In this study, there were 62 patients with depressive neurosis. AInong them, 31 caseswere treated by laseracupuncture, another 31 cases were treated by pharmacotherapy, such as Antide-pressants and Antianxietics. The ...In this study, there were 62 patients with depressive neurosis. AInong them, 31 caseswere treated by laseracupuncture, another 31 cases were treated by pharmacotherapy, such as Antide-pressants and Antianxietics. The course of treatment for each case was 21 days. The therapeutic ef-fects, which were comprehensively evaluated with Hamilton’s Depression Scale (HAMD) and Hamil-ton’s Anxiety Scale (HAMI) as well as Clinical Global Impression Scale (CGI) in combination withtraditional evaluation of clinical therapeutic effect, indicated that treating the depressive neurosis withlaser-acupuncture can obtain sound effects with a clinical effective rate of 90. 32 percent, markedly ef-fective rate of 67. 74 percent. The global scores of Hamilton’s Depression Scale and Hamilton’s Anxi-ety scale after treatment were obviously less than those before treatment (P【0.001 ), similar to theeffects of pharmacotherapy or even much better than those in pharmacotherapy group in some aspects.Treating with laser-acupuncture展开更多
77 cases of neurosis were treated with intelligent(computerized)elec-troacupuncture(IEA)and common electroacupuncture(CEA)at two different wave forms and fre-quencies.The results showed that the markedly effective rat...77 cases of neurosis were treated with intelligent(computerized)elec-troacupuncture(IEA)and common electroacupuncture(CEA)at two different wave forms and fre-quencies.The results showed that the markedly effective rates of IEA and CEA were respectively75% and 60% without a statistically significant difference.For different subtypes of neurosis,thetherapeutic effects of IEC in the treatment 6f neurasthenia and depressive neurosis were superior toand in the treatment of anxiety was inferior to those of CEA.For different syndromes,the curativeeffects of IEA on somatic symptom,depression and asthenic symptom were.superior to and on anxietyand sleep-disorder were not as good as those of CEA.展开更多
Objective:To analyze the prescription and medication rule of traditional Chinese medicine(TCM)in treating cardiac neurosis by using the software of"Traditional Chinese Medicine Inheritance Assistant Platform(V2.5...Objective:To analyze the prescription and medication rule of traditional Chinese medicine(TCM)in treating cardiac neurosis by using the software of"Traditional Chinese Medicine Inheritance Assistant Platform(V2.5)".Methods:China Journal Full-Text Database,Wanfang database,Weipu Chinese Periodical Service Platform and Chinese biomedical literature database were retrieved according to the inclusion and exclusion criteria.Literatures on the treatment of cardiac neurosis with TCM prescriptions were screened out and data mining was carried out using the TCM inheritance assistant platform.Use frequency,commonly used dose,the frequency of properties,flavors and meridian distribution were counted.Association rules and entropy clustering analysis for complex system were used to extract core drug combinations and unsupervised entropy hierarchical clustering was used to predict potential new prescriptions.Results:Through literature retrieval and screening,210 types of prescriptions were finally selected,and 181 types of Chinese herbs were extracted,with cumulative frequency of 2410 times.Among them,there were 46 traditional Chinese medicines that were used more than 15 times.According to the efficacy and indication,they were classified into qi-regulating drugs,tranquilizers,qi-tonifying drugs,heat-clearing drugs,blood-tonifying drugs,etc.According to properties,flavors,and meridian distribution,warm and sweet drugs were the most commonly used,mostly distributing to the heart meridian,followed by liver and spleen meridians.Association rules showed that combination of radix paeoniae and paeonia-bupleurum was the most used;faructus aurantii and bupleurum had the strongest correlation,up to 90%.The network diagram indicated that bupleurum,angelica sinensis,radix paeoniae radix,and poria cocos were the core of the association network.Based on complex system entropy clustering,24 core drug combinations were obtained.The unsupervised entropy hierarchical clustering algorithm was used to extract 12 core drug combinations,and 6 potential new formulae were obtained by further clustering.Conclusion:Regulating qi and blood,addressing both symptoms and causes,and using purgation and tonification at the same time is the principle of the treatment of cardiac neuropathy with TCM.The treatment mainly starts from the heart,liver and spleen,and therapies include soothing the liver and regulating qi,clearing heat and resolving phlegm,tranquilizing and calming the nerves,and prompting blood circulation and diuresis.展开更多
Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challeng...Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challenge and a disturbing necessity for Mia Couto in Voices Made Night （1990） and Bessie Head in Tales of Tenderness and Power （1989）. The position of Couto as a white Mozambican writer and Head as an exiled coloured South African writer, living in her adopted country of Botswana, provides them with privileged neutrality from which to view the effect of the admixture of grinding poverty and violence as they ravage the landscapes of these countries. While Couto does not fail to incorporate the significance of power struggle between FRELIMO （Front for the Liberation of Mozambique） and RENAMO （Mozambique National Resistance） in the ~＇oices Made Night, Head＇s articulation of the complex manipulation of power becomes a resource for constructing a discourse of nationalism in Tales of Tenderness and Power. The paper intends to focus on the correlation between power and economic development in these anthologies. The paper will further examine how political power impacts on the socio-economic well being of the local folks in the Couto＇s Mozambique and Head＇s South Africa.展开更多
Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with ca...Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.展开更多
目的:运用网状Meta分析评价中成药治疗心脏神经官能症的疗效。方法:检索PubMed、Web of Science、EMbase、the Cochrane Library、中国知网、万方、维普,从建库至2023年4月1日中成药治疗心脏神经官能症的随机对照试验。运用RoB2进行偏...目的:运用网状Meta分析评价中成药治疗心脏神经官能症的疗效。方法:检索PubMed、Web of Science、EMbase、the Cochrane Library、中国知网、万方、维普,从建库至2023年4月1日中成药治疗心脏神经官能症的随机对照试验。运用RoB2进行偏倚风险评价、Stata 17SE进行网状Meta分析。结果:共纳入48篇文献,涉及稳心颗粒、舒肝解郁胶囊、参松养心胶囊、心可舒片、养心氏片、逍遥丸、益心舒胶囊、乌灵胶囊和柏子养心丸共9种中成药。网状Meta分析结果显示:总有效率方面最佳为舒肝解郁胶囊;改善躯体化症状方面稳心颗粒最佳;改善焦虑方面心可舒片最佳;改善抑郁方面益心舒胶囊最佳。结论:现有证据表明,中成药联合西医常规治疗心脏神经官能症的疗效优于单用西医常规治疗。展开更多
目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息...目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息,挖掘GeneCards数据库构建疾病靶点。运用STRING(https://string-db.org/)数据库来构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络模型,用Cytoscape 3.8.2可视化分析。采用在线分析平台DAVID v6.8对关键靶点进行京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析和基因本体(gene ontology,GO)富集分析。用R包绘制KEGG信号通路和GO富集分析图。利用AutoDock Vina,Pymol 2.0.1,Openbable3.1.1等软件完成分子对接。结果:甘麦大枣汤中共有107种包括槲皮素、木犀草素、山奈酚、柚皮素、异鼠李素等具有重要生物学作用的活性成分,作用于包括STAT3、JUN、TNF、TPT53、AKT1、EGFR在内的203个疾病药物治疗的潜在靶点。且广泛富集于TNF、HIF-1和Toll样受体的一系列信号通路中,核心活性成分也与核心靶点紧密结合。结论:甘麦大枣汤中黄酮类、三萜类及酚类等成分能与心脏神经官能症的疾病靶点稳定结合,进一步证实了该方剂通过多成分、多靶点、多通路治疗官能症、脏躁、抑郁、焦虑等症,这为中医药治疗心脏神经官能症提供了科学依据和参考。展开更多
文摘In this study, there were 62 patients with depressive neurosis. AInong them, 31 caseswere treated by laseracupuncture, another 31 cases were treated by pharmacotherapy, such as Antide-pressants and Antianxietics. The course of treatment for each case was 21 days. The therapeutic ef-fects, which were comprehensively evaluated with Hamilton’s Depression Scale (HAMD) and Hamil-ton’s Anxiety Scale (HAMI) as well as Clinical Global Impression Scale (CGI) in combination withtraditional evaluation of clinical therapeutic effect, indicated that treating the depressive neurosis withlaser-acupuncture can obtain sound effects with a clinical effective rate of 90. 32 percent, markedly ef-fective rate of 67. 74 percent. The global scores of Hamilton’s Depression Scale and Hamilton’s Anxi-ety scale after treatment were obviously less than those before treatment (P【0.001 ), similar to theeffects of pharmacotherapy or even much better than those in pharmacotherapy group in some aspects.Treating with laser-acupuncture
文摘77 cases of neurosis were treated with intelligent(computerized)elec-troacupuncture(IEA)and common electroacupuncture(CEA)at two different wave forms and fre-quencies.The results showed that the markedly effective rates of IEA and CEA were respectively75% and 60% without a statistically significant difference.For different subtypes of neurosis,thetherapeutic effects of IEC in the treatment 6f neurasthenia and depressive neurosis were superior toand in the treatment of anxiety was inferior to those of CEA.For different syndromes,the curativeeffects of IEA on somatic symptom,depression and asthenic symptom were.superior to and on anxietyand sleep-disorder were not as good as those of CEA.
