Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.

Absolute partial and total ionization cross sections of carbon monoxide with electron collision from 350 eV to 8000 eV

The absolute partial and total cross sections for electron impact ionization of carbon monoxide are reported for electron energies from 350 eV to 8000 eV.The product ions(CO^(+),C^(+),O^(+),CO^(2+),C^(2+),and O^(2+))are measured by employing an ion imaging mass spectrometer and two ion-pair dissociation channels(C^(+)+O^(+)and C^(2+)+O^(+))are identified.The absolute cross sections for producing individual ions and their total,as well as for the ion-pair dissociation channels are obtained by normalizing the data of CO^(+)to that of Ar^(+)from CO-Ar mixture target with a fixed 1:1 ratio.The overall errors are evaluated by considering various kinds of uncertainties.A comprehensive comparison is made with the available data,which shows a good agreement with each other over the energy ranges that are overlapped.This work presents new cross-section data with electron energies above 1000 eV.

0~3岁婴幼儿家长托育服务需求现状及优化策略——基于Kano模型的分析

托育服务是我国老龄少子化背景下重要的民生工程。为探讨0~3岁婴幼儿家长对托育服务的需求层次结构并对托育服务提出对策建议,本研究基于魅力质量理论与Kano模型,通过访谈法与现有文献资料确定了0~3岁婴幼儿家长对托育服务的6个需求维度与41个需求要素。本研究通过Kano问卷收集0~3岁婴幼儿家长的托育服务需求信息,根据Better-Worse系数与平均满意度指标(ASC)确定了2个基本型需求维度、2个期待型需求维度、1个魅力型需求维度、1个无差异型需求维度以及12个基本型需求要素、8个期待型需求要素、13个魅力型需求要素、8个无差异型需求要素及其重要性排序,并据此对家庭托育服务需求特点开展讨论。基于上述分析,研究提出了以下四条托育服务优化策略:完善机构监督制度,保障托育服务质量;健全师资准入培训,提高托育人员素养;做好个性需求管理,提供多元服务形式;加大政策宣传普及,加快普惠托育建设。

Utero-Cutaneous Fistula after Caesarean Section Delivery: Diagnosis and Management of a Rare Complication

Utero-cutaneous fistula following cesarean section is a rare occurrence. We present the case of a 34-year-old woman who presented to our department four years after her second cesarean section with a history of pain and blood discharge from a previous Pfannenstiel incision, during menstruation, with an absence of vaginal menstrual flow. Despite a prior surgical repair operation, her symptoms persisted. A pelvic MRI was done to confirm the diagnosis of utero-cutaneous fistula, and surgical management was pursued. This case report aims to contribute to the existing literature on utero-cutaneous fistula and provide insights into the diagnostic considerations and management strategies for this rare complication.

Caesarean Section in the Mother and Child University Hospital of N’Djamena: Indications and Prognosis

Introduction: Caesarean section is a surgical procedure which allows childbirth after opening the abdominal wall and the uterus. Objective: To study caesarean section in the N’Djamena Mother and Child University Hospital (NMCUH). Patients and Method: This was a cross-sectional, analytic descriptive study over a 5-month period from 10 January to 10 June 2023, focusing on caesarean sections section in the N’Djamena Mother and Child University Hospital (NMCUH). Studied variables were epidemiological, clinical and prognostic. Patients were divided according to the classification of Robson into 10 groups. Results: During the study period, we recorded 724 caesareans sections among 3,565 deliveries, giving a rate of 20.3%. The age group from 25 to 29 represented 39.2%. The average age was 31.2 ± 2.8 years, with extreme ranging from 14 to 44 years. Nulliparous women accounted for 42% and 26% had at least one previous caesarean section (n = 188). Patients with full-term pregnancies (37 - 40 gestational weeks + 6 days) represented 64.1%. Emergency caesareans accounted for 92.8% (n = 672). Robson’s group 1 was noted to be 40.3%. Hemorrhage was the main intraoperative complication, with 7.2%. In post-operatively, anemia was the main complication at 23.8%. We recorded 16 maternal deaths, giving a maternal death rate of 2.2%. Live newborns accounted for 81.1%. Conclusion: Caesarean section is a common procedure in the CHUME maternity unit. The main indications are those of Robson’s group I. Caesarean sections are associated with both maternal and fetal complications.

