Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent years.The substantial energy-density content within these compounds can lead to potentially dangerous...Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent years.The substantial energy-density content within these compounds can lead to potentially dangerous explosive reactions when subjected to external stimuli such as electrical discharge.Therefore,developing a reliable model for predicting their electrostatic discharge sensitivity(ESD)becomes imperative.This study proposes a novel and straightforward model based on the presence of specific groups(-NH_(2) or-NH-,-N=N^(+)-O^(-)and-NNO_(2),-ONO_(2) or-NO_(2))under certain conditions to assess the ESD of NRHECs and their salts,employing interpretable structural parameters.Utilizing a comprehensive dataset comprising 54 ESD measurements of NRHECs and their salts,divided into 49/5 training/test sets,the model achieves promising results.The Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Maximum Error for the training set are reported as 0.16 J,0.12 J,and 0.5 J,respectively.Notably,the ratios RMSE(training)/RMSE(test),MAE(training)/MAE(test),and Max Error(training)/Max Error(test)are all greater than 1.0,indicating the robust predictive capabilities of the model.The presented model demonstrates its efficacy in providing a reliable assessment of ESD for the targeted NRHECs and their salts,without the need for intricate computer codes or expert involvement.展开更多
Many nitrogen-containing aromatic compounds (NACs), such as nitrobenzene (NB), 4-nitrophenol (4-NP), aniline (AN), and 2,4-dinitrophenol (2,4-DNP), are environmentally hazardous, and their removal from conta...Many nitrogen-containing aromatic compounds (NACs), such as nitrobenzene (NB), 4-nitrophenol (4-NP), aniline (AN), and 2,4-dinitrophenol (2,4-DNP), are environmentally hazardous, and their removal from contaminated water is one of the main challenges facing wastewater treatment plants. In this study, synthetic wastewater containing NB, 4-NP, 2,4-DNP, and AN at concentrations ranging from 50 to 180 mg/L was fed into a sequencing batch reactor (SBR). Analyses of the SBR system indicated that it simultaneously removed more than 99% of the NACs at loading rates of 0.36 kg NB/(m^3·d), 0.3 kg 4-NP/(m^3·d), 0.25 kg AN/(m^3·d), and 0.1 kg 2,4-DNP/(m^3·d). Bacterial groups of Bacteriodetes, Candidate division TM7, α-Proteobacteria, and β-Proteobacteria were dominant in the clone libraries of 16S rRNA genes retrieved from the microbial communities in the SBR system. "Cycle tests" designed to alter feeding and aeration parameters of the SBR system demonstrated that the resident microbial biome of the SBR system responded rapidly to changing conditions. Consumption of O2 was concomitant with the apparent mineralization of NACs. Aromatic ring-cleaving dioxygenase activities suggested that (1) AN and NB were degraded via catechol 2,3-dioxygenase; (2) 4-NP was degraded via 1,2,4-benzentriol 1,2-dioxygenase; and (3) 2,4-DNP was degraded via an unresolved pathway.展开更多
The adsorptive denitrogenation from fuels over three metal-organic frameworks(MIL-96(Al),MIL-53(Al)and MIL-101(Cr))was studied by batch adsorption experiments.Four nitrogen-containing compounds(NCCs)pyridine,pyrrole,q...The adsorptive denitrogenation from fuels over three metal-organic frameworks(MIL-96(Al),MIL-53(Al)and MIL-101(Cr))was studied by batch adsorption experiments.Four nitrogen-containing compounds(NCCs)pyridine,pyrrole,quinoline and indole were used as model NCCs in fuels to study the adsorption mechanism.The physicochemical properties of the adsorbents were characterized by XRD,N2physical adsorption,FT-IR spectrum and Hammett indicator method.The metal-organic frameworks(MOFs),especially the MIL-101(Cr)containing Lewis acid sites as well as high specific surface area,can adsorb large quantities of NCCs from fuels.In addition,the adsorptive capacity over MIL-101(Cr)will be different for NCCs with different basicity.The stronger basicity of the NCC is,the more it can be absorbed over MIL-101(Cr).Furthermore,pore size and shape also affect the adsorption capacity for a given adsorbate,which can be proved by the adsorption over MIL-53(Al)and MIL-96(Al).The pseudo-second-order kinetic model and Langmuir equation can be used to describe kinetics and thermodynamics of the adsorption process,respectively.Finally,the regeneration of the used adsorbent has been conducted successfully by just washing it with ethanol.展开更多
