Multiple Data Sources Reveal a New Asian Leaf Litter Toad of Leptobrachella Smith, 1925 (Anura, Megophryidae) from Southwestern China

A new species of Leptobrachella is described from Sichuan Province and Chongqing Municipality,China.Molecular phylogenetic analyses based on mitochondrial and nuclear gene sequences indicated that the new species is genetically divergent from its congeners.It could be identified from its congeners by a combination of followings characters:body size of male 29.1-34.1 mm(n=14),female 34.1-34.9 mm(n=4);dorsal skin rough with large tubercles in size of humeral glands,without conical spines;fringes on toes narrow;ventral body basically floral white with deep grey pigments all over;dorsal body deep greyish brown with smoky black markings;iris gold above,gradually silver bellow;tibia-tarsal articulation reaches the level of the middle of the eye when leg being stretched forward;the main call type with dominant frequency4.08 ± 0.16 kHz(14.1-14.9℃),call duration 170.35± 15.19ms,the number of pulses for the first note in a call 3.50±0.89,and the number of pulses for the second note in a call 5.08±0.77.

New aspects about Supella longipalpa(Blattaria:Blattellidae)

The brown-banded cockroach,Supella longipalpa(Blattaria:Blattellidae)(S.longipalpa),recently has infested the buildings and hospitals in wide areas of Iran,and this review was prepared to identify current knowledge and knowledge gaps about the brown-banded cockroach.Scientific reports and peer-reviewed papers concerning S.longipalpa and relevant topics were collected and synthesized with the objective of learning more about health-related impacts and possible management of S.longipalpa in Iran.Like the German cockroach,the brown-banded cockroach is a known vector for food-borne diseases and drug resistant bacteria,contaminated by infectious disease agents,involved in human intestinal parasites and is the intermediate host of Tnchospirura leptostoma and Moniliformis moniliformis.Because its habitat is widespread,distributed throughout different areas of homes and buildings,it is difficult to control.Considering its possible resistance to insecticides,the control situation may be far more complex.For improved control of S.longipalpa an integrated pest management program is needed.Sanitation,indoor insecticide spraying in the initial cockroach control phase and insecticide formulation baits are recommended simultaneously.

New Asymptotical Stability and Uniformly Asymptotical Stability Theorems for Nonautonomous Difference Equations

New theorems of asymptotical stability and uniformly asymptotical stability for nonautonomous difference equations are given in this paper. The classical Liapunov asymptotical stability theorem of nonautonomous difference equations relies on the existence of a positive definite Liapunov function that has an indefinitely small upper bound and whose variation along a given nonautonomous difference equations is negative definite. In this paper, we consider the case that the Liapunov function is only positive definite and its variation is semi-negative definite. At these weaker conditions, we put forward a new asymptotical stability theorem of nonautonomous difference equations by adding to extra conditions on the variation. After that, in addition to the hypotheses of our new asymptotical stability theorem, we obtain a new uniformly asymptotical stability theorem of nonautonomous difference equations provided that the Liapunov function has an indefinitely small upper bound. Example is given to verify our results in the last.

A New Asymmetric Synthesis of (+)-(3R, 4S, 5R, 7S)-Neoclausenamide via Intramolecular Nucleophilic Attack of Carbon Anion onto Cyclic Sulfate

An intramolecular nucleophilic substitution of carbon anion to cyclic sulfate was first employed in asymmetric synthesis of (+)-(3R, 4S, 5R, 7S)-neoclausenamide 1 which is a novel hepatoprotective lactam isolated from the dry leaves of Chinese folk medicine Clausena lansium (Lour) Skeel. The regioselectivity of beta-attack to this cyclic sulfate, just like its epoxide counterpart was attributed to the increased reactivity of beta-position by the phenyl group.

New Aspects in Foreign Investment Policy

In the wake of the further expansion of China’s opening to the outside world in recent years, quite a few aspects have been supplemented to the policies of absorbing direct foreign investments.

STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 86 SOME NEW ASPECTS ON THE SYNTHESIS OF DIALKYL 1-ISOCYANO-BENZYL-AND/OR ALKYL-PHOSPHONATES

1-Isocyano substituted benzylphosphonates were prepared by dehydration of 1-N-formylamino substituted benzylphosphonates,which were obtained by a tricomponental condensation described by us.Mean- while addition of diethyl phosphite to N-trityl aldimine followed by deprotection,formylation and dehydration gave corresponding 1-isocyano alkylphosphonates in one-pot procedure.

