This paper analyzes the positions and developing situation of the USA and the UK in the field of journalism by statistical comparison of titles consisting "American and British"or"British and American&q...This paper analyzes the positions and developing situation of the USA and the UK in the field of journalism by statistical comparison of titles consisting "American and British"or"British and American"in 28 teaching materials and other publications concerning newspapers and periodicals; based on the order principle of compound nouns,this paper further explores the naming mechanism of"American and British"and"British and American"newspapers periodicals.展开更多
Reading English newspapers and magazines is an effective way to help the students get the latest information worldwide and improve English levels. The present article first analyzes the features of the English newspap...Reading English newspapers and magazines is an effective way to help the students get the latest information worldwide and improve English levels. The present article first analyzes the features of the English newspapers and magazines and then proposes making good use of them through such classroom activities as discussing the hot issue and role-playing to provide more authentic situations in which the students can have chances to practice four English skills, achieving the ideal teaching result.展开更多
Through analyzing current situations of newspapers about agriculture,countryside and farmers and problems impairing development of these newspapers,this paper presents constructive recommendations for combination with...Through analyzing current situations of newspapers about agriculture,countryside and farmers and problems impairing development of these newspapers,this paper presents constructive recommendations for combination with NIE project at operational level.In China,NIE project should not copy foreign experience,but should proceed from rural realities,expend its intension and enrich its extension,and extend coverage of newspaper to all levels in rural areas.In addition,it is recommended to explore new approaches and find a new development road of newspapers about agriculture,countryside and farmers through transforming the publishing mode.展开更多
Using scientific metrological method,this paper analyzed all literature published by top 4 marketing periodicals( JCR,JM,JMR,and MS) in 2009- 2013. It is intended to find out hot issues and frontier topics of current ...Using scientific metrological method,this paper analyzed all literature published by top 4 marketing periodicals( JCR,JM,JMR,and MS) in 2009- 2013. It is intended to find out hot issues and frontier topics of current marketing research through cluster analysis of key words,get to know cooperation and exchange of organizations through analysis of organization cooperative network,explore new topics of marketing researches with the aid of analysis of abrupt change words,and explore evolution path and development rules of marketing researches through co-citation network analysis.展开更多
Chinese newspaper industry has entered into a new historical period;the prospect of newspaper is becoming an important topic of academic and industrial.Facing the media ecological reconstruction brought by media conve...Chinese newspaper industry has entered into a new historical period;the prospect of newspaper is becoming an important topic of academic and industrial.Facing the media ecological reconstruction brought by media convergence,mobile circumstance,and internet plus,the norm of newspaper media in the past has been broken,facing new adjustment.Newspaper explored with hard since it confronted both opportunities and challenges.This article summarizes the basic situation and main advantages of newspaper media development.By analyzing newspaper transformation practice,this paper tries to discuss the future direction and what newspaper media can achieve in view of the current main difficulties.The analysis of the essence and effect of newspaper transformation,as well as the rationalization proposals,will be beneficial for newspaper media to recognize the situation,find the correct position,and create expression,so as to meet both opportunities and challenges.展开更多
The economic and financial sustainability of regional press companies is extremely relevant for the dynamism of this important sector in promoting pluralism of ideas and decentralization of information. In this contex...The economic and financial sustainability of regional press companies is extremely relevant for the dynamism of this important sector in promoting pluralism of ideas and decentralization of information. In this context, the work presented here intends, on one hand, to analyze the importance of the press support system in Macao for its economic and financial sustainability and, on the other hand, to try to understand how they contribute to promoting information pluralism with Portuguese speaking community in a Chinese territory--with special regime. With this purpose, three methodologies were implemented, namely: (1) review of literature and documentary research--reports, articles in the press, scientific articles and academic books related to the topic; (2) analysis of contents of interviews of privileged informants-directors and editors of newspapers addressed to the Portuguese community in the Macao region; and (3) analysis of the impact of support from the Macao Regional Government based on the principles of the Office of Fair Trading (OFT) model.展开更多
