Remarkable progress was made in the development of white-light-emitting diodes （LEDs）. White LEDs provided a light element having a semiconductor InGaN light-emitting chip （blue or UV LEDs） and luminescent phospho...Remarkable progress was made in the development of white-light-emitting diodes （LEDs）. White LEDs provided a light element having a semiconductor InGaN light-emitting chip （blue or UV LEDs） and luminescent phosphors. Here we reported the sialon s-phase of （Sr,Eu）2A12Si10N14O4. Eu^2＋ activator ions that were substituted for the strontium site represented a new type of yeUow-green phosphor that could be excited by blue LEDs used for application in the fabrication of white LEDs.展开更多
目的研究冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者血清骨形态发生蛋白4(bone morphogenetic protein 4,BMP-4),N1-甲基烟酰胺(N1-methylnicotinamide,me-Nam)和血管生成素样蛋白8(angiopoietinlike protein 8,ANGPTL8...目的研究冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者血清骨形态发生蛋白4(bone morphogenetic protein 4,BMP-4),N1-甲基烟酰胺(N1-methylnicotinamide,me-Nam)和血管生成素样蛋白8(angiopoietinlike protein 8,ANGPTL8)水平检测的临床意义。方法选取2018年1月~2020年1月佛山市中医院诊治的86例CHD患者作为CHD组,以健康体检的60例健康人群为对照组,检测CHD组及对照组血清BMP-4,me-Nam,ANGPTL8,血脂及炎症因子水平。比较不同冠状动脉狭窄程度、不同病变支数患者血清BMP-4,me-Nam及ANGPTL8水平。Pearson线性相关分析CHD组患者血清BMP-4,me-Nam和ANGPTL8之间的相关性及三者与Gensini积分、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)的相关性。ROC曲线分析血清BMP-4,me-Nam,ANGPTL8及联合检测对CHD组患者的诊断价值。结果与对照组相比,CHD组患者高血压史、糖尿病史占比较高,TC,TG,LDL-C,IL-6,TNF-α及hs-CRP水平明显增高,HDL-C水平明显降低,差异均有统计学意义(t=5.950~28.084,均P<0.05)。与对照组相比,CHD组患者血清BMP-4,me-Nam,ANGPTL8水平明显增高,差异均有统计学意义(t=14.201,13.495,37.538,均P<0.05)。随着Gensini积分升高或病变支数的增加,CHD患者的血清BMP-4,me-Nam,ANGPTL8有逐渐升高的趋势(χ^(2)=80.976,75.688,108.641,均P<0.05)。CHD患者血清BMP-4表达与me-Nam,ANGPTL8表达呈显著正相关(r=0.567,0.610,均P<0.05),me-Nam与ANGPTL8的表达呈显著正相关(r=0.562,P=0.000)。血清BMP-4,me-Nam,ANGPTL8及联合检测的曲线下面积分别为0.707(95%CI:0.601~0.812),0.713(95%CI:0.612~0.833),0.759(95%CI:0.667~0.850)及0.847(95%CI:0.722~0.908),联合诊断的诊断效能大于任一单一指标的诊断效能。结论CHD患者血清BMP-4,me-Nam及ANGPTL8水平升高,三者与血脂、炎症因子、冠状动脉狭窄程度及病变支数有关,检测其水平可为CHD病情评估提供一定参考。展开更多
A range of new compounds such as N1,N4-bis（diphenylmethlene）benzene-l,4-diamine zirconium （IV） chloride [{（Ar）2NC6HsN（Ar）z}ZrCl4] （Ar = C6H5） complex counting the chelating amine and chloride in position tra...A range of new compounds such as N1,N4-bis（diphenylmethlene）benzene-l,4-diamine zirconium （IV） chloride [{（Ar）2NC6HsN（Ar）z}ZrCl4] （Ar = C6H5） complex counting the chelating amine and chloride in position trans have been prepared. Well-defined NI,N4-bis（diphenylmethlene）benzene-l,4-diamine zirconium （IV） chloride [{（Ar）2NC6H5N（Ar）2}ZrCl4] （Ar = C6H5） was obtained by stoichiometric addition of {（Ar）2NC6H5N（Ar）2} （Ar = C6H5） and {ZrC14} in ethanol at reflex temperature. IR, 1H NMR, electronic properties using hyperchem program study has been improved for this compound such as bond distance, and this compound was also defined as electric conductivity which proves to be useful for conductively compound.展开更多
