New models to study vulvodynia: hyperinnervation and nociceptor sensitization in the female genital tract

Vulvodynia is a prevalent form of chronic pain, most com- monly affecting the vaginal vestibule （vestibulodynia） （Pukall et al., 2016）. Women with vulvodynia describe intense pain in response to light touch of the affected region, such that sexual function and other activities can be severely limited. Medical costs associated with vulvodynia are high, exceeding $21 billion annually in the United States （Xie et al., 2012）. The high level of direct medical costs has been linked to high treatment failure rates. Many women with the disorder consult multiple practitioners and undergo multiple courses of treatment with limited benefit.

Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis

BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.

Study on the Construction and Evaluation System of Clinical Midwifery Teaching Faculty under the New Nursing Model

Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 2022 to March 2023,10 clinical teaching teachers and 20 midwifery interns from Beijing Anzhen Hospital affiliated with Capital Medical University were selected as the subjects of this study.The clinical teaching teachers and midwifery interns were divided into an observation group and a control group,with each group including 5 clinical teaching teachers and 10 midwifery interns.The observation group received daily management and evaluation under the new nursing model,while the control group received management and evaluation under the traditional nursing model.The teaching quality evaluation of clinical midwifery teaching teachers by midwifery interns,the exit exam scores of midwifery interns,and the scores of clinical teaching teachers’internship lectures and teaching rounds were compared between the two groups.Results:In the observation group,the scores for teaching attitude,teaching skills,and teaching management in the teaching quality evaluation of clinical midwifery teaching teachers were higher than those in the control group.The professional theory scores(91.28±3.64)and overall nursing comprehensive scores(92.56±4.38)of midwifery interns in the observation group were higher than those of midwifery interns in the control group(81.58±2.27 and 80.29±3.33,respectively).The scores for internship lectures(89.32±4.15)and teaching rounds(90.64±5.52)in the observation group were also significantly higher than those in the control group(80.46±3.28 and 81.24±4.38,respectively),and the differences were statistically significant(P<0.05).Conclusion:The management of the clinical midwifery teaching faculty under the new nursing model effectively improved the quality of clinical teaching.It significantly enhanced the teaching effectiveness of clinical teaching teachers and the proficiency of midwifery interns in clinical operations,making it worthy of promotion and use.

Exploration on New Campus Courier Service Models

Recently,e-commerce develops rapidly,advancing express delivery services,but the whole logistics are incomplete,especially for the issue of ＂the last one-kilometer ＂.For example,the research reviewed status quo and problems of Tianjin Agricultural University and made improvements on campus delivery services to explore the status quo and resolving ways,exploit the hint business opportunity in campus express model,improve efficiency and service attitude and get doublewin of both parties involved.

New Developments on Existence and Uniqueness of Solutions to Some Models in Atmospheric Dynamics

This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.

A New Model of Software Engineering Education and Exploration of Professional Curriculum Teaching

This paper focuses on the problems,opportunities,and challenges faced by software engineering education in the new era.We have studied the core ideas of the new model and reform,the specific measures implemented,and the challenges and solutions faced.The new model and reform must focus on cultivating practical abilities,introducing interdisciplinary knowledge,and strengthening innovation awareness and entrepreneurial spirit.The process of reform and innovation is carried out from the aspects of teaching methods,teaching means,and course performance evaluation in the teaching practice of software engineering courses.We adopt a method of“question guiding,simple and easy to understand,flexible and diverse,and emphasizing practical results”,optimizing the curriculum design,providing diverse learning opportunities,and establishing a platform for the industry-university-research cooperation.Our teaching philosophy is to adhere to the viewpoint of innovative teaching ideas,optimizing teaching methods and teaching means,and comprehensively improving the teaching quality and level of software engineering education.

Structure of the Quarks and a New Model of Protons and Neutrons: Answer to Some Open Questions

The described structural model tries to answer some open questions such as: Why do quarks not exist in the open state? Where are the antiparticles from the Big Bang?

