According to structure function and lightning damage of a cable car, a feasible method of lightning strike risk evaluation for a cable car was put forward based on the evaluation model and evaluation method in the sta...According to structure function and lightning damage of a cable car, a feasible method of lightning strike risk evaluation for a cable car was put forward based on the evaluation model and evaluation method in the standard IEC62305-2. According to the difference between common buildings and cable cars, problems of height non-uniformity of equivalent section caused by inclination of the cable car and diversity of lightning activity regularity caused by the large area were resolved, and expected annual average frequency of lightning strike was calculated using three dimensional graphic approach and regional lightning characteristic analysis. Based on different types of damage process and loss consequences, according to interception effect against lightning invasion of the lightning protection measures and the method of probability selection proposed in the standard, the probability of casu- alty caused by direct lightning strike in a cable car and a waiting area as well as probabilities of casualty caused by failure of electronic information systems were cal- culated.展开更多
Mixed adenoneuroendocrine carcinoma(MANEC)is a malignant tumor with adenocarcinoma and neuroendocrine components,with≥30%of each component required.MANEC of the ampulla is rare.To the best of our knowledge,only 15 ca...Mixed adenoneuroendocrine carcinoma(MANEC)is a malignant tumor with adenocarcinoma and neuroendocrine components,with≥30%of each component required.MANEC of the ampulla is rare.To the best of our knowledge,only 15 cases of MANEC of the ampulla have been reported in the English-language literature.Here,we report two cases of MANEC of the ampulla in two womenaged 43 and 60 years,which was confirmed by histology after pancreaticoduodenectomy.These tumors contained neuroendocrine and adenocarcinoma components.The neuroendocrine components were positive for chromogranin A(Cg A),synaptophysin(Syn)and CD56 by immunostaining.The adenocarcinoma components were negative for Cg A,Syn and CD56.Both cases were T3N0M0(StageⅢA).They survived for 15 and 20 mo after surgery,respectively.A brief discussion about the histopathological features,clinical behavior and treatment of MANEC of ampulla,and review of the relevant literature are presented.展开更多
The Newton Raphson iteration and QR algorithm are combined to search the Hpf bifurcation point of the vehicle running on straight track and on large radius curved tracks. Limit cycles that are bifurcated from the equ...The Newton Raphson iteration and QR algorithm are combined to search the Hpf bifurcation point of the vehicle running on straight track and on large radius curved tracks. Limit cycles that are bifurcated from the equilibrium points and the saddle node bifurcation point are computed through employing a variable step Runge Kutta method and the Poincaré map. Finally, numerical simulations are carried out for the stability of a high speed passenger car operating on straight and large radius curved tracks. The influences of the radius of curvature and the superelevation of the track on the stability of the vehicle system are investigated.展开更多
How to simulate interior aerodynamic noise accurately is an important question of a car interior noise reduction. The unsteady aerodynamic pressure on body surfaces is proved to be the key effect factor of car interio...How to simulate interior aerodynamic noise accurately is an important question of a car interior noise reduction. The unsteady aerodynamic pressure on body surfaces is proved to be the key effect factor of car interior aerodynamic noise control in high frequency on high speed. In this paper, a detail statistical energy analysis （SEA） model is built. And the vibra-acoustic power inputs are loaded on the model for the valid result of car interior noise analysis. The model is the solid foundation for further optimization on car interior noise control. After the most sensitive subsystems for the power contribution to car interior noise are pointed by SEA comprehensive analysis, the sound pressure level of car interior aerodynamic noise can be reduced by improving their sound and damping characteristics. The further vehicle testing results show that it is available to improve the interior acoustic performance by using detailed SEA model, which comprised by more than 80 subsystems, with the unsteady aerodynamic pressure calculation on body surfaces and the materials improvement of sound/damping properties. It is able to acquire more than 2 dB reduction on the central frequency in the spectrum over 800 Hz. The proposed optimization method can be looked as a reference of car interior aerodynamic noise control by the detail SEA model integrated unsteady computational fluid dynamics （CFD） and sensitivity analysis of acoustic contribution.展开更多
