Rh系统抗-D与抗-E抗体共同致新生儿溶血病的研究分析

目的:研究1例Rh系统2种不规则抗体(抗-D、抗-E)同时存在导致新生儿溶血病。方法:通过临床资料提供,对产妇进行血型分析,不规则抗体筛查及抗体特异性鉴定,抗体效价分析;对新生儿进行直接抗人球蛋白试验、游离试验、放散试验及抗体特异性分析。结果:产妇不规则抗体阳性,抗体为Rh系统抗-D与抗-E,IgG抗-D效价为512,IgG抗-E效价为2;新生儿直接抗人球蛋白试验阳性、放散试验检出抗-D和抗-E抗体,游离试验检出抗-D抗体。结论:经新生儿三项实验诊断新生儿溶血病成立,积极给予对症治疗,患儿康复出院。

Midwifery Students’ Confidence in New-Born Care at Completion of Training in Selected Midwifery Schools in Zambia. A Multicentric Study: A Case of Zambia

Background: Quality education is one of the important factors in empowering midwives to provide quality health care services to mothers and newborns irrespective of their practice settings. Due to lack of standardization of the duration, content, and structure of midwifery education and different pathways to midwifery across the world, midwives may lack the confidence to deliver quality health care services in the main domain of the ICM competences. Aim: To assess the confidence of final year midwifery students in the domain of new-born care based on the ICM midwifery competencies. Methods: The first phase consisted of a quick situation analysis of midwifery education and regulation in Zambia, followed by a cross-sectional survey through a self-administered questionnaire to assess the confidence of final year midwifery students. Results: Most (51.9%) of the respondents were aged between 18 and 28 years, and majority of them were placed in Levels 1, 2 and 3 Hospitals and also clinics for their clinical practice, with between one hundred to ten thousand annual births, followed by 16.9% who were placed in Level 3 hospitals only. Most students (38.3%) reported receiving classroom instruction by both Lecture and Demonstration. Few students (22.7%) responded that they were not satisfied with their clinical supervision, while 77.3% were satisfied. There was significant association between confidence to perform skills independently and having enough time to practice on models in the labs (p value = 0.024), confidence when practiced for the first time on mothers (p value = 0.007) and satisfaction with supervision during clinical practice (p value = 0.000). Binary logistic regression of characteristics associated with confidence to perform new-born skills independently revealed significant association between satisfaction with clinical supervision and confidence to perform skills independently, 95% CI [1.83, 15.37]. Conclusion: Midwifery students need quality training both theoretically and practically in order for them to gain confidence in newborn care upon completion of their training. They need adequate time to practice on models in the skills laboratory, and need adequate clinical supervision for them to gain confidence in performing new born skills independently.

Transition of Depressive Symptoms and Anxiety Symptoms According to Parity and Associations of These Symptoms with Feelings for Involvement with Newborn Infants during a 6-Month Postpartum Period

Background: Depressive symptoms and anxiety symptoms during the postpartum period affect physical health and child rearing and that these effects are important social issues. Objective: The aims of this study were to clarify the differences in the transition of depressive symptoms and anxiety symptoms according to parity during a 6-month postpartum period and to clarify the differences in associations of depressive symptoms and anxiety symptoms with feelings for involvement with newborn infants in primiparous and multiparous postpartum women. Methods: The design of this study was a longitudinal investigation. This study was conducted from February 2017 to July 2018 in Japan. By using self-administered questionnaires that included questions on psychological symptoms in a standard climacteric scale and questions on feelings for involvement with newborn infants, we collected data at 3 days postpartum, 2 weeks postpartum, one month postpartum, 3 months postpartum and 6 months postpartum. Results: Responses to all of the questionnaires were obtained from 121 (52.8%) of 229 women. The score for depressive symptoms in primiparous women was significantly higher than that in multiparous women at 3 days postpartum. Depressive symptoms and anxiety symptoms showed peaks at 2 weeks postpartum in both primiparous women and multiparous women, but depressive symptoms reoccurred from 3 months postpartum to 6 months postpartum in primiparous women and anxiety symptoms reoccurred from one month to 3 months postpartum in multiparous women. Depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with mother’s sleeping time. Conclusion: Changes in depressive symptoms and anxiety symptoms were different in primiparous women and multiparous women during a 6-month postpartum period. In addition, depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with sleeping time in postpartum women.