A new nickel（II） complex [NiL2]（DMF）4 （HL = 2＇-[4-N,N＇-（dimethylamino- benzylidene）]-3,5-dihydroxybenzoylhydrazide） has been synthesized and its structure was characterized by IR,UV-Vis,1H NMR and elemental ...A new nickel（II） complex [NiL2]（DMF）4 （HL = 2＇-[4-N,N＇-（dimethylamino- benzylidene）]-3,5-dihydroxybenzoylhydrazide） has been synthesized and its structure was characterized by IR,UV-Vis,1H NMR and elemental analysis. The fluorescence emission mechanism of the complex was discussed by fluorimetric spectra. The single-crystal structure was determined by X-ray diffraction analysis. The crystal belongs to the triclinic system,space group P1 with a = 0.9918（4）,b = 1.1297（4）,c = 1.1331（4） nm,α = 76.860（7）,β = 75.105（6）,γ = 89.022（7）°,V = 1.1936（8） nm^3,Z = 1,μ = 0.472 mm^-1,Dc = 1.319 g/cm^3,F（000） = 502 and Rint = 0.0913. In the title compound,the nickel（II） atom is four-coordinated with two nitrogen atoms from amide and two oxygen atoms from keto group. The complex is centrosymmetric with nickel located at the center.展开更多
Condensation of D-glucose, o-phenylenediamine and N,N-benzylphenylhydrazine hydrochloride (NNBPHH) in a one-pot reaction, or condensation of 2-(D-arabino-tetritol-1-yl) quinoxaline and NNBPHH, gave 3-(D-erythro-glycer...Condensation of D-glucose, o-phenylenediamine and N,N-benzylphenylhydrazine hydrochloride (NNBPHH) in a one-pot reaction, or condensation of 2-(D-arabino-tetritol-1-yl) quinoxaline and NNBPHH, gave 3-(D-erythro-glycerol-1- yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure of the latter was determined by 1H NMR spectroscopy and by synthesis using phenylhydrazine hydrochloride instead of NNBPHH. Condensation of D-glucose and 4,5-dichloro-o-phenylenediamine gave 6,7-dichloro-2-(D-arabino-tetritol-1-yl)quinoxaline, which upon condensation with NNBPHH gave the corresponding 6,7-dichloro-3-(D-erythro-glycerol-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure and mechanism of formation of these compounds are discussed.展开更多
基金Project supported by the Economic Affair (95-EC-17-A-07-S1-043)the National Science Council (94-2113-M-002-030)
文摘Remarkable progress was made in the development of white-light-emitting diodes （LEDs）. White LEDs provided a light element having a semiconductor InGaN light-emitting chip （blue or UV LEDs） and luminescent phosphors. Here we reported the sialon s-phase of （Sr,Eu）2A12Si10N14O4. Eu^2＋ activator ions that were substituted for the strontium site represented a new type of yeUow-green phosphor that could be excited by blue LEDs used for application in the fabrication of white LEDs.
