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Flashback phenomenon and residual neurological deficits after the use of "bath salt" 3, 4-methylenedioxypyrovalerone
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作者 Aaron R.Mangold Thomas P Bravo +2 位作者 Stephen J.Traub Steven A.Maher Christopher A.Lipinski 《World Journal of Emergency Medicine》 CAS 2014年第1期63-66,共4页
BACKGROUND: The use and abuse of designer drugs has been recognized for decades; however there are many derivatives of compounds that make their way into the community. Abuse of compound(s) known on the street as &quo... BACKGROUND: The use and abuse of designer drugs has been recognized for decades; however there are many derivatives of compounds that make their way into the community. Abuse of compound(s) known on the street as "bath salt" is on the rise.METHODS: We report the case of a 33-year-old man who complained of "flashbacks" and right arm shaking that followed a night of "bath salt" snorting. The active compound methylenedioxypyrovalerone methamphetamine(MDPV) was confirmed; however, analysis of three different "bath salt" products showed difference in their active components.RESULTS: The patient's symptoms remained stable and he was discharged home after observation in the emergency department with instructions to return for any symptom progression.CONCLUSION: Practitioners should be aware of the abuse of the compounds and that not all "bath salt" products contain MDPV. 展开更多
关键词 Residual neurological deficits Methylenedioxypyrovalerone methamphetamine Emergency Department
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Steel bar penetrating cervical spinal canal without neurological injury:A case report
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作者 Qin Zhang Tao Ding +1 位作者 Xiao-Feng Gu Yi Liu 《World Journal of Clinical Cases》 SCIE 2024年第17期3214-3220,共7页
BACKGROUND We report a rare case of cervical spinal canal penetrating trauma and review the relevant literatures.CASE SUMMARY A 58-year-old male patient was admitted to the emergency department with a steel bar penetr... BACKGROUND We report a rare case of cervical spinal canal penetrating trauma and review the relevant literatures.CASE SUMMARY A 58-year-old male patient was admitted to the emergency department with a steel bar penetrating the neck,without signs of neurological deficit.Computed tomography(CT)demonstrated that the steel bar had penetrated the cervical spinal canal at the C6–7 level,causing C6 and C7 vertebral body fracture,C6 left lamina fracture,left facet joint fracture,and penetration of the cervical spinal cord.The steel bar was successfully removed through an open surgical procedure by a multidisciplinary team.During the surgery,we found that the cervical vertebra,cervical spinal canal and cervical spinal cord were all severely injured.Postoperative CT demonstrated severe penetration of the cervical spinal canal but the patient returned to a fully functional level without any neurological deficits.CONCLUSION Even with a serious cervical spinal canal penetrating trauma,the patient could resume normal work and life after appropriate treatment. 展开更多
关键词 Cervical spinal canal Penetrating trauma Steel bar neurological deficit Case report
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Effect of comprehensive nursing on swallowing function and quality of life in patients with ischemic stroke
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作者 Bo Zhou Lim Gek Mui 《World Journal of Clinical Cases》 SCIE 2024年第19期3657-3661,共5页
Hu et al explored the impact of comprehensive nursing model on swallowing function and quality of life in patients with ischemic stroke.They divided 172 patients into the control group(routine care)and the research gr... Hu et al explored the impact of comprehensive nursing model on swallowing function and quality of life in patients with ischemic stroke.They divided 172 patients into the control group(routine care)and the research group(comprehensive care),and used standard scales to evaluate the swallowing function,neurological deficit,anxiety and depression,daily living ability,and exercise of the two groups of patients before and after care.Changes in indicators of function,quality of life,and compliance.The results showed that compared with the control group,patients in the study group achieved significant improvements in various indicators,with a lower incidence of adverse reactions and higher satisfaction with care.These data suggest that the comprehensive nursing model can significantly improve the swallowing function,quality of life and satisfaction of patients with ischemic stroke.In the future,the development of comprehensive nursing models needs to focus on technological innovation,humanized services,continuing education and training,multi-disciplinary collaboration,optimal allocation of resources,standardized practice and evaluation,etc.,in order to improve nursing effects and promote the improvement of medical service quality. 展开更多
关键词 Ischemic stroke Comprehensive nursing Swallowing function Quality of life neurological deficit
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Herpes Simplex Virus Encephalitis Complicated by Acute Ischemic Stroke
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作者 Simona Zlatanova Oliana Boykinova 《Advances in Infectious Diseases》 CAS 2024年第2期387-392,共6页
Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly i... Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly in patients with clinically suspected viral encephalitis before serological confirmation of the diagnosis. Despite antiviral treatment, it is associated with significant mortality and a wide range of neurologic sequelae or neuropsychiatric disorders. Clinical presentation includes fever, headache, altered mental status, and focal or generalized seizures. In some cases, it can present with focal neurological deficits, such as an acute stroke. The aim of this study is to identify rare complications of HSVE. Presentation: We present a case of a 71-year-old female patient with herpes virus encephalitis and an ischemic cerebral accident. The findings of CT scan of the brain revealed an extensive right temporal hypodensity. CSF findings include an elevated protein level, normal glucose level and pleocytosis with lymphocyte predominance. The lumbar tap confirmed the presence of herpes simplex virus type 1 with polymerase chain reaction (PCR) in the CSF. Neurological manifestations include focal neurological deficit with left-sided hemiparesis and coma. After 40 days of complex therapy, an improvement in the mental state was observed. Conclusion: There are varying degrees of neurologic sequelae among survivors in children and adults despite the antiviral treatment. Herpes simplex encephalitis has significant morbidity and high mortality due to the lack of prophylactic treatment and preventable strategies. 展开更多
关键词 Herpes Virus Encephalitis Focal neurological Deficit Altered Mental Status Stroke Chameleon Persistently Positive CSF
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CLINICAL STUDY ON THE TREATMENT OF ACUTE CEREBRAL INFARCTION WITH ACUPUNCTURE COMBINED WITH MEDICINES
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作者 朱首豪 沈庆伟 +2 位作者 林敉祥 王少贞 张庆臣 《World Journal of Acupuncture-Moxibustion》 2005年第3期8-12,共5页
Objective: To observe the therapeutic effect of acupuncture combined with medicines for acute cerebral infarction and to study its mechanism. Methods; A total of 80 acute cerebral infarction patients were evenly rand... Objective: To observe the therapeutic effect of acupuncture combined with medicines for acute cerebral infarction and to study its mechanism. Methods; A total of 80 acute cerebral infarction patients were evenly randomized into treabnent and control groups. Patients of treatment group were treated with acupuncture of Baihui (百会 GV 20), Fengchi (风池 GB 20), Jiquan (极泉 HT 1 ), Neiiguen ( 内关 PC 6), etc. and those of control group treated with conventional medicines as low molecular dextran, compound Red Sage injection, Citicolinum, etc. Scores of clinical neurological deficits, blood flow velocity peak (Vp) and mean blood flow velocity (Vm) of the bilateral internal carotid artery (ICA), middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), basilar artery (BA) and vertebral artery (VA) were detected with transcranial Doppler (TCO) were analyzed before and after treatment. Results: After 12 days' treatment, the neurological deficit scores in both treatment and control groups decreased significantly, and the difference values of the score of the former group was significantly bigger than these of the later group (P〈0.01). Vp and Vm of all the detected arteries in treatment group and bilateral ACA, MCA and PCA of control group increased significantly in comparison with pre-treatment (P〈0.05, P〈0.01) ; and the difference values of Vm of bilateral MCA and VA (between post- and pre-treatment) of treatment group were significantly bigger than those of control group (P〈0.01). Conclusion; The therapeutic effect of acupuncture combined with medication is significantly superior to that of simple medication in the treatment of acute cerebral infarction. 展开更多
关键词 Cerebral infarction Acupuncture therapy neurological deficits Cerebral blood flow
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Immediate effects of scalp acupuncture with twirling reinforcing manipulation on hemiplegia following acute ischemic stroke: a hidden association study 被引量:28
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作者 Xiao-zheng Du Chun-ling Bao +1 位作者 Gui-rong Dong Xu-ming Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第5期758-764,共7页
Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we p... Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui(GV20) and Taiyang(EX-HN5). We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave(Hmax/Mmax), muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of "Deficiency and Excess". The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper and lower limbs, reflected by the variation in the Hmax/Mmax ratio, is crucial for recovery of motor function from hemiplegia. 展开更多
关键词 nerve regeneration traditional Chinese medicine needling reinforcing manipulation hemiplegia due to acute ischemic stroke im- mediate effect association algorithm artificial neural network algorithm neurological deficit score simplified Fugl-Meyer assessment Hmax/Mmax traditional Chinese medicine syndromes scalp acupoints neural regeneration
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Use of various CT imaging methods for diagnosis of acute ischemic cerebrovascular disease 被引量:21
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作者 Gang Wang Xue Cheng Xianglin Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第7期655-661,共7页
Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perf... Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perfusion imaging, 29 cases in the cerebral infarction group and 10 cases in the transient ischemic attack group presented with abnormal blood flow perfusion, which corresponded to the clinical symptoms. By CT angiography, various degrees of vascular stenosis could be detected in 41 patients, including 33 in the cerebral infarction group and eight in the transient ischemic attack group. The incidence of intracranial artery stenosis was higher than that of extracranial artery stenosis. The intracranial artery stenosis was located predominantly in the middle cerebral artery and carotid artery siphon, while the extracranial artery stenosis occurred mainly in the bifurcation of the common carotid artery and the opening of the vertebral artery. There were 34 cases (83%) with convict vascular stenosis and perfusion abnormalities, and five cases (45%) with perfusion abnormalities but without convict vascular stenosis. The incidence of cerebral infarction in patients with National Institutes of Health Stroke Scale scores 〉 5 points during onset was significantly higher than that in patients with National Institutes of Health Stroke Scale scores 〈 5 points. These experimental findings indicate that the combined application of various CT imaging methods allows early diagnosis of acute ischemic cerebrovascular disease, which can comprehensively analyze the pathogenesis and severity of acute ischemic cerebrovascular disease at the morphological and functional levels. 展开更多
关键词 neural regeneration NEUROIMAGING clinical practice multi-slice spiral CT CT perfusion imaging CTangiography ischemic cerebrovascular disease DIAGNOSIS cerebraJ infarction transient ischemicattack perfusion neurological function deficit grants-supported paper photographs-containingpaper NEUROREGENERATION
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Changes in synapse quantity and growth associated protein 43 expression in the motor cortex of focal cerebral ischemic rats following catalpol treatment 被引量:10
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作者 Dong Wan Huifeng Zhu +1 位作者 Yong Luo Peng Xie 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第18期1380-1385,共6页
The present study investigated the effects of catalpol, the main constituent of the Chinese herb Rehmannia root, on neurons following brain ischemia, A rat model of focal permanent brain ischemia was established using... The present study investigated the effects of catalpol, the main constituent of the Chinese herb Rehmannia root, on neurons following brain ischemia, A rat model of focal permanent brain ischemia was established using electrocoagulation, The rats were intrapedtoneally injected with catalpol, at a dose of 5 mg/kg, daily for 1 week, Results showed that the number of neuronal synapses in the motor cortex and growth associated protein 43 expression were increased following catalpol treatment, indicating that catalpol might contribute to neuroplasticity and ameliorate functional neurological deficits induced by cerebral ischemia. 展开更多
关键词 CATALPOL growth-associated protein 4:3 neurological function permanent middle cerebral artery occlusion behavioral assessment neurological deficit NEUROPLASTICITY neural regeneration
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Lumbopelvic Fixation and Sacral Decompression for U-shaped Sacral Fractures: Surgical Management and Early Outcome 被引量:9
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作者 Yuan-long XIE Lin CAI +4 位作者 An-song PING Jun LEI Zhou-ming DENG Chao HU Xiao-bing ZHU 《Current Medical Science》 SCIE CAS 2018年第4期684-690,共7页
U-shaped sacral fractures are rare and often difficult to diagnose primarily due to the difficulty in obtaining adequate imaging and the severe associated injuries. These fractures are highly unstable and frequently c... U-shaped sacral fractures are rare and often difficult to diagnose primarily due to the difficulty in obtaining adequate imaging and the severe associated injuries. These fractures are highly unstable and frequently cause neurological deficits. The majority of surgeons have limited experience in management of U-shaped sacral fractures. No standard treatment protocol for U-shaped sacral fractures has been available till now. This study aimed to examine the management of U-shaped sacral fractures and the early outcomes. Clinical data of 15 consecutive patients with U-shaped sacral fracture who were admitted to our trauma center between 2009 and 2014 were retrospectively analyzed. Demographics, fracture classification, mechanism of injury and operative treatment and deformity angle were assessed. All the patients were treated with lumbopelvic fixation or (and) sacral decompression. EQ-5d score was applied to evaluate the patients' quality of life. Of the 15 consecutive patients with U-shaped sacral fracture, the mean age was 28.8 years (range: 15-55 years) at the time of injury. There were 6 females and 9 males. The mean follow- up time was 22.7 months (range: 9-47 months) and mean full weight-bearing time was 9.9 weeks (range: 8-14 weeks). Ten patients received lumbopelvic fixation and sacral decompression, one lombosacral fixation, and 4 merely sacral decompression due to delayed diagnosis or surgery. The post-operation deformity angle (mean 27.87°, and range: 8°-90°) of the sacrum was smaller than that pre-operation (mean 35.67; range: 15-90) with no significance difference noted. At the latest follow-up, all patients obtained neurological recovery with different extents. Visual analogue score (VAS) was reduced from preoperative 7.07 (range: 5-9) to postoperetive 1.93 (range: 1-3). All patients could walk without any aid after treatment. Eight patients were able to care for themselves and undertook some daily activities. Five patients had returned to work full time. In conclusion, lumbopelvic fixation is an effective method for stabilization of U-shaped sacral fractures with fewer complications developed. Effective reduction and firm fixation are the prerequisite of early mobilization and neurological recovery. Sacral decompression effectively promotes neurological recovery even in patients with old U-shaped sacral fractures. 展开更多
