Objective:To analyze the basis and medication rules of Chinese herbs in the regulation of necroptosis.Methods:With the help of GeneCards,DrugBank,TTD,DisGeNET,OMIM database to collect the action targets of necroptosis...Objective:To analyze the basis and medication rules of Chinese herbs in the regulation of necroptosis.Methods:With the help of GeneCards,DrugBank,TTD,DisGeNET,OMIM database to collect the action targets of necroptosis,the TCMSP database to obtain the target‑related compounds and Chinese herbs,and the ADME criteria and Lipinski rule as the conditions for screening,to build the target‑compound,target‑compound‑Chinese herbs network.The information of Chinese herbal medicine's sexual taste and meridian was collected,and the drug use pattern was analyzed.The information on the property,flavor and channel tropism of Chinese herbs was collected to analyze the medication laws.Molecular docking of core targets and compounds in the network with AutoDockTools software,and PyMOL software was used to display the combinations with good docking results.Results:A total of 12 potential targets acting on necroptosis were obtained,matching to 191 candidate compounds and 366 herbal medicines.Quercetin,wogonin,triptolide,licochalcone a,ellipticine are more important and may be the main small molecule substances underlying the regulation of necroptosis.The more important Chinese herbs are Licorice,Forsythia,Salivae Miltiorrhizae,Ginkgo Leaf,Eucommia ulmoides Oliv,etc.The herbal medicines are mainly bitter and pungent,with cold and warm taste,which were attributed to the liver and lung meridians.BCL2‑beta‑sitosterol、MAPK14‑luteolin、MAPK14‑formononetin、TP53‑formononetin are better molecular docking results,which have strong docking activity.Conclusion:The study systematically analyzes the material basis of regulating necroptosis and summarizes the general rule of regulating necroptosis in Chinese medicine,which provides ideas for clinical development of agents to interfere with necroptosis.展开更多
Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated ...Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated polymedia environment as the object of study to review the theoretical history of “mediatization,” and explores new consumption’s emergence, essence, and related issues systematically through deductive reasoning. More specifically, this paper is to first interpret the mediatization theory and then analyze two dimensions(i.e., the formation of mediatized consumption and the resultant reinvention of practice rules) from the perspective of media affordances. On this basis, we conclude mediatized consumption’s essence, forms, and practice rules. This study indicates that new consumption is essentially mediatized consumption, which concerns “media-shaped consumption” and “consumption-shaped media,” and that new consumption has two representations;consumption-oriented media and banal consumption. Media affordances make new consumption fields human-oriented, connecting “people” and “things,” and are becoming a major contributor to the formation of mediatized consumption. Thus, the practice rules concerning “people, goods, and fields” in the new consumption sector are reinvented;the social interactions in the “middle region” are highlighted;the imaginative, narrative, and social characteristics of goods are emphasized;and the cross-field integration of consumption is realized.展开更多
The megalopolis is a unique system that offers unique opportunities for a person.But in return,this system requires respecting its rules of life,as well as creating and maintaining new social relationships.This is a v...The megalopolis is a unique system that offers unique opportunities for a person.But in return,this system requires respecting its rules of life,as well as creating and maintaining new social relationships.This is a very complex problem especially for religious sphere,because there are a lot of different religion representatives in megalopolis.Babylon is a symbol of megalopolis.Megalopolis problems can be called Babylon problems.New megalopolis religion(the religious rules)can be called New Babylon religion.In order to explore the religious code(rules)for the megalopolis life,this paper makes an analysis from the following three aspects:the religion problems existing in the megalopolis;the general sources of world religion;and the relationship between religion and modern science.Finally,the conclusion is drawn that the modern life of society in a megalopolis allows individualizing not only educational,but also religious sphere,which will create the necessary feedback effect and help to solve internal conflicts of residents at their initial stage,as well as to create common religious rules for megalopolis—our common home.展开更多
Editor’s words The author puts forward some problems involving in CIETAC Arbitration Rules 2000 such as the third nation- ality of the presiding arbitrator, the full autonomy of the parties to choose Arbitration Rule...Editor’s words The author puts forward some problems involving in CIETAC Arbitration Rules 2000 such as the third nation- ality of the presiding arbitrator, the full autonomy of the parties to choose Arbitration Rules and the improvement of applying for interim measures and so on, which are welcomed by CIETAC, though some of which CIETAC does do that in practice, for instance, appointing the third nationalities as presiding arbitrator, and some of which the improvement shall be followed by the law, for instance, the problem of interim measures. We hope there are more articles contributed to arbitration in China directly deal with the theory and practice of arbitration in China as well as all over the world.展开更多
