The pancreas exerts endocrine and exocrine functions in energy balance.The neural innervation and immune milieu are both crucial in supporting pancreatic homeostasis.The neuronal network connects the pancreas with the...The pancreas exerts endocrine and exocrine functions in energy balance.The neural innervation and immune milieu are both crucial in supporting pancreatic homeostasis.The neuronal network connects the pancreas with the central nervous system(CNS)and the enteric nervous system(ENS)and sustains metabolic activities.The nerves in the pancreas are categorized as spinal sensory afferent fibers,vagal sensory afferent nerves,autonomic fibers of both sympathetic and parasympathetic divisions,and fibers from the ENS and intrapancreatic ganglia.They innervate different regions and various cell types,which collectively determine physiological functions.Studies have established that the diverse pathological conditions,including pancreatitis,diabetes,and pancreatic tumor,are attributed to aberrant immune reactions;however,it is largely not clear how the neuronal network may influence the disease conditions.Enlightened by the recent advances illuminating the organ-wide neuronal architecture and the dysfunctions in pancreatic disorders,this review will highlight emerging opportunities to explore the cellular interrelationship,particularly the neuroimmune components in pancreatic health and diseases.展开更多
基金supported by the National Natural Science Foundation of China(32225019,3239400331822018,31770936)the National Key R&D Program of China(2023YFC2306300)+2 种基金Beijing Natural Science Foundation(5222010)the Tsinghua University(School of Medicine)-Xiamen Changgeng Hospital Co Ltd Joint Research Center for Anaphylactic Diseasesupported by the Center for Life Sciences,the Institute for Immunology,and School of Medicine at Tsinghua University.
文摘The pancreas exerts endocrine and exocrine functions in energy balance.The neural innervation and immune milieu are both crucial in supporting pancreatic homeostasis.The neuronal network connects the pancreas with the central nervous system(CNS)and the enteric nervous system(ENS)and sustains metabolic activities.The nerves in the pancreas are categorized as spinal sensory afferent fibers,vagal sensory afferent nerves,autonomic fibers of both sympathetic and parasympathetic divisions,and fibers from the ENS and intrapancreatic ganglia.They innervate different regions and various cell types,which collectively determine physiological functions.Studies have established that the diverse pathological conditions,including pancreatitis,diabetes,and pancreatic tumor,are attributed to aberrant immune reactions;however,it is largely not clear how the neuronal network may influence the disease conditions.Enlightened by the recent advances illuminating the organ-wide neuronal architecture and the dysfunctions in pancreatic disorders,this review will highlight emerging opportunities to explore the cellular interrelationship,particularly the neuroimmune components in pancreatic health and diseases.
