Ground subsidence mechanism of a filling mine with a steeply inclined ore body

Long-term field monitoring finds that serious surface subsidence can still occur even if the high strength cemented fill method is adopted.Combining the results of numerical simulations with global position system(GPS)monitoring,we took a typical filling mining mine with a steeply inclined ore body as an example,and explored its ground subsidence mechanism.The results show that the ground subsidence caused by the mining of steep ore body is characterized by two settlement centers and a significantly uneven spatial distribution,which is visibly different from ground subsidence characteristic of the coal mine.The subsidence on the hanging wall is much larger than that on the footwall,and the settlement center tends to move to the hanging wall with the increase of mining depth.The backfill improves the strength and surrounding rock bearing capacity,which leads to a lag of about 3 years of the subsidence.However,under the actions of continuous and repeated mining disturbances,the supporting effect of the backfill can only reduce the amplitude of the deformation,but it cannot prevent the occurrence of settlement.

Geochemical Characteristics,Genesis of Concealed Cu-rich Ore Body in the Jinchuan Deposit,Northwestern China,and Its Prospecting

The Jinchuan deposit is hosted by the olivine-rich ultramafic rock body, which is the thirdlargest magmatic sulfide Ni-Cu deposit in the world currently being exploited. Seeking new relaying resources in the deep and the border of the deposit becomes more and more important. The ore body, ore and geochemistry characteristics of the concealed Cu-rich ore body are researched. Through spatial analysis and comparison with the neighboring II1 main ore body, the mineralization rule of the concealed Cu-rich ore body is summed up. It is also implied that Cu-rich magma may exist between Nirich magma and ore pulp during liquation differentiation in deep-stage chambers, which derives from deep-mantle Hi-MgO basalt magma. It is concluded that the type of ore body has features of both magmatic liquation and late reconstruction action. It has experienced three stages： deep liquation and pulsatory injection of the Cu- and PPGE-rich magma, concentration of tectonic activation, and the later magma hydrothermal superimposition. In addition, the Pb and S isotopes indicate the magma of I6 concealed Cu-rich ore body originates predominantly from mantle; however, it is interfused by minute crust material. Finally, it is inferred that the genesis of the Cu-Ni sulfide deposit is complex and diverse, and the prospect of seeking new deep ore bodies within similar deposits is promising, especially Cu-rich ore bodies.

Application of Tectono Geochemical Study in Deep Concealed Ore Body Exploration--As the Huize Super-Large Lead-Zinc Deposit an exemple

1 Geological Background of Minerlization or Geologic Setting The northeast of Yunnan1 Pb-Zn-Ag-Ge polymetallic ore district is an important part of the southwestern margin of the Yangtze block Sichuan-Yunnan-Guizhou

Location Prediction of Blind Ore bodies in Shuijingtun Gold Mine, Zhangjiakou, China

By analyzing the metallogenic conditions and prospecting marks of F 8 fault belt in Shiujingtun Gold Mine, the geochemical samples were collected along F 8 fault belt and prospecting profile normal to the F 8 fault belt. Gold and its indicator elements were tested with X ray fluorescence spectrometry and the content distribution diagram of Au, Ag, Hg and As along the F 8 fault belt was performed. The geochemical primary halo model and the Grey system model of F 8 fault belt are established. With these element distribution features and models, the blind ore bodies in the F 8 fault belt were predicted. Engineering prospect shows that the industrial orebodies have been discovered and the prediction results are dependable.

Forecast of blind ore body in Zhangcaigou area around Wulaga gold deposit

By the study of metallogenetic conditions and ore-controlling factors, the metallogenetic indicators in geology, geochemistry and geophysics about Wulaga gold deposit have been obtained. Using the indicators the blind ore bodies have been forecasted in Zhangcaigou area. By drilling check, a gold-bearing ore body with 3 m thickness in an average tenor of 20.4×10 -6 at the depth of 70 m has been found in the forecast area. It shows that the forecast method should be effective.