基金Natural Science Foundation of Beijing(No.7202126)Fund for Science and Technology Development of TCM in Beijing(No.JJ-2020-38)。
文摘Objective:To analyze the prescription and medication rule of traditional Chinese medicine(TCM)in treating cardiac neurosis by using the software of"Traditional Chinese Medicine Inheritance Assistant Platform(V2.5)".Methods:China Journal Full-Text Database,Wanfang database,Weipu Chinese Periodical Service Platform and Chinese biomedical literature database were retrieved according to the inclusion and exclusion criteria.Literatures on the treatment of cardiac neurosis with TCM prescriptions were screened out and data mining was carried out using the TCM inheritance assistant platform.Use frequency,commonly used dose,the frequency of properties,flavors and meridian distribution were counted.Association rules and entropy clustering analysis for complex system were used to extract core drug combinations and unsupervised entropy hierarchical clustering was used to predict potential new prescriptions.Results:Through literature retrieval and screening,210 types of prescriptions were finally selected,and 181 types of Chinese herbs were extracted,with cumulative frequency of 2410 times.Among them,there were 46 traditional Chinese medicines that were used more than 15 times.According to the efficacy and indication,they were classified into qi-regulating drugs,tranquilizers,qi-tonifying drugs,heat-clearing drugs,blood-tonifying drugs,etc.According to properties,flavors,and meridian distribution,warm and sweet drugs were the most commonly used,mostly distributing to the heart meridian,followed by liver and spleen meridians.Association rules showed that combination of radix paeoniae and paeonia-bupleurum was the most used;faructus aurantii and bupleurum had the strongest correlation,up to 90%.The network diagram indicated that bupleurum,angelica sinensis,radix paeoniae radix,and poria cocos were the core of the association network.Based on complex system entropy clustering,24 core drug combinations were obtained.The unsupervised entropy hierarchical clustering algorithm was used to extract 12 core drug combinations,and 6 potential new formulae were obtained by further clustering.Conclusion:Regulating qi and blood,addressing both symptoms and causes,and using purgation and tonification at the same time is the principle of the treatment of cardiac neuropathy with TCM.The treatment mainly starts from the heart,liver and spleen,and therapies include soothing the liver and regulating qi,clearing heat and resolving phlegm,tranquilizing and calming the nerves,and prompting blood circulation and diuresis.
文摘Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challenge and a disturbing necessity for Mia Couto in Voices Made Night （1990） and Bessie Head in Tales of Tenderness and Power （1989）. The position of Couto as a white Mozambican writer and Head as an exiled coloured South African writer, living in her adopted country of Botswana, provides them with privileged neutrality from which to view the effect of the admixture of grinding poverty and violence as they ravage the landscapes of these countries. While Couto does not fail to incorporate the significance of power struggle between FRELIMO （Front for the Liberation of Mozambique） and RENAMO （Mozambique National Resistance） in the ~＇oices Made Night, Head＇s articulation of the complex manipulation of power becomes a resource for constructing a discourse of nationalism in Tales of Tenderness and Power. The paper intends to focus on the correlation between power and economic development in these anthologies. The paper will further examine how political power impacts on the socio-economic well being of the local folks in the Couto＇s Mozambique and Head＇s South Africa.
文摘Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.
文摘目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息,挖掘GeneCards数据库构建疾病靶点。运用STRING(https://string-db.org/)数据库来构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络模型,用Cytoscape 3.8.2可视化分析。采用在线分析平台DAVID v6.8对关键靶点进行京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析和基因本体(gene ontology,GO)富集分析。用R包绘制KEGG信号通路和GO富集分析图。利用AutoDock Vina,Pymol 2.0.1,Openbable3.1.1等软件完成分子对接。结果:甘麦大枣汤中共有107种包括槲皮素、木犀草素、山奈酚、柚皮素、异鼠李素等具有重要生物学作用的活性成分,作用于包括STAT3、JUN、TNF、TPT53、AKT1、EGFR在内的203个疾病药物治疗的潜在靶点。且广泛富集于TNF、HIF-1和Toll样受体的一系列信号通路中,核心活性成分也与核心靶点紧密结合。结论:甘麦大枣汤中黄酮类、三萜类及酚类等成分能与心脏神经官能症的疾病靶点稳定结合,进一步证实了该方剂通过多成分、多靶点、多通路治疗官能症、脏躁、抑郁、焦虑等症,这为中医药治疗心脏神经官能症提供了科学依据和参考。