剖宫产术不同体位穿刺腰麻-硬膜外联合麻醉效果及对新生儿影响

目的:探讨剖宫产不同体位穿刺腰麻-硬膜外联合麻醉效果及对新生儿影响。方法:选取2020年7月-2022年7月本院择期剖宫产足月产妇90例,根据腰麻-硬膜外联合麻醉穿刺体位不同随机均分为坐位组(45例)和卧位组(45例),比较两组手术麻醉效果、血流动力学指标、不良反应以及新生儿结局。结果:坐位组术中麻黄碱总用量(8.5±1.5mg)低于卧位组(10.3±1.8mg),且到达T5时间(9.4±2.7min)以及达到最终阻滞平面时间(12.7±2.9min)均短于卧位组(13.8±2.7min、16.5±3.1min),镇痛效果优于卧位组,麻醉后血流动力学指标优于卧位组,术后恶心呕吐、头痛、低血压和产后出血等不良反应总发生率(15.6%)低于卧位组(35.6%)(P<0.05),两组新生儿出生1min 5minApgar评分及窒息情况无差异(P>0.05),但新生儿脐动脉血pH值坐位组(7.32±0.05)高于卧位组(7.27±0.09)(P<0.05)。结论:剖宫产腰麻-硬膜外联合麻醉穿刺体位采用坐位的麻醉效果和血流动力学指标优于卧位穿刺,术后不良反应减少,对新生儿无明显影响。

The Nanjing International Symposium of New Frontiers in Cancer Research(Nov 9-10,2007)

The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between China and other countries to speed up translation of new findings in basic cancer biology into disease prevention, diagnosis, and treatment. We hope to use this conference as a forum to create a unique opportunity for exchange in current discoveries, fostering multidisciplinary collaborations, and identification of future opportunities in cancer treatment and patient care. There will be four sessions in this symposium：

Application of vertically integrated sampling approach to study of new production via ^(234)Th -^(238)U disequilibria

The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in large spatial and temporal scales. The ~234Th/ ~238U disequilibrium is an effective method for the study of new production. Two sampling strategies, vertically integrated sampling ap proach based on trapezoidal integration principle and discrete layer sampling approach, were compared in the studies of the xiamen Bay and the northern South China Sea. The scavenging fluxes and removal fluxes of ~234Th and the residence times for dissolved and particulate ~234Th were calculated. The coinci dent results from two Sampling approach suggest that vertically integrated sampling approach is not only effective and reliable, but also significantly reduces the number and volume of samples. It allows us to study new production by ba ^(234)Th - ^(238)U disequilibria in large spatial scale.

Evaluation of the Quality of the Setting up of Early Mother-Born Interactions

The maternity process that has unfolded throughout the pregnancy, undergoes a turning point that occurs most of the time during the stay in diaper: place for installation of early mother-born interactions. The objective of the study is the evaluation of the quality of the establishment of early motherborn interactions as well as the effect of maternal feeling disruption on these interactions. It is a prospective study, focused on a total of 102 maternal-New-born dyads, in the unit of maternity series, at Rabat Children’s Hospital, University Hospital of Ibn Sina. It was based on a scale and an evaluation grid: the Mother-to-Infant Bonding Scale MIBQ and an evaluation grid of early mother-child interactions. The results showed that the age of the youth who is dominated at 60% (between 21 and 30 years), and that the primiparity was at 54% and 51% healthy;the correlation analysis between MIBQ and the grid shows that there is a significant correlation of average size with the emotional stability of the mother (p = 0.014 < 0.05), the quality of the attachment of the baby as his mother at the moment breastfeeding (p = 0.011 < 0.05) and the quality of the observed family context (p = 0.017 < 0.05). The installation of the mother-child relationship therefore depends on maternal capacities to recognize her place as a mother and to recognize the needs of their child, but it also depends on the child’s ability to show signs of attachment, his feelings of discomfort and pleasure.