As the most powerful nation in the world, the U.S. presidential election campaign drew a lot of attention from the media around the world. This study examines how party-orientation and market-orientation newspapers in...As the most powerful nation in the world, the U.S. presidential election campaign drew a lot of attention from the media around the world. This study examines how party-orientation and market-orientation newspapers in China presented 2008 U.S. presidential election campaign to their audience, and how the news serve for the reproduction of domestic dominated ideology and safeguarding domestic political needs. It adopted content analysis and textual analysis as research methods. The results show that Party newspaper tends to serve domestic political ideology, while market-oriented newspapers showed mixed attitude toward political demand. Although market newspapers, out of the concern of political safety, employed some tactic to comply with the demand of dominated ideology to some extent, their cooperation was limited since their main purpose was commercial success and their presentation even destroy the aim of linkage politics for the reasons include acquiring market profit and/or pursuit of professional value. This study is a positive effort to make up the current research gap of studies on international news in Chinese media.展开更多
On March 15,2019,in order to study and implement General Secretary Xi Jinping's speech on deepening reform and cultivating worldclass scientific and technological journals,the eighth working meeting of serial peri...On March 15,2019,in order to study and implement General Secretary Xi Jinping's speech on deepening reform and cultivating worldclass scientific and technological journals,the eighth working meeting of serial periodicals of the People's Medical Publishing House (PMPH),meeting of the ninth editorial board of the Chinese Journal for Clinicians,and the second editorial board of the Global Health Journal were held in Beijing.展开更多
Interactivity in online newspapers is the focus of this chapter in eliciting readers’evaluation of Zambian online newspapers.This aspect of the study investigates and characterises the motivations(gratification sough...Interactivity in online newspapers is the focus of this chapter in eliciting readers’evaluation of Zambian online newspapers.This aspect of the study investigates and characterises the motivations(gratification sought)for use of interactivity features(“process motivation”)and how widely they are used.It also attempts to ascertain the gratification obtained from their use among readers.The probable relationships between use of the interactivity features(“audience interactivity”)and gratification obtained from them(“process gratification”)and the impact of the perceived credibility of the online newspapers on gratification are also examined.Past studies present mixed results on use of interactivity and gratification obtained from it.This study finds that use of interactivity in Zambian online newspapers is at a low level,although among the three broad categorisations of features of online newspapers,interactivity attracts greater use than hyper-textuality and multi-mediality.Human interactivity features-“knowing what others think about an issue”,“chat on the Facebook page of the newspaper”,“ability to navigate on the Facebook page of the newspaper”,and“posting own comments on stories”-are the main motivations for use of online newspapers,the most frequently used,and the most gratifying to the readers.While readers express an interest in interacting with other readers via online newspapers,they seem less interested in posting their own stories as“citizen journalists”and linking up with the publishers and editors.This finding challenges the notion that all new media are catalysts of participatory and cyclic communication.展开更多
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in...Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption.CD301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone regeneration.However,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain elusive.In this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)macrophages.We first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA sequencing.Moreover,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)macrophages.The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages.The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis progressed.Furthermore,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in periodontitis.Additionally,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages phenotype.In a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.展开更多
The carbon black(CB)is introduced to manufacture CB/graphene oxide(GO)composite material to mitigate limitations of GO as a saturable absorber with the excellent performance in ultrafast fiber lasers.At a central wave...The carbon black(CB)is introduced to manufacture CB/graphene oxide(GO)composite material to mitigate limitations of GO as a saturable absorber with the excellent performance in ultrafast fiber lasers.At a central wavelength of 1555.5 nm,the stable mode-locked pulse with width of 656 fs,repetition rate of 20.16 MHz,and high signal-to-noise ratio of 82.07 dB is experimentally obtained.Additionally,experimental observations for pulsation phenomena of vector biperiodic solitons combining period-1 and period-17,period-2 and period-32,period-3 and period-36 are verified via simulations.展开更多
