Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing n...Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing new and important drugs. The person in charge for the platform is a pharmaceutical science professor of Peking University School of Pharmaceutical Sciences. The plaform selects the following as the main research areas： late-model carrier drug delivery system, biotechnological drug delivery system, mucous and transdermal drug delivery system, oral controlled-release drug delivery system, and four corresponding research teams are set up to study in depth the main problems and key issues.展开更多
Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing n...Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing new and important drugs. The person in charge for the platform is a pharmaceutical science professor of Peking University School of Pharmaceutical Sciences. The plaform selects the following as the main research areas： late-model carrier drug delivery system, biotechnological drug delivery system,展开更多
Paclitaxel is a promising antineoplastic agent against a variety of human solid tumors, such as ovary, breast, lung, head and neck tumors, and melanoma. Owing to its poor solubility, the fast available formulation ofp...Paclitaxel is a promising antineoplastic agent against a variety of human solid tumors, such as ovary, breast, lung, head and neck tumors, and melanoma. Owing to its poor solubility, the fast available formulation ofpaclitaxel （Taxol） exists as a non-aqueous concentrate composed of Cremophor EL （polyethoxylated castor oil） and ethanol. It must be diluted to a suitable aqueous solution prior to long time intravenous infusion. Based on the components and usage, Taxol has serious adverse effects and is inconvenient for clinical use. To address these problems, the development of a less-toxic, better-tolerated, Cremophor EL-free formulation of paclitaxel has been attempted. In recent years, new drug delivery systems （DDS） including albumin-based nanoparticles, micelles, liposomes, etc. have been investigated. In this review, we present the formulations and delivery technologies of paclitaxel for injection and focus on some of preclinical and clinical experience on the formulations which are already on the market or under clinical stages. Finally, possible nanotechnology advantages, existing challenges and future perspectives of paclitaxel delivery are highlighted.展开更多
文摘Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing new and important drugs. The person in charge for the platform is a pharmaceutical science professor of Peking University School of Pharmaceutical Sciences. The plaform selects the following as the main research areas： late-model carrier drug delivery system, biotechnological drug delivery system, mucous and transdermal drug delivery system, oral controlled-release drug delivery system, and four corresponding research teams are set up to study in depth the main problems and key issues.
文摘Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing new and important drugs. The person in charge for the platform is a pharmaceutical science professor of Peking University School of Pharmaceutical Sciences. The plaform selects the following as the main research areas： late-model carrier drug delivery system, biotechnological drug delivery system,
基金Key Project from the Ministry of Science and Technology(Grant No.2014ZX09507001-010)Innovation Team of Ministry of Education(Grant No.BMU20110263)
文摘Paclitaxel is a promising antineoplastic agent against a variety of human solid tumors, such as ovary, breast, lung, head and neck tumors, and melanoma. Owing to its poor solubility, the fast available formulation ofpaclitaxel （Taxol） exists as a non-aqueous concentrate composed of Cremophor EL （polyethoxylated castor oil） and ethanol. It must be diluted to a suitable aqueous solution prior to long time intravenous infusion. Based on the components and usage, Taxol has serious adverse effects and is inconvenient for clinical use. To address these problems, the development of a less-toxic, better-tolerated, Cremophor EL-free formulation of paclitaxel has been attempted. In recent years, new drug delivery systems （DDS） including albumin-based nanoparticles, micelles, liposomes, etc. have been investigated. In this review, we present the formulations and delivery technologies of paclitaxel for injection and focus on some of preclinical and clinical experience on the formulations which are already on the market or under clinical stages. Finally, possible nanotechnology advantages, existing challenges and future perspectives of paclitaxel delivery are highlighted.