THE LOGARITHMIC SOBOLEV INEQUALITY FOR A SUBMANIFOLD IN MANIFOLDS WITH ASYMPTOTICALLY NONNEGATIVE SECTIONAL CURVATURE

In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality,this inequality contains a term involving the mean curvature.

Postpartum Quality of Life in Primiparous Women after Normal Vaginal Delivery versus Caesarean Section

Background: Studies on either postnatal quality of life in general or studies that compare quality of life in new mothers after different mode of delivery are limited. An investigation on health related quality of life measures in women after different type of delivery showed that women who had vaginal delivery had better health related quality of life compared to those who had caesarean section. However, the best method of delivery, vaginal or caesarean for postpartum quality of life is a difficult question as it is a matter of controversy both from professional’s perspectives and from women’s experience during childbirth. Objective: To compare postpartum quality of life in primiparous women after vaginal delivery versus caesarean section. Methods: Prospective cross-sectional study was conducted at the department of Obstetrics and Gynecology, Salmaniya medical complex in Kingdom of Bahrain. 500 primiparous women who gave birth either vaginally or by cesarean section answered a questionnaire designed to include general information, questions from short form health survey questionnaire (SF-36) and specific questions regarding postnatal related symptoms. Results: Body pain, fatigue, wound pain, headache and backache were significantly higher in cesarean section group as compared to vaginal delivery group (p-value Conclusion: Cesarean delivery has negatively affected the quality of life (QOL) of primiparous women. More studies with larger sample sizes should be conducted to examine the effects of cesarean delivery on QOL in both primiparous and multiparas within a shorter period after delivery. .

Correlation between psychological resilience and burnout among female employees in a shopping mall in Xi Xian new area,China:A cross-sectional survey-Retraction

In the article titled“Correlation between psychological resilience and burnout among female employees in a shopping mall in Xi Xian New Area,China:A cross-sectional survey”by Zhang Q and Liu L(J Integr Nurs 2021;3(3):117-121.doi:10.4103/jin.jin_14_21),[1]the content and results data of this article was questioned by International database(Web of Science)institution.This article was then investigated by the publisher and Journal of Integrative Nursing(JIN).

Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source.Neutron energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission measurements.The on-beam background was determined using Co,In,Ag,and Cd filters.The excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling program.The present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation curve.Good agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding region.This measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy range.This provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

Factors Associated with Acute Respiratory Infections in Children Aged 0 - 5 Years in the Yénawa District of Cotonou (Benin) in 2023

Introduction: Acute respiratory infections remain one of the main causes of mortality in children aged 0 to 5. This work aimed to study the associated factors with the occurrence of acute respiratory infections in children 0 to 5 years old in Yénawa, Cotonou in 2023. Subjects and Method: It was an analytical cross-sectional study of children aged 0 - 5 years and their mothers in Yénawa, selected by four-degree random sampling. The sampling size, calculated using the Schwartz formula, was 126 children and 126 mothers. The dependent variable was the occurrence of acute respiratory infections. The independent variables were classified into four groups: socio-demographic and economic characteristics, behavioral factors, child-related factors, and environmental factors. Data collected by observation and questionnaire survey were analyzed using STATA version 15 software. Associated factors were investigated by bivariate analysis and multiple logistic regression, at the 5% significance level. Results: A total of 126 children aged 0 - 5 years and 126 mothers were surveyed, aged 23.5 (11 - 36) months and 30 (18 - 48) years respectively. The prevalence of acute respiratory infections was 74.60% (CI95% = 66.89 to 82.30). The associated factors were the mother’s age between 18 and 28 (OR = 10.77;CI95% = 1.89 to 61.27;p = 0.007), the use of charcoal/wood for cooking (OR = 7.36;IC = 1.99 to 27.10;p = 0.003)), children's poor personal hygiene (OR = 8.87;IC = 2.92 to 26.97;p 0.001)), and cohabitation with domestic animals (OR = 7.27;IC = 1.67 to 31.71;p = 0.015). Conclusion: Communicating with mothers about the factors identified will help reduce the prevalence of acute respiratory infections in children aged 0 to 5.