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and...Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.Sinensetin(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant activities.Our study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular mechanisms.We found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory conditions.Administered Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in vivo.By molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence assays.Chromatin immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor HO-1.Further functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant effects.Additionally,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative stress.Overall,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.展开更多
For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits ...For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits of the regular system are obtained. Under different parametric conditions, various sufficient conditions to guarantee the existence of analytical and non-analytical solutions of the singular system are given by using singular traveling wave theory. For certain special cases, some explicit and exact parametric representations of traveling wave solutions are derived such as analytical periodic waves and non-analytical periodic cusp waves. Further, two-dimensional wave plots of analytical periodic solutions and non-analytical periodic cusp wave solutions are drawn to visualize the dynamics of the equation.展开更多
The seismic performance of rubber concrete-layered periodic foundations are significantly influenced by their design,in which the band gaps play a paramount role.Aiming at providing better designs for these foundation...The seismic performance of rubber concrete-layered periodic foundations are significantly influenced by their design,in which the band gaps play a paramount role.Aiming at providing better designs for these foundations,this study first proposes and validates the analytical formulas to approximate the bounds of the first few band gaps.In addition,the mapping relations linking the frequencies of different band gaps are presented.Furthermore,an optimal design method for these foundations is developed,which is validated through an engineering example.It is demonstrated that ensuring the superstructure’s resonance zones are completely covered by the corresponding periodic foundation’s band gaps can achieve satisfactory vibration attenuation effects,which is a good strategy for the design of rubber concrete layered periodic foundations.展开更多
A well-known hazardous metal and top contaminant in wastewater is hexavalent chromium. The two forms of most commonly found chromium are chromate ( CrO 4 2− ) and dichromate ( Cr 2 O 7 2− ). Leather tanning, cooling t...A well-known hazardous metal and top contaminant in wastewater is hexavalent chromium. The two forms of most commonly found chromium are chromate ( CrO 4 2− ) and dichromate ( Cr 2 O 7 2− ). Leather tanning, cooling tower blow-down, plating, electroplating, rinse water sources, anodizing baths etc. are the main sources of Cr (VI) contamination. The Cr (VI) is not only non-biodegradable in the environment but also carcinogenic to living population. It is still difficult to treat Cr contaminated waste water effectively, safely, eco-friendly, and economically. As a result, many techniques have been used to treat Cr (VI)-polluted wastewater, including adsorption, chemical precipitation, coagulation, ion-exchange, and filtration. Among these practices, the most practical method is adsorption for the removal of Cr (VI) from aqueous solutions, which has gained widespread acceptance due to the ease of use and affordability of the equipment and adsorbent. It has been revealed that Fe-based adsorbents’ oxides and hydroxides have high adsorptive potential to lower Cr (VI) content below the advised threshold. Fe-based adsorbents were also discovered to be relatively cheap and toxic-free in Cr (VI) treatment. Fe-based adsorbents are commonly utilized in industry. It has been discovered that nanoparticles of Fe-, Ti-, and Cu-based adsorbents have a better capacity to remove Cr (VI). Cr (VI) was effectively removed from contaminated water using mixed element-based adsorbents (Fe-Mn, Fe-Ti, Fe-Cu, Fe-Zr, Fe-Cu-Y, Fe-Mg, etc.). Initial findings suggest that Cr (VI) removal from wastewater may be accomplished by using magnesium ferrite nanomaterials as an efficient adsorbent.展开更多
Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic ...Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic wave propagation.The PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap,analyze the wave propagation mechanisms,and further form its geometrical and physical criteria for tuning the elastic wave propagation.With the equivalent model,we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability,and investigate the wave propagation characteristics through the PCBPS.To validate the equivalent system,the finite element method(FEM)is employed.It is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical characteristics.The findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.展开更多