关键词 lumbopelvic fixation sacral decompression U-SHAPED sacral fractures neurological deficit surgical management
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Effects of tanshinone Ⅱ sodium sulfonate plus cinepazide maleate on the hemorrheologic indexes and blood lipids in patients with acute cerebral infarction 被引量:3
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作者 Chunliang Li Mingzhu Zhang +1 位作者 Haijun Zheng Fengzhi Xue 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第4期225-229,共5页
BACKGROUND: The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia, etc. Thus it has become one of the target for treating cerebral inf... BACKGROUND: The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia, etc. Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine. OBJECTIVE: To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction, and compare the results with those of simple cinepazide maleate treatment. DESIGN: A non-randomized case-controlled observation. SETTINGS: Hebei North University; the Second Affiliated Hospitals of Hebei North University; the Third Affiliated Hospitals of Hebei North University, PARTICIPANTS: Eighty-six inpatients with cerebral infarction were selected from the infirmary, the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006. They were all diagnosed to have acute cerebral infarction by CT or MRI, and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995. Meanwhile, 40 teachers and medical staff of voluntary physical examinees were selected as the control group. Informed contents were obtained from all the patients and their relatives. METHODS: The patients were divided into combined treatment group (n=43) and simple treatment group (n=3). In the combined treatment group, the patients were administrated with 160 mg cinepazide maleate injection (Beijing Four-ring Pharmaceutical, Co.,Ltd, No. H200220125; 80 mg/2 mL) added in 5% glucose, and 40 mg tanshinone Ⅱ sodium sulfonate (Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd., No. H31022558, 10 mg/2 mL) added in 250 mL normal saline. In the simple treatment group, the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline. They were treated for 1 or 2 courses, once a day, and 14 days as a course. The patients were detected before treatment and at 14 and 28 days after treatment respectively. ① Determination of hemorrheologic indexes: Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter; Plasma viscosity with LBY-F200B automatic plasma viscosity meter; Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction. ② Determination of blood lipids: The serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were determined. ③ Severity of neurological deficit: The total score of neurological deficit score (NDS) ranged from 0 to 45 points, 0 - 15 points was taken as mild, 16 - 30 points as moderate and 31 - 45 points as severe.④ Evaluation of curative effects: Generally cured: NDS decreased by 91% - 100%, and disabled severity of grade 0; Significantly improved: NDS decreased by 46% - 90%, and disabled severity of grades 1 - 3; Improved: NDS decreased by 18% - 45%; No change: NDS decreased by less than 18%; Aggravated: NDS increased by more than 18%. Generally cured and significant improved were taken as significant effect. ⑤ The adverse events and side effects after medication were observed. MAIN OUTCOME MEASURES: ① Results of hemorrheologic indexes and blood lipids; ② NDS results in the combined treatment group and simple treatment group; ③ Therapeutic effects and adverse events. RESULTS: All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results. ① Results of hemorrheologic indexes and blood lipids: The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group; The hemorrheologic indexes after treatment were obviously improved in both groups. But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group (P 〈 0.05); The levels of TC, TG and LDL-C after treatment in the combined treatment group were obviously lowered (P 〈 0.05), whereas those in the simple treatment group were not significantly changed (P 〉 0.05). ② NDS results: The NDS scores at 14 and 28 days after treatment in the combined treatment group [(6.23±2.34), (4.27± 1.83) points] were obviously lower than those in the simple treatment group [(8.76±3.41), (6.65±2.49) points, P 〈 0.05]. ③ Therapeutic effects and side effects: The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively. In the combined treatment group, 1 case suffered from palpitation, dizziness and agrypnia. In the simple treatment group, 1 case suffered from palpitation, dizziness and agrypnia, 1 case had itch of skin. All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower. No drug withdrawal occurred in the patients due to the adverse events. CONCLUSION: Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction, and its curative effect is faster than that of simple cinepazide maleate treatment. 展开更多
