In the early modern times in China, local planners have made several construction plans for Hangzhou's old city center and the West Lake, resulting in the gradual formation of a city-lake integrated urban form, wh...In the early modern times in China, local planners have made several construction plans for Hangzhou's old city center and the West Lake, resulting in the gradual formation of a city-lake integrated urban form, which is valued nowadays for its uniqueness and characteristically Chinese cityscape aesthetics. The key plan that spurred this process of linking the old city with the West Lake was a plan titled "Building a New Market"(1914). By elucidating the time, process, and contents of the plan, this paper analyzes the spatial transformation of the lakefront districts based on old maps, and then interprets how it led the forming process of the "city-lake integrated" urban form in Hangzhou.展开更多
The quality of pharmaceutical products plays a crucial role in healthcare systems such as hospitals for better patient services. Drug Supply Chain Management requires approaches to uncertainty and risk consideration. ...The quality of pharmaceutical products plays a crucial role in healthcare systems such as hospitals for better patient services. Drug Supply Chain Management requires approaches to uncertainty and risk consideration. This study is a comprehensive multi-objective mathematical model considering the uncertainties and potential reserves in supply and medicine. The proposed model includes three general objective functions that minimize total production costs, including the costs of transportation, maintenance, breakdown, collection, and disposal of waste. The model also maximizes the quality of potential storage. The results show the proposed method has a high quality to solve the model and leads to the optimization of the results to provide the drug supply chain for the proposed example. We have identified three important risks and uncertainties in addressing drug supply planning: the indefinite duration of the licensing process, the risk of a forced brand change, and indefinite repayment levels that lead to varied demand diversification. The results of comparison with other multi-objective optimization methods in existing articles also show better performance of the proposed model. A significant cost reduction results from implementing our model instead of using the over-storage role to estimate the volume of active drug elements, as seen in today’s industry.展开更多
文摘In the early modern times in China, local planners have made several construction plans for Hangzhou's old city center and the West Lake, resulting in the gradual formation of a city-lake integrated urban form, which is valued nowadays for its uniqueness and characteristically Chinese cityscape aesthetics. The key plan that spurred this process of linking the old city with the West Lake was a plan titled "Building a New Market"(1914). By elucidating the time, process, and contents of the plan, this paper analyzes the spatial transformation of the lakefront districts based on old maps, and then interprets how it led the forming process of the "city-lake integrated" urban form in Hangzhou.
文摘The quality of pharmaceutical products plays a crucial role in healthcare systems such as hospitals for better patient services. Drug Supply Chain Management requires approaches to uncertainty and risk consideration. This study is a comprehensive multi-objective mathematical model considering the uncertainties and potential reserves in supply and medicine. The proposed model includes three general objective functions that minimize total production costs, including the costs of transportation, maintenance, breakdown, collection, and disposal of waste. The model also maximizes the quality of potential storage. The results show the proposed method has a high quality to solve the model and leads to the optimization of the results to provide the drug supply chain for the proposed example. We have identified three important risks and uncertainties in addressing drug supply planning: the indefinite duration of the licensing process, the risk of a forced brand change, and indefinite repayment levels that lead to varied demand diversification. The results of comparison with other multi-objective optimization methods in existing articles also show better performance of the proposed model. A significant cost reduction results from implementing our model instead of using the over-storage role to estimate the volume of active drug elements, as seen in today’s industry.