剧场建筑设计中的文化传承与现代创新--佛山粤剧文化园设计

文化传承与现代创新的交融与平衡始终是设计中未曾间断的脉络。不是简单的向历史致敬,也非张扬的展现夺目,希望设计新建部分就像是从历史建筑身体里迸发出的新生命,带来有戏剧感的强烈空间感受。厚重的历史与情感,要传承下去,需要具有现代意识和未来前瞻性,离不开时代因素与现代技术元素;以古为新,以科技赋能,不断创新。

Treatment of Dyes Wastewater by a New Kind of Bio - Fluid Bed

A new kind of bio-fluid bed used to treat dyes wastewater is described in detail due to its several special features,such as high removal efficiency,simple struc-ture,shock load resistance,etc.By means of analyzing the experiment data,the results show that the dye wastewater’s organic matter is removed greatly after be-ing treated by this new kind of bio-fluid bed.On the other hand,the removal efficiency of chromaticity of

Screening of New Born and Infants for Hearing by OAE

The present study was carried out in the department of the otorhinolaryngology at a Secondary health care institute, with the aim of screening of new born (especially high risk) for hearing with OAE (Oto Acoustic Emission test). Loss of impairment of auditory sense is the most prevalent deficit of all sensory organs. Hearing impairment causes a huge impact on one’s social, educational, and economic wellbeing. There are about 5 - 6 infants who have hard of hearing out of 1000 neonates. It was carried out over a period of 15 months (April 21 to July 22) in association with department of Paediatrics. 645 new born and infants were screened by DPOAE (Distortion Product Oto Acoustic Emission) test for congenital hearing impairment. 54 new born infants out of 645 neonates screened showed “refer” in our study. To decrease the burden of morbidity of hearing loss in the society, universal new born hearing screening (UNBHS) policy is the concept to diagnose and treat at the earliest age of affected child, because early detection remains the primary element to decrease the associated morbidity.

NEW SOLID BASE DERIVED FROM AIPO4-5 SUPPORTED KF

Dispersion of KF on AlPO4-5 molecular sieve created basic sites and caused 1654 cm- band of bidentate carbonate in CO2 adsorption.After pre-treated above 823K. 5%KF/AlPO4-5exhibited basic catalytic activity in the isomerization of butenes at 273K. and the activity increasedwith the pre-treatment temperature up to 923K.

Wave Dynamics of the Average Annual Temperature Surface Air Layer New Delhi for 1931-2021

The identification method revealed asymmetric fluctuations in the dynamics of the average annual temperature in New Delhi from 1931 to 2021,that is,for 90 years.An analysis of the wave patterns of climate until 2110 was carried out.Geotechnology of the Himalayan passage was proposed to reduce heat waves in India and China.Formulas containing four and 18 fluctuations were adopted for forecasting.Models give an increase in the heat wave from 2021,which is the fourth component.As a result,the landscape of the Himalayan mountains and the deserts of Thar and Takla Makan create a regional climate system that is original for the land of the Earth.In this system,oscillatory temperature adaptation in the future will be several times greater than the global warming rate predicted in the IPCC CMIP5 report.Between 2001 and 2019 the largest temperature increase wave maximum was observed in New Delhi at 0.65℃ in 2012-2013.In the sixth phase from 2036 to 2049,an ecological catastrophe will break out in New Delhi.According to calculations,the maximum value of the average annual temperature in New Delhi was 25.82℃ in 2017.Since then,the cooling has continued for four years,which will continue until 2028.The temperature will drop to 22.54℃ due to a change in solar activity by 3.28℃.Then by 2044,the average annual temperature in New Delhi will increase to 31.03℃,or the increment will be 31.03-22.54=8.49℃.In 2035,the climate in New Delhi will become hotter compared to 2021.The increase in the heat wave is noticeable.From 1931 to 2049 there will be six half-periods of cooling and warming:1)23;2)23;3)20;4)18;5)15;6)13 years old.The most dangerous is the sixth stage.It is proposed at the fifth stage for 15 years until 2037 in northern India to the Takla Makan desert in China to build a passage up to 350 km long,10 km-20 km wide and at least 4.5 km high.

