ILS进近飞行程序高度损失余度影响因素仿真研究

针对国内飞行程序超障计算准则方面定量研究较少的问题,并为真实反映各类飞机在ILS进近程序中的高度损失(HL)余度数值,本文通过构建飞机着陆—复飞过程的仿真框架,考虑了影响HL值的因素,通过运动学仿真得出ILS进近中不同类别典型航空器的HL值,并与现有飞行程序设计规范中的值进行比较分析。通过模拟计算和结果分析,结果表明使用气压式高度表时,现有规范的公布值与仿真结果较为吻合,但在使用无线电高度表时,现有规范的公布值与仿真结果存在一定差异。

神经胶质瘤患者术前血清NLRP3、ILs表达水平对预后的影响研究

目的研究术前NLR家族Pyrin域蛋白3(NLR family pyrin domain-containing protein 3,NLRP3)、白细胞介素(Interleukin,ILs)表达谱特征对神经胶质瘤患者手术预后的影响。方法以2019年1月-2022年12月新疆医科大学第二附属医院神经外科收治的86例神经胶质瘤患者为研究对象,根据患者术后1年内随访情况将患者划分为手术预后良好组(n=52)和手术预后不良组(n=34)。对比两组患者一般临床资料及术前NLRP3、ILs(IL-1β、IL-4、IL-12、IL-17、IL-33)表达谱的表达水平差异。采用Spearman相关性分析,经单因素及多因素Logistic回归分析筛选神经胶质瘤患者手术预后不良的危险因素,通过受试者工作特征(Receiver operating characteristic,ROC)曲线评价各危险因素对患者手术预后的影响。结果与手术预后良好组比较,手术预后不良组患者肿瘤大小、肿瘤周围水肿患者比例、合并癫痫发作史患者比例、血清NLRP3、IL-1β、IL-4、IL-33水平均升高,术前卡氏功能状态评分、血清IL-12水平均降低,差异有统计学意义(P<0.05);Spearman相关性分析结果表明,肿瘤大小、肿瘤周围水肿、有癫痫发作史、血清中NLRP3、IL-1β、IL-4、IL-33水平均与手术预后不良呈正相关性,卡氏功能状态评分、IL-12与手术预后不良呈负相关性(P<0.05);单因素及多因素Logistic回归分析表明血清中NLRP3、IL-1β、IL-4水平均是神经胶质瘤患者手术预后不良的重要危险因素,IL-12是神经胶质瘤患者手术预后不良的重要保护因素(P<0.05);ROC曲线分析表明NLRP3、IL-1β、IL-4、IL-12独立及联合对于神经胶质瘤患者手术预后不良均具有较高预测效能(P<0.05)。结论神经胶质瘤患者NLRP3、ILs水平较高均是手术预后不良的重要危险因素,通过早期干预减轻神经胶质瘤患者炎症水平可能有利于改善手术治疗效果。

猪FoxP3、IL-10双重实时荧光定量PCR方法建立及应用

旨在建立双重实时荧光定量PCR(RT-qPCR)方法,对叉头框蛋白P3(FoxP3)、白细胞介素10(IL-10)的RNA转录进行定量检测。设计并合成FoxP3、IL-10的扩增引物和荧光探针,优化引物浓度、退火温度,建立RT-qPCR方法,检测猪圆环病毒2型(PCV2)感染外周血调节性T淋巴细胞(Treg)和免疫器官中FoxP3和IL-10的mRNA含量;根据Western blot检测蛋白表达验证方法的可靠性。结果:建立的RT-qPCR方法呈现“S”型扩增曲线,相关系数R^(2)≥0.99;转化生长因子-β(TGF-β)、干扰素-γ(IFN-γ)、白细胞介素2(IL-2)、白细胞介素4(IL-4)、白细胞介素6(IL-6)和白细胞介素17(IL-17)等基因的核酸模板和阴性对照均无扩增曲线,最低检测浓度10 copies/μL,批内、批间变异系数分别为0.87%、1.84%;PCV2攻毒组外周血Treg细胞中FoxP3和IL-10的mRNA含量均出现明显升高,FoxP3的mRNA含量在攻毒第14天到达峰值,IL-10的mRNA含量在攻毒第10天到达峰值,PCV2感染后导致胸腺、淋巴结和脾脏中FoxP3和IL-10转录水平升高;Western blot检测表明,FoxP3蛋白表达量在攻毒第14天、第28天,IL-10在攻毒第10天和第14天显著高于对照组,与RT-qPCR结果一致。综上,本研究建立的猪FoxP3、IL-10双重RT-qPCR方法具有特异、敏感、检测稳定可靠的特点,对于评价猪体的免疫应答水平和机体免疫稳态具有重要意义。