关键词 cinepazide maleate TANSHINONE cerebral infarction neurological deficit score (NDS) hemorrheologic blood lipid curative effect
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Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke 被引量:21
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作者 Yi-hao Deng Hong-yun He +1 位作者 Li-qiang Yang Peng-yue Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第7期1108-1114,共7页
The temporal dynamics of neuronal autophagy and apoptosis in the ischemic penumbra following stroke remains unclear.Therefore,in this study,we investigated the dynamic changes in autophagy and apoptosis in the penumbr... The temporal dynamics of neuronal autophagy and apoptosis in the ischemic penumbra following stroke remains unclear.Therefore,in this study,we investigated the dynamic changes in autophagy and apoptosis in the penumbra to provide insight into potential therapeutic targets for stroke.An adult Sprague-Dawley rat model of permanent ischemic stroke was prepared by middle cerebral artery occlusion.Neuronal autophagy and apoptosis in the penumbra post-ischemia were evaluated by western blot assay and immunofluorescence staining with antibodies against LC3-Ⅱ and cleaved caspase-3,respectively.Levels of both LC3-Ⅱ and cleaved caspase-3 in the penumbra gradually increased within 5 hours post-ischemia.Thereafter,levels of both proteins declined,especially LC3-Ⅱ.The cerebral infarct volume increased slowly 1–4 hours after ischemia,but subsequently increased rapidly until 5 hours after ischemia.The severity of the neurological deficit was positively correlated with infarct volume.LC3-Ⅱ and cleaved caspase-3 levels were high in the penumbra within 5 hours after ischemia,and after that,levels of these proteins decreased at different rates.LC3-Ⅱ levels were reduced to a very low level,but cleaved caspase-3 levels remained high 72 hours after ischemia.These results indicate that there are temporal differences in the activation status of the autophagic and apoptotic pathways.This suggests that therapeutic targeting of these pathways should take into consideration their unique temporal dynamics. 展开更多
关键词 neuronal autophagy permanent infarct deficit caspase neurological targeting occlusion unclear
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Effect of post-stroke sensory disorders on the recovery processes of motor function and activity of daily living A non-randomized synchronical controlled trial 被引量:1
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作者 Junfeng Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第12期744-746,共3页
BACKGROUND: In the rehabilitation of stroke patients, clinicians usually concentrate on motor problems, such as spasm of limbs and restriction of joint motion, while sensory and perceptive problems are almost always ... BACKGROUND: In the rehabilitation of stroke patients, clinicians usually concentrate on motor problems, such as spasm of limbs and restriction of joint motion, while sensory and perceptive problems are almost always neglected, although they are just as important. One such area is the sensory disorder. OBJECTIVE: To evaluate the motor function and activities of daily living in stroke patients with and without sensory disorders after treatment of integrated western and Chinese medicine. DESIGN: A non-randomized synchronically controlled trial. SETTING: First Affiliated Hospital of Tianjin College of Traditional Chinese Medicine. PARTICIPANTS: Totally 500 stroke inpatients were selected from the Department of Acupuncture and Massage, the First Affiliated Hospital of Tianjin College of Traditional Chinese Medicine from January 2003 to December 2004. They all had suffered from stroke in the last 4 weeks and accompanied by sensory disorder of the ipsilateral limb to different severity. The patients were all accorded with the Diagnostic and Efficacy Evaluative Standards for Stroke (in trial) set by the Encephalopathy Emergency Assistant Group, the State Administration of Traditional Chinese Medicine in 1995, and they were diagnosed by imaging examination. The patients were stratified into sensory disorder group (n =220) and normal sense group (n =280). Informed consent for the detected items and therapeutic program was obtained from the relatives of all the participants. The study was approved by the hospital ethical committee. METHODS: All the patients were treated with acupuncture of Xing Nao Kai Qiao for restoring consciousness and inducing resuscitation, assisted by traditional Chinese medicine and western medicine specific to corresponding symptoms. The therapeutic principles were restoring consciousness and inducing resuscitation, nourishing liver and kidney, and dredging meridian. In addition, the patients were given western medical treatments for decreasing intracranial pressure, thrombolysis, reducing blood viscosity, anticoagulation, anti-arteriosclerosis, ameliorating microcirculation, also administrated with activator for nerve cells. MAIN OUTCOME MEASURES: (1) The severity of motor function deficit was evaluated using clinical neurological deficit score for stroke patients set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995; (2) The activities of daily living was evaluated with Barthel Index, the