The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological ...The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).展开更多
Confucius＇s ＂No Child Left Behind＂ education ideology which was put forward two thousand years ago reflected the importance of education for educators and the simple pursuit of educational equity at that time. Educ...Confucius＇s ＂No Child Left Behind＂ education ideology which was put forward two thousand years ago reflected the importance of education for educators and the simple pursuit of educational equity at that time. Education Fair is the current composition content of China＇s basic education dream. Practicing ＂No Child Left Behind＂ education is the cornerstone to achieve China＇s fair education dream. Making implementing continuing education in order to achieve ＂No Child Left Behind＂ equitable education as a research issue, based on analyzing the status and problems of educational equity issues under the perspective of NCLB, the author explored the realistic way through multi-channel and diverse continuing education to achieve ＂No Child Left Behind ＂equitable education.展开更多
The media has played an important role in raising the public awareness and knowledge on child abuse.Yet,we do not know how child psychological maltreatment was presented in the media and how it might colour our common...The media has played an important role in raising the public awareness and knowledge on child abuse.Yet,we do not know how child psychological maltreatment was presented in the media and how it might colour our common understanding of the problem.This article presents the results of a qualitative research on social representations of child psychological maltreatment in the Quebec media.More specifically,the study aimed to investigate how child abuse and child psychological maltreatment were presented in the Quebec media when psychological maltreatment was formally integrated into the Youth Protection Act in 2006.85 newspaper articles were analyzed.We identified various forms of anchoring and objectivation of social representations,including the emotional anchoring and objectivation of abuse in moral outrage,compassion,and fear,as well as various metaphors,personifications,and antinomies related to the issue.Cross-sectional analysis of the data revealed the thematic anchoring of representations of child maltreatment in the thêmata self/other and justice/injustice.This article discusses the implications of these results regarding social exclusion and the othering process of marginalized groups.Finally,we will address the repercussions of these thêmata on current solutions and action plans to end child abuse and maltreatment.展开更多
The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by ...The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by women in England. It has played an important role in promoting women’s equal rights and breaking patriarchal absolutism. However, there was much compromise in the legal basis for the legislation and the legal provisions, resulting in debates on the legislation that have greatly diluted the revolutionary significance of the Act. Starting with the Marxist argument on bourgeois family legislation, this paper analyzes the legislative and judicial practice of guardianship of minors before and after the promulgation of the Act in the United Kingdom. In view of its impact on the United Nations Convention on the Rights of the Child, this paper attempts to re-evaluate the historical status of this act.展开更多
目的探讨奥马珠单抗治疗儿童过敏性哮喘的临床疗效。方法选取2021年8月至2022年3月首都医科大学附属北京儿童医院过敏反应科确诊为过敏性哮喘并应用奥马珠单抗治疗的患儿。根据治疗有效性全球评估(global evaluation of treatment effec...目的探讨奥马珠单抗治疗儿童过敏性哮喘的临床疗效。方法选取2021年8月至2022年3月首都医科大学附属北京儿童医院过敏反应科确诊为过敏性哮喘并应用奥马珠单抗治疗的患儿。根据治疗有效性全球评估(global evaluation of treatment effectiveness,GETE)分析患儿治疗16周时的临床疗效,并观察治疗4周和16周时儿童哮喘控制测试(childhood asthma control test/asthma control test,c-ACT/ACT)得分,哮喘和鼻炎视觉模拟评分(visual analogue scale,VAS),哮喘生活质量调查问卷(mini Asthma Quality of Life Questionnaire,mini-AQLQ)得分,每日激素剂量,血清总IgE、肺功能和呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)情况。结果共纳入35例患儿,其中77.1%的患儿在治疗16周时对奥马珠单抗有“极好”或“好”的应答。与治疗前相比,治疗4周和16周时患儿的c-ACT/ACT得分均升高[25.0(20.3,26.8)分,24.5(21.5,27.0)分比23.0(18.0,23.0)分;23.5(21.3,24.8)分,24.5(24.0,25.0)分比22.0(18.0,24.8)分],哮喘VAS[1.0(0.0,2.8)分,1.0(0.0,1.0)分比2.3(0.6,6.3)分]和鼻炎VAS[1.0(0.0,4.8)分,1.4(0.1,3.0)分比4.7(2.1,5.9)分]均下降,哮喘mini-AQLQ评分均升高[98.5(93.0,103.0)分,103.0(98.5,103.8)分比91.0(83.3,96.5)分],差异均有统计学意义(P<0.05)。与治疗前相比,治疗16周时患儿的每日激素剂量下降[100.0(71.0,150.0)μg比160.0(125.0,200.0)μg]、血清总IgE明显升高[1593.0(1131.0,2367.0)kU/L比684.0(331.0,1489.0)kU/L],差异均有统计学意义(P=0.000)。与治疗前相比,治疗16周时患儿肺功能指标无明显改善,差异均无统计学意义(P>0.05),但FeNO显著降低,差异有统计学意义(P<0.05)。结论在过敏性哮喘儿童中应用奥马珠单抗,可以减少患儿临床症状和糖皮质激素的剂量,改善患儿生活质量。展开更多
文摘The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).
