Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role ...Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.展开更多
目的分析2018-2022年国家自然科学基金(National Natural Science Foundation of China,NSFC)医学免疫学领域结题项目,探讨该领域的发展现状及存在的问题,为未来项目申请和优化资金导向提供参考。方法以科学基金共享服务网作为数据来源...目的分析2018-2022年国家自然科学基金(National Natural Science Foundation of China,NSFC)医学免疫学领域结题项目,探讨该领域的发展现状及存在的问题,为未来项目申请和优化资金导向提供参考。方法以科学基金共享服务网作为数据来源,获取2018-2022年NSFC医学免疫学领域已结题项目的项目名称、项目类别、资助经费、分支学科代码、依托单位、项目关键词、研究成果等信息,并借助Microsoft Excel 2021、CiteSpace 6.1.R6和VOSviewer 1.6.18软件进行可视化分析。结果2018-2022年NSFC医学免疫学领域结题项目共1206项,资助经费60154.5万元,来自30个省、市和自治区,其中57.88%的项目集中在上海(191项)、北京(184项)、江苏(136项)、广东(127项)、山东(60项),南方地区的结题数量是北方地区的2.43倍;所有项目分属160家依托单位,主要集中在综合类大学,其中上海交通大学以64项的结题量排名第一;研究成果主要体现在期刊论文(7481篇)、人才培养(1748人)和专利(授权269项)三个方面;分支学科主要集中在H1104(炎症、感染与免疫)和H1107(自身免疫性疾病),其中类风湿关节炎(rheumatoid arthritis,RA)和系统性红斑狼疮(systemic lupus erythematosus,SLE)是该研究领域的热点疾病,巨噬细胞是热点细胞。结论2018-2022年,NSFC医学免疫学领域结题项目在地域、依托单位、研究成果类别和分支学科之间存在明显差异,研究热点主要集中在免疫调节和自身免疫性疾病。展开更多
Objective To put forward some suggestions for the improvement of the evaluation system of Shenzhen Industrial Park of Shenzhen-Hong Kong Innovation Cooperation Zone by studying the scientific research project evaluati...Objective To put forward some suggestions for the improvement of the evaluation system of Shenzhen Industrial Park of Shenzhen-Hong Kong Innovation Cooperation Zone by studying the scientific research project evaluation and management system of Japan Agency for Medical Research and Development(AMED).Methods Through literature review,lessons were drawn from the review and management policies and methods of biomedical projects implemented by Japan AMED.Then some reference was provided to the review and management of the projects in Shenzhen Industrial Park.Results and Conclusion A basic review framework has been set up in Shenzhen Industrial Park,which consists of scientific research management institution of Shenzhen Industrial Park,Third-Party Review Institution and Science Committee.However,there are three problems in this system:unclear selection criteria of review experts,insufficient supervision and lack of project evaluation standards.These problems can be solved by establishing an expert think tank,setting up graded project supervisors to have the dynamic monitoring,and developing a general evaluation scale for evaluating scientific research projects in Shenzhen Industrial Park.展开更多
Adiposity,synonymous with obesity,is prevalent among both children and adults with type 1 diabetes in China.Recent literature underscored the pathophysiological and socioeconomic factors associated with adiposity,and ...Adiposity,synonymous with obesity,is prevalent among both children and adults with type 1 diabetes in China.Recent literature underscored the pathophysiological and socioeconomic factors associated with adiposity,and consistently highlighted its impact on cardiovascular,kidney,and metabolic diseases among Chinese individuals with type 1 diabetes.Addressing and managing adiposity in individuals with type 1 diabetes are complicated and entail comprehensive approaches including lifestyle modifications,cognitive-behavioral therapy,insulin dose titration,and other diabetes treatment medications.The condition calls for coordination among policymakers,researchers,clinicians,and patients.展开更多