Lineaperpetua gen.nov.:a new diatom genus in the Thalassiosirales supported by morphology and molecular data

Based on a combination of morphology and molecular data of ribosomal DNA genes,a new diatom genus Lineaperpetua gen.nov.Yu,You,Kociolek&Wang is described.The features that help define Lineaperpetua at the level of genus include:a tangentially undulated valve face;continuous cribra areolae on the valve interior consisting of pores arranged as strips;single rimoportula located inside the ring of marginal fultoportulae.Additionally,phylogenetic analysis based on nuclear small subunit(SSU)rDNA sequences and nuclear large subunit(LSU)rDNA gene placed the three strains of L.lacustris in a single,monophyletic clade at a considerable sequence distance from the other genera(Thalassiosira,Conticribra,Planktoniella,Shinodiscus,and other genera)belonging to Thalassiosirales.Despite the similarities with some species of Thalassiosira,Conticribra,and Spicaticribra,the suite of features found in Lineaperpetua differentiate it from these other genera.These molecular data and morphological characters suggest an affinity of the new genus to the Thalassiosiraceae.

New findings of Changxingaspis(Xiushuiaspidae,Galeaspida)from the Silurian of Tarim Basin and Zhejiang Province,China

New discovery of the early Silurian fossil fish Changxingaspis(Xiushuiaspidae,Galeaspida),Changxingaspis nianzhongi sp.nov.and C.gui,are described from the Tataertag Formation in Tarim Basin and the Kangshan Formation in Zhejiang Province,respectively.C.nianzhongi mainly differs from C.gui in the shape of the median dorsal opening that is transverse elliptic with a width/length ratio of about 3.0,the long lateral transverse canals extending to the lateral margin of the headshield,and the second lateral transverse canal with dichotomous branchings.Discovery of C.nianzhongi from the Tataertag Formation and C.gui from the Kangshan Formation provide direct evidence on the specific level for the correlation between these two formations,which further supports the Silurian fish-bearing red beds in northwest Zhejiang belonging to the Silurian Lower Red Beds(LRBs)rather than the Upper Red Beds(URBs).Additionally,as the first record of the Changxingaspis in Tarim Basin,it extends the paleogeographical distribution of this genus from the South China Block to the Tarim Block,providing new evidence to support faunal exchanges between these two blocks and the hypothesis of a united Tarim-South China Block during the early Silurian.

A new infrageneric classification of Gastrochilus(Orchidaceae:Epidendroideae)based on molecular and morphological data

Gastrochilus is an orchid genus containing 73 species of mainly epiphytic on trees or rocks in mountain forests of tropical and subtropical Asia.Previous phylogenetic analyses and morphological assessments have failed to produce a well-resolved phylogeny at the infrageneric level.In the present study,a new infrageneric classification of Gastrochilus is proposed based on thoroughly morphological and phylogenetic analyses based on 52 species.Our phylogenetic analysis divided the genus into six sections including three new sections,G.sect.Pseudodistichi,G.sect.Brachycaules and G.sect.Acinacifolii.We also reinstate G.suavis to the specific rank.Furthermore,two new species,G.armeniacus Jun Y.Zhang,B.Xu&Yue H.Cheng and G.minjiangensis Jun Y.Zhang,B.Xu&Yue H.Cheng,are described and illustrated.A key to six sections of the genus is presented.

New direction for surgery:Super minimally invasive surgery

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm because of its lesser invasiveness.However,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients post-operation.Thus,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.

Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

Climate change vulnerability assessment in the new urban planning process in Tanzania

Climate change vulnerability assessment is an essential tool for identifying regions that are most susceptible to the impacts of climate change and designing effective adaptation actions that can reduce vulnerability and enhance long-term resilience of these regions.This study explored a framework for climate change vulnerability assessment in the new urban planning process in Jangwani Ward,Tanzania.Specifically,taking flood as an example,this study highlighted the steps and methods for climate change vulnerability assessment in the new urban planning process.In the study area,95 households were selected and interviewed through purposeful sampling.Additionally,10 respondents(4 females and 6 males)were interviewed for Focus Group Discussion(FGD),and 3 respondents(1 female and 2 males)were selected for Key Informant Interviews(KII)at the Ministry of Lands,Housing and Human Settlements Development.This study indicated that climate change vulnerability assessment framework involves the assessment of climatic hazards,risk elements,and adaptive capacity,and the determination of vulnerability levels.The average hazard risk rating of flood was 2.3.Socioeconomic and livelihood activities and physical infrastructures both had the average risk element rating of 3.0,and ecosystems had the average risk element rating of 2.9.Adaptive capacity ratings of knowledge,technology,economy or finance,and institution were 1.6,1.9,1.4,and 2.2,respectively.The vulnerability levels of socioeconomic and livelihood activities and physical infrastructure were very high(4.0).Ecosystems had a high vulnerability level(3.8)to flood.The very high vulnerability level of socioeconomic and livelihood activities was driven by high exposure and sensitivity to risk elements and low adaptive capacity.The study recommends adoption of the new urban planning process including preparation,planning,implementation,and monitoring-evaluation-review phases that integrates climate change vulnerability assessment in all phases.

Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

BACKGROUND Bone metastasis has various negative impacts.Activities of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may increase.It is estimated that at least 5%cancer patients might be suffering from bone metastases.In 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone Metastasis.Since then,the therapeutic outcomes for patients have gradually improved.As life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be achieved.AIM To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone metastasis.METHODS For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was calculated.The association with survival was determined for each factor.RESULTS Data from 136 patients were obtained.The 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was developed.Other factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced cancer.It is necessary not only to simply extend survival time,but also to maintain ADL and improve QOL.CONCLUSION Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly required.Guidelines and scoring system for prognosis need to be revised promptly.

Development of Rural Tourism Industry under the Background of New Rural Construction : A Case Study of Henghe of Boluo County in Huizhou City

Henghe Town in Boluo County of Huizhou is taken as the research object for analysis.The research and analysis on the tourism industry in Henghe Town of Boluo County are conducted,and the basic situation of rural tourism construction in Henghe Town is sorted out.The forms of tourism industry in Henghe Town and the problems in rural tourism development are identified,and some targeted suggestions and countermeasures are proposed.It hopes to provide ideas and references for the construction of beautiful rural areas in mountainous areas of Guangdong Province,and theoretical reference and practical significance for the development of rural tourism in mountainous areas of Guangdong Province.

The 2018 new asset management regulation and LGFV bonds in China

While the local government debts and local government financing vehicle(LGFV)bonds underwent reconstruction,in 2018 the new asset management regulation introduced some tighter measures to restrain shadow banking business and to mitigate the moral hazard issue that led to an ongoing boom of the LGFV market.This paper examines the impacts of the 2018 new asset management regulation on the credit spread of newly issued LGFV bonds and explores how the new asset management regulation affects the implicit guarantee of local governments in the LGFV market that has piled up systemic risks.We find that the release of the new asset management regulation has raised the credit spread of LGFV bonds at issuance.More importantly,the credit spread becomes increasingly sensitive to the local governments’financial capacity and credibility right after the introduction of the new asset management regulation.Therefore,investors are compensated by more risk premiums for holding LGFV bonds issued by the local governments with a weaker balance sheet.Consequently,the implicit guarantee problem in the LGFV bond market has worsened.

College English Curriculum Reform in the Context of New Engineering Education:Taking Wuhan University of Technology as an Example

With the introduction of“new engineering,new medical science,new agricultural science,and new liberal arts”construction,the reform of college English teaching is also imperative.Scholars nationwide have conducted attempts in different aspects of college English teaching and produced fruitful results.Yet,more efforts should be made.This paper discusses the reforms made by Wuhan University of Technology,focusing on the reformation of curriculum.

It’s Time for New Insights into Renovascular Hypertension at the Molecular Level

At the cellular level, reduced kidney perfusion in atherosclerotic renal arthery disease (ARVD), induces hypoxia, activation of the renin-angiotensin-aldosterone system (RAAS) and cytokine activation. Impaired blood flow in the kidneys creates a microenvironment triggering significant cytokine production, contributing to vascular damage and endothelial disfunction. Interactions between cytokines and endothelial, glomerular, and tubular cells often result in increased vessel permeability, and fibrosis, and contribute to the development of chronic kidney disease (CKD). Molecules such as endothelins, prostaglandins, and nitric oxide play a crucial role at the molecular level. The imbalance between vasoconstrictor and vasodilator factors contributes to vascular dysfunction. Oxidative stress and inflammatory processes at the cellular level contribute to endothelial damage and structural changes in blood vessels. Mineralocorticoid receptor antagonists (MRAs) therapy in the context of ARVD holds promise in reducing fibrosis, promoting angiogenesis and enhancing overall outcomes in patients with this pathology. Recent data also indicates the antioxidative, anti-inflammatory, and antifibrotic effects of SGLT2 inhibitors. They reduce oxidative stress caused by hypoxic conditions and enhance renal perfusion, contributing to the preservation of cellular function. Studies employing Blood Oxygen Level-Dependent (BOLD) imaging have identified adaptations to reduced blood flow, volume, and glomerular filtration rate in post-stenotic kidneys that preserve oxygenation in the medulla and cortex during medical therapy. Data from the literature indicate that despite the partial recovery of renal hypoxia and restoration of blood flow after revascularization, inflammatory cytokines and injury biomarkers remain elevated, and the glomerular filtration rate (GFR) does not recover in ARVD. Restoration of vascular patency alone has failed to reverse tubulointerstitial damage and partially explains the limited clinical benefit of renal stenting. Considering these findings, BOLD MR imaging emerges as a technique capable of providing insights into the critical juncture of irreversibility in ARVD. However, further research is needed to monitor renal hypoxia following renal artery stenting and the inflammatory response over an extended period in conjunction with optimal therapy involving MRAs and SGLT2 agonists. The aim of research at the molecular level enables the identification of potential therapeutic modalities targeting specific molecular pathways, opening the door to innovative approaches in treating renovascular hypertension.