隆德概念对重型颅脑损伤患者脑脊液IL-6、继发性脑水肿及预后影响的研究

目的观察运用隆德概念治疗重型颅脑损伤患者的临床效果。方法选取2022年8月—2023年10月柳州市人民医院重症医学科收治的50例重型颅脑损伤患者,采用随机数字表法分为对照组和观察组,每组25例。对照组采用常规治疗方法,观察组在常规治疗基础上运用隆德概念治疗。观察两组患者入ICU时及入ICU后24 h、3 d、7 d、14 d脑脊液白细胞介素-6(IL-6)水平、脑水肿CT评估量、颅内压(ICP)以及治疗前后格拉斯哥昏迷评分(GCS)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、ICU停留时间及3个月后格拉斯哥预后评分(GOS)。结果与入ICU时相比,入ICU后24 h、3 d、7 d、14 d两组患者脑脊液IL-6水平、脑水肿CT评估量及ICP均不同程度升高;入ICU后24 h、3 d,观察组脑脊液IL-6水平、CT评估量低于对照组;入ICU后7 d,观察组脑脊液IL-6水平、脑水肿CT评估量及ICP低于对照组;入ICU后14 d,观察组ICP低于对照组,差异均有统计学意义(P<0.05)。治疗后,GCS评分高于对照组、APACHEⅡ评分低于对照组,ICU停留时间短于对照组,GOS预后良好率高于对照组,差异均有统计学意义(P<0.05)。结论隆德概念可以有效减少重型颅脑损伤患者脑脊液IL-6,控制伤后炎症反应,减轻继发性脑水肿,降低ICP,改善预后。

基于安全性建模的民机ILS信号设计

针对当前均匀分布的仪表着陆系统(instrument landing system, ILS)信号无法反映出真实安全性变化的问题,提出了基于高斯量化的ILS安全性信号设计方法。首先,基于运行安全性确定安全范围并在此基础上进行逆向设计,对飞行安全性进行高斯量化。然后,从提高飞行员情景意识出发,提出在安全范围内的不同偏移角度下,仪表刻度变化率与安全性变化率保持一致的安全性信号设计方法。最后,构建了飞行员认知模型,在民机最后进近场景中,对不同初始偏航角度进行了仿真实验。仿真实验结果表明,所提方法提升了民机进近着陆阶段的安全性。

基本ILS面在净空障碍物安全评估方法中的应用

为了应对我国机场净空破坏现象频发的问题,本文基于机场净空和城市发展的突出矛盾,提出了一种新的净空障碍物管理方法。传统的净空障碍物评估方法主要依靠障碍物限制面对机场超高建筑物和构筑物进行高度限制和处理。但实际运用中存在安全成本高昂但效益有限的问题。针对此问题,本文采用基本ILS面和障碍物限制面OLS相结合的方法,通过精密进近程序中飞机进近所需通过的最低安全曲线,全面评估障碍物的安全性。采用该方法可以具体了解障碍物的超高情况及其对当前飞行程序下运行安全的影响,避免了单纯依靠障碍物限制面的管理方法所带来的安全成本过高的问题,并为净空障碍物的进一步处理提供思路和参考。