文摘Confucius＇s ＂No Child Left Behind＂ education ideology which was put forward two thousand years ago reflected the importance of education for educators and the simple pursuit of educational equity at that time. Education Fair is the current composition content of China＇s basic education dream. Practicing ＂No Child Left Behind＂ education is the cornerstone to achieve China＇s fair education dream. Making implementing continuing education in order to achieve ＂No Child Left Behind＂ equitable education as a research issue, based on analyzing the status and problems of educational equity issues under the perspective of NCLB, the author explored the realistic way through multi-channel and diverse continuing education to achieve ＂No Child Left Behind ＂equitable education.
基金This work was supported by the Fonds de Recherche,Sociétéet Culture[209689,2016-2020]the Ontario Graduate Scholarship Program[2017-2018-2019-2020].
文摘The media has played an important role in raising the public awareness and knowledge on child abuse.Yet,we do not know how child psychological maltreatment was presented in the media and how it might colour our common understanding of the problem.This article presents the results of a qualitative research on social representations of child psychological maltreatment in the Quebec media.More specifically,the study aimed to investigate how child abuse and child psychological maltreatment were presented in the Quebec media when psychological maltreatment was formally integrated into the Youth Protection Act in 2006.85 newspaper articles were analyzed.We identified various forms of anchoring and objectivation of social representations,including the emotional anchoring and objectivation of abuse in moral outrage,compassion,and fear,as well as various metaphors,personifications,and antinomies related to the issue.Cross-sectional analysis of the data revealed the thematic anchoring of representations of child maltreatment in the thêmata self/other and justice/injustice.This article discusses the implications of these results regarding social exclusion and the othering process of marginalized groups.Finally,we will address the repercussions of these thêmata on current solutions and action plans to end child abuse and maltreatment.
文摘The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by women in England. It has played an important role in promoting women’s equal rights and breaking patriarchal absolutism. However, there was much compromise in the legal basis for the legislation and the legal provisions, resulting in debates on the legislation that have greatly diluted the revolutionary significance of the Act. Starting with the Marxist argument on bourgeois family legislation, this paper analyzes the legislative and judicial practice of guardianship of minors before and after the promulgation of the Act in the United Kingdom. In view of its impact on the United Nations Convention on the Rights of the Child, this paper attempts to re-evaluate the historical status of this act.
文摘目的探讨奥马珠单抗治疗儿童过敏性哮喘的临床疗效。方法选取2021年8月至2022年3月首都医科大学附属北京儿童医院过敏反应科确诊为过敏性哮喘并应用奥马珠单抗治疗的患儿。根据治疗有效性全球评估(global evaluation of treatment effectiveness,GETE)分析患儿治疗16周时的临床疗效,并观察治疗4周和16周时儿童哮喘控制测试(childhood asthma control test/asthma control test,c-ACT/ACT)得分,哮喘和鼻炎视觉模拟评分(visual analogue scale,VAS),哮喘生活质量调查问卷(mini Asthma Quality of Life Questionnaire,mini-AQLQ)得分,每日激素剂量,血清总IgE、肺功能和呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)情况。结果共纳入35例患儿,其中77.1%的患儿在治疗16周时对奥马珠单抗有“极好”或“好”的应答。与治疗前相比,治疗4周和16周时患儿的c-ACT/ACT得分均升高[25.0(20.3,26.8)分,24.5(21.5,27.0)分比23.0(18.0,23.0)分;23.5(21.3,24.8)分,24.5(24.0,25.0)分比22.0(18.0,24.8)分],哮喘VAS[1.0(0.0,2.8)分,1.0(0.0,1.0)分比2.3(0.6,6.3)分]和鼻炎VAS[1.0(0.0,4.8)分,1.4(0.1,3.0)分比4.7(2.1,5.9)分]均下降,哮喘mini-AQLQ评分均升高[98.5(93.0,103.0)分,103.0(98.5,103.8)分比91.0(83.3,96.5)分],差异均有统计学意义(P<0.05)。与治疗前相比,治疗16周时患儿的每日激素剂量下降[100.0(71.0,150.0)μg比160.0(125.0,200.0)μg]、血清总IgE明显升高[1593.0(1131.0,2367.0)kU/L比684.0(331.0,1489.0)kU/L],差异均有统计学意义(P=0.000)。与治疗前相比,治疗16周时患儿肺功能指标无明显改善,差异均无统计学意义(P>0.05),但FeNO显著降低,差异有统计学意义(P<0.05)。结论在过敏性哮喘儿童中应用奥马珠单抗,可以减少患儿临床症状和糖皮质激素的剂量,改善患儿生活质量。
