Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression w...Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression was evaluated immunohistochemically using the modified H-score method.Results:The present study included 20%of patients with stage I disease,22%of patients with stage II disease,18%of patients with stage III disease,and 40%of patients with stage IV disease.Nibrin showed a significant positive correlation with moderately/poorly differentiated tumor tissues(P=0.028),while significant inverse correlation of Nibrin expression was observed with tumor size(P=0.018)and tumor stage(P=0.039).Further,using univariate survival analysis it was observed that strong Nibrin expression was significantly associated with disease relapse in early stage OSCC patients(P=0.049).Conclusion:Thus,the present study revealed that Nibrin could be used as a prognostic marker in patients with early stage OSCC.展开更多
基金supported by the Gujarat Cancer Society and the Gujarat Cancer and Research Institute.
文摘Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression was evaluated immunohistochemically using the modified H-score method.Results:The present study included 20%of patients with stage I disease,22%of patients with stage II disease,18%of patients with stage III disease,and 40%of patients with stage IV disease.Nibrin showed a significant positive correlation with moderately/poorly differentiated tumor tissues(P=0.028),while significant inverse correlation of Nibrin expression was observed with tumor size(P=0.018)and tumor stage(P=0.039).Further,using univariate survival analysis it was observed that strong Nibrin expression was significantly associated with disease relapse in early stage OSCC patients(P=0.049).Conclusion:Thus,the present study revealed that Nibrin could be used as a prognostic marker in patients with early stage OSCC.