Objectives: To summarize the current status and outlook of pancreatic duct drainage in the learning curve period of laparoscopic pancreaticoduodenectomy (LPD). Methods: By searching the literature related to the effic...Objectives: To summarize the current status and outlook of pancreatic duct drainage in the learning curve period of laparoscopic pancreaticoduodenectomy (LPD). Methods: By searching the literature related to the efficacy analysis of internal versus external pancreatic duct drainage in pancreaticoduodenectomy (OPD) and the learning curve period of laparoscopic pancreaticoduodenectomy in recent years at home and abroad and making a review. Results: Because of the complexity of the LPD surgical procedure, the high technical requirements and the high complication rate, it is necessary for the operator and his/her team to carry out a certain number of cases to pass through the learning curve in order to have a basic mastery of the procedure. In recent years, more and more pancreatic surgeons have begun to promote and use pancreatic duct drains. However, no consensus conclusion has been reached on whether to choose internal or external drainage for pancreatic duct placement and drainage in LPD. Conclusions: Intraoperative application of pancreatic duct drainage reduces the incidence of pancreatic fistula during the learning curve of laparoscopic pancreaticoduodenectomy. However, external pancreatic duct drainage and internal pancreatic duct drainage have both advantages and disadvantages, so when choosing the drainage method, one should choose the appropriate drainage method in conjunction with one’s own conditions, so as to reduce the incidence of complications.展开更多
Yopougon, located in the western part of the Autonomous District of Abidjan, is the most heavily populated municipality in Côte d’Ivoire. However, this area is prone to floods and landslides during the rainy sea...Yopougon, located in the western part of the Autonomous District of Abidjan, is the most heavily populated municipality in Côte d’Ivoire. However, this area is prone to floods and landslides during the rainy season. The study aims to assess recent flood risks in the municipality of Yopougon of the Autonomous District of Abidjan. To achieve this objective, the study analyzed two types of data: daily rainfall from 1971 to 2022 and parameters derived from a Numerical Field and Altitude Model (NFAM). The study examined six rainfall parameters using statistical analysis and combined land use maps obtained from the NFAM of Yopougon. The results indicated that, in 67% of cases, extreme rainfall occurred mainly between week 3 of May and week 1 of July. The peak of extreme rainfall was observed in week 2 of June with 15% of cases. These are critical periods of flood risks in the Autonomous District of Abidjan, especially in Yopougon. In addition, there was variability of rainfall parameters in the Autonomous District of Abidjan. This was characterized by a drop of annual and seasonal rainfall, and an increase of numbers of rainy days. Flood risks in Yopougon are, therefore, due to the regular occurrence of rainy events. Recent floods in Yopougon were caused by normal rains ranging from 55 millimeters (mm) to 153 mm with a return period of less than five years. Abnormal heavy rains of a case study on June 20-21, 2022 in Yopougon were detected by outputs global climate models. Areas of very high risk of flood covered 18% of Yopougon, while 31% were at high risk. Climate information from this study can assist authorities to take in advance adaptation and management measures.展开更多
A novel three-dimensional numerical model is proposed to investigate the effect of tool eccentricity on the coupled thermal and material flow characteristics in friction stir welding(FSW) process.An asymmetrical bound...A novel three-dimensional numerical model is proposed to investigate the effect of tool eccentricity on the coupled thermal and material flow characteristics in friction stir welding(FSW) process.An asymmetrical boundary condition at the tool-workpiece interface,and the dynamic mesh technique are both employed for the consideration of the tool eccentricity during tool rotating.It is found that tool eccentricity induces the periodical variation of the heat densities both at the tool-workpiece interface and inside the shear layer,but the fluctuation amplitudes of the heat density variations are limited.However,it is demonstrated that tool eccentricity results in significant variation of the material flow behavior in one tool rotating period.Moreover,the material velocity variation at the retreating side is particularly important for the formation of the periodic characteristics in FSW.The modeling result is found to be in good agreement with the experimental one.展开更多
The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social order.To improve the seismic resilience of city road networks,a resilience ...The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social order.To improve the seismic resilience of city road networks,a resilience evaluation method used in the post-earthquake emergency period is proposed.The road seismic damage index of a city road network can consider the influence of roads,bridges and buildings along the roads,etc.on road capacity after an earthquake.A function index for a city road network is developed,which reflects the connectivity,redundancy,traffic demand and traffic function of the network.An optimization model for improving the road repair order in the post-earthquake emergency period is also developed according to the resilience evaluation,to enable decision support for city emergency management and achieve the best seismic resilience of the city road network.The optimization model is applied to a city road network and the results illustrate the feasibility of the resilience evaluation and optimization method for a city road network in the post-earthquake emergency period.展开更多
文摘This paper analyzes the positions and developing situation of the USA and the UK in the field of journalism by statistical comparison of titles consisting "American and British"or"British and American"in 28 teaching materials and other publications concerning newspapers and periodicals; based on the order principle of compound nouns,this paper further explores the naming mechanism of"American and British"and"British and American"newspapers periodicals.