The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a...The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a'-benzoyl ketene N. N-acetals 3a-b were treated by t-BuONa/t- BuOH Solution. 8- benzoyl-pyrido[1.2-a] pyrimidine 4 was produced.展开更多
This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, be...This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, benzothiazole, purine and derivatives, indole, indanol, piperidine and derivative, diphenylamine, N- phenylanthranilic acid, 8- OH- quinoline, naphthol, diphenylether have been tritiated by catalytic exchange method using tritiated water and platinum catalyst (from the dioxide and sodium borohydride), and the pattern of labelling has been assigned by ~3H NMR spectroscopy. The results show that this exchange process can give general labelling compounds at various time and temperatures. For 4-Br-diphenylether, Raney nickel was used instead of Pt as a catalyst.展开更多
The Zr-H bond of zirconocene hydridochloride was heterolyzed at room temperature by five compounds containing nitrogen and hydroxyl group to give Cp(Q)2ZrCl(1) (Cp = cyclopentadienyl and Q = 8-quinolinoyl ) , Cp (Q-Me...The Zr-H bond of zirconocene hydridochloride was heterolyzed at room temperature by five compounds containing nitrogen and hydroxyl group to give Cp(Q)2ZrCl(1) (Cp = cyclopentadienyl and Q = 8-quinolinoyl ) , Cp (Q-Me )2ZrCl (2) , Cp(5,7-Br2Q)2ZrCl(3), Cp2(2-pyridoyl)ZrCl(4) , and Cp(2-aminoethanoyl)2ZrCl(5), which were characterized by elemental analysis, IR, and 1H NMR spectroscopy. The molecular structure of 1 was confirmed by X-ray diffraction determination. The crystal of 1 crystallized monoclinically, space group P21/n a= 0.9004(2), b=1.3961(2), c = 1. 6056(2) nm, β=99. 48(1)°? V=1. 9906 nm3, Z = 4, and Dc=1. 582 g/cm3. The coordination polyhedron around the Zr atom can be described as a distorted octahedron. The Zr-N bonds of 0. 2364(3) and 0. 2377(4) nm suggest that they are coordination bonds. The two planar 8-quinolinoyl groups as bidentate ligands chelate with Zr atom, forming a dihedral angle of 108. 4(1)°?展开更多
The DFT-based (density fimctional theory) ab initio quantum mechanical methods have been applied to study the basicity of the nitrogen-containing compounds in petroleum. The results have indicated that there is a di...The DFT-based (density fimctional theory) ab initio quantum mechanical methods have been applied to study the basicity of the nitrogen-containing compounds in petroleum. The results have indicated that there is a distinct relationship between the protonation energy of nitrogen-containing compounds and their basicity. The more negative the protonation energy, the stronger the basicity is. It has been also found that aliphatic amines are more basic than pyridines or aromatic amines, and all these compounds are more basic than pyrroles. The addition of the aromatic rings can influence the basicity of anilines, while the 5- and 6-membered heterocyclic compounds function differently. The solvent properties may affect the basicity of these nitrogen-containing compounds.展开更多
Using cation exchange resin(D72,Amberlyst-15) as catalyst, Mannich-type reaction of 5-amino-1,2,4-triazole 1, containing guanidine substructure, provides an efficient synthesis of a new kind of bicyclic P- and N-conta...Using cation exchange resin(D72,Amberlyst-15) as catalyst, Mannich-type reaction of 5-amino-1,2,4-triazole 1, containing guanidine substructure, provides an efficient synthesis of a new kind of bicyclic P- and N-containing compounds, 6-phospha-4,5,6-trihydroimidazolo [2,3-e] 1,2,4-triazole 4.展开更多
6,7-Methylenedioxy-3-thia-1(2H,4H)acridone and the related acridine-fused quinolines and pyridines,and also their flavylium-perchlorates were synthesized.The structures of all these compounds prepared are characterize...6,7-Methylenedioxy-3-thia-1(2H,4H)acridone and the related acridine-fused quinolines and pyridines,and also their flavylium-perchlorates were synthesized.The structures of all these compounds prepared are characterized by elemental analysis.IR and H-NMR spectra.展开更多