Canopy air curtain （CAC） technology has been developed by the National Institute for Occupational Safety and Health （NIOSH） for use on continuous miners and subsequently roof bolting machines in underground coal m...Canopy air curtain （CAC） technology has been developed by the National Institute for Occupational Safety and Health （NIOSH） for use on continuous miners and subsequently roof bolting machines in underground coal mines to protect operators of these machines from overexposure to respirable coal mine dust. The next logical progression is to develop a CAC for shuttle cars to protect operators from the same overexposures. NIOSH awarded a contract to Marshall University and J.H. Fletcher to develop the shuttle car CAC. NIOSH conducted laboratory testing to determine the dust control efficiency of the shuttle car CAC. Testing was conducted on two different cab configurations： a center drive similar to that on a Joy 10SC32AA cab model and an end drive similar to that on a Joy 10SC32AB cab model. Three different ventilation velocities were tested-0.61, 2.0, 4.3 rrds （120, 400, and 850 fpm）. The lowest, 0.61 m/s （120 fpm）, represented the ventilation velocity encountered during loading by the continuous miner, while the 4.3 m/s （850 fpm） velocity represented ventilation velocity airflow over the shuttle car while tramming against ventilation airflow. Test results showed an average of the dust control efficiencies ranging from 74 to 83% for 0.61 m/s （120 fpm）, 39%-43% for 2.0 m/s （400 fpm）, and 6%-16% for 4.3 m/s （850 fpm）. Incorporating an airflow spoiler to the shuttle car CAC design and placing the CAC so that it is located 22.86 cm （9 in.） forward of the operator improved the dust control efficiency to 51%-55% for 4.3 m/s （850 fpm） with minimal impact on dust control efficiencies for lower ventilation velocities. These laboratory tests demonstrate that the newly developed shuttle car CAC has the potential to successfully protect shuttle car operators from coal mine respirable dust overexposures.展开更多
This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,w...This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.展开更多
A K-nearest neighbor （K-NN） based nonparametric regression model was proposed to predict travel speed for Beijing expressway. By using the historical traffic data collected from the detectors in Beijing expressways,...A K-nearest neighbor （K-NN） based nonparametric regression model was proposed to predict travel speed for Beijing expressway. By using the historical traffic data collected from the detectors in Beijing expressways, a specically designed database was developed via the processes including data filtering, wavelet analysis and clustering. The relativity based weighted Euclidean distance was used as the distance metric to identify the K groups of nearest data series. Then, a K-NN nonparametric regression model was built to predict the average travel speeds up to 6 min into the future. Several randomly selected travel speed data series, collected from the floating car data （FCD） system, were used to validate the model. The results indicate that using the FCD, the model can predict average travel speeds with an accuracy of above 90%, and hence is feasible and effective.展开更多
Travel times have been traditionally estimated from data collected by roadway sensors. Recently, new tech- nologies, such as cell phone tracking, license plate matching, automatic vehicle identifications and video det...Travel times have been traditionally estimated from data collected by roadway sensors. Recently, new tech- nologies, such as cell phone tracking, license plate matching, automatic vehicle identifications and video detection, are employed for this purpose. In this study, the data collected by TRANSMIT readers, Bluetooth sensors, and INRIX are assessed by comparing each to the ＂ground truth＂ travel times collected by probe vehicles carrying GPS-based naviga- tion devices. Travel times of probe vehicles traveling on the study segment of 1-287 in New Jersey were collected in 2009. Statistical measures, such as standard deviation, average absolute speed error, and speed error bias, were used to make an in-depth analysis. The accuracy of each travel time estimation method is analyzed. The data collected by Bluetooth sensors and the TRANSMIT readers seem more consistent with the ground true data, and slightly outperform the data reported by 1NRIX. This study established a procedure for analyzing the accuracy of floating car data （FCD） collected by different technologies.展开更多
目的分离纯化碧根果致敏原Car i 1,并对其结构进行表征鉴定。方法以新鲜碧根果果仁为原料,通过粉碎、脱脂、浸提、粗分级、凝胶过滤层析,对碧根果致敏原蛋白Car i 1进行分离纯化。结合十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、液相色谱-串...目的分离纯化碧根果致敏原Car i 1,并对其结构进行表征鉴定。方法以新鲜碧根果果仁为原料,通过粉碎、脱脂、浸提、粗分级、凝胶过滤层析,对碧根果致敏原蛋白Car i 1进行分离纯化。结合十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、液相色谱-串联质谱法和免疫印迹法3种方法对Cari1进行鉴定,并通过圆二色谱仪与紫外分光光度计表征其二、三级结构。结果本方法纯化获得碧根果致敏原Cari1,单轮制备量可达5 mg以上,且纯度大于95%,蛋白质高级结构未被破坏,能够被全部3名碧根果过敏患者的血清准确识别。结论该纯化方法技术路线简单、设备要求低且单次制备量高,总得率可达65%,操作便捷,为碧根果致敏原Car i 1的相关研究奠定了物质基础。展开更多