文摘Reading English newspapers and magazines is an effective way to help the students get the latest information worldwide and improve English levels. The present article first analyzes the features of the English newspapers and magazines and then proposes making good use of them through such classroom activities as discussing the hot issue and role-playing to provide more authentic situations in which the students can have chances to practice four English skills, achieving the ideal teaching result.
文摘Through analyzing current situations of newspapers about agriculture,countryside and farmers and problems impairing development of these newspapers,this paper presents constructive recommendations for combination with NIE project at operational level.In China,NIE project should not copy foreign experience,but should proceed from rural realities,expend its intension and enrich its extension,and extend coverage of newspaper to all levels in rural areas.In addition,it is recommended to explore new approaches and find a new development road of newspapers about agriculture,countryside and farmers through transforming the publishing mode.
基金Supported by Project of National Natural Science Foundation(71273102)Fundamental Research Funds for the Central Universities(2012RW004)
文摘Using scientific metrological method,this paper analyzed all literature published by top 4 marketing periodicals( JCR,JM,JMR,and MS) in 2009- 2013. It is intended to find out hot issues and frontier topics of current marketing research through cluster analysis of key words,get to know cooperation and exchange of organizations through analysis of organization cooperative network,explore new topics of marketing researches with the aid of analysis of abrupt change words,and explore evolution path and development rules of marketing researches through co-citation network analysis.
文摘Chinese newspaper industry has entered into a new historical period;the prospect of newspaper is becoming an important topic of academic and industrial.Facing the media ecological reconstruction brought by media convergence,mobile circumstance,and internet plus,the norm of newspaper media in the past has been broken,facing new adjustment.Newspaper explored with hard since it confronted both opportunities and challenges.This article summarizes the basic situation and main advantages of newspaper media development.By analyzing newspaper transformation practice,this paper tries to discuss the future direction and what newspaper media can achieve in view of the current main difficulties.The analysis of the essence and effect of newspaper transformation,as well as the rationalization proposals,will be beneficial for newspaper media to recognize the situation,find the correct position,and create expression,so as to meet both opportunities and challenges.
文摘The economic and financial sustainability of regional press companies is extremely relevant for the dynamism of this important sector in promoting pluralism of ideas and decentralization of information. In this context, the work presented here intends, on one hand, to analyze the importance of the press support system in Macao for its economic and financial sustainability and, on the other hand, to try to understand how they contribute to promoting information pluralism with Portuguese speaking community in a Chinese territory--with special regime. With this purpose, three methodologies were implemented, namely: (1) review of literature and documentary research--reports, articles in the press, scientific articles and academic books related to the topic; (2) analysis of contents of interviews of privileged informants-directors and editors of newspapers addressed to the Portuguese community in the Macao region; and (3) analysis of the impact of support from the Macao Regional Government based on the principles of the Office of Fair Trading (OFT) model.
