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血清NT-proBNP、HMGB1及sTREM-1水平在脓毒症急性肺损伤预后评估中的价值
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作者 王晓林 李静 +2 位作者 范志强 佟庆 黄艳丽 《川北医学院学报》 CAS 2024年第2期222-225,共4页
目的:分析血清N末端脑钠肽前体(NT-proBNP)、高迁移率族蛋白B1(HMGB1)、可溶性髓系细胞触发受体-1(sICAM-1)水平与在脓毒症急性肺损伤(ALI)预后评估中的价值。方法:选取104例脓毒症ALI患者为研究对象(ALI组),以肺部超声评分(LUS)将其分... 目的:分析血清N末端脑钠肽前体(NT-proBNP)、高迁移率族蛋白B1(HMGB1)、可溶性髓系细胞触发受体-1(sICAM-1)水平与在脓毒症急性肺损伤(ALI)预后评估中的价值。方法:选取104例脓毒症ALI患者为研究对象(ALI组),以肺部超声评分(LUS)将其分为轻度组(n=50)、中度组(n=36)、重度组(n=18);另选取80例单纯性脓毒症患者为对照组。采用酶联免疫吸附法检测血清NT-proBNP、HMGB1、sICAM-1水平,以脓毒症ALI患者28 d预后情况将其分为生存组和死亡组,绘制受试者工作特征曲线(ROC)评估NT-proBNP、HMGB1、sICAM-1及联合预测预后的价值。结果:脓毒症ALI组NT-proBNP、HMGB1、sTREM-1水平均高于对照组(P<0.05);不同严重程度的脓毒症ALI组患者NT-proBNP、HMGB1、sTREM-1值比较,差异均有统计学意义(P<0.05),且均表现为脓毒症ALI轻度组患者<中度组<重度组(P<0.05);Spearman相关性分析显示,NT-proBNP、HMGB1、sTREM-1与严重程度正相关(P<0.05);生存组NT-proBNP、HMGB1、sTREM-1水平均低于死亡组(P<0.05),三者联合检测预测预后的曲线下面积高于单一指标预测。结论:脓毒症ALI患者血清NT-proBNP、HMGB1、sTREM-1水平较高,三者联合检测对于预后有较高的评估价值。 展开更多
关键词 脓毒症 急性肺损伤 nt-PROBNP HMGB1 STREM-1 预后
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HBP、NT-proBNP及β_(2)-MG与脓毒血症病情严重程度的相关性及预后评估价值
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作者 苟鑫 封凯旋 +2 位作者 马斌 王小兵 黄晓丽 《检验医学与临床》 CAS 2024年第12期1759-1763,共5页
目的探讨肝素结合蛋白(HBP)、氨基末端脑钠肽前体(NT-proBNP)及β_(2)-微球蛋白(β_(2)-MG)与脓毒血症病情严重程度的相关性,并分析其对患者预后的评估价值。方法选取2021年9月至2023年6月在上海市第六人民医院金山分院诊治的脓毒血症患... 目的探讨肝素结合蛋白(HBP)、氨基末端脑钠肽前体(NT-proBNP)及β_(2)-微球蛋白(β_(2)-MG)与脓毒血症病情严重程度的相关性,并分析其对患者预后的评估价值。方法选取2021年9月至2023年6月在上海市第六人民医院金山分院诊治的脓毒血症患者69例作为研究对象,对其临床资料进行回顾性分析。按病情严重程度将患者分为一般脓毒血症组(23例)、严重脓毒血症组(23例)和脓毒血症休克组(23例),另选取同期在上海市第六人民医院金山分院住院的非脓毒血症患者23例为对照组。根据28 d病死率将脓毒血症患者分为生存组和死亡组。检测并比较各组患者血清HBP、NT-proBNP、β_(2)-MG水平及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分,采用Pearson相关分析血清HBP、NT-proBNP、β_(2)-MG水平与APACHEⅡ评分的相关性,并利用受试者工作特征(ROC)曲线分析其对脓毒血症患者死亡的预测价值。结果一般脓毒血症组、严重脓毒血症组、脓毒血症休克组血清HBP、NT-proBNP、β_(2)-MG水平及APACHEⅡ评分均高于对照组(P<0.05);HBP、NT-proBNP、β_(2)-MG水平及APACHEⅡ评分表现为一般脓毒血症组<严重脓毒血症组<脓毒血症休克组,任意两组间比较,差异均有统计学意义(P<0.05)。死亡组血清HBP、NT-proBNP、β_(2)-MG水平及APACHEⅡ评分均高于生存组(P<0.05)。Pearson相关分析结果显示,脓毒血症患者血清HBP、NT-proBNP、β_(2)-MG水平与APACHEⅡ评分呈正相关(r=0.645、0.776、0.593,P<0.05)。ROC曲线分析结果显示,HBP、NT-proBNP、β_(2)-MG联合检测预测脓毒血症患者死亡的AUC为0.870(95%CI:0.730~1.000),明显高于HBP、NT-proBNP、β_(2)-MG单独检测的AUC[0.768(95%CI:0.598~0.937)、0.792(95%CI:0.653~0.932)、0.814(95%CI:0.645~0.984)],差异均有统计学意义(Z=2.705,P=0.007;Z=2.496,P=0.013;Z=2.126,P=0.033)。结论检测血清HBP、NT-proBNP、β_(2)-MG水平有助于判断脓毒血症患者病情严重程度及评估患者预后,3项指标联合检测可预测患者死亡风险。 展开更多
关键词 脓毒血症 肝素结合蛋白 氨基末端脑钠肽前体 β_(2)-微球蛋白 病情严重程度 预后
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沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响
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作者 陈吉丽 王艳飞 吕彩萍 《生命科学仪器》 2024年第1期53-55,58,共4页
目的探讨沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响。方法选取2022年4月至2023年5月云南省昆明市第一人民医院心内科收治的150例心力衰竭患者为研究对象,根据就诊时间分为两组。参照组采用沙库巴曲... 目的探讨沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭的疗效及对NT-proBNP的影响。方法选取2022年4月至2023年5月云南省昆明市第一人民医院心内科收治的150例心力衰竭患者为研究对象,根据就诊时间分为两组。参照组采用沙库巴曲缬沙坦治疗,实验组在参照组基础上使用冻干重组人脑利钠肽治疗。对比两组治疗效果、心功能、血浆BNP、NT-proBNP水平及不良反应发生情况。结果实验组治疗总有效率高于参照组,差异有统计学意义(P<0.05)。实验组干预后心率低于参照组,每搏量及LVEF均高于参照组,差异有统计学意义(P<0.05)。实验组干预后血浆BNP、NT-proBNP水平均低于参照组,差异有统计学意义(P<0.05)。实验组不良反应发生率低于参照组,差异有统计学意义(P<0.05)。结论沙库巴曲缬沙坦联合冻干重组人脑利钠肽治疗心力衰竭可显著提高疗效,降低血浆BNP及NT-proBNP水平,改善患者心功能,减少不良反应。 展开更多
关键词 沙库巴曲缬沙坦 冻干重组人脑利钠肽 心力衰竭 nt-PROBNP