higher the score, the better the independence, and the less the dependence. RESULTS: All the 500 stroke patients were involved in the final analysis of results. (1) The neurological deficit scores before treatment had no significant difference between the two groups (P 〉 0.05), but the scores after treatment were significantly decreased as compared with those before treatment in both groups (t =6.59, 12.43, P 〈 0.01). The neurological deficit score after treatment in the normal sense group was significantly lower than that in the sensory disorder group (t =1.63, P 〈 0.05). (2) The scores of activities of daily living after treatment were significantly increased as compared with those before treatment in both groups (t =16.03, 25.10, P 〈 0.01). The scores of activities of daily living in the normal sense group were higher than those in the sensory disorder group both before and after treatment (t =6.07, 14.26, P 〈 0.05). CONCLUSION: Sensory disorders have obvious negative effects on the recovery of motor function and activities of daily living of stroke patients. 展开更多
关键词 STROKE sensory disorder neurological deficit score activities of daily living
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SURGICAL TREATMENT OF METASTATIC SPINAL TUMOR 被引量:1
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作者 徐宏光 王以朋 +2 位作者 邱贵兴 叶启彬 张嘉 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第3期183-188,共6页
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关键词 metastatic cancer spinal pain neurologic deficit surgery Objectives. To evaluate the effect of surgical treatment on metastatic spinal tumor.Methods. The results of surgical intervention for metastatic spinal tumor of 31 consecutive
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Generalized seizure, the only manifestation of a small ischemic atherothrombotic infarction 被引量:2
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作者 Assadollahi Marjan Ramezani Mahtab +1 位作者 Karimialavijeh Ehsan Mirfazaelian Hadi 《World Journal of Emergency Medicine》 CAS 2016年第1期71-73,共3页
BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological deficit.Presentation of a small ischemic atherothr... BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological deficit.Presentation of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very rare.METHODS:We reported a patient with acute small ischemic atherothrombotic infarction associated with an episode of generalized tonic-clonic seizure,a rare clinical manifestation in this type of stroke.The patient was treated with anti-epileptic therapy after admission.RESULTS:The patient was discharged with oral administration of phenytoin 100 mg TDS,aspirin 80 mg daily,and atorvastatin 40 mg daily.CONCLUSION:Small ischemic atherothrombotic infarction can present only with a seizure without any focal neurological deficit. 展开更多
关键词 Small ischemic atherothrombotic infarction SEIZURE neurological deficit
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Ischemia and reperfusion injury of the spinal cord:experimental strategies to examine postischemic paraplegia 被引量:3
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作者 Florian Simon Alexander Oberhuber 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第3期414-415,共2页
Thoracoabdominal aortic replacement,necessary in case of injuries,aneurysms and dissections,shows a high complication rate as a consequence of the perioperative ischemia/reperfusion-sequence(I/R).Clamping above and ... Thoracoabdominal aortic replacement,necessary in case of injuries,aneurysms and dissections,shows a high complication rate as a consequence of the perioperative ischemia/reperfusion-sequence(I/R).Clamping above and below the lesion leads to the spinal cord suffering from ischemia.Clamping times of less than 30 minutes show only a small risk of neurological deficit, 展开更多
关键词 deficit minutes neurological replacement injuries suffering consequence longer thoracic subsequent
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Total flavonoid of Litsea coreana leve exerts anti-oxidative effects and alleviates focal cerebral ischemia/reperfusion injury
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作者 Shuying Dong Xuhui Tong +4 位作者 Jun Li Cheng Huang Chengmu Hu Hao Jiao Yuchen Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第34期3193-3202,共10页
In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of foc... In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive control drug. Results of neurological deficit scoring, 2,3,5-triphenyl tetrazolium chloride staining, hematoxylin-eosin staining and biochemical tests showed that TFLC at different doses significantly alleviated cerebral ischemia-induced neurological deficits and histopathological changes, and reduced infarct volume. Moreover, it suppressed the increase in the levels of nitrates plus nitrites, malondialdehyde and lactate dehydrogenase, and it diminished the reduction in glu- tathione, superoxide dismutase and catalase activities induced by cerebral ischemia/reperfusion injury. Compared with edaravone, the protective effects of TFLC at low and medium doses (25, 50 mg/kg) against cerebral ischemia/reperfusion injury were weaker, while the protective effects at high dose (100 mg/kg) were similar. Our experimental findings suggest that TFLC exerts neuroprotective effects against focal cerebral ischemia/reperfusion injury in rats, and that the effects may be asso- ciated with its antioxidant activities. 展开更多