文摘As the most powerful nation in the world, the U.S. presidential election campaign drew a lot of attention from the media around the world. This study examines how party-orientation and market-orientation newspapers in China presented 2008 U.S. presidential election campaign to their audience, and how the news serve for the reproduction of domestic dominated ideology and safeguarding domestic political needs. It adopted content analysis and textual analysis as research methods. The results show that Party newspaper tends to serve domestic political ideology, while market-oriented newspapers showed mixed attitude toward political demand. Although market newspapers, out of the concern of political safety, employed some tactic to comply with the demand of dominated ideology to some extent, their cooperation was limited since their main purpose was commercial success and their presentation even destroy the aim of linkage politics for the reasons include acquiring market profit and/or pursuit of professional value. This study is a positive effort to make up the current research gap of studies on international news in Chinese media.
文摘On March 15,2019,in order to study and implement General Secretary Xi Jinping's speech on deepening reform and cultivating worldclass scientific and technological journals,the eighth working meeting of serial periodicals of the People's Medical Publishing House (PMPH),meeting of the ninth editorial board of the Chinese Journal for Clinicians,and the second editorial board of the Global Health Journal were held in Beijing.
文摘Interactivity in online newspapers is the focus of this chapter in eliciting readers’evaluation of Zambian online newspapers.This aspect of the study investigates and characterises the motivations(gratification sought)for use of interactivity features(“process motivation”)and how widely they are used.It also attempts to ascertain the gratification obtained from their use among readers.The probable relationships between use of the interactivity features(“audience interactivity”)and gratification obtained from them(“process gratification”)and the impact of the perceived credibility of the online newspapers on gratification are also examined.Past studies present mixed results on use of interactivity and gratification obtained from it.This study finds that use of interactivity in Zambian online newspapers is at a low level,although among the three broad categorisations of features of online newspapers,interactivity attracts greater use than hyper-textuality and multi-mediality.Human interactivity features-“knowing what others think about an issue”,“chat on the Facebook page of the newspaper”,“ability to navigate on the Facebook page of the newspaper”,and“posting own comments on stories”-are the main motivations for use of online newspapers,the most frequently used,and the most gratifying to the readers.While readers express an interest in interacting with other readers via online newspapers,they seem less interested in posting their own stories as“citizen journalists”and linking up with the publishers and editors.This finding challenges the notion that all new media are catalysts of participatory and cyclic communication.
基金supported by the National Natural Science Foundation of China(82025011,82220108018,82270981,82100975,82201078)the National Key R&D Program of China(2021YFC2400405)+1 种基金the Fundamental Research Funds for the Central Universities(2042023kfyq022042022dx0003).
文摘Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption.CD301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone regeneration.However,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain elusive.In this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)macrophages.We first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA sequencing.Moreover,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)macrophages.The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages.The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis progressed.Furthermore,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in periodontitis.Additionally,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages phenotype.In a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.
基金supported by the National Natural Science Foundation of China(Grant Nos.12261131495 and 12475008)the Scientific Research and Developed Fund of Zhejiang A&F University(Grant No.2021FR0009).
文摘The carbon black(CB)is introduced to manufacture CB/graphene oxide(GO)composite material to mitigate limitations of GO as a saturable absorber with the excellent performance in ultrafast fiber lasers.At a central wavelength of 1555.5 nm,the stable mode-locked pulse with width of 656 fs,repetition rate of 20.16 MHz,and high signal-to-noise ratio of 82.07 dB is experimentally obtained.Additionally,experimental observations for pulsation phenomena of vector biperiodic solitons combining period-1 and period-17,period-2 and period-32,period-3 and period-36 are verified via simulations.
基金supported by National Natural Science Foundation of China(82001050,82173871)Natural Science Foundation of Jiangsu Province(BK20190135)+2 种基金Fundamental Research Funds for the Central Universities(021414380503)“3456”Cultivation Program for Junior Talents of Nanjing Stomatological Hospital,Medical School of Nanjing University(0222R209)Jiangsu Provincial Medical Key Discipline Cultivation Unit(JSDW202246).
文摘Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.Sinensetin(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant activities.Our study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular mechanisms.We found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory conditions.Administered Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in vivo.By molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence assays.Chromatin immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor HO-1.Further functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant effects.Additionally,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative stress.Overall,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.