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基于NT的心理调适干预对稳定型心绞痛患者心理健康、希望水平及生存质量的影响
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作者 赵艳 杨杰 张继伟 《罕少疾病杂志》 2024年第1期132-133,共2页
目的探讨基于叙事疗法(NT)的心理调适干预对稳定型心绞痛患者心理健康、希望水平及生存质量的影响。方法选取2020年5月-2022年4月本院收治的200例稳定型心绞痛患者,随机将患者分为NT组和常规干预组,每组各100例,常规干预组患者采用常规... 目的探讨基于叙事疗法(NT)的心理调适干预对稳定型心绞痛患者心理健康、希望水平及生存质量的影响。方法选取2020年5月-2022年4月本院收治的200例稳定型心绞痛患者,随机将患者分为NT组和常规干预组,每组各100例,常规干预组患者采用常规基础护理干预,NT组在常规干预组的基础上采用基于NT的心理调适干预,两组患者均持续干预3个月。在干预前后,比较NT组和常规干预组患者的汉密尔顿抑郁量表(HAMD)评分和汉密尔顿焦虑量表(HAMA),比较两组患者的Herth希望量表(HHI)、比较两组患者身体活动受限程度(PL)评分。结果与干预前相比,干预后NT组和常规干预组患者HAMD评分、HAMA评分均降低,干预后,NT组患者HAMD评分、HAMA评分均低于常规干预组(P<0.05);与干预前相比,干预后NT组和常规干预组患者PL评分、HHI评分升高,干预后,NT组PL评分、HHI评分高于对照组(P<0.05)。结论基于NT的心理调适干预能够减轻稳定性心绞痛患者负性情绪,提高患者生活希望和生存质量。 展开更多
关键词 基于nt的心理调适干预 稳定型心绞痛 心理健康 希望水平 生存质量
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Characterization of Leaf Photosynthetic Properties for No-Tillage Rice 被引量:5
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作者 CHEN Song XIA Guo-mian +2 位作者 ZHAO Wei-ming WU Fei-bo ZHANG Guo-ping 《Rice science》 SCIE 2007年第4期283-288,共6页
A study was conducted to determine the influence of no-tillage cultivation on leaf photosynthesis of rice plants under field conditions. Experiments with the treatments, no-tillage and conventional tillage were carrie... A study was conducted to determine the influence of no-tillage cultivation on leaf photosynthesis of rice plants under field conditions. Experiments with the treatments, no-tillage and conventional tillage were carried out at three locations (Jiaxing, Hangzhou and Xiaoshan, Zhejiang Province, China) for two years (2005 and 2006). Grain yield was constant in Jiaxing, but slightly higher in Hangzhou and Xiaoshan under no-tillage cultivation than that under conventional cultivation. In comparison with the conventional cultivation, no-tillage cultivation showed less biomass accumulation before heading and higher capacity of matter production during grain filling. A significantly higher leaf net photosynthetic rate was observed for the plants under no-tillage than for those under conventional tillage. The fluorescence parameter (Fv/Fm) in leaf did not show any difference between the two cultivations. The effect of cultivation management on transpiration rate (Tr) and SPAD value of rice leaf was dependent on the location and year. 展开更多
关键词 PHOTOSYntHESIS LEAF RICE no-tillage PLOUGH YIELD
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Inter-annual changes in the aggregate-size distribution and associated carbon of soil and their effects on the straw-derived carbon incorporation under long-term no-tillage 被引量:8
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作者 YIN Tao ZHAO Cai-xia +2 位作者 YAN Chang-rong DU Zhang-liu HE Wen-qing 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第11期2546-2557,共12页
Converting from conventional tillage to no-tillage influences the soil aggregate-size distribution and thus soil organic carbon (SOC) stabilization. However, the dynamics of soil aggregation and the straw-derived ca... Converting from conventional tillage to no-tillage influences the soil aggregate-size distribution and thus soil organic carbon (SOC) stabilization. However, the dynamics of soil aggregation and the straw-derived carbon (C) incorporation within aggregate fractions are not well understood. An experiment was established in 2004 to test the effects