化疗联合全身热疗治疗Ⅳ期非小细胞肺癌临床观察

目的:探讨化疗联合全身热疗对Ⅳ期非小细胞肺癌患者的治疗效果。方法:对37例ECOG-PS评分为0-2分的Ⅳ期非小细胞肺癌患者进行化疗联合全身热疗治疗,与同期35例单纯化疗患者比较疗效。化疗方案采用含铂类(顺铂或卡铂)方案:TP(紫杉醇+顺铂或卡铂)方案、NP(长春瑞滨+顺铂或卡铂)方案。全身热疗采用上海华源WB-Ⅰ型全身热疗系统进行治疗,每个周期化疗第1天开始,同时进行热疗,1次/天,每次时长40-60min,直肠温度38℃-39.5℃,8-10次/周期,每化疗2个周期后进行疗效评价,进展的患者改用未用过的二线化疗方案,总疗程6个周期,观察12个月。结果:实验组与对照组有效率、症状缓解率、1年生存率分别为:59.4%和40.0%、75.7%和60.0%、48.6%和37.1%(P<0.05)。两组毒副反应主要为胃肠道反应和骨髓抑制,胃肠道反应0-Ⅱ度33例和30例,Ⅲ度4例和5例;骨髓抑制0-Ⅱ度29例和28例,Ⅲ度8例和7例(P>0.05)。经过相应的药物治疗,均能很快恢复。结论:化疗联合全身热疗治疗Ⅳ期非小细胞肺癌较单一化疗提高了疗效,不增加患者的毒副反应,是综合治疗晚期非小细胞肺癌的有效手段之一。

Interpretation of residual gravity anomaly caused by simple shaped bodies using very fast simulated annealing global optimization

A very fast simulated annealing（VFSA） global optimization is used to interpret residual gravity anomaly.Since,VFSA optimization yields a large number of best-fitted models in a vast model space;the nature of uncertainty in the interpretation is also examined simultaneously in the present study.The results of VFSA optimization reveal that various parameters show a number of equivalent solutions when shape of the target body is not known and shape factor ＇q＇ is also optimized together with other model parameters.The study reveals that amplitude coefficient k is strongly dependent on shape factor.This shows that there is a multi-model type uncertainty between these two model parameters derived from the analysis of cross-plots.However,the appraised values of shape factor from various VFSA runs clearly indicate whether the subsurface structure is sphere,horizontal or vertical cylinder type structure.Accordingly,the exact shape factor（1.5 for sphere,1.0 for horizontal cylinder and 0.5 for vertical cylinder）is fixed and optimization process is repeated.After fixing the shape factor,analysis of uncertainty and cross-plots shows a well-defined uni-model characteristic.The mean model computed after fixing the shape factor gives the utmost consistent results.Inversion of noise-free and noisy synthetic data as well as field data demonstrates the efficacy of the approach.

Occurrence of Manganese Ore Deposits and Their Mineralogy in Vizianagaram-Visakhapatnam Manganese Ores Belt (Andhra Pradesh) India

The Manganese deposits of Andhra Pradesh are associated with a thick sequence of Precambrian rocks, belonging to Khondalite and Charnockite groups of Dharwar Supergroup that forms part of 2500 to 3000 m.y. old Eastern Ghat complex of India. The study area is the Manganese deposits of Vizianagram-Visakhapatnam Manganese Belt of Andhra Pradesh. The study area lies about 150 km NE of Visakhapatnam between 18°12′N - 18°30′N and 83°20′E - 83°45′E. The mineralization of Manganese ores is confined to different rock types, belonging to both Khondalite and Charnockite groups, where they are dispersed throughout the country rocks as small lenses, pockets, veins and irregular bodies of varying dimensions. Quartz, garnet, clay, limonite and apatite are the common gangue minerals in the Manganese ores. The presence of quartz, garnet and apatite brings down the grade of the ore. Ferruginous laterite and ochre generally work as capping of the Manganese deposits. The various Manganese ore minerals present in these deposits are indentified as 1) Primary minerals-braunite, bixbyite, vredenburgite, jacobsite and hausmannite, 2) secondary minerals-psilomelane, cryptomelane, hollandite, pyrolusite and wad. The primary ore minerals are considered to be syngenetic and regionally metamorphosed while, the associated secondary ore minerals are formed due to alteration of the primary ores.