A new mixed-mode phase-field model for crack propagation of brittle rock

Study on crack propagation process of brittle rock is of most significance for cracking-arrest design and cracking-network optimization in rock engineering.Phase-field model(PFM)has advantages of simplicity and high convergence over the common numerical methods(e.g.finite element method,discrete element method,and particle manifold method)in dealing with three-dimensional and multicrack problems.However,current PFMs are mainly used to simulate mode-I(tensile)crack propagation but difficult to effectively simulate mode-II(shear)crack propagation.In this paper,a new mixed-mode PFM is established to simulate both mode-I and mode-II crack propagation of brittle rock by distinguishing the volumetric elastic strain energy and deviatoric elastic strain energy in the total elastic strain energy and considering the effect of compressive stress on mode-II crack propagation.Numerical solution method of the new mixed-mode PFM is proposed based on the staggered solution method with self-programmed subroutines UMAT and HETVAL of ABAQUS software.Three examples calculated using different PFMs as well as test results are presented for comparison.The results show that compared with the conventional PFM(which only simulates the tensile wing crack but not mode-II crack propagation)and the modified mixed-mode PFM(which has difficulty in simulating the shear anti-wing crack),the new mixed-mode PFM can successfully simulate the whole trajectories of mixed-mode crack propagation(including the tensile wing crack,shear secondary crack,and shear anti-wing crack)and mode-II crack propagation,which are close to the test results.It can be further extended to simulate multicrack propagation of anisotropic rock under multi-field coupling loads.

Parameters of new three-water model based on nuclear magnetic experiment and optimization algorithm

Clastic rock reservoir is the main reservoir type in the oil and gas field.Archie formula or various conductive models developed on the basis of Archie’s formula are usually used to interpret this kind of reservoir,and the three-water model is widely used as well.However,there are many parameters in the threewater model,and some of them are difficult to determine.Most of the determination methods are based on the statistics of large amount of experimental data.In this study,the authors determine the value of the parameters of the new three-water model based on the nuclear magnetic data and the genetic optimization algorithm.The relative error between the resistivity calculated based on these parameters and the resistivity measured experimentally at 100%water content is 0.9024.The method studied in this paper can be easily applied without much experimental data.It can provide reference for other regions to determine the parameters of the new three-water model.

Research on the New Mode of college students’mental Health Education under the Network environment

With the rapid development of science andtechnology, internet technology has become matureincreasingly. It has become an important part ofpeople’s work, life and study. At the same time, thenetwork environment has also brought an impact onthe physical and mental health of college students.Nowadays, the quality and level of college students’mental health education has become society topics.College psychological health education work shouldkeep pace with the network environment developmentand the students’ physical and mental development.It is the effective innovation of psychological healtheducation work. The new model of college students’psychological health education development isconstructed. It is improve the level of students’ physicaland mental health development, and the psychologicalquality of college students is strengthen. Based onthis, this paper analyzes the existing problems on thecollege students’ mental health development. Under thenetwork environment, it proposes an effective method toconstruct a new mode of college students’ mental healtheducation .

New lumped-mass-stick model based on modal characteristics of structures: development and application to a nuclear containment building

In this study, a new lumped-mass-stick model （LMSM） is developed based on the modal characteristics of a structure such as eigenvalues and eigenvectors. The simplified model, named the ＂frequency adaptive lumped-massstick model,＂ hasonly a small number of stick elements and nodes to provide the same natural frequencies of the structure and is applied to a nuclear containment building. To investigate the numerical performance of the LMSM, a time history analysis is carried out on both the LMSM and the finite element model （FEM） for a nuclear containment building. A comparison of the results shows that the dynamic responses of the LMSM in terms of displacement and acceleration are almost identical to those of the FEM. In addition, the results in terms of floor response spectra at certain elevations are also in good agreement.

Sodium iodate induced retinal degeneration: new insights from an old model

Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,

A New Model for Correlation between the Marine Benthic Oxygen Isotope and Red Clay Magnetic Susceptibility on the Chinese Loess Plateau

Objective Aeolian sediments on the Chinese Loess Plateau contain some of the best continental archives of palaeoclimate change in the Late Cenozoic. The consensus that alternating MS in loess-paleosols in China was due to the strengthening and weakening of the East Asian palaeomonsoon provides an excellent climate record when correlated with global ice volume. Significantly, new basal dates from the red clay underlying the loess-paleosol sequence indicate that wind-blown dust began to accumulate on the Chinese Loess Plateau at least 22 million years ago. There are differences of opinion,

A New Example of Retrograde Solubility Model for Carbonate Rocks

Objective The dissolution and precipitation of carbonate during burial diagenetic process controls the reservoir property in deep buried strata. The geological process related with it has become a research focus during recent years. The most important dissolution fluids to carbonates are probably H2S and CO2 as byproducts of sulfate reduction in deep-buried setting with sulfate minerals, but carbonates are more soluble in relatively low temperature, which is the so-called retrograde solubility. Several geological processes can result in the decrease of temperature, including the upward migration of thermal fluids and tectonic uplift.

