Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the prima...Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.展开更多
Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupli...Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupling,which is dependent or not dependent on astrocytes.The increase inflow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature.More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling,espe-cially the implications of astrocytes.展开更多
The body is observed to function optimally in life in some individuals while others have various problems.In the complexity involved,this paper describes saliently the mechanisms for biological robustness from birth a...The body is observed to function optimally in life in some individuals while others have various problems.In the complexity involved,this paper describes saliently the mechanisms for biological robustness from birth and subsequent neuro-vascular and core matching patterns well-coordinated till adulthood.These mechanisms the individual develops and maintains his core to keep vitality against environmental perturbations and they can be dysfunctional.The three related dimensions of the fascial organization,the co-directed nervous and perfusional elements in the body are emphasized.Re-understanding of these mechanisms in the body-map can be useful to revise the basis for re-defining our therapies.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 30770685)
文摘Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.
文摘Normal brain function requires continuous supply of oxygen and glucose in a strict manner.The close spatial and temporal relationship between neural activity and cerebral bloodflow(CBF)is termed as neurovascular coupling,which is dependent or not dependent on astrocytes.The increase inflow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature.More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling,espe-cially the implications of astrocytes.
文摘The body is observed to function optimally in life in some individuals while others have various problems.In the complexity involved,this paper describes saliently the mechanisms for biological robustness from birth and subsequent neuro-vascular and core matching patterns well-coordinated till adulthood.These mechanisms the individual develops and maintains his core to keep vitality against environmental perturbations and they can be dysfunctional.The three related dimensions of the fascial organization,the co-directed nervous and perfusional elements in the body are emphasized.Re-understanding of these mechanisms in the body-map can be useful to revise the basis for re-defining our therapies.
