Newborn hearing screening(NHS) programs are essential to identify hearing loss early in life and to improve outcomes in children. In Saudi Arabia, the national NHS program has been operational since 2016;however, few ...Newborn hearing screening(NHS) programs are essential to identify hearing loss early in life and to improve outcomes in children. In Saudi Arabia, the national NHS program has been operational since 2016;however, few studies have evaluated its status, and none have covered all provinces across the country. This cross-sectional retrospective study provides an overview of the program's status across all provinces, focusing on screening coverage rates, referral/fail rates, and follow-up procedures. In 2021, 199,034 newborns were screened, with a coverage rate of 92.6% and an overall referral/fail rate of 1.87%. These performance measures provide a foundation for future progress and improvements. This study highlights the importance of ongoing efforts to enhance the program's effectiveness and sustainability.展开更多
To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to ...To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening （UNHS） were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn＇t pass the heating screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit （NICU）, neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity （OR=16.285, 95% CI 3.379--78,481）, neonatal disease （OR=34;968, 95% CI 2.720 449.534）, family history of congenital hearing loss （OR=69.488, 95% CI 4.417--1093.300） and birth weight （OR=0.241, 95% CI 0.090--0.648）. It is concluded that parity, neonatal disease and family history of heating loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.展开更多
Objective: To determine the incidence of hearing impairment in a standardized population of neonates seeking care in a tertiary hospital in Northwest India. Universal hearing screening is implemented in many developed...Objective: To determine the incidence of hearing impairment in a standardized population of neonates seeking care in a tertiary hospital in Northwest India. Universal hearing screening is implemented in many developed countries. However, neither universal screening, nor high risk screening, exists in India. The incidence of hearing loss in India is found to be 1 to 6 per 1000 newborns screened [1-3]. Screening only the high risk neonates misses 50% of babies with hearing loss [4,5], hence a cost effective universal screening is the viable option to sustain such a program. In our study, the possible burden of hearing disability was evaluated in babies born at a tertiary care hospital in Northwest India. One thousand newborns were screened using Transient Evoked OtoAcoustic Emissions (TEOAE) and 28.6% of them had risk factors. Four out of One Thousand were detected with hearing loss. Brain Stem Evoked Response (BERA) was used to confirm and determine the extent and the type of deafness in the neonates who were screened positive.展开更多
Hearing loss is the most common neurosensory deficit.It results froma variety of heritable and acquired causes and is linked to multiple deleterious effects on a child’s development that can be ameliorated by prompt ...Hearing loss is the most common neurosensory deficit.It results froma variety of heritable and acquired causes and is linked to multiple deleterious effects on a child’s development that can be ameliorated by prompt identification and individualized therapies.Diagnosing hearing loss in newborns is challenging,especially in mild or progressive cases,and its management requires a multidisciplinary team of healthcare providers comprising audiologists,pediatricians,otolaryngologists,and genetic counselors.While physiologic newborn hearing screening has resulted in earlier diagnosis of hearing loss than ever before,a growing body of knowledge supports the concurrent implementation of genetic and cytomegalovirus testing to offset the limitations inherent to a singular screening modality.In this review,we discuss the contemporary role of screening for hearing loss in newborns as well as future directions in its diagnosis and treatment.展开更多
目的通过新生儿听力和耳聋基因联合筛查及听力学诊断结果分析,进一步明确联合筛查的意义。方法以2013年7月至2015年6月间出生普通产科出生活产新生儿为研究对象,出生48小时后进行新生儿听力初筛,同时采集足跟血进行耳聋基因筛查。初筛...目的通过新生儿听力和耳聋基因联合筛查及听力学诊断结果分析,进一步明确联合筛查的意义。方法以2013年7月至2015年6月间出生普通产科出生活产新生儿为研究对象,出生48小时后进行新生儿听力初筛,同时采集足跟血进行耳聋基因筛查。初筛未通过者42天回产院复筛。复筛仍未通过者及耳聋基因筛查未通过者均于3月龄转诊至6家儿童听力障碍诊治机构接受听力诊断性检测和遗传咨询服务。通过对采集的联合筛查及听力诊断数据信息加以统计分析,开展研究。结果 30835例新生儿接受了听力和耳聋基因的联合筛查,联合筛查率占同期活产新生儿的97.6%,联合筛查推广和执行力度较为充分,社会认同度高。其中听力两步筛查未通过率1.51%,。耳聋基因筛查未通过率4.73%。联合筛查显示耳聋基因筛查未通过群体中听力筛查的未通过率(3.8%)高于基因筛查通过者(1.4%),P<0.001,提示听力筛查和耳聋基因筛查未通过者互为联合筛查的高危人群。1457例耳聋基因筛查未通过者中GJB2基因突变者占比最高(55.4%),其235del C位点突变最为常见(72.5%),其次是SLC26A4基因(34.3%)。线粒体12s r RNA基因突变共74例(5.1%)。1457例中共发现纯合和复合杂合突变5例,4例明确听力损失。单杂合突变1452例,检出不同程度听力损失14例。结论实践证明新生儿听力和耳聋基因联合筛查可行性强,临床应用易于推广。新生儿听力和耳聋基因筛查联合开展,相互裨益,是目前防聋筛查的最佳模式。展开更多