This paper introduces a hybrid approach combining Green’s function Monte Carlo(GFMC)method with projected entangled pair state(PEPS)ansatz.This hybrid method regards PEPS as a trial state and a guiding wave function ...This paper introduces a hybrid approach combining Green’s function Monte Carlo(GFMC)method with projected entangled pair state(PEPS)ansatz.This hybrid method regards PEPS as a trial state and a guiding wave function in GFMC.By leveraging PEPS’s proficiency in capturing quantum state entanglement and GFMC’s efficient parallel architecture,the hybrid method is well-suited for the accurate and efficient treatment of frustrated quantum spin systems.As a benchmark,we applied this approach to study the frustrated J_(1)–J_(2) Heisenberg model on a square lattice with periodic boundary conditions(PBCs).Compared with other numerical methods,our approach integrating PEPS and GFMC shows competitive accuracy in the performance of ground-state energy.This paper provides systematic and comprehensive discussion of the approach of our previous work[Phys.Rev.B 109235133(2024)].展开更多
Peking Union Medical College(PUMC),as the representative work of Chinese modern architecture,has had a great impact on the development of Chinese modern architecture.Its advanced and complete concealed works contain g...Peking Union Medical College(PUMC),as the representative work of Chinese modern architecture,has had a great impact on the development of Chinese modern architecture.Its advanced and complete concealed works contain great value and are valuable materials for the study of Chinese modern architecture.This paper studies the concealed works of PUMC,enriches the research data in this field,and summarizes the transformation design scheme of concealed works in the protection and repair of ancient buildings of PUMC.展开更多
[目的]探讨舒肝明目汤含药血清对大鼠脉络膜血管内皮细胞(CECs)增殖的影响及与HIF1α-VEGF-Notch1通路相关的调节机制。[方法]CECs细胞在常氧和低氧条件下进行培养,检测低氧条件下舒肝明目汤含药血清对CECs增殖移行能力的影响;并采用实...[目的]探讨舒肝明目汤含药血清对大鼠脉络膜血管内皮细胞(CECs)增殖的影响及与HIF1α-VEGF-Notch1通路相关的调节机制。[方法]CECs细胞在常氧和低氧条件下进行培养,检测低氧条件下舒肝明目汤含药血清对CECs增殖移行能力的影响;并采用实时荧光定量PCR法(RT-PCR)和免疫印迹法(Western blot)技术检测细胞中低氧诱导因子1α(HIF1α)、血管内皮生长因子(VEGF)和Notch1 m RNA和蛋白表达的水平。[结果]与正常组相比,低氧组CECs的增殖移行能力明显提高(P<0.01),CECs中HIF1α、VEGF和Notch1 m RNA及蛋白表达明显增多(P<0.01)。经含药血清处理后,CECs增殖移行能力较低氧组显著下降(P<0.01),同时HIF1α和VEGF m RNA及蛋白表达降低(P<0.01,P<0.05),而Notch1表达进一步增高(P<0.01)。[结论]舒肝明目汤含药血清通过上调Notch1表达及下调HIF1α-VEGF通路活性抑制CECs增殖迁移,从而减少脉络膜新生血管生成。展开更多
基金supported by the National Natural Science Foundation of China,No.82171521(to CL)the Special Funds ofTaishan Scholars Project of Shandong Province,No.tsqn202211368(to CL)+2 种基金the Natural Science Foundation of Shandong Province,Nos.ZR2022YQ65(to CL),ZR2021MH073(to CL),ZR2019PH109(to WW)the Projects of Medical and Health Technology Development Program in Shandong Province,China,Nos.202003090720(to DZ),202003070728(to JL),2019 WS329(to DW)the Scientific Research Foundation of Binzhou Medical University,No.BY2018KJ21(to DW)。
文摘Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.