To elucidate the effects of Fe_(2)O_(3) on nitrogen transformation during sludge pyrolysis,thermogravimetry coupled with mass spectrometry(TG-MS)was used to investigate the influences of Fe_(2)O_(3) on the pyrolysis c...To elucidate the effects of Fe_(2)O_(3) on nitrogen transformation during sludge pyrolysis,thermogravimetry coupled with mass spectrometry(TG-MS)was used to investigate the influences of Fe_(2)O_(3) on the pyrolysis characteristics and the release of important gaseous NO_(x) precursors such as HCN and NH_(3) during pyrolysis of three typical amino acids in urban sludge.The results show that after Fe_(2)O_(3) addition,the total weight loss rate of the three amino acids and the initial decomposition temperature of proline are reduced.The release amounts of NH_(3),HCN,CH_(3)CN,and HNCO from these three representative amino acids—glumatic,arginine,and proline,decrease in the order of arginine,glutamic,proline.The generation of Fe-N complexes,reduces the generation of NH_(3),HCN,CH_(3)CN,and HNCO while the catalysis effects of Fe_(2)O_(3) on the formation of H and H2 play a promoting role in the generation of NH_(3),HCN,CH_(3)CN,and HNCO.The results would provide an experimental and theoretical basis for subsequent research on the NOx precursor formation mechanisms during pyrolysis or combustion of Fe-containing sludge or sludge with additives containing Fe.展开更多
Some new Schiff bases were synthesized by the condensation of equimolar quantities of salicylaldehyde and 2-amino-5-phenylazo-pyridine or its derivatives in dry benzene(1):Metal complexes of the type ML_2and M'L_3...Some new Schiff bases were synthesized by the condensation of equimolar quantities of salicylaldehyde and 2-amino-5-phenylazo-pyridine or its derivatives in dry benzene(1):Metal complexes of the type ML_2and M'L_3 where M=Cu^(2+),Co^(2+),Ni^(2+),Mn^(2+)Pd^(2+),M'=Fe^(3+)and L=different newly synthesized monobasic Schiff bases were prepared in absolute ethanolic medium(2)and characterized by elementary analysis,conductance measurements,infrared spectra,electronic spectra,magnetic moments studies.展开更多
A new heterocyclic compound,named 5,5 -diisobutoxy-2,2 -bifuran(1),and four known compounds(2-5) were isolated from the roots of Cyathula officinalis Kuan.Their structures were elucidated by spectroscopic methods.Amon...A new heterocyclic compound,named 5,5 -diisobutoxy-2,2 -bifuran(1),and four known compounds(2-5) were isolated from the roots of Cyathula officinalis Kuan.Their structures were elucidated by spectroscopic methods.Among these compounds,5,5 - dibutoxy-2,2 -bifuran(2) was isolated for the first time from this plant.展开更多
A novel eleven-membered heterocyclic compound with high nitrogen has been isolated from the marine alga Sargassum vachell collected from the South China Sea. Its structure has been established by verity of spectroscop...A novel eleven-membered heterocyclic compound with high nitrogen has been isolated from the marine alga Sargassum vachell collected from the South China Sea. Its structure has been established by verity of spectroscopic techniques such as IR. EIMS. ID NMR. H-1-(HCOSY)-H-1. HMQC, HMBC.展开更多
The X2Ge=Si: (X = H, Me, F, reaction is a new area for the study of silylene between singlet CI2Ge=Si: and formaldehyde CI, Br, Ph, At...) is a new species. Its cycloaddition chemistry. The mechanism of cycloaddit...The X2Ge=Si: (X = H, Me, F, reaction is a new area for the study of silylene between singlet CI2Ge=Si: and formaldehyde CI, Br, Ph, At...) is a new species. Its cycloaddition chemistry. The mechanism of cycloaddition reaction has been investigated with CCSD(T)//MP2/6-31G* method. From the potential energy profile, it can be predicted that the reaction has two competitive dominant reaction pathways. The reaction rule presented is that the two reactants firstly form a four-membered Ge-heterocyclic ring silylene through the [2+2] cycloaddition reaction. Owing to the 3p unoccupied orbital of Si: atom in the four-membered Ge-heterocyclic ring silylene and the π orbital of formaldehyde forming a π-p donor-acceptor bond, the four-membered Ge-heterocyclic ring silylene further combines with formaldehyde to form an intermediate. Because the Si: atom in intermediate shows sp3 hybridization after transition state, the intermediate isomerizes to a spiro-Si-heterocyclic ring compound involving Ge via a transition state. Simultaneously, the ring strain of the four-membered Ge-heterocyclic ring silylene makes it isomerize to a twisted four-membered ring product. The research result indicates the laws of cycloaddition reaction between X2Ge=Si: (X = H, Me, F, C1, Br, Ph, Ar...) and the asymmetric g-bonded compounds, which are significant for the synthesis of small-ring and spiro-Si-heterocyclic ring compound involving Ge The study extends the research area and enriches the research content of silvlene chemistrv.展开更多