MMA-co-ILS对PVDF超滤膜的亲水性改性及其抗菌性研究

本文针对聚偏氟乙烯(PVDF)超滤膜展开了亲水改性及抗污染性能改性。通过原位聚合技术引入具有亲水性的离子液体。本文采用溴化1-丁基-3-乙烯基咪唑(ILs)作为亲水性添加剂,同时引入甲基丙烯酸甲酯(MMA)作为相容剂,通过精确控制反应条件确保添加剂在聚合过程中均匀分散,以实现离子液体的有效整合。此后,应用相转换技术制备出最终的PVDF复合膜。结果表明,改性后的PVDF膜性能明显提升。水接触角从改性前的86.99°显著降低至68.62°,纯水通量高达552.7 L/(m^(2)·h),平衡含水率由11.8%上升至59.68%。牛血清蛋白(BSA)截留率相对纯PVDF膜有所上升,达到90.13%,且有较强的抗菌性,在水处理分离膜领域具有好的应用前景。

Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial treatment.The objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected infections.METHODS:This was a retrospective study.Between January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on imaging.Clinical data,including conventional microbial test results and antimicrobial treatment before and after NGS,were collected.Data were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS results.RESULTS:The median time from hospitalization to NGS sampling was 19 d.Clinically relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and Candida.In the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days later.The antimicrobial treatment was subsequently adjusted according to the susceptibility test results.Overall,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients with suspected infections.

Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections

Objective This study aimed to explore the diagnostic value of novel technique-targeted next-generation sequencing(tNGS)of bronchoalveolar lavage fluid(BALF)in pulmonary mycobacterial infections.Methods This retrospective study was conducted on patients who underwent bronchoscopy and tNGS,smear microscopy,and mycobacterial culture of BALF.Patients with positive Mycobacterium tuberculosis(MTB)culture or GeneXpert results were classified into the tuberculosis case group.Those diagnosed with nontuberculous mycobacteria(NTM)-pulmonary disease(NTM-PD)composed the case group of NTM-PD patients.The control group comprised patients without tuberculosis or NTM-PD.Sensitivity,specificity,and receiver operating characteristic(ROC)curves were used to evaluate the diagnostic performance.Results For tuberculosis patients with positive mycobacterial culture results,the areas under the ROC curves(AUCs)for tNGS,GeneXpert,and smear microscopy were 0.975(95%CI:0.935,1.000),0.925(95%CI:0.859,0.991),and 0.675(95%CI:0.563,0.787),respectively.For tuberculosis patients with positive GeneXpert results,the AUCs of tNGS,culture,and smear microscopy were 0.970(95%CI:0.931,1.000),0.850(95%CI:0.770,0.930),and 0.680(95%CI:0.579,0.781),respectively.For NTM-PD,the AUCs of tNGS,culture,and smear-positive but GeneXpert-negative results were 0.987(95%CI:0.967,1.000),0.750(95%CI:0.622,0.878),and 0.615(95%CI:0.479,0.752),respectively.The sensitivity and specificity of tNGS in NTM-PD patients were 100%and 97.5%,respectively.Conclusion tNGS demonstrated superior diagnostic efficacy in mycobacterial infection,indicating its potential for clinical application.

Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients

Background:For patients with lung cancer,timely identification of new lung lesions as infectious or non-infectious,and accurate identification of pathogens is very important in improving OS of patients.As a new auxiliary examination,metagenomic next-generation sequencing(mNGS)is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases,compared with conventional microbial tests(CMTs).We designed this study tofind out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavagefluid(BALF).Materials and Methods:This study was a real-world retrospective review based on electronic medical records of lung cancer patients with bronchoalveolar lavage(BAL)and BALF commercial mNGS testing as part of clinical care from 1 April 2019 through 30 April 2022 at The First Affiliated Hospital of Sun Yat-sen University.164 patients were included in this study.Patients were categorized into the pulmonary non-infectious disease(PNID)group(n=64)and the pulmonary infectious disease(PID)group(n=100)groups based onfinal diagnoses.Results:BALF mNGS increased the sensitivity rate by 60%compared to CMTs(81%vs.21%,p<0.05),whereas there was no significant difference in specificity(75%vs.98.4%,p>0.1).Among the patients with PID,bacteria were the most common cause of infection.Fungal infections occurred in 32%of patients,and Pneumocystis Yersini was most common.Patients with Tyrosine kinase inhibitors(TKIs)therapy possess longer overall survival(OS)than other anti-cancer agents,the difference between TKIs and immuno-checkpoint inhibitors(ICIs)was insignificant(median OS TKIs vs.ICIs vs.Anti-angiogenic vs.Chemo vs.Radiotherapy=76 vs.84 vs.61 vs.58 vs.60).Conclusions:our study indicates that BALF mNGS can add value by improving overall sensitivity in lung cancer patients with potential pulmonary infection,and was outstanding in identifying Pneumocystis infection.It could be able to help physicians adjust the follow-up treatment to avoid the abuse of antibiotics.