水平砂岩层Ⅳ级围岩隧道二台阶法开挖技术

文章结合梧州至柳州高速公路土建工程№A01-7标段枫木界隧道Ⅳ级围岩开挖工程实例,从开挖方法、钻爆设计、超欠挖情况、超前地质预报、监控量测及施工控制要点等方面详细介绍了在水平砂岩层隧道Ⅳ级围岩中采用二台阶法开挖的技术经验,为类似隧道钻爆法开挖施工提供一定的参考借鉴。

扶正化瘀319方治疗慢性乙型肝炎及其对纤维化血清学指标的影响

扶正化瘀３１９方治疗慢性乙型肝炎５６例，并以大黄虫丸治疗的１９例患者为对照，临床有效率分别为８７．５％和６８．４％。该方不但能有效地改善肝功能及临床症状，且能降低患者显著增高的血清单胺氧化酶Ｂ（ＭＡＯ－Ｂ）活性，金属蛋白酶组织抑制因子－１（ＴＩＭＰ）、Ⅲ型前胶原肽、Ⅳ型胶原、透明质酸及层粘蛋白（ＬＮ）的含量，提高尿羟脯氨酸（Ｈｙｐ）排泄量（Ｐ＜０．００１～０．０５）。与对照组相比，除ＴＩＭＰ外．改善程度均以观察组为著。表明该方对慢性乙型肝炎具有较好的治疗效果，在一定程度上抑制了肝纤维化的进展。

砂砾岩体沉积旋回划分及对比方法——以济阳坳陷盐家地区沙四段上亚段为例

针对砂砾岩体纵向和横向对比难度大、严重制约油气勘探的实际问题,系统总结建立了一套砂砾岩体沉积旋回划分及对比方法。首先在精细砂砾岩体沉积成因模式研究的基础上,建立了"以多沉积作用形成的垂向上有序组合的正旋回沉积体为基本单元、以岩相突变面为沉积旋回界面进行单井沉积旋回划分;以扇缘稳定泥岩为标志层,由扇缘向扇中、扇根进行沉积旋回井间对比"的砂砾岩体旋回划分对比模式。其次在该模式的指导下,总结了利用岩心资料标定成像测井和重构岩性识别曲线进行单井沉积旋回划分,在高分辨率时频分析约束下进行井间地层对比的砂砾岩体旋回划分对比方法。该方法成功应用于济阳坳陷盐家地区沙四段上亚段,将其划分为8个中期旋回,并通过井间地层对比建立了等时地层格架,有利地指导了该区的油气勘探。

基于自噬途径探讨黄芪甲苷抑制糖尿病肾病系膜细胞NLRP3炎症小体活化通路及机制

目的:观察黄芪甲苷对高糖刺激的小鼠肾小球系膜细胞(SV40)核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体活化通路的抑制作用,并基于线粒体自噬途径探究其作用机制。方法:小鼠SV40细胞分别在含有0~80μmol/L黄芪甲苷的DMEM培养基中体外培养48 h,通过细胞活力测试筛选出适宜的黄芪甲苷浓度进行后续实验。实验分为正常对照组(葡萄糖5.6 mmol/L)、高糖组(葡萄糖30 mmol/L)、黄芪甲苷低剂量组(葡萄糖30 mmol/L+黄芪甲苷10μmol/L)、黄芪甲苷中剂量组(葡萄糖30 mmol/L+黄芪甲苷20μmol/L)、黄芪甲苷高剂量组(葡萄糖30 mmol/L+黄芪甲苷40μmol/L),观察黄芪甲苷对小鼠SV40细胞的影响。结果:CCK-8检测结果提示黄芪甲苷浓度达到80μmol/L时小鼠SV40细胞活力明显下降,故本次研究分别选用10、20、40μmol/L作为低、中、高剂量黄芪甲苷进行后续实验。与正常对照组比较,高糖会降低小鼠SV40细胞活力并促进细胞凋亡,并可增加活性氧(ROS)与炎症因子水平,扩大炎症与氧化应激反应,LC3、Beclin1表达水平明显下调,自噬受到抑制。与高糖组比较,黄芪甲苷中、高剂量组细胞凋亡、炎症因子、ROS水平和NLRP3、Caspase-1表达水平均降低(P<0.05或P<0.01),细胞活力、LC3、Beclin-1表达水平均升高(P<0.05或P<0.01)。透射电镜观察发现高糖会减少自噬体产生,黄芪甲苷组自噬体的数目明显多于高糖组。结论:高糖可导致小鼠SV40细胞处于微炎症状态,扩大氧化应激反应并激活NLRP3炎症小体,黄芪甲苷可以抑制NLRP3表达,并提高线粒体自噬,起到减缓DN疾病进展的作用。

