Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China

This study aimed to evaluate the sensitivity and specificity of the new clinical diagnostic and classification criteria for Kashin-Beck disease （KBD） using six clinical markers： flexion of the distal part of fingers, deformed fingers, enlarged finger joints, shortened fingers, squat down, and dwarfism. One-third of the total population in Linyou County was sampled by stratified random sampling.

New Method for Building Vector of Diagnostic Signs to Classify Technical States of Marine Diesel Engine by Torsional Vibrations on Shaft-Line

Vector of diagnostic signs(VDS)using torsional vibration(TV)signal on the main propulsion plant(MPP)is the vector of z maxima(or minima)values of the TV signal in accordance with the cylinder firing orders.The technical states of the marine diesel engine(MDE)include R=z+1 classes and are presented in z-dimensional space coordinate of VDS.The presentation of Dk,k=1÷R using z diagnostic signs(Vi,i=1÷z)is nonfigurative and quite complicated.This paper aims to develop a new method for converting VDS from z-dimensional to 2-dimensional space(two-axes)based on the firing orders of the diesel cylinders,as an equivalent geometrical sign of the all diagnostic signs.The proposed model is useful for presenting a technical state Dk in two-dimensional space(x,y)for better visualization.The paper verifies the simulation of the classification illustration of the 7–state classes for the MDE 6S46-MCC,installed on the motor vessel(MV)34000DWT,using the new above mentioned method.The seven technical state classes(for 6-cylinder MDE,z=6)are drawn separately and visually in the Descartes.The received results are valuable to improve smart diagnostic system for analyzing normal/misfire states of cylinders in operation regimes.

Advances in acute and chronic pancreatitis

Acute pancreatitis(AP)and chronic pancreatitis are the third leading gastrointestinal causes for admissions and readmissions to hospitals in the United States.This review of articles published between 2019-2022(December)from international sources identified four categories of crucial new findings:The report includes(1)New genetic pathogenic mutations(TRPV6);expected genetic outcomes in a Northern European population;(2)a new serum diagnostic marker for AP-fatty acid ethyl esters-distinguishing acute pancreatitis associated with alcohol;explanations of the impact of monocytes/macrophages on the inflammatory process that defines their future in diagnosis,staging,and treatment;(3)innovations in timing of per os low-fat,solid food intake immediately on admission;resolution of concepts of aggressive parenteral fluid intake;dramatic shifts to nonoperative from operative treatment of infected pancreatic necrosis.Each modification reduced interventions,complications,and lengths-of-stay;and(4)authoritarian recommendations for medical treatment of chronic pain.These advances offer opportunities to initiate newly proven treatments to enhance outcomes,alter the natural history,and envision the future of two diseases that have no known cure.

The Response of Climatic Jump in Summer in North China to Global Warming

To reveal climatic variation over North China, the climatic jumps in summer in Beijing are analyzed using the data of precipitation of summer (June, July, August) during the period of 1841-1993, in which those missed before 1950 were reconstructed by the stepwise regression method with minimum forecast error. The climatic jumps at different scales are analyzed using different diagnostic methods with different decade (10-100 years) windows. Some new methods and ideas are proposed. The variance difference, the linear tendency difference, and the difference of power spectral distribution between the samples before and after the period at the moving point in the center of the series are compared with other methods (for example, Mann—Kendall test, t— test, and accumulative anomaly etc.). Considering the differences among the statistics above, a synthetic jump index is also proposed in order to get the definite jump points in the moving series. The results show that the climatic jumps in the area occurred in the 1890s, the 1910s and the 1920s, and mostly in the 1920s, which suggests that the local climatic jumps in North China have a simultaneous response to the global warming in the hundred-year scales. Key words Climatic jump - New diagnostic statistics - Synthetic jump index - Response to global warming This Study was supported by the “ National Key Programme for Developing Basic Sciences” G1998040901-1.

Innovation： An Eternal Theme in the Development of Pediatrics

The health problems of children differ greatly from those of adults. A child＇s response to illness and stress varies with increasing age. Pediatrics is a discipline that examines all aspects of the well-being of fetuses, infants, children, and adolescents, including their physical, mental, and psychologic growth and development. The development of pediatrics relies on innovation. Innovation is defined as the combination of new ideas, including new concepts, science, technology, and theories, which advance the development of various disciplines of pediatrics. Innovation has a strong influence on pediatrics, especially in promoting the quality of life of children, preventing diseases, and protecting children from health threats. Indeed, innovation is a driving force of the development of pediatric studies, providing the latest knowledge, theories, and technologies in pediatrics.