of two treatments, no-tillage with residue (NT) and conventional tillage without residue (CT), on the soil aggregate-size distribution and SOC stabilization in a continuous maize (Zea mays L.) cropping system located in the semiarid region of northern China. Soil samples were collected from the 0-10 cm layer in 2008, 2010 and 2015, and were separated into four aggregate-size classes (〉2, 0.25-2, 0.053-0.25, and 〈0.053 mm) by wet-sieving. In each year, NT soil had a higher proportion of macroaggregates (i.e., 〉2 and 0.25-2 mm) and associated SOC concentration compared with CT. Additionally, to compare straw-derived C incorporation within NT and CT aggregate fractions, ^13C-labeled straw was incubated with intact NT and CT soils. After 90 days, the highest proportion of 13C-labeled straw-derived C was observed in the 〉2 mm fraction, and this proportion was lower in NT than that in CT soil. Overall, we conclude that long-term continuous NT increased the proportion of macroaggregates and the C concentration within macroaggregates, and the physical protection provided by NT is beneficial for soil C sequestration in the continuous maize cropping system in semiarid regions of northern China. 展开更多
关键词 no-tillage aggregate-size distribution aggregate-associated carbon ^13C-labeled straw
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Effect of experimental warming on soil respiration under conventional tillage and no-tillage farmland in the North China Plain 被引量:6
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作者 TU Chun LI Fa-dong +3 位作者 QIAO Yun-feng ZHU Nong GU Cong-ke ZHAO Xin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第4期967-979,共13页
Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon (C) cycle. We conducted an infrared warming experiment under conventional tillage (CT... Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon (C) cycle. We conducted an infrared warming experiment under conventional tillage (CT) and no-tillage (NT) farmland for winter wheat and summer maize rotation system in North China Plain (NCP). Treatments include CT with and without warming (CTW and CTN), NT with and without warming (NTW and NTN). The results indicated that warming had no sig- nificant effect on soil moisture in irrigated farmland of NCP (P〉0.05). The elevated average soil temperature of 1.1-116℃ in crop growing periods could increase annual soil CO2 emission by 10.3% in CT filed (P〉0.05), but significantly increase it by 12.7% in NT field (P〈0.05), respectively. The disturbances such as plowing, irrigation and precipitation resulted in the obvious soil CO2 emission peaks, which contributed 36.6-40.8% of annual soil cumulative CO2 emission. Warming would enhance these soil CO2 emission peaks; it might be associated with the warming-induced increase of autotrophic respiration and heterotrophic respiration. Compared with un-warming treatments, dissolved organic carbon (DOC) and soil microbial biomass carbon (MBC) in warming treatments were significantly increased by 11.6-23.4 and 12.9-23.6%, respectively, indicating that the positive responses of DOC and MBC to warming in both of two tillage systems. Our study highlights that climate warming may have positive effects on soil C release in NCP in association with response of labile C substrate to warming. 展开更多