Taxonomy and phylogeny of the section Chaetoceros(Chaetocerotaceae,Bacillariophyta),with description of two new species

Chaetoceros Ehrenberg is one of the most diverse genera of planktonic diatoms.The species in section Chaetoceros are characterized by cells and setae having numerous chloroplasts and being widely distributed.However,the delimitations of some species are problematic because of limited morphological information in the classical descriptions.Monoclonal strains of the section Chaetoceros were established,morphological features were studied using light and electron microscopy,and the hypervariable D 1-D 3 region of the nuclear ribosomal large subunit gene was sequenced to address phylogenetic relationships.Fifteen species belonging to the section Chaetoceros were recorded,including two new species,C.hainanensis sp.nov.and C.tridiscus sp.nov.Chaetoceros hainanensis was characterized by straight chains,narrowly lanceolate to hexagonal apertures,sibling setae diverging in nearly right angles,stipule-shaped spines on terminal setae and arrowhead-shaped spines on intercalary setae.C.tridiscus had short straight chains,narrowly lanceolate apertures,arrowhead-shaped spines and circular poroids arranged in a grid pattern on terminal and intercalary setae.The phylogenetic analyses revealed six groups formed by 19 species within the section Chaetoceros,which was found to be monophyletic.The subdivision of the section is still not well understood.The morphological characters within each group varied considerably and molecular information on more species are needed to enrich the phylogenetic profiling.

Research on uninterruptable power supply technology for auxiliary winding of electric locomotive while passing the neutral section

Purpose–Auxiliary power system is an indispensable part of the train;the auxiliary systems of both electric locomotives and EMUs mainly are powered by one of the two ways,which are either from auxiliary windings of traction transformers or from DC-link voltage of traction converters.Powered by DC-link voltage of traction converters,the auxiliary systems were maintained of uninterruptable power supply with energy from electric braking.Meanwhile,powered by traction transformers,the auxiliary systems were always out of power while passing the neutral section of power supply grid and control system is powered by battery at this time.Design/methodology/approach–Uninterrupted power supply of auxiliary power system powered by auxiliary winding of traction transformer was studied.Failure reasons why previous solutions cannot be realized are analyzed.An uninterruptable power supply scheme for the auxiliary systems powered by auxiliary windings of traction transformers is proposed in this paper.The validity of the proposed scheme is verified by simulation and experimental results and on-site operation of an upgraded HXD3C type locomotive.This scheme is attractive for upgrading practical locomotives with the auxiliary systems powered by auxiliary windings of traction transformers.Findings–This scheme regenerates braking power supplied to auxiliary windings of traction transformers while a locomotive runs in the neutral section of the power supply grid.Control objectives of uninterrupted power supply technology are proposed,which are no overvoltage,no overcurrent and uninterrupted power supply.Originality/value–The control strategies of the scheme ensure both overvoltage free and inrush current free when a locomotive enters or leaves the neutral section.Furthermore,this scheme is cost low by employing updated control strategy of software and add both the two current sensors and two connection wires of hardware.