THE EXACT ANALYTICAL SOLUTIONS TO THE NEW MODEL OF RESERVOIR FILTRATION PROBLEM

The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtration and consequently has got, through various forms of limits, the exact analytical solutions of the three common reservoirs (fissure, homogeneous and the two-layered) pressure distribution under the conditions of three boundaries, i.e., infinite boundary, sealed finite boundary and the finite boundary at constant pressures.

New Method of Total Ionizing Dose Compact Modeling in Partially Depleted Silicon-on-Insulator MOSFETs

On the basis of a detailed discussion of the development of total ionizing dose （TID） effect model, a new commercial-model-independent TID modeling approach for partially depleted silicon-on-insulator metal-oxide- semiconductor field effect transistors is developed. An exponential approximation is proposed to simplify the trap charge calculation. Irradiation experiments with 60Co gamma rays for IO and core devices are performed to validate the simulation results. An excellent agreement of measurement with the simulation results is observed.

Structural Fiscal Regulation and Choice of Instruments in the New Normal

Based on the overall consideration of individual behaviors of Ricardian and non-Ricardian households, this paper develops a New Keynesian dynamic stochastic general equilibrium(DSGE) model to form a relatively systematic research framework for analyzing the economic effects of structural fiscal instruments. Our study findsthat great differences exist in the macroeconomic effects of different fiscal instruments, suggesting that the government should prudently select these fiscal instruments in fiscal macro-control. The simulating results of fiscal shocks show that the effect of tax cut is superior to the effect of increased spending. In the context of slowing economic growth and less potent stimulation policy, the government should transform its previous regulatory approach of fiscal policy and shift from hefty spending stimulus policy to structural tax cuts. This paper believes that China should step up the implementation of public-private partnership, increase its spending on social security, healthcare, pension and public services and facilitate the transition toward a service-based government; and that tax policy should focus on structural tax cuts on consumption to promote the transition of demand structure toward consumption-driven.

Rheological Behaviour for Polymer Melts and Concentrated Solutions Part Ⅰ:A New Multiple Reptation Model to Predict the Nonlinear Visco-elasticity with Nagai Chain Constraints in Entangled Polymer Melts

An approach of stochastically statistical mechanics and a unified molecular theory of nonlinear viscoelasticity with constraints of Nagai chain entanglement for polymer melts have been proposed. A multimode model structure for a single polymer chain with n tail segments and N reversible entanglement sites on the test polymer chain is developed. Based on the above model structure and the mechanism of molecular flow by the dynamical reorganization of entanglement sites, the probability distribution function of the end-to-end vectr for a single polymer chain at entangled state and the viscoelastic free energy of deformation for polymer melts are calculated by using the method of the stochastically statistical mechanics. The four types of stress-strain relation and the memory function are derived from this thery. The above theoretical relations are verified by the experimentaf data for various polymer melts. These relations are found to be in good agreement with the experimental results

Risk Management： A New Project Management Perspective

Risk management in Botswana has been very ineffective at assisting projects to be on time, on budget, and meeting client＇s/buyer＇s expectations. Traditional risk management attempts to manage, control, and direct a project through various phases, from planning and design, through procurement, and to construction. However, the risk management in Botswana seems to be either not implemented or not successful. The project performance in Botswana has a poor performance record. The researchers are attempting to identify why the traditional project/risk management is not working. In analyzing the problem in Botswana, the researchers discovered that the traditional risk management model was theoretically unsound, and designed a new project and risk model, with an entirely different approach to risk. The new model is an outgrowth of the highly successful Performance Information Procurement System （PIPS） and the Information Measurement Theory （IMT）/Kashiwagi Solution Model （KSM） concepts. The approach has been presented to some Botswana clients and academics and has received a favorable response. The development of the new risk model will lead to a huge change in the paradigm for delivering projects in Botswana. The theoretical development of the new risk model is ongoing at the University of Botswana as a part of a doctoral dissertation.

A NEW MODEL FOR PHYSICAL ADSORPTION ON SOLID SURFACES

The principal assumptions about equivalence and energy distribution of the asdorption sites on solidsurfaces used by Langmuir for deriving the equation of monomolecular adsorption are generalized and anew physical adsorption model is proposed and tested with experimental data published in literature.Themodels of Langmuir,Freundlich,Temkin etc.are only the special cases.Assuming uniform density distributionof adsorption energy,the isotherm equation is given asn=K.1n[1+（bop）1/Mor n=K.1n[1+（boC）1/M]where n is the amount of adsorption per unit weight or area of solid p or C is tbe pressure of gas or the concen-tration of solution respectively.K,bo,M are constants with physical meanings as described in this paper.This equation can be used over wide range to quantitatively represent the five types of physical adsorptionclassified by Brunauer.