关键词 global warming conventional tillage no-tillage soil respiration dissolved organic carbon soil microbial biomasscarbon
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CD73/NT5E在胶质母细胞瘤中的研究进展
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作者 邵将 李琳 +4 位作者 郭岩松 孙程圆 温稀超 郑克彬 史彦芳 《实用医学杂志》 CAS 北大核心 2024年第3期428-431,438,共5页
胶质瘤是最常见的原发性中枢神经系统肿瘤,主要来源于神经胶质细胞,具有侵袭性强、易复发、预后差的特点。胶质母细胞瘤是恶性程度最高的高级别胶质瘤,临床治疗方法为手术切除为主,辅以放化疗及电场治疗等综合治疗,但治疗效果并不令人... 胶质瘤是最常见的原发性中枢神经系统肿瘤,主要来源于神经胶质细胞,具有侵袭性强、易复发、预后差的特点。胶质母细胞瘤是恶性程度最高的高级别胶质瘤,临床治疗方法为手术切除为主,辅以放化疗及电场治疗等综合治疗,但治疗效果并不令人满意。CD73是一种与腺苷代谢相关的新型免疫检查点,近年来随着肿瘤免疫治疗领域的迅速发展,发现CD73可以通过抑制抗肿瘤免疫反应和促进血管生成来促进肿瘤进展。本文系统综述了CD73的作用机制,并讨论其在胶质瘤中的生物学作用及应用,旨在为胶质瘤患者的治疗提供潜在的治疗方案。 展开更多
关键词 胶质母细胞瘤 CD73/nt5E 腺苷 免疫检查点 免疫治疗
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Suppression of weeds and weed seeds in the soil by stubbles and no-tillage in an arid maize-winter wheat-common vetch rotation on the Loess Plateau of China 被引量:1
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作者 YANG Mei ZHAO Yuxin +2 位作者 YANG Huimin SHEN Yuying ZHANG Xiaoyan 《Journal of Arid Land》 SCIE CSCD 2018年第5期809-820,共12页
Reduced tillage provides ecological and economic benefits to arable land on the Loess Plateau of China, where soil erosion has long been a serious problem and soil water availability is largely restricted. However, hi... Reduced tillage provides ecological and economic benefits to arable land on the Loess Plateau of China, where soil erosion has long been a serious problem and soil water availability is largely restricted. However, high abundances of weeds in reduced tillage systems cause significant yield losses. In this study, we explored the effects of no-tillage and stubble retention on the number and density of weeds and weed seeds in a 12-year maize-winter wheat-common vetch rotation on the Loess Plateau. Four treatments including conventional tillage, no-tillage, conventional tillage+stubble retention and no-tillage+stubble retention were designed and applied. We found that no-tillage increased the number of weed species and weed density in most of the crops, while stubble retention decreased weed density in maize and tended to suppress weeds in both no-tillage treatments(no-tillage and no-tillage+stubble retention). No-tillage led to an increase in the number of weed species in the weed seedbank and tended to increase seed density during the spring growth of winter wheat, but it decreased seed density during post-vetch fallow. Stubble retention tended to reduce seed density during the spring growth of winter wheat and post-vetch fallow. We concluded that no-tillage can promote weeds in the experimental crop rotation, while stubble retention suppresses weeds in untilled fields. The combined effects of stubble retention and no-tillage on weed suppression varied among the three crops. Based on these results, we recommend stubble retention in untilled legume-crop rotations on the Loess Plateau to improve the control of weeds. 展开更多
关键词 agricultural conservation practice crop rotation no-tillage rainfed soil soil seedbank stubble retention weed control
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氯吡格雷联合阿司匹林对急性脑梗死IL-18、IL-33、NT-pro BNP的影响
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作者 王勇 黄春 《中国医学创新》 CAS 2024年第3期73-76,共4页