中国异蝽科二新种记述(半翅目,异翅亚目)

记述了采于我国南方地区的异蝽科昆虫 2新种 ,分属于 2属 ,即壮异蝽属UrochelaDallas的白点壮异蝽Urochelaalbosignatasp .nov .和盲异蝽属UrolabidaWestwood的五峰盲异蝽Urolabidawufenganasp .nov .。量度单位mm。

A Preliminary Study on Fluid Inclusions and Mineralization of Xitieshan Sedimentary-Exhalative (SEDEX) Lead-Zinc Deposit

The Xitieshan lead-zinc deposit is located at the northern margin of the Qaidam Basin, Qinghai Province, China, and had developed a complete marine sedimentary-exhalative system. Our preliminary study of ore-forming fluids shows that fluid inclusions in quartz from altered stockwork rocks that represent the pipe facies have a wide range of temperature and salinity. The intense fluid activities are characteristics of the pipe facies of the exhalative system. Fluid inclusions in carbonates near the unstratified ore bodies hosted in the thick-bedded marble which represents vent-proximal facies are large in size and have moderate to high temperatures. They represent unerupted sub-seafloor fluid activity. Fluids in altered stockwork rocks and carbonates have similar H20-NaCI-CO2 system, both belonging to the sedimentary-exhalative system. The fluids migrate from the pipe facies to the unstratified ore bodies. Boiling of the fluids causes the separation of CO2 vapor and liquid H2O. When the fluids migrate into the unconsolidated thick-bedded marble, the escape of CO2, decreasing temperature and pressure as well as some involvement of seawater into the fluids result in the unmixing of fluids with high and low salinity and deposition of ore-forming materials. The two unmixed fluids were trapped in unconsolidated carbonates and the ore-forming materials were deposited in the unconsolidated carbonates to form the sedimentary-exhalative type unstratified ore bodies. The oreforming temperature of unstratified ore bodies is up to high temperature indicating that there is a huge ore-forming potential in its deep.

Vertical zoning model of fluorite ore-bodies in Zhejiang

THK fluortite in Zhejiang Province is well known. However, the known outcrop mines have been graduallyexhausted by the exploiting over a long time. It has been a task of top priority to explore blind deposits.Study on the vertical zoning model will be very important and useful in the exploration for blind fluoriteore-bodies. 1 Genetic characteristics of fluorite deposits The fluorite deposits in Zhejiang Province are typical vein filling deposits. The minerals forming theores and the alterations of the wall rocks are all relatively simple. Studies show that the ore-forming materials （F and Ca etc. ） mainly come from the Chencai Group metamorphic rocks and the J3-K1 series vol-

Changchengite—A New Iridium Bismuthide-Sulphide from the Yanshan Mountains

Changchengite occurs in chromite orebodies in dunite and in platinum placer deposits in chromite orebodies nearby. The mineral occurs as massive aggregates or veinlets on margins of iridisite (IrS2) and replaces it. Opaque. Lustre metallic. Colour steel-black. Streak black. Hm = 3.7. VHN20= 165 kg/ mm2. Isotropic. Cleavage none. Density 11.96 g/ cm3. Seven electron microprobe analyses give the following mean chemical results (wt. %): S 7.2, Cu 0.3, Te 0.4, Ir 41.2, Pt 2.8 and Bi 47.3 with total 99.1. The simplified formula is IrBiS. The strongest X-ray powder diffraction lines (hkl, d, I) are 210, 2.75 (70); 211, 2.51 (60); 311, 1.860 (100); 440. 1.090 (50) and 600, 1.027 (50). The X-ray powder diffraction pattern is similar to that of mayingite. After the diffraction data are indexed the mineral is determined to be cubic. The space group is P213 with a = 0.6164(4) nm, V = 0.2342 nm3 and Z = 4.