X2Si=Sn:(X = H, Me, F, Cl, Br, Ph, Ar…) are new species of chemistry. The cycloaddition reaction of X2Si=Sn: is a new study field of stannylene chemistry. To explore the rules of cycloaddition reaction between X2Si=S...X2Si=Sn:(X = H, Me, F, Cl, Br, Ph, Ar…) are new species of chemistry. The cycloaddition reaction of X2Si=Sn: is a new study field of stannylene chemistry. To explore the rules of cycloaddition reaction between X2Si=Sn: and the symmetric p-bonded compounds, the cycloaddition reactions of Cl2Si=Sn: and ethylene were selected as model reactions in this paper.The mechanism of cycloaddition reaction between singlet Cl2Si=Sn: and ethylene has been first investigated with the MP2/GENECP(C, H, Cl, Si in 6-311++G**;Sn in LanL2dz) method in this paper. From the potential energy profile, it could be predicted that the reaction has one dominant reaction channel. The reaction rule presented is that the 5p unoccupied orbital of Sn in Cl2Si=Sn: and the π orbital of ethylene forming a p→p donor-acceptor bond, resulting in the formation of an intermediate. Instability of the intermediate makes it isomerize to a four-membered Si-heterocyclic ring stannylene. Because the 5p unoccupied orbital of Sn atom in the four-membered Si-heterocyclic ring stannylene and the π orbital of ethylene form a p→p donor-acceptor bond, the four-membered Si-heterocyclic ring stannylene further combines with ethene to form another intermediate. Because the Sn atom in the intermediate shows sp3 hybridization after transition state, the intermediate isomerizes to a Si-heterocyclic spiro-Sn-heterocyclic ring compound. The research result indicates the laws of cycloaddition reaction between X2Si=Sn: and the symmetric π-bonded compounds. The study opens up a new research field for stannylene chemistry.展开更多
X2Si=Ge: (X = H, Me, F, CI, Br, Ph, Ar...) is a new species. Its cycloaddition reaction is a new area for the study of germylene chemistry. The mechanism of cycloaddition reaction between singlet state Me2Si=Ge: a...X2Si=Ge: (X = H, Me, F, CI, Br, Ph, Ar...) is a new species. Its cycloaddition reaction is a new area for the study of germylene chemistry. The mechanism of cycloaddition reaction between singlet state Me2Si=Ge: and formaldehyde has been investigated with the CCSD(T)//MP2/cc-pvtz method. From the potential energy profile, it could be predicted that the reaction has one dominant reaction pathway. The reaction rule presented is that the two reactants first form a four-membered Si-heterocyclic ring germylene through the [2+2] cycloaddition reaction. Because of the 4p unoccupied orbital of Ge: atom in the four-membered Si-heterocyclic ring germylene and the π orbital of formaldehyde form a π→p donor-acceptor bond, the four-membered Si-heterocyclic ring germylene further combines with formaldehyde to form an intermediate. Because the Ge atom in the intermediate undergoes sp^3 hybridization after transition state, then the intermediate isomerizes to a spiro-Ge-heterocyclic ring compound involving Si via a transition state. The research result indicates the laws of cycloaddition reaction between HzSi=Ge: and formaldehyde. It has important reference value for the cycloaddition reaction between X2Si=Ge: (X = H, Me, F, CI, Br, Ph, Ar…) and asymmetric to-bonded compounds, which is significant for the synthesis of small-ring and spiro-Ge-heterocyclic compounds involving Si. The study extends research area and enriches the research content of germylene chemistry.展开更多
The effects of iodium-heterocyclic compound(3,6-di-[dimethytamino]-dibcnzopyrodoniun formate,IHC-64)on the action potentials and contractile force of the isolatedguinca pig papillary muscles were investigatad.50 μm...The effects of iodium-heterocyclic compound(3,6-di-[dimethytamino]-dibcnzopyrodoniun formate,IHC-64)on the action potentials and contractile force of the isolatedguinca pig papillary muscles were investigatad.50 μmol/L IHC-64 only inhibited contractile forceand had no effect on APA,dv/dt max,APD<sub>5</sub>0 and APD<sub>9</sub>0 of fast action potentials in Tyrode’s so-lution.All of these parametres were depressed by further increasing concentration of IHC-64.InK-rich Tyrodc’s solution,the depressive action of IHC-64 on slow action potentials andcontractile force could be antagonized by incrcased extracellular calcium.These results suggesr thatIHC-64 inhibit not only slow calcium influx but also fast sodium influx,and it may.(?)new calci-urn channd blockcr.展开更多
