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Pyoderma gangrenosum:An important dermatologic condition occasionally associated with rheumatic diseases
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作者 Toshiyuki Yamamoto 《World Journal of Rheumatology》 2015年第2期101-107,共7页
Pyoderma gangrenosum(PG) presents with refractory,sterile,deep ulcers most often on the lower legs.Clinically,PG exhibits four types,i.e.,ulcerative,bullous,pustular,and vegetative types.PG may be triggered by surgica... Pyoderma gangrenosum(PG) presents with refractory,sterile,deep ulcers most often on the lower legs.Clinically,PG exhibits four types,i.e.,ulcerative,bullous,pustular,and vegetative types.PG may be triggered by surgical operation or even by minor iatrogenic procedures such as needle prick or catheter insertion,which is wellknown as pathergy.PG is sometimes seen in association with several systemic diseases including rheumatoid arthritis(RA),inflammatory bowel disease,hematologic malignancy,and Takayasu's arteritis.In particular,various cutaneous manifestations are induced in association with RA by virtue of the activation of inflammatory cells(neutrophils,lymphocytes,macrophages),vasculopathy,vasculitis,drugs,and so on.Clinical appearances of ulcerative PG mimic rheumatoid vasculitis or leg ulcers due to impaired circulation in patients with RA.In addition,patients with PG sometimes develop joint manifestations as well.Therefore,it is necessary for not only dermatologists but also rheumatologists to understand PG. 展开更多
关键词 neutrophilic dermatosis PATHERGY Kebner phenomenon Autoinflammatory disorder
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Oral Pathergy in Sweet’s Syndrome Following Food Bolus Injury
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作者 David Klimpl Thomas Manser Mark Flemmer 《Case Reports in Clinical Medicine》 2016年第4期134-139,共6页
Pathergy is a unique and dramatic clinical finding of exuberant inflammation in response to local trauma. This incompletely understood phenomenon presents with sterile pustules and ulcers after minor cuts or scrapes, ... Pathergy is a unique and dramatic clinical finding of exuberant inflammation in response to local trauma. This incompletely understood phenomenon presents with sterile pustules and ulcers after minor cuts or scrapes, and can be tested by a pricking the skin with a sterile needle. Historically, pathergy was thought to be pathognomonic for Behcet’s syndrome, though it has also been described in several other inflammatory conditions such as pyoderma gangrenosum and acute febrile neutrophilic dermatosis (Sweet’s syndrome). Recognizing Sweet’s syndrome specifically can be challenging due to its atypical clinical course, and understanding the relationship between Sweet’s syndrome and pathergy can offer an important diagnostic clue. We present a case of Sweet’s syndrome presenting with upper airway obstruction and pathergy. To our knowledge, this is the first documented case of Sweet’s syndrome presenting with oral pathergy. 展开更多
关键词 PATHERGY Sweet’s Syndrome Myelodysplastic Syndrome neutrophilic dermatosis
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