New applications and research progress of nano titanium dioxide （TiO2） in coating, environmental protection, chemical industries, cos- metics industry, electronic industrial products, medicine, health and food proce...New applications and research progress of nano titanium dioxide （TiO2） in coating, environmental protection, chemical industries, cos- metics industry, electronic industrial products, medicine, health and food processing fields were summarized in the paper. The results showed that nano TiO2 is the most dynamic one in the new nano material study today, which will have a very important impact on our social economic develop- ment in future. The research and utilization will give people＇s lives enormous changes.展开更多
Complexity is one of the leading features of modem control systems. It is caused by the complex properties of controlled plants and the varied requirements in controller designs. In dealing with the control problems w...Complexity is one of the leading features of modem control systems. It is caused by the complex properties of controlled plants and the varied requirements in controller designs. In dealing with the control problems with complexity, in the past two decades, a lot of papers have been published that reported fruitful results on different theoretical backgrounds and with different methodologies, such as differential geometry-based design methods, hybrid system theory, switching control, neural network-based intelligent control, etc.展开更多
SAN JOSE,Calif.-September 9,2004-Power Integrations,Inc.(NASDAQ:POWI),the leading supplier of high-voltageanalog integrated circuits used in power conversion, todayintroduced LNK302,a new member of the company'sLi...SAN JOSE,Calif.-September 9,2004-Power Integrations,Inc.(NASDAQ:POWI),the leading supplier of high-voltageanalog integrated circuits used in power conversion, todayintroduced LNK302,a new member of the company'sLinkSwitch-TN family of AC- DC power conversion ICs.Designed as a cost-effective replacement for bulky,energy-wasting capacitive droppers and linear transformers,the LinkSwitch-TN family is ideal for use in home applianceand industrial control applications.The addition of展开更多
We report a new embolization method with cobra catheter and balloon catheter in TAE for aneurysms and arterioportal fistula. Embolization for one aneurysm and one arterioportal fistula was performed using a cobra cat...We report a new embolization method with cobra catheter and balloon catheter in TAE for aneurysms and arterioportal fistula. Embolization for one aneurysm and one arterioportal fistula was performed using a cobra catheter, and the target vessel was temporarily blocked using a balloon catheter during the intervention. 2 cases of aneurysms and arterioportal fistula were treated successfully without coils reflux. Application of both cobra catheter with balloon catheter in TAE is effective without complication.展开更多
Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of new technology of integrated Chinese and western medicine...Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases is planned to be held in Nanning,Guangxi in August.展开更多
Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction...Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction,serious bone and展开更多
There is an urgent necessity to introduce the life cycle development method and a Computer-Aided Software Engineering (CASE) environment to support the development of a Computer Integrated Manufacturing (CIM) system. ...There is an urgent necessity to introduce the life cycle development method and a Computer-Aided Software Engineering (CASE) environment to support the development of a Computer Integrated Manufacturing (CIM) system. In this paper, we present several ideas while inquiring how to apply CASE tools to CIM process effectively, and propose five proper applicable paradigms to enhance the possibility of applications that the CIM process may make better use of CASE tools.展开更多
The nonlinear optical （NLO） and optical limiting （OL） properties of three new structures of organic NLO guest host Poly（N-vinylcarbozole）/disperse orange 3 （PVK/DO3）, PVK/disperse orange 13 （PVK/DO13）. and P...The nonlinear optical （NLO） and optical limiting （OL） properties of three new structures of organic NLO guest host Poly（N-vinylcarbozole）/disperse orange 3 （PVK/DO3）, PVK/disperse orange 13 （PVK/DO13）. and PVK/disperse orange 25 （PVK/DO25） as a solution at different concentrations and as a thin-film sample are studied using continuous wave z-scan system at 532 nm. The open-aperture z-scan data of the NLO materials in the solution and thin-film samples displayed two-photon and saturable absorptions, respectively. The PVK/DO13 exhibites the largest and best values of the nonlinearities, such as n2, β, X（3） compared with those of PVK/DO3 and PVK/DO25. This nonlinearity increases as the concentration increases. Tile results indicate that these NLO materials are good candidates for optical switching and OL devices.展开更多
The Journal of Control Theory and Applications （JCTA） publishes high-quality papers on the theory,design,and applications in the systems and control field.This journal is published quarterly.Three types of contribut...The Journal of Control Theory and Applications （JCTA） publishes high-quality papers on the theory,design,and applications in the systems and control field.This journal is published quarterly.Three types of contribution s are regularly considered：展开更多
As peer reviewers of the World Journal of Gastroenterology,our weekly routine involves immersing ourselves in the newly published issue,particularly focusing on the realm of colorectal cancer(CRC)research.We diligentl...As peer reviewers of the World Journal of Gastroenterology,our weekly routine involves immersing ourselves in the newly published issue,particularly focusing on the realm of colorectal cancer(CRC)research.We diligently sift through various contributions,ranging from comprehensive reviews to original articles and other scholarly works.Through meticulous examination,we discern the most notable papers,delving into each with careful scrutiny to distill their merits and shortcomings.Undoubtedly,this undertaking demands considerable time and effort.Yet,it stands as an indispensable pursuit,affording us a profound comprehension of the latest breakthroughs in CRC research.Moreover,these meticulously curated selections furnish readers with invaluable resources,serving as enduring references for the nuanced exploration of this dynamic field.展开更多