Novel molecular material, 1-benzotlliazoly-3 -phenyl --pyrazoline (BTPP) was found to function as bright blue light emitting dye in organic electroluminescent device, and its optical and electric characteristics were ...Novel molecular material, 1-benzotlliazoly-3 -phenyl --pyrazoline (BTPP) was found to function as bright blue light emitting dye in organic electroluminescent device, and its optical and electric characteristics were investigated. This heterocyclic compound exhibited good characteristics of blue photoluminescence and electroluminescence, which had the emission peak at 450 nm. The single layer light-emitting devices using BTPP as light-emitting material dispersed in poly(N- vinylcarbazole) (PVK) and double layer ones using PBD as hole block layer above the light-emitting layer were fabricated using conventional spin-casting and vaccum vapour deposition methods. The introduction of PBD has enhanced electron injection and luminance efficiency, compared with the single layer LEDs.展开更多
2-methoxy-6-oxo-1, 4, 2-diazaphosphorinane-2-oxide 8, phosphorus counterpart of 2, 6-dioxopiperazine, was synthesized as antitumor agent. The new phosphorus heterocycle compound 8 is the key intermediate in the synthe...2-methoxy-6-oxo-1, 4, 2-diazaphosphorinane-2-oxide 8, phosphorus counterpart of 2, 6-dioxopiperazine, was synthesized as antitumor agent. The new phosphorus heterocycle compound 8 is the key intermediate in the synthesis of phosphorus counterpart of bisdioxopiperazine.展开更多
文摘Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent years.The substantial energy-density content within these compounds can lead to potentially dangerous explosive reactions when subjected to external stimuli such as electrical discharge.Therefore,developing a reliable model for predicting their electrostatic discharge sensitivity(ESD)becomes imperative.This study proposes a novel and straightforward model based on the presence of specific groups(-NH_(2) or-NH-,-N=N^(+)-O^(-)and-NNO_(2),-ONO_(2) or-NO_(2))under certain conditions to assess the ESD of NRHECs and their salts,employing interpretable structural parameters.Utilizing a comprehensive dataset comprising 54 ESD measurements of NRHECs and their salts,divided into 49/5 training/test sets,the model achieves promising results.The Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Maximum Error for the training set are reported as 0.16 J,0.12 J,and 0.5 J,respectively.Notably,the ratios RMSE(training)/RMSE(test),MAE(training)/MAE(test),and Max Error(training)/Max Error(test)are all greater than 1.0,indicating the robust predictive capabilities of the model.The presented model demonstrates its efficacy in providing a reliable assessment of ESD for the targeted NRHECs and their salts,without the need for intricate computer codes or expert involvement.
基金Project supported by the Pilot Project of Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-YW-G-009)the National Natural Science Foundation of China (No. 20577067, 30230010).
文摘Many nitrogen-containing aromatic compounds (NACs), such as nitrobenzene (NB), 4-nitrophenol (4-NP), aniline (AN), and 2,4-dinitrophenol (2,4-DNP), are environmentally hazardous, and their removal from contaminated water is one of the main challenges facing wastewater treatment plants. In this study, synthetic wastewater containing NB, 4-NP, 2,4-DNP, and AN at concentrations ranging from 50 to 180 mg/L was fed into a sequencing batch reactor (SBR). Analyses of the SBR system indicated that it simultaneously removed more than 99% of the NACs at loading rates of 0.36 kg NB/(m^3·d), 0.3 kg 4-NP/(m^3·d), 0.25 kg AN/(m^3·d), and 0.1 kg 2,4-DNP/(m^3·d). Bacterial groups of Bacteriodetes, Candidate division TM7, α-Proteobacteria, and β-Proteobacteria were dominant in the clone libraries of 16S rRNA genes retrieved from the microbial communities in the SBR system. "Cycle tests" designed to alter feeding and aeration parameters of the SBR system demonstrated that the resident microbial biome of the SBR system responded rapidly to changing conditions. Consumption of O2 was concomitant with the apparent mineralization of NACs. Aromatic ring-cleaving dioxygenase activities suggested that (1) AN and NB were degraded via catechol 2,3-dioxygenase; (2) 4-NP was degraded via 1,2,4-benzentriol 1,2-dioxygenase; and (3) 2,4-DNP was degraded via an unresolved pathway.