New Approach to Synchronize General Relativity and Quantum Mechanics with Constant “K”-Resulting Dark Matter as a New Fundamental Force Particle

Planck scale plays a vital role in describing fundamental forces. Space time describes strength of fundamental force. In this paper, Einstein’s general relativity equation has been described in terms of contraction and expansion forces of space time. According to this, the space time with Planck diameter is a flat space time. This is the only diameter of space time that can be used as signal transformation in special relativity. This space time diameter defines the fundamental force which belongs to that space time. In quantum mechanics, this space time diameter is only the quantum of space which belongs to that particular fundamental force. Einstein’s general relativity equation and Planck parameters of quantum mechanics have been written in terms of equations containing a constant “K”, thus found a new equation for transformation of general relativity space time in to quantum space time. In this process of synchronization, there is a possibility of a new fundamental force between electromagnetic and gravitational forces with Planck length as its space time diameter. It is proposed that dark matter is that fundamental force carrying particle. By grand unification equation with space-time diameter, we found a coupling constant as per standard model “αs” for that fundamental force is 1.08 × 10-23. Its energy calculated as 113 MeV. A group of experimental scientists reported the energy of dark matter particle as 17 MeV. Thorough review may advance science further.

Measurement and Strategy Research on the Green Development Level for the New Energy Vehicle Industry in Chongqing City

This article takes 2016-2022 as the inspection period to construct an evaluation index system for the green development level of the new energy vehicle industry.The entropy method and comprehensive index are used to measure the green development level of the new energy vehicle industry in Chongqing,and compared with neighboring provinces such as Yunnan,Guizhou,and Sichuan.Policy recommendations are proposed to promote the development of the new energy vehicle industry in Chongqing City.

Contribution to the Knowledge of the Afrotropical Spilomelinae (Lepidoptera, Crambidae): A New Genus in the Tribe Nomophilini Kuznetzov & Stekolnikov 1979 Based on Morphology and DNA Barcoding

The new genus Parathrausta gen.n. in the subfamily Spilomelinae (Lepidoptera, Crambidae) is erected based on a series of specimens collected in the Afrotropical region of Saudi Arabia. The new genus is monotypical, with Parathrausta internervalis sp.n. its type species. The adults of the type species, the male genitalia, the female genitalia and the tympanal organs are described and figured. The new genus is recognized as related by characters in the male and female genitalia with genera in the tribes Steniini Guine, 1854 and Nomophilini Kuznetzov & Stekolnikov, 1979, namely with Bradina Lederer, 1863, Perisyntrocha Meyrick, 1894, Diathrausta Lederer, 1863, Diasemiopsis Munroe, 1957, Diasemiodes Munroe, 1957 and with the genera in the Duponchelia Zeller, 1847 group comprising Duponchelia Zeller, 1847, Penestola Mschler, 1890, Tatobotys Butler, 1880 and Hymenoptychis Zeller, 1852. The character states differentiating the new genus from the comparative genera are discussed. Potential autapomorphies of the new genus are listed. The tribal assignment of the new genus to the Nomophilini Kuznetzov & Stekolnikov, 1979 based on morphological characters is discussed. The support of the tribal and cladistic assignment of the new genus as a sister clade to Diathrausta Lederer, 1863 based phylogenetic analyses (NJ, MP and ML) is shown. An unusually strong genetic divergence of the genus in the COI segment of the mt-DNA based on the Tamura-Nei distance measure from the morphologically related genera is recognized and addressed.