目的研究新生儿普遍听力筛查中确诊为中度以上听力障碍的婴幼儿接受早期干预后的效果。方法2001年11月至2005年6月在上海市儿童听力障碍诊治中心接受听力学评估的听力障碍患儿,在出生后6个月开始接受听力干预,并进行听力学跟踪随访,共...目的研究新生儿普遍听力筛查中确诊为中度以上听力障碍的婴幼儿接受早期干预后的效果。方法2001年11月至2005年6月在上海市儿童听力障碍诊治中心接受听力学评估的听力障碍患儿,在出生后6个月开始接受听力干预,并进行听力学跟踪随访,共计20人为干预组,同样接受听力学评估而不愿接受干预者36人为未干预组,随机选取听力正常年龄相仿的36人为对照组,采用视觉强化行为测听评估他们的耳聋程度,Gesell发育量表评估语言发育得分,并进行统计学分析。结果干预组裸耳平均听阈为73.81±20.63 dB HL,干预后平均听阈为24.33±10.92 dB HL,Gesell语言发育商数得分为92.25±17.32分;未干预组平均听阈为70.47±22.43dB HL,Gesell语言发育商数得分为70.44±29.99分;对照组平均听阈为15.20±6.02 dB HL,Gesell语言发育商数得分为100.29±8.86分。中度耳聋以上干预组与未干预组平均听阈与语言发育商数得分差异有统计学意义(P<0.05)。结论中度以上听力障碍婴幼儿早期干预效果良好,其听觉及言语能力明显高于未干预听障儿。展开更多
文摘Newborn hearing screening(NHS) programs are essential to identify hearing loss early in life and to improve outcomes in children. In Saudi Arabia, the national NHS program has been operational since 2016;however, few studies have evaluated its status, and none have covered all provinces across the country. This cross-sectional retrospective study provides an overview of the program's status across all provinces, focusing on screening coverage rates, referral/fail rates, and follow-up procedures. In 2021, 199,034 newborns were screened, with a coverage rate of 92.6% and an overall referral/fail rate of 1.87%. These performance measures provide a foundation for future progress and improvements. This study highlights the importance of ongoing efforts to enhance the program's effectiveness and sustainability.
基金This project is supported by a grant from the National Natural Sciences Foundation (No. 30100207)a grant from the Top Ten Scientific Research Programs of Shandong Province (No. 2004GG3202003)
文摘To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening （UNHS） were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn＇t pass the heating screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit （NICU）, neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity （OR=16.285, 95% CI 3.379--78,481）, neonatal disease （OR=34;968, 95% CI 2.720 449.534）, family history of congenital hearing loss （OR=69.488, 95% CI 4.417--1093.300） and birth weight （OR=0.241, 95% CI 0.090--0.648）. It is concluded that parity, neonatal disease and family history of heating loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.
文摘Objective: To determine the incidence of hearing impairment in a standardized population of neonates seeking care in a tertiary hospital in Northwest India. Universal hearing screening is implemented in many developed countries. However, neither universal screening, nor high risk screening, exists in India. The incidence of hearing loss in India is found to be 1 to 6 per 1000 newborns screened [1-3]. Screening only the high risk neonates misses 50% of babies with hearing loss [4,5], hence a cost effective universal screening is the viable option to sustain such a program. In our study, the possible burden of hearing disability was evaluated in babies born at a tertiary care hospital in Northwest India. One thousand newborns were screened using Transient Evoked OtoAcoustic Emissions (TEOAE) and 28.6% of them had risk factors. Four out of One Thousand were detected with hearing loss. Brain Stem Evoked Response (BERA) was used to confirm and determine the extent and the type of deafness in the neonates who were screened positive.
基金This project was supported by NIH-NIDCD(Grants No.R01 DC002842,DC012049,and DC017955)(RJHS)NIH-NIDCD(Grant No.5T32DC000040)(RKT).
文摘Hearing loss is the most common neurosensory deficit.It results froma variety of heritable and acquired causes and is linked to multiple deleterious effects on a child’s development that can be ameliorated by prompt identification and individualized therapies.Diagnosing hearing loss in newborns is challenging,especially in mild or progressive cases,and its management requires a multidisciplinary team of healthcare providers comprising audiologists,pediatricians,otolaryngologists,and genetic counselors.While physiologic newborn hearing screening has resulted in earlier diagnosis of hearing loss than ever before,a growing body of knowledge supports the concurrent implementation of genetic and cytomegalovirus testing to offset the limitations inherent to a singular screening modality.In this review,we discuss the contemporary role of screening for hearing loss in newborns as well as future directions in its diagnosis and treatment.