基金supported by the Program for New Century Excellent Talents in University (NCET-04-0270)National Basic Research Program of China (2011CB201301)
文摘The adsorptive denitrogenation from fuels over three metal-organic frameworks(MIL-96(Al),MIL-53(Al)and MIL-101(Cr))was studied by batch adsorption experiments.Four nitrogen-containing compounds(NCCs)pyridine,pyrrole,quinoline and indole were used as model NCCs in fuels to study the adsorption mechanism.The physicochemical properties of the adsorbents were characterized by XRD,N2physical adsorption,FT-IR spectrum and Hammett indicator method.The metal-organic frameworks(MOFs),especially the MIL-101(Cr)containing Lewis acid sites as well as high specific surface area,can adsorb large quantities of NCCs from fuels.In addition,the adsorptive capacity over MIL-101(Cr)will be different for NCCs with different basicity.The stronger basicity of the NCC is,the more it can be absorbed over MIL-101(Cr).Furthermore,pore size and shape also affect the adsorption capacity for a given adsorbate,which can be proved by the adsorption over MIL-53(Al)and MIL-96(Al).The pseudo-second-order kinetic model and Langmuir equation can be used to describe kinetics and thermodynamics of the adsorption process,respectively.Finally,the regeneration of the used adsorbent has been conducted successfully by just washing it with ethanol.
文摘The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a'-benzoyl ketene N. N-acetals 3a-b were treated by t-BuONa/t- BuOH Solution. 8- benzoyl-pyrido[1.2-a] pyrimidine 4 was produced.
文摘This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, benzothiazole, purine and derivatives, indole, indanol, piperidine and derivative, diphenylamine, N- phenylanthranilic acid, 8- OH- quinoline, naphthol, diphenylether have been tritiated by catalytic exchange method using tritiated water and platinum catalyst (from the dioxide and sodium borohydride), and the pattern of labelling has been assigned by ~3H NMR spectroscopy. The results show that this exchange process can give general labelling compounds at various time and temperatures. For 4-Br-diphenylether, Raney nickel was used instead of Pt as a catalyst.
基金Supported by the National Natural Science Foundation of China
文摘The Zr-H bond of zirconocene hydridochloride was heterolyzed at room temperature by five compounds containing nitrogen and hydroxyl group to give Cp(Q)2ZrCl(1) (Cp = cyclopentadienyl and Q = 8-quinolinoyl ) , Cp (Q-Me )2ZrCl (2) , Cp(5,7-Br2Q)2ZrCl(3), Cp2(2-pyridoyl)ZrCl(4) , and Cp(2-aminoethanoyl)2ZrCl(5), which were characterized by elemental analysis, IR, and 1H NMR spectroscopy. The molecular structure of 1 was confirmed by X-ray diffraction determination. The crystal of 1 crystallized monoclinically, space group P21/n a= 0.9004(2), b=1.3961(2), c = 1. 6056(2) nm, β=99. 48(1)°? V=1. 9906 nm3, Z = 4, and Dc=1. 582 g/cm3. The coordination polyhedron around the Zr atom can be described as a distorted octahedron. The Zr-N bonds of 0. 2364(3) and 0. 2377(4) nm suggest that they are coordination bonds. The two planar 8-quinolinoyl groups as bidentate ligands chelate with Zr atom, forming a dihedral angle of 108. 4(1)°?
基金supported by the"973"project envisaged in the State Key Basic R&D Program(2006CB202505).
文摘The DFT-based (density fimctional theory) ab initio quantum mechanical methods have been applied to study the basicity of the nitrogen-containing compounds in petroleum. The results have indicated that there is a distinct relationship between the protonation energy of nitrogen-containing compounds and their basicity. The more negative the protonation energy, the stronger the basicity is. It has been also found that aliphatic amines are more basic than pyridines or aromatic amines, and all these compounds are more basic than pyrroles. The addition of the aromatic rings can influence the basicity of anilines, while the 5- and 6-membered heterocyclic compounds function differently. The solvent properties may affect the basicity of these nitrogen-containing compounds.
文摘Using cation exchange resin(D72,Amberlyst-15) as catalyst, Mannich-type reaction of 5-amino-1,2,4-triazole 1, containing guanidine substructure, provides an efficient synthesis of a new kind of bicyclic P- and N-containing compounds, 6-phospha-4,5,6-trihydroimidazolo [2,3-e] 1,2,4-triazole 4.
文摘6,7-Methylenedioxy-3-thia-1(2H,4H)acridone and the related acridine-fused quinolines and pyridines,and also their flavylium-perchlorates were synthesized.The structures of all these compounds prepared are characterized by elemental analysis.IR and H-NMR spectra.