The fact that InN has a direct bandgap of 0.75eV enables InN-based nitrides devices to cover the wavelength range from UV region to 1.8μm, therefore, emerging as a new material system for optical communication applic...The fact that InN has a direct bandgap of 0.75eV enables InN-based nitrides devices to cover the wavelength range from UV region to 1.8μm, therefore, emerging as a new material system for optical communication applications.展开更多
By virtue of Cauchy’s integral formula in the theory of complex functions,the authors establish an integral representation for the weighted geometric mean,apply this newly established integral representation to show ...By virtue of Cauchy’s integral formula in the theory of complex functions,the authors establish an integral representation for the weighted geometric mean,apply this newly established integral representation to show that the weighted geometric mean is a complete Bernstein function,and find a new proof of the well-known weighted arithmetic-geometric mean inequality.展开更多
Fifteen pyridine and substituted benzene diselenides,seleninic acids and seleninic anhydrides have been synthesized.Among them,4,4'-dipyridinediselenide,bis(2,4-dimethoxyphenyl)diselenide, 2,4-dimethoxyphenyl sele...Fifteen pyridine and substituted benzene diselenides,seleninic acids and seleninic anhydrides have been synthesized.Among them,4,4'-dipyridinediselenide,bis(2,4-dimethoxyphenyl)diselenide, 2,4-dimethoxyphenyl seleninic acid,2-pyridineseleninic acid,2-pyridineseleninic anhydride,4-pyridine- seleninic anhydride,2-nitrophenyl seleninic anhydride and 4-nitrophenyl seleninic anhydride were new compounds.Their regioselective oxidation or dehydrogenation of β-pinene,3β-benzoyloxycholest- 5-ene and androstan-3-one have been studied and compared.2-Pyridineseleninic anhydride is a more efficient oxidant than the others;most of the substituted benzeneseleno derivatives did not give the expected products.展开更多
The key events in the development of the US generic drug industry after the Hatch-Waxman Act of 1984 are systematically reviewed,including the process of approval for generic drugs,bioequivalence issues including“swi...The key events in the development of the US generic drug industry after the Hatch-Waxman Act of 1984 are systematically reviewed,including the process of approval for generic drugs,bioequivalence issues including“switchability”,bioequivalence for complicated dosage forms,patent extension,generic drug safety,generic substitution and low-cost generics.The backlog in generic review,generic drug user fees,and“quality by design”for generic drugs is also discussed.The evolution of the US generic drug industry after the Hatch-Waxman Act in 1984 has afforded several lessons of great benefit to other countries wishing to establish or re-establish a domestic generic drug industry.展开更多
Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical sciences.The nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery an...Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical sciences.The nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological systems.Tremendous progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the attritions.The importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly recognized.Dramatic increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME properties.In this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.展开更多
基金Supported by Key Scientific and Technological Program of Henan Province (112102310424)
文摘New applications and research progress of nano titanium dioxide （TiO2） in coating, environmental protection, chemical industries, cos- metics industry, electronic industrial products, medicine, health and food processing fields were summarized in the paper. The results showed that nano TiO2 is the most dynamic one in the new nano material study today, which will have a very important impact on our social economic develop- ment in future. The research and utilization will give people＇s lives enormous changes.
文摘Complexity is one of the leading features of modem control systems. It is caused by the complex properties of controlled plants and the varied requirements in controller designs. In dealing with the control problems with complexity, in the past two decades, a lot of papers have been published that reported fruitful results on different theoretical backgrounds and with different methodologies, such as differential geometry-based design methods, hybrid system theory, switching control, neural network-based intelligent control, etc.
文摘SAN JOSE,Calif.-September 9,2004-Power Integrations,Inc.(NASDAQ:POWI),the leading supplier of high-voltageanalog integrated circuits used in power conversion, todayintroduced LNK302,a new member of the company'sLinkSwitch-TN family of AC- DC power conversion ICs.Designed as a cost-effective replacement for bulky,energy-wasting capacitive droppers and linear transformers,the LinkSwitch-TN family is ideal for use in home applianceand industrial control applications.The addition of
文摘We report a new embolization method with cobra catheter and balloon catheter in TAE for aneurysms and arterioportal fistula. Embolization for one aneurysm and one arterioportal fistula was performed using a cobra catheter, and the target vessel was temporarily blocked using a balloon catheter during the intervention. 2 cases of aneurysms and arterioportal fistula were treated successfully without coils reflux. Application of both cobra catheter with balloon catheter in TAE is effective without complication.