文摘目的通过新生儿听力和耳聋基因联合筛查及听力学诊断结果分析,进一步明确联合筛查的意义。方法以2013年7月至2015年6月间出生普通产科出生活产新生儿为研究对象,出生48小时后进行新生儿听力初筛,同时采集足跟血进行耳聋基因筛查。初筛未通过者42天回产院复筛。复筛仍未通过者及耳聋基因筛查未通过者均于3月龄转诊至6家儿童听力障碍诊治机构接受听力诊断性检测和遗传咨询服务。通过对采集的联合筛查及听力诊断数据信息加以统计分析,开展研究。结果 30835例新生儿接受了听力和耳聋基因的联合筛查,联合筛查率占同期活产新生儿的97.6%,联合筛查推广和执行力度较为充分,社会认同度高。其中听力两步筛查未通过率1.51%,。耳聋基因筛查未通过率4.73%。联合筛查显示耳聋基因筛查未通过群体中听力筛查的未通过率(3.8%)高于基因筛查通过者(1.4%),P<0.001,提示听力筛查和耳聋基因筛查未通过者互为联合筛查的高危人群。1457例耳聋基因筛查未通过者中GJB2基因突变者占比最高(55.4%),其235del C位点突变最为常见(72.5%),其次是SLC26A4基因(34.3%)。线粒体12s r RNA基因突变共74例(5.1%)。1457例中共发现纯合和复合杂合突变5例,4例明确听力损失。单杂合突变1452例,检出不同程度听力损失14例。结论实践证明新生儿听力和耳聋基因联合筛查可行性强,临床应用易于推广。新生儿听力和耳聋基因筛查联合开展,相互裨益,是目前防聋筛查的最佳模式。
文摘目的探讨群组声刺激听性脑干反应(chained-stimuli auditory brainstem response,CsABR)在新生儿听力复筛中的应用价值。方法对接受听力复筛的295例婴幼儿,在应用畸变产物耳声发射(DPOAE)和自动听性脑干反应(AABR)筛查的基础上增加CsABR测试,复筛未通过的婴幼儿转诊到听力诊断中心,进行1 000 Hz声导抗、DPOAE、诊断型听性脑干反应(ABR)、听性稳态反应(ASSR)等综合听力诊断评估,比较复筛未通过与通过婴幼儿CsABR阈值的差异,分析CsABR阈值与诊断型ABR阈值的相关性和差异,并根据临床诊断结果分析CsABR的敏感性和特异性。结果295例(579耳)均完成CsABR阈值测试,每例婴幼儿完成双耳CsABR测试的时间约为5分钟,其中39例(78耳)完成听力诊断评估;听力复筛未通过的婴幼儿(77耳)CsABR阈值较听力复筛通过者高(P<0.001);CsABR阈值与诊断型ABR阈值显著相关(rs=0.861,P<0.001);CsABR阈值≤70 dB nHL的64耳其平均阈值高于诊断型ABR阈值5.5±8.9 dB;以临床诊断结果(指综合诊断结果,而不是指诊断型ABR结果)作为标准,CsABR阈值大于30 dB nHL为异常,则CsABR的敏感性为95.7%(44/46),特异性为59.4%(19/32);CsABR阈值大于70 dB nHL的13耳中11耳(84.6%)诊断为重度或极重度听力损失。结论CsABR操作简单、测试时间短,是新生儿听力筛查阶段预测听力损失程度的快捷方法,可用于听力筛查未通过婴幼儿的快速听力评估。
文摘目的研究新生儿普遍听力筛查中确诊为中度以上听力障碍的婴幼儿接受早期干预后的效果。方法2001年11月至2005年6月在上海市儿童听力障碍诊治中心接受听力学评估的听力障碍患儿,在出生后6个月开始接受听力干预,并进行听力学跟踪随访,共计20人为干预组,同样接受听力学评估而不愿接受干预者36人为未干预组,随机选取听力正常年龄相仿的36人为对照组,采用视觉强化行为测听评估他们的耳聋程度,Gesell发育量表评估语言发育得分,并进行统计学分析。结果干预组裸耳平均听阈为73.81±20.63 dB HL,干预后平均听阈为24.33±10.92 dB HL,Gesell语言发育商数得分为92.25±17.32分;未干预组平均听阈为70.47±22.43dB HL,Gesell语言发育商数得分为70.44±29.99分;对照组平均听阈为15.20±6.02 dB HL,Gesell语言发育商数得分为100.29±8.86分。中度耳聋以上干预组与未干预组平均听阈与语言发育商数得分差异有统计学意义(P<0.05)。结论中度以上听力障碍婴幼儿早期干预效果良好,其听觉及言语能力明显高于未干预听障儿。
