Many new psychoactive substances(NPSs)with different chemical structures have emerged in the illicit drug market in the last decade.The present work was aimed at the development of a simple method in gas chromatograph...Many new psychoactive substances(NPSs)with different chemical structures have emerged in the illicit drug market in the last decade.The present work was aimed at the development of a simple method in gas chromatography/mass spectrometry(MS)for the determination of NPS of different classes,the use of cannabinoids,and,at the same time,the evaluation of methadone therapy in hair matrix,within our routine analysis control for methadone treatment or from autopsy cases.The determination of synthetic cannabinoids and methadone therapy used an extraction method based on incubation in concentrated sodium hydroxide(NaOH)solution,providing a dissolution of the keratin matrix.The described method was applied on 15 authentic specimens from our cases:five showed the presence of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine(EDDP).The described method can be useful not only in the forensic investigation of NPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social workers.The GC instrument was an Agilent 7820A(Agilent Technologies,Santa Clara,CA,USA),and the detection system was an Agilent 5977B single quadrupole MS operating in selective ion monitoring mode.Wlidation parameters such as limit of detections(LODs),limit of quantifications(LOQs),repeatability,accuracy,and linearity were satisfactory for its application on real specimens.LODs,LOQs,2?2,%CY standard deviation,and the mean concentration for the analyzed compounds are reported in Table lb.Accuracy and repeatability were acceptable for all the analytes at their respective LOQs.Recovery experiments varied from 58.3%to 103.0%,thus allowing the application on authentic specimens.The described method can be useful not only in the forensic investigation ofNPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social workers,such as drivers.展开更多
Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in ｜apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arre...Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in ｜apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arrests. Abuse of a stimulant called Philopon was widespread after the Second World War in ]apan, but the situation was dramatically improved after 1954 because the Japanese government enacted the Stimulant Control Act and restructured the police system and Japanese society recovered from post-war unrest. The situation of drug abuse in Japan has become less serious compared to the past and to the situation in many other countries, because we are taking comprehensive and nationwide measures, including proactive disclosure of the situation, control, drug abuse prevention class, and introduction of partial suspension of sentence. On the other hand, as in many countries, the rapid spread of new psychoactive substances （NPS） in recent years became a serious social issue. The situation of NPS has been rapidly improving due to comprehensive and government-wide measures, but the means of acquisition is quickly shifting to the Internet. It is necessary to strengthen cyber patrol.展开更多
文摘Many new psychoactive substances(NPSs)with different chemical structures have emerged in the illicit drug market in the last decade.The present work was aimed at the development of a simple method in gas chromatography/mass spectrometry(MS)for the determination of NPS of different classes,the use of cannabinoids,and,at the same time,the evaluation of methadone therapy in hair matrix,within our routine analysis control for methadone treatment or from autopsy cases.The determination of synthetic cannabinoids and methadone therapy used an extraction method based on incubation in concentrated sodium hydroxide(NaOH)solution,providing a dissolution of the keratin matrix.The described method was applied on 15 authentic specimens from our cases:five showed the presence of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine(EDDP).The described method can be useful not only in the forensic investigation of NPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social workers.The GC instrument was an Agilent 7820A(Agilent Technologies,Santa Clara,CA,USA),and the detection system was an Agilent 5977B single quadrupole MS operating in selective ion monitoring mode.Wlidation parameters such as limit of detections(LODs),limit of quantifications(LOQs),repeatability,accuracy,and linearity were satisfactory for its application on real specimens.LODs,LOQs,2?2,%CY standard deviation,and the mean concentration for the analyzed compounds are reported in Table lb.Accuracy and repeatability were acceptable for all the analytes at their respective LOQs.Recovery experiments varied from 58.3%to 103.0%,thus allowing the application on authentic specimens.The described method can be useful not only in the forensic investigation ofNPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social workers,such as drivers.
文摘Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in ｜apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arrests. Abuse of a stimulant called Philopon was widespread after the Second World War in ]apan, but the situation was dramatically improved after 1954 because the Japanese government enacted the Stimulant Control Act and restructured the police system and Japanese society recovered from post-war unrest. The situation of drug abuse in Japan has become less serious compared to the past and to the situation in many other countries, because we are taking comprehensive and nationwide measures, including proactive disclosure of the situation, control, drug abuse prevention class, and introduction of partial suspension of sentence. On the other hand, as in many countries, the rapid spread of new psychoactive substances （NPS） in recent years became a serious social issue. The situation of NPS has been rapidly improving due to comprehensive and government-wide measures, but the means of acquisition is quickly shifting to the Internet. It is necessary to strengthen cyber patrol.