Brain abscess from oral microbiota approached by metagenomic next-generation sequencing: A case report and review of literature

BACKGROUND Brain abscess is a serious and potentially fatal disease caused primarily by microbial infection.Although progress has been made in the diagnosis and treatment of brain abscesses,the diagnostic timeliness of pathogens needs to be improved.CASE SUMMARY We report the case of a 54-year-old male with a brain abscess caused by oral bacteria.The patient recovered well after receiving a combination of metagenomic next-generation sequencing(mNGS)-assisted guided medication and surgery.CONCLUSION Therefore,mNGS may be widely applied to identify the pathogenic microor-ganisms of brain abscesses and guide precision medicine.

Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by Mycobacterium houstonense:A case report

BACKGROUND Mycobacterium houstonense(M.houstonense)belongs to the nontuberculous mycobacterium group.Infection caused by M.houstonense is prone to recurrence.CASE SUMMARY We present a patient who was diagnosed with osteomyelitis caused by M.houstonense and treated with a combination of cefoxitin,and amikacin combined with linezolid.CONCLUSION The emergence of metagenomic next-generation sequencing(NGS)has brought new hope for the diagnosis and treatment of listeria meningitis.NGS can analyze a large number of nucleic acid sequences in a short time and quickly determine the pathogen species in the sample.Compared with traditional cerebrospinal fluid culture,NGS can greatly shorten the diagnosis time and provide strong support for the timely treatment of patients.Regarding treatment,NGS can also play an important role.Rapid and accurate diagnosis can enable patients to start targeted treatment as soon as possible and improve the treatment effect.At the same time,by monitoring the changes in pathogen resistance,the treatment plan can be adjusted in time to avoid treatment failure.

Blockchain-as-a-Utility for Next-Generation Healthcare Internet of Things

The scope of the Internet of Things(IoT)applications varies from strategic applications,such as smart grids,smart transportation,smart security,and smart healthcare,to industrial applications such as smart manufacturing,smart logistics,smart banking,and smart insurance.In the advancement of the IoT,connected devices become smart and intelligent with the help of sensors and actuators.However,issues and challenges need to be addressed regarding the data reliability and protection for signicant nextgeneration IoT applications like smart healthcare.For these next-generation applications,there is a requirement for far-reaching privacy and security in the IoT.Recently,blockchain systems have emerged as a key technology that changes the way we exchange data.This emerging technology has revealed encouraging implementation scenarios,such as secured digital currencies.As a technical advancement,the blockchain network has the high possibility of transforming various industries,and the next-generation healthcare IoT(HIoT)can be one of those applications.There have been several studies on the integration of blockchain networks and IoT.However,blockchain-as-autility(BaaU)for privacy and security in HIoT systems requires a systematic framework.This paper reviews blockchain networks and proposes BaaU as one of the enablers.The proposed BaaU-based framework for trustworthiness in the next-generation HIoT systems is divided into two scenarios.The rst scenario suggests that a healthcare service provider integrates IoT sensors such as body sensors to receive and transmit information to a blockchain network on the IoT devices.The second proposed scenario recommends implementing smart contracts,such as Ethereum,to automate and control the trusted devices’subscription in the HIoT services.