目的:分析氯吡格雷联合阿司匹林对急性脑梗死患者血清白细胞介素(IL)-18、IL-33及N末端B型利钠肽原(NT-proBNP)水平及疗效的影响。方法:选取萍乡市人民医院2020年7月—2021年8月收治的急性脑梗死患者72例,以随机数字表法分组,对照组(n=... 目的:分析氯吡格雷联合阿司匹林对急性脑梗死患者血清白细胞介素(IL)-18、IL-33及N末端B型利钠肽原(NT-proBNP)水平及疗效的影响。方法:选取萍乡市人民医院2020年7月—2021年8月收治的急性脑梗死患者72例,以随机数字表法分组,对照组(n=36)在常规治疗基础上使用氯吡格雷治疗,试验组(n=36)在对照组基础上使用阿司匹林治疗,两组均连续服药4周,比较两组炎症因子、NT-proBNP水平,并比较临床疗效及用药不良反应。结果:两组治疗7 d后IL-6、IL-18、IL-33、NT-pro BNP水平均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。试验组临床总有效率为97.22%,高于对照组的77.78%,差异有统计学意义(P<0.05)。试验组总用药不良反应发生率为11.11%,与对照组的8.33%比较,差异无统计学意义(P>0.05)。结论:氯吡格雷联合阿司匹林治疗急性脑梗死,可更好地发挥药效,提高临床效果,降低IL-6、IL-18、IL-33、NT-pro BNP水平,安全有效。 展开更多
关键词 氯吡格雷 阿司匹林 急性脑梗死 白细胞介素-18 白细胞介素-33 N末端B型利钠肽原
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NT超声检测结合无创DNA检测用于高龄孕妇产前筛查的价值分析
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作者 陆丰华 丁杨 王智慧 《实用妇科内分泌电子杂志》 2024年第3期102-104,共3页
目的探讨胎儿颈项透明层(NT)超声检测结合无创DNA检测用于高龄孕妇产前筛查的应用价值。方法选取本院486例进行产检、分娩的高龄单胎孕妇的临床资料,根据孕妇选择产前筛查方法不同,将其分为NT组(n=127例)和联合组(n=359例)。NT组采用NT... 目的探讨胎儿颈项透明层(NT)超声检测结合无创DNA检测用于高龄孕妇产前筛查的应用价值。方法选取本院486例进行产检、分娩的高龄单胎孕妇的临床资料,根据孕妇选择产前筛查方法不同,将其分为NT组(n=127例)和联合组(n=359例)。NT组采用NT超声检测,联合组采用NT超声检测结合无创DNA检测,对比两组胎儿染色体疾病的检出率和漏诊率。结果以羊水穿刺检测结果为金标准,NT组胎儿染色体疾病的检出率为66.67%,联合组胎儿染色体疾病的检出率为80.00%,联合组的检出率高于NT组;NT组漏诊率为33.33%,联合组漏诊率为20.00%,联合组的检测漏诊率低于NT组。结论NT超声检测结合无创DNA检测对高龄孕妇产前筛查有效,胎儿染色体疾病的检出率高,漏诊率低。 展开更多
关键词 nt超声检测 无创DNA检测 高龄孕妇
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血清RDW、NT-proBNP水平联合检测对老年急性心力衰竭患者发生MACE的预测价值
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作者 荆娇莹 朱继法 张晓 《淮海医药》 CAS 2024年第2期142-146,共5页
目的:分析急性心力衰竭(AHF)患者红细胞分布宽度(RDW)、氨基末端B型脑钠肽前体(NT-proBNP)水平及与心功能分级的相关性,探讨二者联合检测对AHF患者发生主要不良心血管事件(MACE)的预测价值。方法:选取某院2018年2月—2020年9月收治的136... 目的:分析急性心力衰竭(AHF)患者红细胞分布宽度(RDW)、氨基末端B型脑钠肽前体(NT-proBNP)水平及与心功能分级的相关性,探讨二者联合检测对AHF患者发生主要不良心血管事件(MACE)的预测价值。方法:选取某院2018年2月—2020年9月收治的136例AHF患者为AHF组,选取同期90例慢性心力衰竭(CHF)患者为CHF组,同期100例健康体检者为健康组,比较三组NT-proBNP、RDW水平。比较不同心功能分级AHF患者血清NT-proBNP、RDW水平及与心功能分级的相关性。随访1年,根据AHF患者是否发生MACE,评估血清RDW、NT-proBNP水平联合检测对AHF患者发生MACE的预测价值。结果:AHF组血清RDW、NT-proBNP水平[(16.79±1.82)%、(6086.22±973.74)pg/mL]高于CHF组[(14.86±1.32)%、(3168.57±875.69)pg/mL]和健康组[(12.81±0.73)%、(128.96±33.64)pg/mL],差异均有统计学意义(P<0.05)。Ⅱ级、Ⅲ级、Ⅳ级AHF患者血清RDW分别为(14.67±0.56)%、(17.62±0.74)%、(19.27±0.46),血清NT-proBNP分别为(5715.64±784.31)pg/mL、(6234.45±850.53)pg/mL、(6512.39±913.03)pg/mL,随着AHF患者心功能分级增加,血清RDW、NT-proBNP水平逐渐升高,差异均有统计学意义(P<0.05)。心功能分级与血清RDW(r=0.607)、NT-proBNP(r=0.614)水平呈正相关(P<0.05)。发生MACE的AHF患者血清RDW、NT-proBNP水平[(18.46±1.63)%、(6481.70±754.38)pg/mL]高于未发生MACE的AHF患者[(16.47±1.42)%、(6009.90±669.75)pg/mL](P<0.05);血清RDW、NT-proBNP水平联合检测预测AHF患者发生MACE的AUC、敏感度、特异度分别为0.944、90.91%、88.60%(P<0.001)。结论:老年AHF患者血清RDW、NT-proBNP处于较高水平,其水平变化与AHF患者心功能分级呈正相关,二者联合检测对AHF患者发生MACE具有较高的预测价值。 展开更多
关键词 急性心力衰竭 红细胞分布宽度 氨基末端B型脑钠肽前体 主要不良心血管事件
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NT5E在上消化道癌中的研究进展
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作者 赵世幸 田云霄 《中文科技期刊数据库(引文版)医药卫生》 2024年第6期0122-0128,共7页
NT5E是一种由NT5E基因编码的糖基磷脂酰肌醇锚定的细胞表面蛋白,在不同组织上广泛表达,NT5E通过多种免疫调节途径促进肿瘤细胞的发生、发展和免疫逃逸。NT5E靶向阻断可能成为一些肿瘤有效的肿瘤免疫治疗及辅助免疫治疗靶点。上消化道癌... NT5E是一种由NT5E基因编码的糖基磷脂酰肌醇锚定的细胞表面蛋白,在不同组织上广泛表达,NT5E通过多种免疫调节途径促进肿瘤细胞的发生、发展和免疫逃逸。NT5E靶向阻断可能成为一些肿瘤有效的肿瘤免疫治疗及辅助免疫治疗靶点。上消化道癌,包括胃癌、食管癌,细胞中NT5E表达水平对肿瘤发生、发展有重要意义,目前多种上消化道癌的抗NT5E相关药物临床试验正在进行中。本文综述了NT5E作为治疗靶点的可能性及机制,以及NT5E在上消化道癌中的意义。 展开更多
关键词 nt5E CD73 肿瘤微环境 胃癌 食管癌
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No-tillage effects on grain yield and nitrogen requirements in hybrid rice transplanted with single seedlings: Results of a long-term experiment