基金National Natural Science Foundation Project(No.82174415)Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences(No.CI2021A05054)Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences(No.CI2021A01818)。
文摘Objective:To analyze the basis and medication rules of Chinese herbs in the regulation of necroptosis.Methods:With the help of GeneCards,DrugBank,TTD,DisGeNET,OMIM database to collect the action targets of necroptosis,the TCMSP database to obtain the target‑related compounds and Chinese herbs,and the ADME criteria and Lipinski rule as the conditions for screening,to build the target‑compound,target‑compound‑Chinese herbs network.The information of Chinese herbal medicine's sexual taste and meridian was collected,and the drug use pattern was analyzed.The information on the property,flavor and channel tropism of Chinese herbs was collected to analyze the medication laws.Molecular docking of core targets and compounds in the network with AutoDockTools software,and PyMOL software was used to display the combinations with good docking results.Results:A total of 12 potential targets acting on necroptosis were obtained,matching to 191 candidate compounds and 366 herbal medicines.Quercetin,wogonin,triptolide,licochalcone a,ellipticine are more important and may be the main small molecule substances underlying the regulation of necroptosis.The more important Chinese herbs are Licorice,Forsythia,Salivae Miltiorrhizae,Ginkgo Leaf,Eucommia ulmoides Oliv,etc.The herbal medicines are mainly bitter and pungent,with cold and warm taste,which were attributed to the liver and lung meridians.BCL2‑beta‑sitosterol、MAPK14‑luteolin、MAPK14‑formononetin、TP53‑formononetin are better molecular docking results,which have strong docking activity.Conclusion:The study systematically analyzes the material basis of regulating necroptosis and summarizes the general rule of regulating necroptosis in Chinese medicine,which provides ideas for clinical development of agents to interfere with necroptosis.
基金a phased research result of the“New Changes in Media and New Consumerism”(18BXW085)a program funded by the National Social Science Fund of China(NSSFC)。
文摘Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated polymedia environment as the object of study to review the theoretical history of “mediatization,” and explores new consumption’s emergence, essence, and related issues systematically through deductive reasoning. More specifically, this paper is to first interpret the mediatization theory and then analyze two dimensions(i.e., the formation of mediatized consumption and the resultant reinvention of practice rules) from the perspective of media affordances. On this basis, we conclude mediatized consumption’s essence, forms, and practice rules. This study indicates that new consumption is essentially mediatized consumption, which concerns “media-shaped consumption” and “consumption-shaped media,” and that new consumption has two representations;consumption-oriented media and banal consumption. Media affordances make new consumption fields human-oriented, connecting “people” and “things,” and are becoming a major contributor to the formation of mediatized consumption. Thus, the practice rules concerning “people, goods, and fields” in the new consumption sector are reinvented;the social interactions in the “middle region” are highlighted;the imaginative, narrative, and social characteristics of goods are emphasized;and the cross-field integration of consumption is realized.
文摘The megalopolis is a unique system that offers unique opportunities for a person.But in return,this system requires respecting its rules of life,as well as creating and maintaining new social relationships.This is a very complex problem especially for religious sphere,because there are a lot of different religion representatives in megalopolis.Babylon is a symbol of megalopolis.Megalopolis problems can be called Babylon problems.New megalopolis religion(the religious rules)can be called New Babylon religion.In order to explore the religious code(rules)for the megalopolis life,this paper makes an analysis from the following three aspects:the religion problems existing in the megalopolis;the general sources of world religion;and the relationship between religion and modern science.Finally,the conclusion is drawn that the modern life of society in a megalopolis allows individualizing not only educational,but also religious sphere,which will create the necessary feedback effect and help to solve internal conflicts of residents at their initial stage,as well as to create common religious rules for megalopolis—our common home.
文摘Editor’s words The author puts forward some problems involving in CIETAC Arbitration Rules 2000 such as the third nation- ality of the presiding arbitrator, the full autonomy of the parties to choose Arbitration Rules and the improvement of applying for interim measures and so on, which are welcomed by CIETAC, though some of which CIETAC does do that in practice, for instance, appointing the third nationalities as presiding arbitrator, and some of which the improvement shall be followed by the law, for instance, the problem of interim measures. We hope there are more articles contributed to arbitration in China directly deal with the theory and practice of arbitration in China as well as all over the world.