Development and characterization of novel polymorphic microsatellite markers for the Korean freshwater snail Semisulcospira coreana and cross-species amplification using next-generation sequencing

Korean freshwater snails of the genus Semisulcospira are widely distributed across East Asia.It has been a very popular nutritional food in Korea,and is an ecologically important water quality indicator because it lives only in clean water.However,no microsatellite markers have been generated to study the population genetic diversity of this genus.In the present study,we developed and characterized 18 novel microsatellite loci from Semisulcospira coreana genomic DNA.The microsatellites were isolated using 454 GS-FLX titanium sequencing and 18 markers were used for genotyping in S.coreana.In addition,we also tested the cross-species transferability of the microsatellite markers in four additional Semisulcospira spp.We identified 18 polymorphic loci and the number of alleles per loci,and their polymorphism information content values ranged from 2 to 17 and 0.203 to 0.902,respectively.The observed and expected heterozygosities of the loci ranged from 0.063 to 0.924 and 0.226 to 0.924,respectively.According to the analysis of the cross-species transferability of these markers,four species,S.forticosta,S.gottschei,S.tegulata,and S.libertina,showed a very high transferability(80%–85%).These results show that this set of nuclear markers could be useful for population genetics studies of this species and closely related species.

A novel Nance-Horan syndrome mutation identified by next-generation sequencing in a Chinese family

AIM: To identify the disease-causing mutation in a fourgeneration Chinese family diagnosed with Nance-Horan syndrome(NHS). METHODS: A Chinese family, including four affected patients and four healthy siblings, was recruited. All family members received ophthalmic examinations with medical histories provided. Targeted next-generation sequencing approach was conducted on the two affected males to screen for their disease-causing mutations. RESULTS: Two male family members diagnosed with NHS manifested bilateral congenital cataracts microcornea, strabismus and subtle facial and dental abnormalities, while female carriers presented posterior Y-sutural cataracts. A novel frameshift mutation(c.3916_3919 del) in the NHS gene was identified. This deletion was predicted to alter the reading frame and generate a premature termination codon after a new reading frame. CONCLUSION: The study discovers a new frameshift mutation in a Chinese family with NHS. The findings broaden the spectrum of NHS mutations that can cause NHS in Chinese patients.

Diagnosis of Acute Q Fever in an Elderly Patient Using Metagenomic Next-Generation Sequencing:A Case Report

Query fever(Q fever)is a globally spread zoonotic disease caused by Coxiella burnetii,commonly found in natural foci but rarely seen in Hebei Province.The clinical manifestations of Q fever are diverse and nonspecific,which often leads to missed or incorrect diagnoses in clinical practice.This article reports a case of acute Q fever diagnosed in an elderly patient using metagenomic next-generation sequencing.

ILS机载设备功能验证模型构建与仿真

在航电任务系统地面功能验证过程中,围绕仪表着陆系统(Instrument Landing System, ILS)的逻辑建模、几何建模与程序仿真,深入分析了ILS的工作原理,建立其在三维空间运行的几何模型,通过程序化仿真其与飞机位置的相对运行过程,计算得出水平航向引导和垂直下滑引导的动态数据。该模型计算数据既能够作为激励数据源,支持航电系统中ILS和显控等机载设备的交联验证,也可作为仿真设备代替机载ILS设备独立工作。经过分析,该方法同样适用于微波着陆系统(Microwave Landing System, MLS)的功能验证工作,并能够根据需要开展CATⅠ/Ⅱ/Ⅲ类多个等级条件下的盲降测试,对提高实际检验效率具有极大的应用价值和推广前景。

Genome sequencing and next-generation sequence data analysis: A comprehensive compilation of bioinformatics tools and databases

Genomics has become a ground-breaking field in all areas of the life sciences. The advanced genomics and the development of high-throughput techniques have lately provided insight into whole-genome characterization of a wide range of organisms. In the post-genomic era, new technologies have revealed an outbreak of prerequisite genomic sequences and supporting data to understand genome wide functional regulation of gene expression and metabolic pathways reconstruction. However, the availability of this plethora of genomic data presents a significant challenge for storage, analyses and data management. Analysis of this mega-data requires the development and application of novel bioinformatics tools that must include unified functional annotation, structural search, and comprehensive analysis and identification of new genes in a wide range of species with fully sequenced genomes. In addition, generation of systematically and syntactically unambiguous nomenclature systems for genomic data across species is a crucial task. Such systems are necessary for adequate handling genetic information in the context of comparative functional genomics. In this paper, we provide an overview of major advances in bioinformatics and computational biology in genome sequencing and next-generation sequence data analysis. We focus on their potential applications for efficient collection, storage, and analysis of genetic data/information from a wide range of gene banks. We also discuss the importance of establishing a unified nomenclature system through a functional and structural genomics approach.