文摘For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits of the regular system are obtained. Under different parametric conditions, various sufficient conditions to guarantee the existence of analytical and non-analytical solutions of the singular system are given by using singular traveling wave theory. For certain special cases, some explicit and exact parametric representations of traveling wave solutions are derived such as analytical periodic waves and non-analytical periodic cusp waves. Further, two-dimensional wave plots of analytical periodic solutions and non-analytical periodic cusp wave solutions are drawn to visualize the dynamics of the equation.
基金National Natural Science Foundation of China under Grant Nos.52078395 and 52178301the Open Projects Foundation of the State Key Laboratory for Health and Safety of Bridge Structures under Grant No.BHSKL19-07-GF+1 种基金the Dawn Program of Knowledge Innovation Project from the Bureau of Science and Technology of Wuhan Municipality under Grant No.2022010801020357the Science Research Foundation of Wuhan Institute of Technology under Grant No.K2021030。
文摘The seismic performance of rubber concrete-layered periodic foundations are significantly influenced by their design,in which the band gaps play a paramount role.Aiming at providing better designs for these foundations,this study first proposes and validates the analytical formulas to approximate the bounds of the first few band gaps.In addition,the mapping relations linking the frequencies of different band gaps are presented.Furthermore,an optimal design method for these foundations is developed,which is validated through an engineering example.It is demonstrated that ensuring the superstructure’s resonance zones are completely covered by the corresponding periodic foundation’s band gaps can achieve satisfactory vibration attenuation effects,which is a good strategy for the design of rubber concrete layered periodic foundations.
文摘A well-known hazardous metal and top contaminant in wastewater is hexavalent chromium. The two forms of most commonly found chromium are chromate ( CrO 4 2− ) and dichromate ( Cr 2 O 7 2− ). Leather tanning, cooling tower blow-down, plating, electroplating, rinse water sources, anodizing baths etc. are the main sources of Cr (VI) contamination. The Cr (VI) is not only non-biodegradable in the environment but also carcinogenic to living population. It is still difficult to treat Cr contaminated waste water effectively, safely, eco-friendly, and economically. As a result, many techniques have been used to treat Cr (VI)-polluted wastewater, including adsorption, chemical precipitation, coagulation, ion-exchange, and filtration. Among these practices, the most practical method is adsorption for the removal of Cr (VI) from aqueous solutions, which has gained widespread acceptance due to the ease of use and affordability of the equipment and adsorbent. It has been revealed that Fe-based adsorbents’ oxides and hydroxides have high adsorptive potential to lower Cr (VI) content below the advised threshold. Fe-based adsorbents were also discovered to be relatively cheap and toxic-free in Cr (VI) treatment. Fe-based adsorbents are commonly utilized in industry. It has been discovered that nanoparticles of Fe-, Ti-, and Cu-based adsorbents have a better capacity to remove Cr (VI). Cr (VI) was effectively removed from contaminated water using mixed element-based adsorbents (Fe-Mn, Fe-Ti, Fe-Cu, Fe-Zr, Fe-Cu-Y, Fe-Mg, etc.). Initial findings suggest that Cr (VI) removal from wastewater may be accomplished by using magnesium ferrite nanomaterials as an efficient adsorbent.
基金supported by the National Natural Science Foundation of China(Nos.12172012 and 11802005)。
文摘Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic wave propagation.The PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap,analyze the wave propagation mechanisms,and further form its geometrical and physical criteria for tuning the elastic wave propagation.With the equivalent model,we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability,and investigate the wave propagation characteristics through the PCBPS.To validate the equivalent system,the finite element method(FEM)is employed.It is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical characteristics.The findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.