Using data from the Economic Advisory Center of the State Information Center(SIC), we examined the spatial patterns of car sales in China at the prefectural level in 2012. We first analyzed the spatial distributions o...Using data from the Economic Advisory Center of the State Information Center(SIC), we examined the spatial patterns of car sales in China at the prefectural level in 2012. We first analyzed the spatial distributions of car sales of different kinds of automakers(foreign automakers, Sino-foreign joint automakers, and Chinese automakers), and then identified spatial clusters using the local Moran's indexes. Location quotient analysis was applied to examine the relative advantage of each type of automaker in the local markets. To explain the variations of car sales across cities, we collected several socioeconomic variables and conducted regression analyses. Further, factor analysis was used to extract independent variables to avoid the problem of multicollinearity. By incorporating a spatial lag or spatial error in the models, we calibrated our spatial regression models to address the spatial dependence problem. The analytical results show that car sales varied significantly across cities in China, and most of the cities with higher car sales were the developed cities. Different automakers exhibit diverse spatial patterns in terms of car sales volume, spatial clusters, and location quotients. The scale and incomes factor were extracted and verified as the two most significant and positive factors that shape the spatial distributions of car sales, and together with the spatial effect, explained most of the variations of car sales across cities.展开更多
It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for...It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is alcohol.It has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does exist.Alcohol may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become possible.After stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also needed.Therefore,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated cirrhosis.In cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal treatments.Despite the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and HR.Therefore,ablation can be regarded as a firstline choice for patients with VES HCC.It is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team.展开更多
Hepatocellular carcinoma(HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is generally poor, the5-year survival rate is ...Hepatocellular carcinoma(HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is generally poor, the5-year survival rate is > 70% if patients are diagnosed at an early stage. However, early diagnosis of HCC is complicated by the coexistence of inflammation and cirrhosis. Thus, novel biomarkers for the early diagnosis of HCC are required. Currently, the diagnosis of HCC without pathological correlation is achieved by analyzing serum α.fetoprotein levels combined with imaging techniques. Advances in genomics and proteomics platforms and biomarker assay techniques over the last decade have resulted in the identification of numerous novel biomarkers and have improved the diagnosis of HCC. The most promising biomarkers,such as glypican-3, osteopontin, Golgi protein-73 and nucleic acids including microRNAs, are most likely to become clinically validated in the near future. These biomarkers are not only useful for early diagnosis of HCC, but also provide insight into the mechanisms driving oncogenesis. In addition, such molecular insight creates the basis for the development of potentially more effective treatment strategies. In this article,we provide an overview of the biomarkers that are currently used for the early diagnosis of HCC.展开更多
Lung cancer is a common malignancy in the world; however symptomatic colonic metastasis from primary lung cancer is rare. A 64-year-old man was originally found poorly differentiated squamous cell carcinoma of right l...Lung cancer is a common malignancy in the world; however symptomatic colonic metastasis from primary lung cancer is rare. A 64-year-old man was originally found poorly differentiated squamous cell carcinoma of right lung and received right lower lobectomy and lymph node dissection. Three years later, the patient presented to our emergency room with the symptom of upper abdominal pain and weight loss. Abdominal palpation and computed tomography scan of the abdomen revealed a large mass measuring 7.6 cm × 8.5 cm in the ascending colon. Colonoscopy and biopsy revealed poorly differentiated squamous cell carcinoma with similar morphological pattern to that of the previous lung cancer. Chemotherapy was given and the patient died 5 mo later. Lung cancer metastatic to the colon confers a poor prognosis: overall survival ranged from 5 wk to 1 year, with a median survival of 3 mo after the diagnosis of the colonic metastasis.展开更多
基金Supported by the Scientific Research Project of Hebei Meteorological Bureau in 2014(14ky20)~~
文摘According to structure function and lightning damage of a cable car, a feasible method of lightning strike risk evaluation for a cable car was put forward based on the evaluation model and evaluation method in the standard IEC62305-2. According to the difference between common buildings and cable cars, problems of height non-uniformity of equivalent section caused by inclination of the cable car and diversity of lightning activity regularity caused by the large area were resolved, and expected annual average frequency of lightning strike was calculated using three dimensional graphic approach and regional lightning characteristic analysis. Based on different types of damage process and loss consequences, according to interception effect against lightning invasion of the lightning protection measures and the method of probability selection proposed in the standard, the probability of casu- alty caused by direct lightning strike in a cable car and a waiting area as well as probabilities of casualty caused by failure of electronic information systems were cal- culated.