关键词 neural regeneration total flavonoids of Litseainjury oxidative stress NEUROPROTECTION coreana leve focal cerebral ischemia/reperfusioninfarct volume neurological deficit scores MALONDIALDEHYDE GLUTATHIONE superoxide dismutase grants-supported paper NEUROREGENERATION
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Plasma level of neuron specific enolase in patients with acute cerebral infarction:A case-control study
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作者 Guoping Tian Yang Zhang Weiping Cheng 《Neural Regeneration Research》 SCIE CAS CSCD 2009年第1期62-66,共5页
BACKGROUND: The plasma level of neuron specific enolase (NSE) can be used to diagnose and evaluate neuronal injury and predict early prognosis. OBJECTIVE: To observe the dynamic changes in plasma levels of NSE in ... BACKGROUND: The plasma level of neuron specific enolase (NSE) can be used to diagnose and evaluate neuronal injury and predict early prognosis. OBJECTIVE: To observe the dynamic changes in plasma levels of NSE in patients with acute cerebral infarction, and to investigate its correlations with disease severity and prognosis. DESIGN, TIME AND SETTING: This non-randomized, concurrent case-control experiment was performed at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007. PARTICIPANTS: Eighteen patients with acute cerebral infarction, who received treatment at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007, were recruited into the patient group. An additional 10 healthy individuals, who received health examinations simultaneously, were included as controls. METHODS: Following admission (within 3 days) and at days 6, 12, and 30 subsequent to acute cerebral infarction attack, 3 mL venous blood was taken from each patient before the morning meal to determine the plasma level of NSE by enzyme-labeled immunosorbent assay. One-time blood extraction was performed in each healthy subject during the health examination for the same purpose as in patients. At 6 and 30 days following acute cerebral infarction attack, CT examination was performed for calculation of cerebral infarction volume according to the Tada formula. Following admission and at 30 days of disease invasion, all patients were scored by the National Institutes of Health Stroke Scale (NIHSS, 13 items). MAIN OUTCOME MEASURES: Comparison of NSE plasma level between acute cerebral infarction patients and healthy individuals; correlations of NSE plasma level in acute cerebral infarction patients with cerebral infarction volume, NIHSS score, and prognosis. RESULTS: Following admission and at days 6 and 12 of disease invasion, the plasma level of NSE was significantly higher in the patient group than in the control group (P 〈 0.05). Following admission and at day 30 of disease invasion, the NIHSS scores of the patient group were 17.706 and 11.222, respectively. Following admission and at day 6 of disease invasion, the plasma level of NSE was positively correlated with cerebral infarction volume (r = 0.503, 0.435, P 〈 0.05), but it was negatively correlated with NIHSS score (r = -0.571, 0.368, P 〈 0.05). The plasma level of NSE was mostly correlated with cerebral infarction volume, followed by NIHSS score, and lastly prognosis, with regression coefficients of 0.386, 0.343, and 0.340, respectively. CONCLUSION: The plasma level of NSE is higher in patients with acute cerebral infarction than in the healthy population. It can reflect infarct severity and predict early prognosis of acute cerebral infarction. 展开更多
关键词 neuron specific enolase acute cerebral infarction PROGNOSIS functional neurological deficit
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Magnetic resonance perfusion imaging evaluation in perfusion abnormalities of the cerebellum after supratentorial unilateral hyperacute cerebral infarction
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作者 Pan Liang Yunjun Yang +3 位作者 Weijian Chen Yuxia Duan Hongqing Wang Xiaotong Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第12期906-911,共6页
Magnetic resonance imaging (MRI) data of 10 patients with hyperacute cerebral infarction (≤6 hours) were retrospectively analyzed.Six patients exhibited perfusion defects on negative enhancement integral maps,fou... Magnetic resonance imaging (MRI) data of 10 patients with hyperacute cerebral infarction (≤6 hours) were retrospectively analyzed.Six patients exhibited perfusion defects on negative enhancement integral maps,four patients exhibited perfusion differences in pseudo-color on mean time to enhance maps,and three patients exhibited perfusion differences in pseudo-color on time to minimum maps.Dynamic susceptibility contrast-enhanced perfusion weighted imaging revealed a significant increase in region negative enhancement integral in the affected hemisphere of patients with cerebral infarction.The results suggest that dynamic susceptibility contrast-enhanced perfusion weighted imaging can clearly detect perfusion abnormalities in the cerebellum after unilateral hyperacute cerebral infarction. 展开更多
关键词 magnetic resonance imaging magnetic resonance-perfusion-weighted imaging cerebral infarction cerebral perfusion functional neurological deficit
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Thoracic pyogenic infectious spondylitis presented as pneumothorax:A case report
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作者 Mi-Kyung Cho Byeong-Ju Lee +1 位作者 Jae-Hyeok Chang Young-Mo Kim 《World Journal of Clinical Cases》 SCIE 2021年第6期1402-1407,共6页
