Objective: To probe into the significance of Nitric Oxide (NO) in ischemic cerebral damage and effect of ligustrazine on it. Methods: The NO contents in cerebrospinal fluid (CSF) and plasma of 20 controls and 62 patie...Objective: To probe into the significance of Nitric Oxide (NO) in ischemic cerebral damage and effect of ligustrazine on it. Methods: The NO contents in cerebrospinal fluid (CSF) and plasma of 20 controls and 62 patients with arteriosclerotic thrombotic cerebral infarction (ligustrazine group and common treatment group) were determined with Griess method before and after treatment. Results:The NO content in CSF before treatment was higher in severe type, it was higher than that in moderate type, and than that in mild type,again higher than that in control group (all P < 0. 05) and was positively correlated with the size of infarction (P < 0. 01 ). There was no significant difference between the plasma NO content of patients and that of control group (P < 0. 05), but there was a trend that plasma NO content decreased as the patient's condition worsened. After treatment, the curative effect and plasma NO content of ligustrazine group were both markedly higher than those of common treatment group (P < 0. 05, 0. 05 ).There were no significant differences between CSF NO contents of the two groups, respectively, and that of control group (P > 0. 05,0. 05). Conclusion: Excessive NO produced in brain tissue and insufficient plasma NO participate the course of ischemic brain damage.Ligustrazine could increase the contents of plasma NO selectively.Original article on CJIM(Chin) 1998; 18(6). 342展开更多
For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present st...For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present study established middle cerebral artery occlusion models in rats using the thrombosis method. Shallow needling and conventional needling at the bilateral Neiguan （PC 6） and Gongsun （SP 4） acupoints improved neurological function of middle cerebral artery occlusion rats, increased the expression of the anti-apoptotic Bcl-2, inhibited the expression of the pro-apoptotic Bax, and reduced the expression of the vasoactive substances nitric oxide synthase and endothelin-1. However, these changes were more pronounced in the shallow needling group, indicating that shallow needling is more effective in inhibiting brain ischemic injury.展开更多
文摘Objective: To probe into the significance of Nitric Oxide (NO) in ischemic cerebral damage and effect of ligustrazine on it. Methods: The NO contents in cerebrospinal fluid (CSF) and plasma of 20 controls and 62 patients with arteriosclerotic thrombotic cerebral infarction (ligustrazine group and common treatment group) were determined with Griess method before and after treatment. Results:The NO content in CSF before treatment was higher in severe type, it was higher than that in moderate type, and than that in mild type,again higher than that in control group (all P < 0. 05) and was positively correlated with the size of infarction (P < 0. 01 ). There was no significant difference between the plasma NO content of patients and that of control group (P < 0. 05), but there was a trend that plasma NO content decreased as the patient's condition worsened. After treatment, the curative effect and plasma NO content of ligustrazine group were both markedly higher than those of common treatment group (P < 0. 05, 0. 05 ).There were no significant differences between CSF NO contents of the two groups, respectively, and that of control group (P > 0. 05,0. 05). Conclusion: Excessive NO produced in brain tissue and insufficient plasma NO participate the course of ischemic brain damage.Ligustrazine could increase the contents of plasma NO selectively.Original article on CJIM(Chin) 1998; 18(6). 342
基金the National Natural Science Foundation of China, No. 3076031918
文摘For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present study established middle cerebral artery occlusion models in rats using the thrombosis method. Shallow needling and conventional needling at the bilateral Neiguan （PC 6） and Gongsun （SP 4） acupoints improved neurological function of middle cerebral artery occlusion rats, increased the expression of the anti-apoptotic Bcl-2, inhibited the expression of the pro-apoptotic Bax, and reduced the expression of the vasoactive substances nitric oxide synthase and endothelin-1. However, these changes were more pronounced in the shallow needling group, indicating that shallow needling is more effective in inhibiting brain ischemic injury.