Highly Accurate Golden Section Search Algorithms and Fictitious Time Integration Method for Solving Nonlinear Eigenvalue Problems

This study sets up two new merit functions,which are minimized for the detection of real eigenvalue and complex eigenvalue to address nonlinear eigenvalue problems.For each eigen-parameter the vector variable is solved from a nonhomogeneous linear system obtained by reducing the number of eigen-equation one less,where one of the nonzero components of the eigenvector is normalized to the unit and moves the column containing that component to the right-hand side as a nonzero input vector.1D and 2D golden section search algorithms are employed to minimize the merit functions to locate real and complex eigenvalues.Simultaneously,the real and complex eigenvectors can be computed very accurately.A simpler approach to the nonlinear eigenvalue problems is proposed,which implements a normalization condition for the uniqueness of the eigenvector into the eigenequation directly.The real eigenvalues can be computed by the fictitious time integration method(FTIM),which saves computational costs compared to the one-dimensional golden section search algorithm(1D GSSA).The simpler method is also combined with the Newton iterationmethod,which is convergent very fast.All the proposed methods are easily programmed to compute the eigenvalue and eigenvector with high accuracy and efficiency.

Comparative efficacy and safety between endoscopic submucosal dissection,surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.

Clinical Value of Predictive Nursing Intervention on Deep Venous Thrombosis of Lower Extremities after Cesarean Section

[Objectives]To explore the clinical nursing value of predictive nursing intervention in patients with deep venous thrombosis of lower extremities after cesarean section.[Methods]From December 2022 to April 2023,105 pregnant and lying-in women who were hospitalized in the Gynecology Department of Pingquan Hospital and underwent cesarean section and met the inclusion criteria were included as the study objects.According to the medical records,they were divided into observation group(n=52 cases)and control group(n=53 cases).The clinical experimental subjects were divided into two groups.One group was the control group with routine nursing,and the other group was the observation group with predictive nursing intervention.The number of cases of deep venous thrombosis of lower extremities in the two groups was recorded to evaluate the clinical value.[Results]The incidence of deep venous thrombosis of lower extremities in the two groups after cesarean section was compared,and it was suggested that the incidence of the observation group was lower than that of the control group(P<0.05).[Conclusions]Special predictive nursing intervention can greatly reduce the incidence of deep venous thrombosis of lower extremities after cesarean section,improve nursing satisfaction,and improve clinical efficacy,which is worthy of recommendation.

Reinforcement Technology for Soft Soil Roadbed in the Widened Section of Expressway Expansion

This article examines the soft soil roadbed reinforcement technology for widened sections of highways in a specific project.It provides an overview of the project,the principles of soft soil roadbed reinforcement technology for wide sections,and its practical application.The analysis aims to offer guidance on applying soft soil roadbed wide section reinforcement technology and enhancing the overall quality of similar projects.

Study on the Construction Technology of Subgrade Pavement in Road and Bridge Settlement Section

With the continuous development of China’s economy,the construction of roads and bridges work has put forward higher requirements.Due to various factors,the long-term use of roads and bridges will produce a settlement phenomenon.Therefore,it is crucial to address settlement issues during the construction of roads and bridges to ensure that the quality of subgrade and pavement construction meets national regulations.This paper introduces the harm of subgrade pavement subsidence,analyzes the causes of subgrade pavement deformation,and discusses the technical points of subgrade pavement construction,hoping to provide some reference for relevant practitioners.