文摘To elucidate the effects of Fe_(2)O_(3) on nitrogen transformation during sludge pyrolysis,thermogravimetry coupled with mass spectrometry(TG-MS)was used to investigate the influences of Fe_(2)O_(3) on the pyrolysis characteristics and the release of important gaseous NO_(x) precursors such as HCN and NH_(3) during pyrolysis of three typical amino acids in urban sludge.The results show that after Fe_(2)O_(3) addition,the total weight loss rate of the three amino acids and the initial decomposition temperature of proline are reduced.The release amounts of NH_(3),HCN,CH_(3)CN,and HNCO from these three representative amino acids—glumatic,arginine,and proline,decrease in the order of arginine,glutamic,proline.The generation of Fe-N complexes,reduces the generation of NH_(3),HCN,CH_(3)CN,and HNCO while the catalysis effects of Fe_(2)O_(3) on the formation of H and H2 play a promoting role in the generation of NH_(3),HCN,CH_(3)CN,and HNCO.The results would provide an experimental and theoretical basis for subsequent research on the NOx precursor formation mechanisms during pyrolysis or combustion of Fe-containing sludge or sludge with additives containing Fe.
文摘Some new Schiff bases were synthesized by the condensation of equimolar quantities of salicylaldehyde and 2-amino-5-phenylazo-pyridine or its derivatives in dry benzene(1):Metal complexes of the type ML_2and M'L_3 where M=Cu^(2+),Co^(2+),Ni^(2+),Mn^(2+)Pd^(2+),M'=Fe^(3+)and L=different newly synthesized monobasic Schiff bases were prepared in absolute ethanolic medium(2)and characterized by elementary analysis,conductance measurements,infrared spectra,electronic spectra,magnetic moments studies.
基金the Natural Science Foundation of Tianjin(No.06YFJMJC15800) for the financial support.
文摘A new heterocyclic compound,named 5,5 -diisobutoxy-2,2 -bifuran(1),and four known compounds(2-5) were isolated from the roots of Cyathula officinalis Kuan.Their structures were elucidated by spectroscopic methods.Among these compounds,5,5 - dibutoxy-2,2 -bifuran(2) was isolated for the first time from this plant.
文摘A novel eleven-membered heterocyclic compound with high nitrogen has been isolated from the marine alga Sargassum vachell collected from the South China Sea. Its structure has been established by verity of spectroscopic techniques such as IR. EIMS. ID NMR. H-1-(HCOSY)-H-1. HMQC, HMBC.
基金supported by the National Natural Science Foundation of China(No.51102114)
文摘The X2Ge=Si: (X = H, Me, F, reaction is a new area for the study of silylene between singlet CI2Ge=Si: and formaldehyde CI, Br, Ph, At...) is a new species. Its cycloaddition chemistry. The mechanism of cycloaddition reaction has been investigated with CCSD(T)//MP2/6-31G* method. From the potential energy profile, it can be predicted that the reaction has two competitive dominant reaction pathways. The reaction rule presented is that the two reactants firstly form a four-membered Ge-heterocyclic ring silylene through the [2+2] cycloaddition reaction. Owing to the 3p unoccupied orbital of Si: atom in the four-membered Ge-heterocyclic ring silylene and the π orbital of formaldehyde forming a π-p donor-acceptor bond, the four-membered Ge-heterocyclic ring silylene further combines with formaldehyde to form an intermediate. Because the Si: atom in intermediate shows sp3 hybridization after transition state, the intermediate isomerizes to a spiro-Si-heterocyclic ring compound involving Ge via a transition state. Simultaneously, the ring strain of the four-membered Ge-heterocyclic ring silylene makes it isomerize to a twisted four-membered ring product. The research result indicates the laws of cycloaddition reaction between X2Ge=Si: (X = H, Me, F, C1, Br, Ph, Ar...) and the asymmetric g-bonded compounds, which are significant for the synthesis of small-ring and spiro-Si-heterocyclic ring compound involving Ge The study extends the research area and enriches the research content of silvlene chemistrv.