基金Shenyang Philosophy and Social Science Planning Fund(SZ202001L)Social Science Planning Fund of Liaoning Province(L19BGL03)。
文摘Objective To put forward some suggestions for the improvement of the evaluation system of Shenzhen Industrial Park of Shenzhen-Hong Kong Innovation Cooperation Zone by studying the scientific research project evaluation and management system of Japan Agency for Medical Research and Development(AMED).Methods Through literature review,lessons were drawn from the review and management policies and methods of biomedical projects implemented by Japan AMED.Then some reference was provided to the review and management of the projects in Shenzhen Industrial Park.Results and Conclusion A basic review framework has been set up in Shenzhen Industrial Park,which consists of scientific research management institution of Shenzhen Industrial Park,Third-Party Review Institution and Science Committee.However,there are three problems in this system:unclear selection criteria of review experts,insufficient supervision and lack of project evaluation standards.These problems can be solved by establishing an expert think tank,setting up graded project supervisors to have the dynamic monitoring,and developing a general evaluation scale for evaluating scientific research projects in Shenzhen Industrial Park.
基金Supported by 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYYC24001.
文摘Adiposity,synonymous with obesity,is prevalent among both children and adults with type 1 diabetes in China.Recent literature underscored the pathophysiological and socioeconomic factors associated with adiposity,and consistently highlighted its impact on cardiovascular,kidney,and metabolic diseases among Chinese individuals with type 1 diabetes.Addressing and managing adiposity in individuals with type 1 diabetes are complicated and entail comprehensive approaches including lifestyle modifications,cognitive-behavioral therapy,insulin dose titration,and other diabetes treatment medications.The condition calls for coordination among policymakers,researchers,clinicians,and patients.
基金Project supported by the National Natural Science Foundation of China(Grant No.11934020)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302402).
文摘This paper introduces a hybrid approach combining Green’s function Monte Carlo(GFMC)method with projected entangled pair state(PEPS)ansatz.This hybrid method regards PEPS as a trial state and a guiding wave function in GFMC.By leveraging PEPS’s proficiency in capturing quantum state entanglement and GFMC’s efficient parallel architecture,the hybrid method is well-suited for the accurate and efficient treatment of frustrated quantum spin systems.As a benchmark,we applied this approach to study the frustrated J_(1)–J_(2) Heisenberg model on a square lattice with periodic boundary conditions(PBCs).Compared with other numerical methods,our approach integrating PEPS and GFMC shows competitive accuracy in the performance of ground-state energy.This paper provides systematic and comprehensive discussion of the approach of our previous work[Phys.Rev.B 109235133(2024)].
文摘Peking Union Medical College(PUMC),as the representative work of Chinese modern architecture,has had a great impact on the development of Chinese modern architecture.Its advanced and complete concealed works contain great value and are valuable materials for the study of Chinese modern architecture.This paper studies the concealed works of PUMC,enriches the research data in this field,and summarizes the transformation design scheme of concealed works in the protection and repair of ancient buildings of PUMC.
文摘[目的]探讨舒肝明目汤含药血清对大鼠脉络膜血管内皮细胞(CECs)增殖的影响及与HIF1α-VEGF-Notch1通路相关的调节机制。[方法]CECs细胞在常氧和低氧条件下进行培养,检测低氧条件下舒肝明目汤含药血清对CECs增殖移行能力的影响;并采用实时荧光定量PCR法(RT-PCR)和免疫印迹法(Western blot)技术检测细胞中低氧诱导因子1α(HIF1α)、血管内皮生长因子(VEGF)和Notch1 m RNA和蛋白表达的水平。[结果]与正常组相比,低氧组CECs的增殖移行能力明显提高(P<0.01),CECs中HIF1α、VEGF和Notch1 m RNA及蛋白表达明显增多(P<0.01)。经含药血清处理后,CECs增殖移行能力较低氧组显著下降(P<0.01),同时HIF1α和VEGF m RNA及蛋白表达降低(P<0.01,P<0.05),而Notch1表达进一步增高(P<0.01)。[结论]舒肝明目汤含药血清通过上调Notch1表达及下调HIF1α-VEGF通路活性抑制CECs增殖迁移,从而减少脉络膜新生血管生成。