文摘Mixed adenoneuroendocrine carcinoma(MANEC)is a malignant tumor with adenocarcinoma and neuroendocrine components,with≥30%of each component required.MANEC of the ampulla is rare.To the best of our knowledge,only 15 cases of MANEC of the ampulla have been reported in the English-language literature.Here,we report two cases of MANEC of the ampulla in two womenaged 43 and 60 years,which was confirmed by histology after pancreaticoduodenectomy.These tumors contained neuroendocrine and adenocarcinoma components.The neuroendocrine components were positive for chromogranin A(Cg A),synaptophysin(Syn)and CD56 by immunostaining.The adenocarcinoma components were negative for Cg A,Syn and CD56.Both cases were T3N0M0(StageⅢA).They survived for 15 and 20 mo after surgery,respectively.A brief discussion about the histopathological features,clinical behavior and treatment of MANEC of ampulla,and review of the relevant literature are presented.
文摘The Newton Raphson iteration and QR algorithm are combined to search the Hpf bifurcation point of the vehicle running on straight track and on large radius curved tracks. Limit cycles that are bifurcated from the equilibrium points and the saddle node bifurcation point are computed through employing a variable step Runge Kutta method and the Poincaré map. Finally, numerical simulations are carried out for the stability of a high speed passenger car operating on straight and large radius curved tracks. The influences of the radius of curvature and the superelevation of the track on the stability of the vehicle system are investigated.
基金supported by National Natural Science Foundation of China (Grant No. 51175214)Scientific and Technological Planning Project of China (Grant No. 2011BAG03B01-1)Based Research Operation Expenses Project of Jilin University, China (Grant No. 421032572415)
文摘How to simulate interior aerodynamic noise accurately is an important question of a car interior noise reduction. The unsteady aerodynamic pressure on body surfaces is proved to be the key effect factor of car interior aerodynamic noise control in high frequency on high speed. In this paper, a detail statistical energy analysis （SEA） model is built. And the vibra-acoustic power inputs are loaded on the model for the valid result of car interior noise analysis. The model is the solid foundation for further optimization on car interior noise control. After the most sensitive subsystems for the power contribution to car interior noise are pointed by SEA comprehensive analysis, the sound pressure level of car interior aerodynamic noise can be reduced by improving their sound and damping characteristics. The further vehicle testing results show that it is available to improve the interior acoustic performance by using detailed SEA model, which comprised by more than 80 subsystems, with the unsteady aerodynamic pressure calculation on body surfaces and the materials improvement of sound/damping properties. It is able to acquire more than 2 dB reduction on the central frequency in the spectrum over 800 Hz. The proposed optimization method can be looked as a reference of car interior aerodynamic noise control by the detail SEA model integrated unsteady computational fluid dynamics （CFD） and sensitivity analysis of acoustic contribution.