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作者 HUANG Min CHEN Jia-na +2 位作者 CAO Fang-bo ZOU Ying-bin Norman Uphoff 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第1期24-32,共9页
This study was conducted to determine whether,and if so how,the grain yield and nitrogen(N) requirements of hybrid rice transplanted as single seedlings are affected by no-tillage(NT) practices.A fixed field experimen... This study was conducted to determine whether,and if so how,the grain yield and nitrogen(N) requirements of hybrid rice transplanted as single seedlings are affected by no-tillage(NT) practices.A fixed field experiment was done at the Experimental Farm of Hunan Agricultural University in Changsha,Hunan Province,China,from 2004 to 2014.Grain yield and yield attributes(panicle number per m2,spikelet number per panicle,spikelet filling percentage,grain weight,total biomass,and harvest index) were evaluated as well as the N-use characteristics(total N uptake,internal N-use efficiency,and N requirements) of hybrid rice transplanted as single seedlings comparing NT with conventional tillage(CT).A significant finding was that there were no significant differences in grain yield,yield attributes,and N-use characteristics between CT and NT.Averaged across the 11 years,grain yield and N requirements were 9.51 t ha^(-1) and 20.2 kg t^(-1) under CT and 9.33 t ha^(-1) and 20.0 kg t^(-1) under NT,respectively.There were significant yearly variations in grain yield,yield attributes,and N-use characteristics observed under both CT and NT.The yearly variation in grain yield was related to simultaneous changes in spikelet number per panicle,grain weight,total biomass,and harvest index.Also,it was found that grain yield was positively correlated with internal N-use efficiency but negatively correlated with N requirements.It is concluded that grain yield and N requirements in hybrid rice when transplanted as single seedlings are not affected adversely by NT.The results of this study suggest that(1) compatible relationships among yield attributes can be established in hybrid rice that is transplanted as single seedlings,and(2) higher grain yield and higher N-use efficiency can be concurrently achieved in hybrid rice transplanted as single seedlings. 展开更多
关键词 grain yield hybrid rice NITROGEN requirements no-tillage TRANSPLAntING of single seedlings
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Physiological Mechanism of High and Stable Yield of No-tillage Cast-transplanted Rice
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作者 LIU Jun, HUANG Qing, FU Hua, LU Xiu-ming, LIU Huai-zhen and LI Kang-huo( Rice Research Institute , Guangdong Academy of Agricultural Sciences , Guangzhou 510640 , P.R. China) 《Agricultural Sciences in China》 CAS CSCD 2002年第4期404-409,共6页
Four years' successive comparative experiments showed that no-tillage cast-transplanted rice (NTCTR), compared with conventional tillage cast-transplanted rice (CK), grew slower and produced less tillers at the ea... Four years' successive comparative experiments showed that no-tillage cast-transplanted rice (NTCTR), compared with conventional tillage cast-transplanted rice (CK), grew slower and produced less tillers at the early growing stage; but, it had shorter ineffective tillering time, less nutrition consumption, stronger individual growth and more uniform growth between individuals and the colony. These characteristics contribute to the increase not only in the productive tiller percentage but also in the ear quality. Furthermore, the flag leaf of NTCTR had higher photosynthetic rate during the filling stage and no early senescence phenomenon at the late stage, which facilitated the accumulation and the transportation of carbohydrates and improved grain setting rate. 展开更多