BACKGROUND Pyogenic infectious spondylitis(PIS)is a rare condition,with an incidence between 0.2 and 2 cases per 100000 per annum.It’s most common symptom-back or neck pain-occurs in more than 90%of cases.Herein,we r... BACKGROUND Pyogenic infectious spondylitis(PIS)is a rare condition,with an incidence between 0.2 and 2 cases per 100000 per annum.It’s most common symptom-back or neck pain-occurs in more than 90%of cases.Herein,we reported a case of thoracic PIS accompanied by pneumothorax in a 65-year-old male patient.CASE SUMMARY A 65-year-old man presented with right chest pain and dyspnea.The initial erect posteroanterior chest radiography revealed pneumothorax,which was further evaluated by chest computed tomography,revealing pleural effusion in the right lung and a paravertebral abscess with bony destruction of vertebral body.Based on magnetic resonance imaging,the patient was diagnosed with thoracic infectious spondylitis with an anterior paravertebral abscess.He was prescribed antibiotics and underwent neurosurgery due to aggravated symptoms and neurologic deficit.Tissue examination revealed that the cause of pleural effusion and pneumothorax was Staphylococcus aureus infection contiguously spread to lung pleura.After several surgical treatments with intravenous antibiotic therapy for two months and transition to oral antibiotics(rifampin 600 mg qd and ciprofloxacin 500 mg bid),the patient received physical therapy to recover balance.One month after discharge,the patient had no chest pain or dyspnea,and exhibited no elevation in inflammatory markers or new thoracic lesions.CONCLUSION To our knowledge,this is the very first report of a case of thoracic PIS with pneumothorax. 展开更多
关键词 Chest pain PNEUMOTHORAX Pleural effusion Neurologic deficits SPONDYLITIS Case report
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The multiple effects of hyperhomocysteinemia in patients with mildto- moderate stroke
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作者 Pu Yin Xue-Cun Gu 《Life Research》 2020年第4期141-147,共7页
Background:The main purpose of this article is to explore the differences between mild-to-moderate acute stroke patients with hyperhomocysteine and similar patients with normal homocysteine in risk factors,cerebral ar... Background:The main purpose of this article is to explore the differences between mild-to-moderate acute stroke patients with hyperhomocysteine and similar patients with normal homocysteine in risk factors,cerebral arterial stenosis,neurological deficit,cognitive function impairment.The subjects included gender,body mass index,whether to combine hypertension,blood glucose level,blood lipid,national institutes of health stroke scale(NIHSS)score,whether to combine cerebral arterial stenosis and Montreal cognitive assessment scores.Method:Twentyseven mild-to-moderate acute stroke patients with hyperhomocysteinemia(NIHSS score≤15 points)and 34 mildto-moderate acute stroke patients without hyperhomocysteinemia were admitted in the past year as the research objects.N=27 stroke patients with hyperhomocysteine were set as the experimental group,and N=34 patients without hyperhomocysteine were set as the control group.A retrospective study of clinical data from both groups of patients was conducted.Compare the data of the 2 groups of patients with differences in the above study data,and then explore the specific impact of hyperhomocysteinemia on the above experimental indicators.Results:(1)NIHSS scores of patients in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).(2)The incidence of cerebrovascular stenosis(including intracranial and extracranial arteries)in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).(3)The degree of cognitive impairment in the experimental group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).(4)The proportion of male patients in the study group was significantly higher than that in the control group(P<0.05).(5)The level of homocysteine in the experimental group was positively correlated with NIHSS score(r=0.602,P<0.05)and negatively correlated with Montreal cognitive assessment score(r=−0.551,P<0.05).Conclusion:Mildto-moderate stroke patients with hyperhomocysteinemia are more likely to have severe neurological deficits,and most patients will be associated with more severe intracranial arterial and extracranial arterial stenosis.Mild-tomoderate stroke patients with high homocysteine are more likely to develop cognitive impairment.Finally,high homocysteine levels were associated with neurological impairment and cognitive impairment.Therefore,clinically,patients with acute stroke and hyperhomocysteinemia should be actively treated with hypohomocysteine,and it is recommended to improve cerebrovascular evaluation(computed tomography angiography or magnetic resonance angiography)for hospitalized patients even with hemorrhagic stroke.Stroke patients with hyperhomocysteinemia should be given more aggressive treatment(ischemic stroke patients should be given more optimized antithrombotic therapy,hemorrhagic stroke patients should be given more aggressive dehydrating cranial pressure reduction,et al.).Finally,brain protectants and cognitive function improvement therapy can be given in advance to prevent cognitive function deterioration. 展开更多
关键词 HYPERHOMOCYSTEINEMIA Cerebral arterial stenosis neurological deficit Cognitive impairment
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