基金supported by the National Natural Science Foundation of China(No.51102114)
文摘X2Si=Sn:(X = H, Me, F, Cl, Br, Ph, Ar…) are new species of chemistry. The cycloaddition reaction of X2Si=Sn: is a new study field of stannylene chemistry. To explore the rules of cycloaddition reaction between X2Si=Sn: and the symmetric p-bonded compounds, the cycloaddition reactions of Cl2Si=Sn: and ethylene were selected as model reactions in this paper.The mechanism of cycloaddition reaction between singlet Cl2Si=Sn: and ethylene has been first investigated with the MP2/GENECP(C, H, Cl, Si in 6-311++G**;Sn in LanL2dz) method in this paper. From the potential energy profile, it could be predicted that the reaction has one dominant reaction channel. The reaction rule presented is that the 5p unoccupied orbital of Sn in Cl2Si=Sn: and the π orbital of ethylene forming a p→p donor-acceptor bond, resulting in the formation of an intermediate. Instability of the intermediate makes it isomerize to a four-membered Si-heterocyclic ring stannylene. Because the 5p unoccupied orbital of Sn atom in the four-membered Si-heterocyclic ring stannylene and the π orbital of ethylene form a p→p donor-acceptor bond, the four-membered Si-heterocyclic ring stannylene further combines with ethene to form another intermediate. Because the Sn atom in the intermediate shows sp3 hybridization after transition state, the intermediate isomerizes to a Si-heterocyclic spiro-Sn-heterocyclic ring compound. The research result indicates the laws of cycloaddition reaction between X2Si=Sn: and the symmetric π-bonded compounds. The study opens up a new research field for stannylene chemistry.
基金supported by the National Natural Science Foundation of China(No.51102114)
文摘X2Si=Ge: (X = H, Me, F, CI, Br, Ph, Ar...) is a new species. Its cycloaddition reaction is a new area for the study of germylene chemistry. The mechanism of cycloaddition reaction between singlet state Me2Si=Ge: and formaldehyde has been investigated with the CCSD(T)//MP2/cc-pvtz method. From the potential energy profile, it could be predicted that the reaction has one dominant reaction pathway. The reaction rule presented is that the two reactants first form a four-membered Si-heterocyclic ring germylene through the [2+2] cycloaddition reaction. Because of the 4p unoccupied orbital of Ge: atom in the four-membered Si-heterocyclic ring germylene and the π orbital of formaldehyde form a π→p donor-acceptor bond, the four-membered Si-heterocyclic ring germylene further combines with formaldehyde to form an intermediate. Because the Ge atom in the intermediate undergoes sp^3 hybridization after transition state, then the intermediate isomerizes to a spiro-Ge-heterocyclic ring compound involving Si via a transition state. The research result indicates the laws of cycloaddition reaction between HzSi=Ge: and formaldehyde. It has important reference value for the cycloaddition reaction between X2Si=Ge: (X = H, Me, F, CI, Br, Ph, Ar…) and asymmetric to-bonded compounds, which is significant for the synthesis of small-ring and spiro-Ge-heterocyclic compounds involving Si. The study extends research area and enriches the research content of germylene chemistry.
文摘The effects of iodium-heterocyclic compound(3,6-di-[dimethytamino]-dibcnzopyrodoniun formate,IHC-64)on the action potentials and contractile force of the isolatedguinca pig papillary muscles were investigatad.50 μmol/L IHC-64 only inhibited contractile forceand had no effect on APA,dv/dt max,APD<sub>5</sub>0 and APD<sub>9</sub>0 of fast action potentials in Tyrode’s so-lution.All of these parametres were depressed by further increasing concentration of IHC-64.InK-rich Tyrodc’s solution,the depressive action of IHC-64 on slow action potentials andcontractile force could be antagonized by incrcased extracellular calcium.These results suggesr thatIHC-64 inhibit not only slow calcium influx but also fast sodium influx,and it may.(?)new calci-urn channd blockcr.
基金supported by the National "863" project !863 -307-05-05(02) National Natural Science foundation!69637010
文摘Novel molecular material, 1-benzotlliazoly-3 -phenyl --pyrazoline (BTPP) was found to function as bright blue light emitting dye in organic electroluminescent device, and its optical and electric characteristics were investigated. This heterocyclic compound exhibited good characteristics of blue photoluminescence and electroluminescence, which had the emission peak at 450 nm. The single layer light-emitting devices using BTPP as light-emitting material dispersed in poly(N- vinylcarbazole) (PVK) and double layer ones using PBD as hole block layer above the light-emitting layer were fabricated using conventional spin-casting and vaccum vapour deposition methods. The introduction of PBD has enhanced electron injection and luminance efficiency, compared with the single layer LEDs.
文摘2-methoxy-6-oxo-1, 4, 2-diazaphosphorinane-2-oxide 8, phosphorus counterpart of 2, 6-dioxopiperazine, was synthesized as antitumor agent. The new phosphorus heterocycle compound 8 is the key intermediate in the synthesis of phosphorus counterpart of bisdioxopiperazine.