文摘Objectives: To summarize the current status and outlook of pancreatic duct drainage in the learning curve period of laparoscopic pancreaticoduodenectomy (LPD). Methods: By searching the literature related to the efficacy analysis of internal versus external pancreatic duct drainage in pancreaticoduodenectomy (OPD) and the learning curve period of laparoscopic pancreaticoduodenectomy in recent years at home and abroad and making a review. Results: Because of the complexity of the LPD surgical procedure, the high technical requirements and the high complication rate, it is necessary for the operator and his/her team to carry out a certain number of cases to pass through the learning curve in order to have a basic mastery of the procedure. In recent years, more and more pancreatic surgeons have begun to promote and use pancreatic duct drains. However, no consensus conclusion has been reached on whether to choose internal or external drainage for pancreatic duct placement and drainage in LPD. Conclusions: Intraoperative application of pancreatic duct drainage reduces the incidence of pancreatic fistula during the learning curve of laparoscopic pancreaticoduodenectomy. However, external pancreatic duct drainage and internal pancreatic duct drainage have both advantages and disadvantages, so when choosing the drainage method, one should choose the appropriate drainage method in conjunction with one’s own conditions, so as to reduce the incidence of complications.
文摘Yopougon, located in the western part of the Autonomous District of Abidjan, is the most heavily populated municipality in Côte d’Ivoire. However, this area is prone to floods and landslides during the rainy season. The study aims to assess recent flood risks in the municipality of Yopougon of the Autonomous District of Abidjan. To achieve this objective, the study analyzed two types of data: daily rainfall from 1971 to 2022 and parameters derived from a Numerical Field and Altitude Model (NFAM). The study examined six rainfall parameters using statistical analysis and combined land use maps obtained from the NFAM of Yopougon. The results indicated that, in 67% of cases, extreme rainfall occurred mainly between week 3 of May and week 1 of July. The peak of extreme rainfall was observed in week 2 of June with 15% of cases. These are critical periods of flood risks in the Autonomous District of Abidjan, especially in Yopougon. In addition, there was variability of rainfall parameters in the Autonomous District of Abidjan. This was characterized by a drop of annual and seasonal rainfall, and an increase of numbers of rainy days. Flood risks in Yopougon are, therefore, due to the regular occurrence of rainy events. Recent floods in Yopougon were caused by normal rains ranging from 55 millimeters (mm) to 153 mm with a return period of less than five years. Abnormal heavy rains of a case study on June 20-21, 2022 in Yopougon were detected by outputs global climate models. Areas of very high risk of flood covered 18% of Yopougon, while 31% were at high risk. Climate information from this study can assist authorities to take in advance adaptation and management measures.
基金the financial support from the National Natural Science Foundation of China (Nos. 52005297, 52035005)the Key Research and Development Program of Shandong Province, China (No. 2021ZLGX01)。
文摘A novel three-dimensional numerical model is proposed to investigate the effect of tool eccentricity on the coupled thermal and material flow characteristics in friction stir welding(FSW) process.An asymmetrical boundary condition at the tool-workpiece interface,and the dynamic mesh technique are both employed for the consideration of the tool eccentricity during tool rotating.It is found that tool eccentricity induces the periodical variation of the heat densities both at the tool-workpiece interface and inside the shear layer,but the fluctuation amplitudes of the heat density variations are limited.However,it is demonstrated that tool eccentricity results in significant variation of the material flow behavior in one tool rotating period.Moreover,the material velocity variation at the retreating side is particularly important for the formation of the periodic characteristics in FSW.The modeling result is found to be in good agreement with the experimental one.
基金National Natural Science Foundation of China under Grant Nos.U1939210 and 51825801。
文摘The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social order.To improve the seismic resilience of city road networks,a resilience evaluation method used in the post-earthquake emergency period is proposed.The road seismic damage index of a city road network can consider the influence of roads,bridges and buildings along the roads,etc.on road capacity after an earthquake.A function index for a city road network is developed,which reflects the connectivity,redundancy,traffic demand and traffic function of the network.An optimization model for improving the road repair order in the post-earthquake emergency period is also developed according to the resilience evaluation,to enable decision support for city emergency management and achieve the best seismic resilience of the city road network.The optimization model is applied to a city road network and the results illustrate the feasibility of the resilience evaluation and optimization method for a city road network in the post-earthquake emergency period.