7 patients, 4 had relapse-free survival of 14, 14, 16 and 28 months respectively.It is concluded that SCCC is an aggressive tumor with propensity for early pelvis lymph node metastases.Early-stage patients should be treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.
文摘宫颈小细胞神经内分泌癌(small cell neuroendocrine carcinoma of the cervix,SCNCC)早期易发生淋巴转移,病理表现独特,易复发,预后差。报告1例SCNCCⅢC1r期病例资料,患者因间断性阴道出血伴下腹痛1个月余就诊,结合盆腔磁共振成像、全腹CT及宫腔镜活检结果诊断为SCNCCⅢC1r期,根据2022年美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)指南,结合该患者病情,给予患者3个周期的卡铂+依托泊苷新辅助化疗,后行腹腔镜下广泛性子宫切除术+双侧卵巢切除术+双侧输卵管切除术+盆腔淋巴结清扫术+腹主动脉旁淋巴结切除术+抗肿瘤药物腹腔灌注治疗(奈达铂冲洗腹腔)+双侧输尿管支架植入术,术后继续化疗3个周期,术后随访13个月未见复发。
文摘目的:通过文献复习探讨宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理特点、生物学行为、治疗及预后情况。方法:应用检索Meta Med及CHKD期刊全文数据库检索系统,以"宫颈恶性肿瘤、小细胞癌和神经内分泌癌"为关键词,分别或联合检索1998-01-2008-06的相关文献80篇。纳入标准:1)组织发生;2)临床病理特点;3)化疗、放疗和综合治疗疗效;4)预后分析。根据纳入标准,精选59篇文献,最后纳入分析28篇文献。结果:SCCC是一种罕见的宫颈原发恶性肿瘤,与普通的子宫颈癌相比,SCCC具有高度侵袭性,常早期发生远处转移和局部复发,预后差。正确的临床诊断需联合光镜、电镜和免疫组化检查。因发病率低和各中心累积的病例数有限,目前尚无规范的治疗方法。手术是治疗早期SCCC的重要手段,同步放化疗可用于治疗晚期SCCC患者,联合化疗和放疗可能改善预后。临床期别是决定预后的重要因素。结论:SCCC预后差,强调早期诊断和综合治疗,由于SCCC罕见,需长时间才能积累一定数量的患者资料,建议通过多中心协作以探求最佳的治疗方案。
文摘目的探讨子宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理学特征、免疫表型、与人乳头瘤病毒(human papilloma virus,HPV)的关系及预后。方法采用免疫组化En Vision法对35例SCCC进行检测及PCR法进行HPV检测并分型。结果患者年龄29~76岁,中位年龄47岁。临床表现主要为不规则阴道出血。组织学上28例为单纯型小细胞癌,7例合并其他类型癌或癌前病变。镜下见小而深染的圆形或短梭形肿瘤细胞,呈巢状或条索状排列,胞质稀少,核仁不明显,坏死及核分裂象多见。免疫表型:神经内分泌标志物NSE(30/35)、CD56(27/35)、Syn(28/35)、CgA(20/35)阳性;其他标志物p16(29/35)、PAX-8(3/35)、TTF-1(15/35)及p63(12/35)阳性;Ki-67增殖指数均>50%。27例HPV检测结果为阳性,8例为阴性。29例随访时间3个月~6年,4例复发或转移,8例死亡。结论 SCCC组织学形态与其他部位小细胞癌类似,其发病与高危型HPV感染相关;常表达p16及TTF-1,PAX-8多呈阴性;预后差。