虫草多糖通过IL-23/IL-17通路对缺血性脑卒中大鼠的作用及其机制研究

目的 探讨虫草多糖(CSP)通过白细胞介素-23(IL-23)/IL-17通路对缺血性脑卒中(IS)大鼠模型的作用及其机制。方法 将大鼠分为假手术组、模型组、脑心通组、虫草多糖低剂量组、虫草多糖高剂量组,利用大脑中动脉栓塞(MCAO)复制大鼠IS模型,术后3 d用激光散斑检测脑血流变化;以Bederson评分、改良大鼠神经功能缺损评分对大鼠神经功能进行评估;利用苏木精-伊红、尼氏体染色法观察各组大鼠脑组织病理形态学变化;使用Western blotting检测脑组织中IL-23/IL-17通路中IL-23、IL-23R、IL-17、ACT、TRAF6蛋白表达。结果 各组大鼠模型复制后神经功能学评分较假手术组高(P <0.05);除假手术组外,各组间两两比较,差异均无统计学意义(P>0.05)。脑心通组模型复制后3 d神经功能学评分较模型组低(P <0.05),虫草多糖低剂量组、虫草多糖高剂量组较模型组低(P <0.05)。与假手术组比较,模型复制后大鼠患侧大脑血流明显减弱,出现大片缺血区域,患侧血流值比健侧血流值比值降低(P <0.05);与模型组相比,脑心通组、虫草多糖低剂量组、虫草多糖高剂量组患侧血流加强,缺血区域减少,患侧血流值比健侧血流值比值增高(P <0.05)。HE染色结果显示,假手术组大鼠脑组织细胞排列有序,形态正常,细胞质结构正常,淡染,细胞核大且清晰,核仁完整;模型组缺血半暗带区细胞明显呈不规律分布,排列紊乱,细胞核皱缩甚至消失,出现大量细胞坏死,组织结构损伤严重。与模型组比较,脑心通组、虫草多糖低剂量组、虫草多糖高剂量组细胞损伤均有所减轻,坏死细胞数量减少,组织形态有所恢复。尼氏体染色结果显示,假手术组神经细胞和尼氏体数量丰富,形态正常,细胞排列整齐,未见坏死细胞;与假手术组比较,模型组神经细胞出现变形,细胞排列混乱,间质疏松,尼氏体数量减少,分布边缘化;与模型组比较,脑心通组、虫草多糖低剂量组、虫草多糖高剂量组细胞状态得到改善,尼氏体数量增多,细胞形态趋于规整、排列较为整齐。模型组IL-23、IL-23R、IL-17、ACT1、TRAF6蛋白相对表达量较假手术组高,虫草多糖低剂量组、虫草多糖高剂量组较模型组低(P <0.05)。结论 证实CSP对MCAO大鼠具有一定的保护作用,并可能通过调节IL-23/IL-17相关通路来实现。

外周血T淋巴细胞亚群、IL-37联合PNI对多发性骨髓瘤患者化疗效果及预后的预测价值

目的探讨外周血T淋巴细胞亚群、白细胞介素-37(IL-37)联合预后营养指数(PNI)对多发性骨髓瘤(MM)患者化疗效果及预后的预测价值。方法选取2020年01月~2023年01月入院治疗的103例MM患者作为研究对象,采集治疗前患者外周血T淋巴细胞亚群、IL-37、PNI,探讨接受化疗的MM患者外周血T淋巴细胞亚群、IL-37、PNI对短期疗效、预后的评估价值。结果CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、IL-37、PNI均为MM患者化疗疗效的独立影响因素(P<0.05)。CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、IL-37、PNI曲线下面积(AUC)分别为0.719(95%CI:0.619~0.820)、0.764(95%CI:0.670~0.858)、0.732(95%CI:0.625~0.840)、0.700(95%CI:0.598~0.802)、0.779(95%CI:0.689~0.869)、0.750(95%CI:0.654~0.845),联合预测AUC为0.852(95%CI:0.777~0.926)。结论外周血T淋巴细胞亚群、IL-37、PNI水平为MM患者化疗疗效的独立影响因素,并且对MM患者预后具有较好的诊断效能。