文摘Canopy air curtain （CAC） technology has been developed by the National Institute for Occupational Safety and Health （NIOSH） for use on continuous miners and subsequently roof bolting machines in underground coal mines to protect operators of these machines from overexposure to respirable coal mine dust. The next logical progression is to develop a CAC for shuttle cars to protect operators from the same overexposures. NIOSH awarded a contract to Marshall University and J.H. Fletcher to develop the shuttle car CAC. NIOSH conducted laboratory testing to determine the dust control efficiency of the shuttle car CAC. Testing was conducted on two different cab configurations： a center drive similar to that on a Joy 10SC32AA cab model and an end drive similar to that on a Joy 10SC32AB cab model. Three different ventilation velocities were tested-0.61, 2.0, 4.3 rrds （120, 400, and 850 fpm）. The lowest, 0.61 m/s （120 fpm）, represented the ventilation velocity encountered during loading by the continuous miner, while the 4.3 m/s （850 fpm） velocity represented ventilation velocity airflow over the shuttle car while tramming against ventilation airflow. Test results showed an average of the dust control efficiencies ranging from 74 to 83% for 0.61 m/s （120 fpm）, 39%-43% for 2.0 m/s （400 fpm）, and 6%-16% for 4.3 m/s （850 fpm）. Incorporating an airflow spoiler to the shuttle car CAC design and placing the CAC so that it is located 22.86 cm （9 in.） forward of the operator improved the dust control efficiency to 51%-55% for 4.3 m/s （850 fpm） with minimal impact on dust control efficiencies for lower ventilation velocities. These laboratory tests demonstrate that the newly developed shuttle car CAC has the potential to successfully protect shuttle car operators from coal mine respirable dust overexposures.
基金Project(2016YFB1200505-016)supported by the National Key Research and Development Program of ChinaProject(51675537)supported by the National Natural Science Foundation of ChinaProject(2018zzts161)supported by the Independent Exploration and Innovation Project of Central South University,China。
文摘This paper proposes a novel collision post structure designed to improve the crashworthiness of subway cab cars.The structure provides two innovative features:1)a simpler connection between the post and the car roof,which gives a more reasonable load transfer path to reduce the stress concentration at the joint;and 2)a stiffness induction design that provides an ideal deformation model to protect the safe space of the cab cars.The novel collision post structure was evaluated with finite element analysis,and a prototype cab car was mechanically tested.The results demonstrate that the deformation response was stable and agreed well with the expected ideal mode.The maximum load was 874.17 kN and the responses remained well above the elastic design load of 334 kN as required by the design specification.In addition,there was no significant tearing failure during the whole test process.Therefore,the novel collision post structure proposed has met the requirements specified in new standard to improve the crashworthiness of subway cab cars.Finally,the energy absorption efficiency and light weight design highlights were also summarized and discussed.
基金The Project of Research on Technologyand Devices for Traffic Guidance (Vehicle Navigation)System of Beijing Municipal Commission of Science and Technology(No H030630340320)the Project of Research on theIntelligence Traffic Information Platform of Beijing Education Committee
文摘A K-nearest neighbor （K-NN） based nonparametric regression model was proposed to predict travel speed for Beijing expressway. By using the historical traffic data collected from the detectors in Beijing expressways, a specically designed database was developed via the processes including data filtering, wavelet analysis and clustering. The relativity based weighted Euclidean distance was used as the distance metric to identify the K groups of nearest data series. Then, a K-NN nonparametric regression model was built to predict the average travel speeds up to 6 min into the future. Several randomly selected travel speed data series, collected from the floating car data （FCD） system, were used to validate the model. The results indicate that using the FCD, the model can predict average travel speeds with an accuracy of above 90%, and hence is feasible and effective.
文摘Travel times have been traditionally estimated from data collected by roadway sensors. Recently, new tech- nologies, such as cell phone tracking, license plate matching, automatic vehicle identifications and video detection, are employed for this purpose. In this study, the data collected by TRANSMIT readers, Bluetooth sensors, and INRIX are assessed by comparing each to the ＂ground truth＂ travel times collected by probe vehicles carrying GPS-based naviga- tion devices. Travel times of probe vehicles traveling on the study segment of 1-287 in New Jersey were collected in 2009. Statistical measures, such as standard deviation, average absolute speed error, and speed error bias, were used to make an in-depth analysis. The accuracy of each travel time estimation method is analyzed. The data collected by Bluetooth sensors and the TRANSMIT readers seem more consistent with the ground true data, and slightly outperform the data reported by 1NRIX. This study established a procedure for analyzing the accuracy of floating car data （FCD） collected by different technologies.