动脉血酮体比及血清Ⅳ型胶原检测在肝癌病人手术治疗中的临床意义

目的 探讨测定动脉血酮体比 (AKBR)和血清Ⅳ型胶原 (Ⅳ C)在肝癌病人手术及预后评估中的意义。方法 在手术前后对 2 0例行部分肝切除的原发性肝癌病人连续测定AKBR和血清Ⅳ C并与术后并发症发生情况作对比。结果 按术后AKBR分成 3组 ,A组 (10例 ) :始终≥ 0 7;B组(7例 ) :波动在 0 4和 0 7之间 ;C组 (3例 ) :降在 0 4之下。各组并发症发生率依次为 2 0 % ,4 3 % ,和10 0 %。按术后Ⅳ C分为两组 :<2 0 0 μg L的Ⅰ组中A ,B ,C各有 8例 (72 7% ) ,3例 (2 7 3 % )和 0例 ;≥2 0 0 μg L的Ⅱ组中A ,B ,C各有 2例 (2 2 2 % ) ,4例 (4 4 4% )和 3例 (3 3 3 % )。两组构成比差异有显著意义 (P <0 0 5)。结论 术后连续测定AKBR和Ⅳ C有助于判断病人肝功能储备 ,指导治疗和评价预后。

Ⅳ级截骨术在椎间盘组织嵌入椎体陈旧性胸腰椎骨折并后凸畸形手术治疗中的应用

目的探讨后路Ⅳ级截骨术在椎间盘组织嵌入骨折椎体的陈旧性胸腰椎骨折并后凸畸形手术治疗中的应用价值。方法回顾性分析自2015-01—2017-12诊治的36例椎间盘组织嵌入椎体陈旧性胸腰椎骨折并后凸畸形,行后路Ⅳ级截骨(经椎弓根V形截骨并切除相邻椎间盘)、椎弓根钉内固定、全椎板减压椎间植骨融合术治疗。比较术前、术后1周、术后3个月疼痛VAS评分、伤椎Cobb角、ODI指数。结果 36例均获得随访,随访时间平均9.2(3～18)个月。所有患者腰背部疼痛均明显缓解,未出现脊髓神经功能损伤加重,术后6个月均有明确的椎间骨性融合影像学表现。术后1周疼痛VAS评分、伤椎Cobb角、ODI指数较术前明显改善,差异有统计学意义(P<0.05);术后3个月疼痛VAS评分、ODI指数较术后1周进一步改善,但伤椎Cobb角较术后1周有所丢失,差异有统计学意义(P<0.05)。结论对于椎间盘组织嵌入椎体陈旧性胸腰椎骨折并后凸畸形患者,Ⅳ级截骨术是一种合适的治疗选择,可以取得良好的疗效。

The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen Ⅳ

The highly conserved doublesex(dsx) and doublesex/mab-3 related(Dmrt) genes control sexually dimorphic traits across animals. The dsx gene encodes sex-specific transcription factors, Dsx^(M) in males and Dsx^(F) in females, which function differentially and often oppositely to establish sexual dimorphism. Here, we report that mutations in dsx, or overexpression of dsx, result in abnormal distribution of the basement membrane(BM) protein Collagen Ⅳ in the fat body. We find that Dsx isoforms regulate the expression of Collagen Ⅳ in the fat body and its secretion into the BM of other tissues. We identify the procollagen lysyl hydroxylase(dPlod) gene, which is involved in the biosynthesis of Collagen Ⅳ, as a direct target of Dsx. We further show that Dsx regulates Collagen Ⅳ through d Plod-dependent and independent pathways. These findings reveal how Dsx isoforms function in the secretory fat body to regulate Collagen Ⅳ and remotely establish sexual dimorphism.

Source of ore-forming substances and theoretical problems of metallogeny relevant to the Bayan Obo Fe-REE ore deposits in Inner Mongolia,China

The source of rare earth elements （REE） ore-forming substances is identified to be extremelydistinct from that of iron ores.The Bayan Obo Fe-REE ore deposits were generated by a composite processof both crustal and mantle source mineralization.The original iron bodies are of a sedimentary deposit fromsupergenesis,while the REE ores have been formed by mantle fluid metasomatism superimposed upon thepre-existing iron bodies.It is believed that the REE ore deposit would be controlled by intracontinental hotspot.The H8 dolomite in mine regions belongs to normal sedimentary carbonate rock,its C and O isotopiccomposition rules out the possibility comparable with magrnatic carbonatite.The Sm-Nd isochrons of separatedREE minerals have shown two REE peak mineralization periods:early-middle Proterozoic （1 700 Ma±480 Ma） andCaledonia （424-402 Ma）.