关键词 RICE no-tillage cast-transplanted rice(ntCTR) PHYSIOLOGY
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Effects of Five Years Adoption of No-Tillage Systems for Vegetables Crops in Soil Organic Matter Contents
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作者 Carlos E. P. Lima ítalo M. R. Guedes +4 位作者 Juscimar da Silva Flávia A. Alcantara Nuno R. Madeira Agnaldo D. F. Carvalho Mariana R. Fontenelle 《Agricultural Sciences》 2018年第1期117-128,共12页
Vegetables productions systems are done normally with intense soil tillage causing a strong decline of soil quality. Use of conservation systems can be an alternative to recover this quality. In order to evaluate the ... Vegetables productions systems are done normally with intense soil tillage causing a strong decline of soil quality. Use of conservation systems can be an alternative to recover this quality. In order to evaluate the effects of such systems on soil organic matter, an experiment has been conducted in randomized blocks design and factorial scheme 3 × 2: three soil management systems (no-tillage;reduced tillage and conventional tillage) and two cover crops (maize single;and intercropping maize with gray velvet bean—Stizolobium niveum);and repeated measures over time. Soil samples were collected before the implementation of the experiment and at the end of each crop cycle until the fifth crop cycle. Carbon associated with humic substances is also determined in 0 - 5 cm, 5 - 10 cm and 10 - 30 cm at the end of the last crop cycle. The SOM content was higher in RT (48.34 g·kg-1) than in the CT (39.48 g·kg-1) at the end of the fifth crop cycle. SOM content in NT (44.92 g·kg-1) was statistically equal to RT and CT, during the same period. In 0 - 5 cm, carbon contents associated to the humic substances present the same behavior of SOM contents in 0 - 10 cm. Probably these results are associated with the capacity of each system to improve superficial contents of SOM stable fractions. It follows that the conservation systems used are alternatives to the cultivation vegetables in order to improve soil organic matter contents. 展开更多
关键词 no-tillage Reduced TILLAGE SOIL Conservation SOIL Management
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孕早期胎儿NT筛查在产前超声筛查单胎妊娠孕妇中的价值分析
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作者 师霞君 杨蓉 +1 位作者 杨映霞 郭家元 《影像研究与医学应用》 2024年第2期178-180,183,共4页
目的:研究孕早期胎儿颈项透明层(NT)筛查的实施价值,分析其在产前超声筛查单胎妊娠孕妇中的实施效果。方法:收集2023年3月—10月定西市人民医院收治的100例单胎妊娠孕妇的临床资料,所有孕妇均进行产前超声筛查及二维彩超、早期血清学、N... 目的:研究孕早期胎儿颈项透明层(NT)筛查的实施价值,分析其在产前超声筛查单胎妊娠孕妇中的实施效果。方法:收集2023年3月—10月定西市人民医院收治的100例单胎妊娠孕妇的临床资料,所有孕妇均进行产前超声筛查及二维彩超、早期血清学、NT筛查,以随访结果为金标准,分析不同年龄段产妇NT增厚率、不同NT厚度妊娠结局及NT筛查的价值。结果:不同NT厚度妊娠结局比较显示与NT厚度2.5~<3.0mm组、3.0~<5.0mm组、≥5.0mm组相比,<2.5mm组的正常胎儿数量较多(P<0.05)。随访结果显示,异常妊娠结局孕妇14例,二维彩超准确检出20例,早期血清学筛查准确检出15例,NT筛查准确检出14例;NT筛查灵敏度、准确率高于二维彩超(P<0.05),NT筛查与早期血清学筛查对比灵敏度、特异度、准确率差异无统计学意义(P>0.05)。结论:孕早期胎儿NT筛查实施价值高,具有较高的诊断准确率、特异度、灵敏度,可以通过NT厚度对染色体异常、胎儿畸形发育等情况进行分析。 展开更多
关键词 单胎妊娠孕妇 产前超声筛查 孕早期 胎儿nt筛查 妊娠结局 nt增厚率