文摘目的分离纯化碧根果致敏原Car i 1,并对其结构进行表征鉴定。方法以新鲜碧根果果仁为原料,通过粉碎、脱脂、浸提、粗分级、凝胶过滤层析,对碧根果致敏原蛋白Car i 1进行分离纯化。结合十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、液相色谱-串联质谱法和免疫印迹法3种方法对Cari1进行鉴定,并通过圆二色谱仪与紫外分光光度计表征其二、三级结构。结果本方法纯化获得碧根果致敏原Cari1,单轮制备量可达5 mg以上,且纯度大于95%,蛋白质高级结构未被破坏,能够被全部3名碧根果过敏患者的血清准确识别。结论该纯化方法技术路线简单、设备要求低且单次制备量高,总得率可达65%,操作便捷,为碧根果致敏原Car i 1的相关研究奠定了物质基础。
基金Under the auspices of National Natural Science Foundation of China(No.41301143)
文摘Using data from the Economic Advisory Center of the State Information Center(SIC), we examined the spatial patterns of car sales in China at the prefectural level in 2012. We first analyzed the spatial distributions of car sales of different kinds of automakers(foreign automakers, Sino-foreign joint automakers, and Chinese automakers), and then identified spatial clusters using the local Moran's indexes. Location quotient analysis was applied to examine the relative advantage of each type of automaker in the local markets. To explain the variations of car sales across cities, we collected several socioeconomic variables and conducted regression analyses. Further, factor analysis was used to extract independent variables to avoid the problem of multicollinearity. By incorporating a spatial lag or spatial error in the models, we calibrated our spatial regression models to address the spatial dependence problem. The analytical results show that car sales varied significantly across cities in China, and most of the cities with higher car sales were the developed cities. Different automakers exhibit diverse spatial patterns in terms of car sales volume, spatial clusters, and location quotients. The scale and incomes factor were extracted and verified as the two most significant and positive factors that shape the spatial distributions of car sales, and together with the spatial effect, explained most of the variations of car sales across cities.
文摘It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is alcohol.It has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does exist.Alcohol may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become possible.After stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also needed.Therefore,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated cirrhosis.In cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal treatments.Despite the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and HR.Therefore,ablation can be regarded as a firstline choice for patients with VES HCC.It is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team.
文摘Hepatocellular carcinoma(HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is generally poor, the5-year survival rate is > 70% if patients are diagnosed at an early stage. However, early diagnosis of HCC is complicated by the coexistence of inflammation and cirrhosis. Thus, novel biomarkers for the early diagnosis of HCC are required. Currently, the diagnosis of HCC without pathological correlation is achieved by analyzing serum α.fetoprotein levels combined with imaging techniques. Advances in genomics and proteomics platforms and biomarker assay techniques over the last decade have resulted in the identification of numerous novel biomarkers and have improved the diagnosis of HCC. The most promising biomarkers,such as glypican-3, osteopontin, Golgi protein-73 and nucleic acids including microRNAs, are most likely to become clinically validated in the near future. These biomarkers are not only useful for early diagnosis of HCC, but also provide insight into the mechanisms driving oncogenesis. In addition, such molecular insight creates the basis for the development of potentially more effective treatment strategies. In this article,we provide an overview of the biomarkers that are currently used for the early diagnosis of HCC.
基金Supported by Grants from the Program for Innovative Research Team in Zhejiang Province No.2012R10046 and grants from Administration of Chinese Traditional Medicine of Zhejiang Province No.2011ZB080
文摘Lung cancer is a common malignancy in the world; however symptomatic colonic metastasis from primary lung cancer is rare. A 64-year-old man was originally found poorly differentiated squamous cell carcinoma of right lung and received right lower lobectomy and lymph node dissection. Three years later, the patient presented to our emergency room with the symptom of upper abdominal pain and weight loss. Abdominal palpation and computed tomography scan of the abdomen revealed a large mass measuring 7.6 cm × 8.5 cm in the ascending colon. Colonoscopy and biopsy revealed poorly differentiated squamous cell carcinoma with similar morphological pattern to that of the previous lung cancer. Chemotherapy was given and the patient died 5 mo later. Lung cancer metastatic to the colon confers a poor prognosis: overall survival ranged from 5 wk to 1 year, with a median survival of 3 mo after the diagnosis of the colonic metastasis.