文摘目的研究冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者血清骨形态发生蛋白4(bone morphogenetic protein 4,BMP-4),N1-甲基烟酰胺(N1-methylnicotinamide,me-Nam)和血管生成素样蛋白8(angiopoietinlike protein 8,ANGPTL8)水平检测的临床意义。方法选取2018年1月~2020年1月佛山市中医院诊治的86例CHD患者作为CHD组,以健康体检的60例健康人群为对照组,检测CHD组及对照组血清BMP-4,me-Nam,ANGPTL8,血脂及炎症因子水平。比较不同冠状动脉狭窄程度、不同病变支数患者血清BMP-4,me-Nam及ANGPTL8水平。Pearson线性相关分析CHD组患者血清BMP-4,me-Nam和ANGPTL8之间的相关性及三者与Gensini积分、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)的相关性。ROC曲线分析血清BMP-4,me-Nam,ANGPTL8及联合检测对CHD组患者的诊断价值。结果与对照组相比,CHD组患者高血压史、糖尿病史占比较高,TC,TG,LDL-C,IL-6,TNF-α及hs-CRP水平明显增高,HDL-C水平明显降低,差异均有统计学意义(t=5.950~28.084,均P<0.05)。与对照组相比,CHD组患者血清BMP-4,me-Nam,ANGPTL8水平明显增高,差异均有统计学意义(t=14.201,13.495,37.538,均P<0.05)。随着Gensini积分升高或病变支数的增加,CHD患者的血清BMP-4,me-Nam,ANGPTL8有逐渐升高的趋势(χ^(2)=80.976,75.688,108.641,均P<0.05)。CHD患者血清BMP-4表达与me-Nam,ANGPTL8表达呈显著正相关(r=0.567,0.610,均P<0.05),me-Nam与ANGPTL8的表达呈显著正相关(r=0.562,P=0.000)。血清BMP-4,me-Nam,ANGPTL8及联合检测的曲线下面积分别为0.707(95%CI:0.601~0.812),0.713(95%CI:0.612~0.833),0.759(95%CI:0.667~0.850)及0.847(95%CI:0.722~0.908),联合诊断的诊断效能大于任一单一指标的诊断效能。结论CHD患者血清BMP-4,me-Nam及ANGPTL8水平升高,三者与血脂、炎症因子、冠状动脉狭窄程度及病变支数有关,检测其水平可为CHD病情评估提供一定参考。
文摘A range of new compounds such as N1,N4-bis（diphenylmethlene）benzene-l,4-diamine zirconium （IV） chloride [{（Ar）2NC6HsN（Ar）z}ZrCl4] （Ar = C6H5） complex counting the chelating amine and chloride in position trans have been prepared. Well-defined NI,N4-bis（diphenylmethlene）benzene-l,4-diamine zirconium （IV） chloride [{（Ar）2NC6H5N（Ar）2}ZrCl4] （Ar = C6H5） was obtained by stoichiometric addition of {（Ar）2NC6H5N（Ar）2} （Ar = C6H5） and {ZrC14} in ethanol at reflex temperature. IR, 1H NMR, electronic properties using hyperchem program study has been improved for this compound such as bond distance, and this compound was also defined as electric conductivity which proves to be useful for conductively compound.
基金Project supported by the Natural Science Foundation of Zhejiang Province (Y406049)Education Committee Foundation of Zhejiang Province (No. 20060079)
文摘A new nickel（II） complex [NiL2]（DMF）4 （HL = 2＇-[4-N,N＇-（dimethylamino- benzylidene）]-3,5-dihydroxybenzoylhydrazide） has been synthesized and its structure was characterized by IR,UV-Vis,1H NMR and elemental analysis. The fluorescence emission mechanism of the complex was discussed by fluorimetric spectra. The single-crystal structure was determined by X-ray diffraction analysis. The crystal belongs to the triclinic system,space group P1 with a = 0.9918（4）,b = 1.1297（4）,c = 1.1331（4） nm,α = 76.860（7）,β = 75.105（6）,γ = 89.022（7）°,V = 1.1936（8） nm^3,Z = 1,μ = 0.472 mm^-1,Dc = 1.319 g/cm^3,F（000） = 502 and Rint = 0.0913. In the title compound,the nickel（II） atom is four-coordinated with two nitrogen atoms from amide and two oxygen atoms from keto group. The complex is centrosymmetric with nickel located at the center.
文摘Condensation of D-glucose, o-phenylenediamine and N,N-benzylphenylhydrazine hydrochloride (NNBPHH) in a one-pot reaction, or condensation of 2-(D-arabino-tetritol-1-yl) quinoxaline and NNBPHH, gave 3-(D-erythro-glycerol-1- yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure of the latter was determined by 1H NMR spectroscopy and by synthesis using phenylhydrazine hydrochloride instead of NNBPHH. Condensation of D-glucose and 4,5-dichloro-o-phenylenediamine gave 6,7-dichloro-2-(D-arabino-tetritol-1-yl)quinoxaline, which upon condensation with NNBPHH gave the corresponding 6,7-dichloro-3-(D-erythro-glycerol-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure and mechanism of formation of these compounds are discussed.