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TDI-Tei指数联合NT-proBNP对急性心肌梗死患者预后的预测价值
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作者 邢璐 张志强 韩霞 《山东第一医科大学(山东省医学科学院)学报》 CAS 2024年第1期13-18,共6页
目的 探讨TDI-Tei指数(tissue doppler imaging-Tei index)联合血清N-端脑利钠肽前体(N-terminal pro-Btype brain natriuretic peptide,NT-proBNP)对经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗术后的急性心肌梗死(... 目的 探讨TDI-Tei指数(tissue doppler imaging-Tei index)联合血清N-端脑利钠肽前体(N-terminal pro-Btype brain natriuretic peptide,NT-proBNP)对经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗术后的急性心肌梗死(acute myocardial infarction,AMI)患者远期预后的预测价值。方法 选取2021年3月1日至2022年6月30日在济南市人民医院接受急诊PCI治疗术的201例AMI患者,术后随访12个月,根据是否发生不良心血管事件(major adverse cardiovascular events,MACEs)将其分为发生组(n=50)与未发生组(n=151)。收集患者临床资料,采用多因素logistic回归,分析术后72 h内的TDI-Tei指数、血清NT-proBNP水平与AMI患者PCI术后发生MACEs的关系,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析两者分别以及联合对AMI患者PCI术后发生MACEs的预测价值。结果 发生组年龄、门-导丝时间、糖尿病、冠脉Gensini评分、术后心率、心肌钙蛋白I(cardiac troponin I,cTnI)、尿酸、TDI-Tei指数、NT-proBNP均高于未发生组,左室射血分数低于未发生组,差异均有统计学意义(P <0.001);多因素logistic回归分析显示,术后心率、TDI-Tei指数及NT-proBNP是AMI患者PCI术后12个月内发生MACEs的独立预测因素(P <0.001);ROC曲线分析显示,血清NT-proBNP的曲线下面积(area under curve, AUC)为0.86,敏感度为76%,特异度为82.8%。TDI-Tei指数的AUC为0.940,敏感度为80%,特异度为94.7%。两指标联合预测的AUC更高,为0.961,敏感度为86%,特异度为97.4%。结论 TDI-Tei指数及NT-proBNP是AMI患者PCI术后12个月内发生MACEs的独立预测因素,两者联合对AMI患者PCI术后12个月内发生MACEs的预测价值更具临床意义。 展开更多
关键词 急性心肌梗死 TDI-Tei指数 nt-PROBNP 预后
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胎儿NT超声检测联合颜面轮廓超声指标筛查在唐氏综合征诊断中的应用价值
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作者 沈春明 戴斌 《中外医学研究》 2024年第1期63-67,共5页
目的:探讨胎儿颈后透明层(NT)超声检测联合颜面轮廓超声指标筛查在唐氏综合征诊断中的应用价值。方法:回顾性选取2019年1月—2023年6月在江苏盛泽医院进行胎儿唐氏综合征筛查并确诊的101例孕妇为观察组,并选取同期胎儿筛查结果正常的80... 目的:探讨胎儿颈后透明层(NT)超声检测联合颜面轮廓超声指标筛查在唐氏综合征诊断中的应用价值。方法:回顾性选取2019年1月—2023年6月在江苏盛泽医院进行胎儿唐氏综合征筛查并确诊的101例孕妇为观察组,并选取同期胎儿筛查结果正常的80例孕妇作为对照组。比较两组胎儿NT厚度、额-上颌(FMF)角、上颌-鼻根-下颌(MNM)角和鼻前组织厚度与鼻骨长度比值(PT/NBL)及各指标诊断结果,并绘制受试者工作曲线(ROC)分析NT厚度单独、联合FMF角及联合FMF角和PT/NBL的诊断效能。结果:两组MNM角比较,差异无统计学意义(P>0.05),观察组NT厚度、FMF角及PT/NBL显著大于对照组,差异有统计学意义(P<0.05);观察组NT厚度增加,FMF角增大和PT/NBL增大的检出率均显著高于对照组,差异有统计学意义(P<0.05);MNM角减小的检出率与对照组比较,差异无统计学意义(P>0.05)。NT厚度、FMF角和PT/NBL三者联合诊断唐氏综合征的曲线下面积(AUC)为0.940,明显高于NT厚度诊断(0.878)和NT厚度联合FMF角诊断(0.887)。结论:NT增厚、FMF角增大、PT/NBL增大与胎儿唐氏综合征有关,与NT厚度单独和NT厚度联合FMF角相比,联用NT厚度、FMF角和PT/NBL三项参数进行胎儿唐氏综合征筛查具有较高的诊断价值。 展开更多
关键词 胎儿 唐氏综合征 颈后透明层超声 颜面轮廓超声 诊断
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沙库巴曲缬沙坦对慢性心力衰竭患者AngⅡ、ALD、NT-proBNP水平及心功能的影响
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作者 钟晶晶 许海涛 陈小翠 《中外医学研究》 2024年第10期57-60,共4页
目的:探究沙库巴曲缬沙坦对慢性心力衰竭(CHF)患者血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、N末端B型利钠肽前体(NT-proBNP)水平及心功能的影响。方法:选取2021年1月—2023年1月荆州市第三人民医院收治的65例CHF患者为研究对象。根据随机抽... 目的:探究沙库巴曲缬沙坦对慢性心力衰竭(CHF)患者血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、N末端B型利钠肽前体(NT-proBNP)水平及心功能的影响。方法:选取2021年1月—2023年1月荆州市第三人民医院收治的65例CHF患者为研究对象。根据随机抽签法将其分为对照组(32例)与观察组(33例)。对照组给予缬沙坦片,观察组给予沙库巴曲缬沙坦钠片。比较两组治疗前及治疗6个月后实验室指标、生活质量及心功能。结果:治疗6个月后,两组AngⅡ、ALD、NT-pro BNP水平均下降,观察组AngⅡ、ALD、NT-pro BNP水平均低于对照组,差异有统计学意义(P<0.05)。治疗6个月后,两组左心室射血分数(LVEF)升高,左心室收缩期内径(LVESD)及左心室舒张期内径(LVEDD)均降低,观察组LVEF显著高于对照组,LVESD、LVEDD显著低于对照组,差异有统计学意义(P<0.05)。治疗6个月后,两组身体、情绪及其他评分均下降,观察组身体、情绪及其他评分均低于对照组,差异有统计学意义(P<0.05)。结论:沙库巴曲缬沙坦治疗CHF患者,可降低AngⅡ、ALD、NT-proBNP水平,减轻心脏负荷,改善患者心功能,促进生活质量提高。 展开更多
关键词 沙库巴曲缬沙坦 慢性心力衰竭 血管紧张素Ⅱ 醛固酮 N末端B型利钠肽前体
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