文摘Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases is planned to be held in Nanning,Guangxi in August.
文摘Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction,serious bone and
文摘There is an urgent necessity to introduce the life cycle development method and a Computer-Aided Software Engineering (CASE) environment to support the development of a Computer Integrated Manufacturing (CIM) system. In this paper, we present several ideas while inquiring how to apply CASE tools to CIM process effectively, and propose five proper applicable paradigms to enhance the possibility of applications that the CIM process may make better use of CASE tools.
文摘The nonlinear optical （NLO） and optical limiting （OL） properties of three new structures of organic NLO guest host Poly（N-vinylcarbozole）/disperse orange 3 （PVK/DO3）, PVK/disperse orange 13 （PVK/DO13）. and PVK/disperse orange 25 （PVK/DO25） as a solution at different concentrations and as a thin-film sample are studied using continuous wave z-scan system at 532 nm. The open-aperture z-scan data of the NLO materials in the solution and thin-film samples displayed two-photon and saturable absorptions, respectively. The PVK/DO13 exhibites the largest and best values of the nonlinearities, such as n2, β, X（3） compared with those of PVK/DO3 and PVK/DO25. This nonlinearity increases as the concentration increases. Tile results indicate that these NLO materials are good candidates for optical switching and OL devices.
文摘The Journal of Control Theory and Applications （JCTA） publishes high-quality papers on the theory,design,and applications in the systems and control field.This journal is published quarterly.Three types of contribution s are regularly considered：
基金Supported by The Shandong Province Medical and Health Science and Technology Development Plan Project,No.202203030713The Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University,No.YTFY2022KYQD06。
文摘As peer reviewers of the World Journal of Gastroenterology,our weekly routine involves immersing ourselves in the newly published issue,particularly focusing on the realm of colorectal cancer(CRC)research.We diligently sift through various contributions,ranging from comprehensive reviews to original articles and other scholarly works.Through meticulous examination,we discern the most notable papers,delving into each with careful scrutiny to distill their merits and shortcomings.Undoubtedly,this undertaking demands considerable time and effort.Yet,it stands as an indispensable pursuit,affording us a profound comprehension of the latest breakthroughs in CRC research.Moreover,these meticulously curated selections furnish readers with invaluable resources,serving as enduring references for the nuanced exploration of this dynamic field.
文摘The fact that InN has a direct bandgap of 0.75eV enables InN-based nitrides devices to cover the wavelength range from UV region to 1.8μm, therefore, emerging as a new material system for optical communication applications.
文摘By virtue of Cauchy’s integral formula in the theory of complex functions,the authors establish an integral representation for the weighted geometric mean,apply this newly established integral representation to show that the weighted geometric mean is a complete Bernstein function,and find a new proof of the well-known weighted arithmetic-geometric mean inequality.
文摘Fifteen pyridine and substituted benzene diselenides,seleninic acids and seleninic anhydrides have been synthesized.Among them,4,4'-dipyridinediselenide,bis(2,4-dimethoxyphenyl)diselenide, 2,4-dimethoxyphenyl seleninic acid,2-pyridineseleninic acid,2-pyridineseleninic anhydride,4-pyridine- seleninic anhydride,2-nitrophenyl seleninic anhydride and 4-nitrophenyl seleninic anhydride were new compounds.Their regioselective oxidation or dehydrogenation of β-pinene,3β-benzoyloxycholest- 5-ene and androstan-3-one have been studied and compared.2-Pyridineseleninic anhydride is a more efficient oxidant than the others;most of the substituted benzeneseleno derivatives did not give the expected products.
文摘The key events in the development of the US generic drug industry after the Hatch-Waxman Act of 1984 are systematically reviewed,including the process of approval for generic drugs,bioequivalence issues including“switchability”,bioequivalence for complicated dosage forms,patent extension,generic drug safety,generic substitution and low-cost generics.The backlog in generic review,generic drug user fees,and“quality by design”for generic drugs is also discussed.The evolution of the US generic drug industry after the Hatch-Waxman Act in 1984 has afforded several lessons of great benefit to other countries wishing to establish or re-establish a domestic generic drug industry.
基金supported in part by grants from the National Institutes of Health (CA023074,CA092596,ES004940,ES006694,and ES020867,USA)。
文摘Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical sciences.The nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological systems.Tremendous progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the attritions.The importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly recognized.Dramatic increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME properties.In this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.