Tenda AX12路由器0-Day栈溢出漏洞挖掘方法

随着5G技术对物联网发展的加速,预计到2025年将会有约250亿台物联网设备连接到人们的生活。其中承担物联网设备网络管理角色的路由器使用量非常大,但是路由器存在众多安全问题,通过路由器设备进行攻击,可以非法获取用户信息。为了维护网络安全,提前发现路由器的漏洞具有重要的研究意义。本文以Tenda AX12路由器为研究对象,从固件入手对其进行0-Day栈溢出漏洞挖掘研究,并提出了基于危险函数追踪的逆向分析漏洞挖掘方法。首先从危险函数中分析函数所在前端的对应位置,将前后端对应;然后对固件中的Web服务进行分析,对其中可能发生栈溢出的httpd二进制代码进行危险函数分析,该方法使用反汇编代码对危险函数的普通形式和展开形式进行定位,并对危险函数进行参数分析和动态检测;接着通过搭建仿真模拟机在模拟机上运行该服务的二进制文件,并在Web前端页面对潜在漏洞位置进行数据包捕捉;最后根据前期分析的危险函数参数情况对包进行改写并发送,以此来触发漏洞,验证漏洞的存在性,同时验证该危险函数是否发生栈溢出。为了更真实地确定漏洞存在,我们又在真实设备上验证漏洞的真实存在性和可利用性。实验结果表明了该漏洞的挖掘检测方法的有效性,我们分别在不同型号的路由器上挖掘到4个0-Day漏洞,并且经过与SaTC工具进行对比实验结果表明该检测方法能够更准确的定位到出现漏洞的函数位置。

连续变截面箱梁主墩0号块复杂受力模式与力学仿真分析

连续变截面箱梁是钢箱梁桥中应用较多的型式,具有受力复杂、施工变形控制难的特点.依托雄安新区骨干路网京雄高速高碑店连接线白沟河特大桥项目,结合钢箱梁结构异性结构设计理论,采用线性监测、毫米波雷达监测、埋设应变片应力监测与数值仿真分析相结合的方法,获得连续变截面箱梁主墩0号块各项受力变形数据,得到了连续变截面箱梁主墩0号块复杂受力模式的工作机制.结果表明:1)针对线性监测、内应力监测与毫米波雷达监测,提出了连续变截面箱梁主墩0号块控制阀值范围,内应力变化范围为0.71~12.58 MPa,沉降量0.78~-0.2 mm;2)对比分析线性监测与内应力监测数据,并对其进行拟合回归,构建了主墩0号块变形受力模型;3)通过提取主墩0号块毫米波雷达波谱图,获取其变形异常点数据,分析得出了连续变截面箱梁主墩0号块失稳破坏工作机制.上述研究成果可为连续变截面箱梁主墩0号块设计参数优化、主墩施工质量控制与施工工艺优化提供理论支撑与技术指导.

2018—2020年福建地区猪瘟病毒E0基因遗传变异分析

为了了解2018—2020年福建地区猪瘟病毒流行及遗传变异情况,收集福建省不同地区临床发病猪的血液和肺脏、脾脏、淋巴结等组织样本1464份,采用RT-nPCR的方法对样品进行CSFV检测,对部分CSFV阳性样品E0基因进行克隆测序。结果显示,CSFV总体阳性率为1.9%(29/1464),并获得13株CSFV E0基因序列。同源性分析发现所得13株CSFV E0基因之间的同源性在82.2%-99.7%,其中11株CSFV E0基因与1.1亚型代表毒株HCLV的核苷酸同源性为99.0%~99.9%,与Shimen株的核苷酸同源性94.1%~95.0%;1株与2.1c型参考毒株HNSD-2012核苷酸同源性为98.2%;1株与2.1d亚型毒株CSFV/JPN/2018核苷酸同源性为99.6%。遗传进化分析发现,10株CSFV与HCLV、C-ZJ-2008、Shimen和Brescia处于同一分支,属于1.1亚型;1株CSFV与HNSD-2012等位于同一分支,属于2.1c亚亚型;1株与CSFV/JPN/2018等位于同一分支,属于2.1d亚亚型。氨基酸序列分析发现,13株毒株与HCLV等代表毒株在重要的Rnase活性位点高度保守,其中2株2.1亚型毒株与HCLV毒株相比,其在第35位非关键氨基酸残基上发生由G→E的突变。结果表明福建地区CSFV流行情况趋向多样化,提示仍需加强对CSFV流行及遗传变异的持续监测,为猪瘟的诊断及有效防控奠定基础。