Eurovet Unveils the New Image of Hong Kong Mode Lingerie 2010 March 30-31, at the Hong Kong Convention and Exhibition Centre

Organized by Eurovet, the world’s leading lingerie and beachwear trade show organizer and supported by Hong

脐血T细胞IL-4基因表达及其调控

目的探讨脐血T细胞中活化T细胞核因子(NF AT)的活性与IL 4基因表达调控的关系。方法采用ELISA和RT PCR法测定受抗CD3 +PMA刺激后 ,18例脐血单个核细胞(CBMC)IL 4基因及其mRNA的表达 ;电泳迁移率转换试验(EMSA) ,测定10例CBMCNF AT的活性。22例成人外周血单个核细胞(PBMC)为对照。结果CBMC培养上清液中IL 4为(12.4±1.5)ng/L ,较PBMC明显低下〔(37.5±5.5)ng/L ,P∨0.01〕 ;CBMCIL 4mR NA的表达较PBMC明显减少 ;PBMC核蛋白内NF AT的活性较强 ,CBMC则几乎测不出NF AT的活性。结论在转录水平缺乏NF AT调控与脐血T细胞IL 4mRNA的转录水平低下有关 ;也是脐血T细胞表达IL 4水平低下的重要原因。

缺氧缺血性脑病患儿血清MMP-9水平动态变化及意义

目的:研究缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)新生儿血清中金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平的动态变化,探讨MMP-9水平和新生儿脑缺氧缺血后脑损伤程度之间的关系。方法:用酶联免疫吸附法测定24例HIE患者发病后1天、3天、7天血清MMP-9浓度,并与健康对照组比较。结果:HIE患者发病后1天、3天、7天,血清MMP-9水平分别为(34.11±1.10)pg/mL、(37.50±4.96)pg/mL、(33.42+0.73)pg/mL,均高于对照组水平(31.48±3.27)pg/mL,差异有统计学意义(P<0.05),以发病第3天水平最高,此后呈降低趋势。重度HIE患者发病后第3天血清MMP-9水平高于中、轻度组(P<0.05)。阿氏评分值与HIE发病后第3天血清MMP-9水平呈直线负相关(r=-0.692 p=0.000)。结论:HIE患者发病早期血清MMP-9水平即升高,提示MMP-9可能参与了HIE的发病机制。病情越严重,血清MMP-9升高越明显,提示血清MMP-9水平可能是判断病情的严重程度及预后的辅助指标。

缺氧缺血新生鼠脑组织Nogo-A含量变化

目的探讨Nogo-A在缺氧缺血新生鼠脑组织中含量变化及其意义。方法将SD大鼠的7日龄新生鼠(n=64)随机分为8组:4个不同时段的缺氧缺血后脑损伤组(HIBD后6h,24h,72h,7d组)和相对时段的假手术对照组,采用Nogo-A(S-19)多克隆抗体免疫组织化学SP法。结果Nogo-A在HIBD后24h组新生鼠脑组织中含量明显升高达到峰值,72h及7d组降低,与假手术组无统计学差异。结论Nogo-A在实验性缺氧缺血脑损伤后含量升高,可能抑制了中枢神经系统的再生。

血清S-100蛋白对早期预测新生儿围生期脑损伤预后的价值

目的:探讨血清S-100蛋白变化与新生儿围生期脑损伤预后的关系,为早期预测新生儿围生期脑损伤预后和早期干预及治疗提供依据。方法:选择40例围生期脑损伤新生儿为研究组,选择20例同期出生的正常新生儿为对照组。两组均于生后48～72h进行血样采集,采用ELISA法测定血S-100水平,以盖塞尔量表定期追踪两组发育情况。结果:研究组血S-100蛋白水平高于对照组[(1.55±0.79)μg/Lvs(0.62±0.46)μg/L,t=4.89,P<0.01],盖塞尔量表评价两组发育情况,两组间平均发育商比较显示3月龄始研究组低于对照组,差异有统计学意义。结论:测定血S-100蛋白变化对早期预测围生期脑损伤儿预后有较高的价值。