The high-precision GPS data observed from the northeast margin of the Qinghai-Xizang （Tibet） block and the Sichuan-Yunnan GPS monitoring areas in 1991 （1993）, 1999 and 2001 revealed that： before the Kunlun earthq...The high-precision GPS data observed from the northeast margin of the Qinghai-Xizang （Tibet） block and the Sichuan-Yunnan GPS monitoring areas in 1991 （1993）, 1999 and 2001 revealed that： before the Kunlun earthquake with Ms =8.1 on November 14, 2001, the dynamic variation features of horizontal movement-deformation field in the north and east marginal tectonic areas of the Qinghai-Xizang （Tibet） block had some correlated features. That is to say, under the general background of inherited movement, the movement intensifies in the two areas weakened synchronously and the state of deformation changed when the great earthquake was impending. Analysis and study in connection with geological structures showed that before the Kunlun Ms8.1 earthquake, the correlated variations of movement-deformation on the boundaries of Qinghai-Xizang （Tibet） block were related to the disturbing stress field caused by the extensive and rapid stress-strain accumulation in the late stage of large earthquake preparation. Owing to the occurrence of large earthquake inside the block, the release of large amount of strain energy, and the adjustment of tectonic stress field, in relevant structural positions （especially zones not penetrated by historical strong earthquake ruptures） in boundary zones where larger amount of strain energy was accumulated, stress-strain may be further accumulated or else released through rupture.展开更多
A novel process for manufacturing A1-0.70Fe-0.24Cu alloy conductor was proposed, which includes horizontal continuous casting and subsequent continuous extrusion forming （Conform）. The mechanical properties, electri...A novel process for manufacturing A1-0.70Fe-0.24Cu alloy conductor was proposed, which includes horizontal continuous casting and subsequent continuous extrusion forming （Conform）. The mechanical properties, electrical conductivity and the compressed creep behaviour of the alloy were studied. The results indicate that the Conform process induces obvious grain refinement, strain-induced precipitation of AI7CuzFe phase and the transformation of crystal orientation distribution. The processed alloy has good comprehensive mechanical properties and electrical conductivity. Moreover, a better creep resistance under the conditions of 90 ~C and 76 MPa is shown compared with pure A1 and annealed copper, and the relationship between primary creep strain and time may comply with the logarithmic law. The enhanced properties are attributed to the grain refinement as well as the fine and homogeneously distributed thermally stable A1Fe and A17Cu2Fe precipitation phases.展开更多
Marine controlled source electromagnetic signal could be used in mineral resource exploration,reservoir appraisal and communicative technique in ocean. It's necessary to study the electromagnetic generated by MCSE...Marine controlled source electromagnetic signal could be used in mineral resource exploration,reservoir appraisal and communicative technique in ocean. It's necessary to study the electromagnetic generated by MCSEM. The propagation of the electromagnetic fields from a controlled source in the marine environment was studied with virtual interface method combined with discrete complex image method. Transmitter of finite length current source is approximated by dipole (HED) . A three-layered model is accepted,with sea water as intermediate conductive layer under air and a relatively high resistive seabed as basement,possibly containing a hydrogen layer of higher resistivity. The electromagnetic fields in whole space thus computed show that: (1) the spatial distribution of field component depends on its type; (2) inline Ex component is more sensitive to reservoir layer than that in broadside; (3) The airwave affects marine electromagnetic (MEM) exploration when sea water is relatively shallow; in the case of deep water MEM exploration,the airwave influence could be neglected; and (4) an appropriate frequency should be selected in order to balance the signal strength and electromagnetic induction effect.展开更多
The onset of retinal degenerative disease is often associated with neuronal loss. Therefore, how to regenerate new neurons to restore vision is an important issue. NeuroD1 is a neural transcription factor with the abi...The onset of retinal degenerative disease is often associated with neuronal loss. Therefore, how to regenerate new neurons to restore vision is an important issue. NeuroD1 is a neural transcription factor with the ability to reprogram brain astrocytes into neurons in vivo. Here, we demonstrate that in adult mice, NeuroD1 can reprogram Müller cells, the principal glial cell type in the retina, to become retinal neurons. Most strikingly, ectopic expression of NeuroD1 using two different viral vectors converted Müller cells into different cell types. Specifically, AAV7 m8 GFAP681::GFP-ND1 converted Müller cells into inner retinal neurons, including amacrine cells and ganglion cells. In contrast, AAV9 GFAP104::ND1-GFP converted Müller cells into outer retinal neurons such as photoreceptors and horizontal cells, with higher conversion efficiency. Furthermore, we demonstrate that Müller cell conversion induced by AAV9 GFAP104::ND1-GFP displayed clear dose-and time-dependence. These results indicate that Müller cells in adult mice are highly plastic and can be reprogrammed into various subtypes of retinal neurons.展开更多
文摘The high-precision GPS data observed from the northeast margin of the Qinghai-Xizang （Tibet） block and the Sichuan-Yunnan GPS monitoring areas in 1991 （1993）, 1999 and 2001 revealed that： before the Kunlun earthquake with Ms =8.1 on November 14, 2001, the dynamic variation features of horizontal movement-deformation field in the north and east marginal tectonic areas of the Qinghai-Xizang （Tibet） block had some correlated features. That is to say, under the general background of inherited movement, the movement intensifies in the two areas weakened synchronously and the state of deformation changed when the great earthquake was impending. Analysis and study in connection with geological structures showed that before the Kunlun Ms8.1 earthquake, the correlated variations of movement-deformation on the boundaries of Qinghai-Xizang （Tibet） block were related to the disturbing stress field caused by the extensive and rapid stress-strain accumulation in the late stage of large earthquake preparation. Owing to the occurrence of large earthquake inside the block, the release of large amount of strain energy, and the adjustment of tectonic stress field, in relevant structural positions （especially zones not penetrated by historical strong earthquake ruptures） in boundary zones where larger amount of strain energy was accumulated, stress-strain may be further accumulated or else released through rupture.
基金Project(20130161110007) supported by the Doctoral Program of Higher Education of China
文摘A novel process for manufacturing A1-0.70Fe-0.24Cu alloy conductor was proposed, which includes horizontal continuous casting and subsequent continuous extrusion forming （Conform）. The mechanical properties, electrical conductivity and the compressed creep behaviour of the alloy were studied. The results indicate that the Conform process induces obvious grain refinement, strain-induced precipitation of AI7CuzFe phase and the transformation of crystal orientation distribution. The processed alloy has good comprehensive mechanical properties and electrical conductivity. Moreover, a better creep resistance under the conditions of 90 ~C and 76 MPa is shown compared with pure A1 and annealed copper, and the relationship between primary creep strain and time may comply with the logarithmic law. The enhanced properties are attributed to the grain refinement as well as the fine and homogeneously distributed thermally stable A1Fe and A17Cu2Fe precipitation phases.
基金Supperted by project of the National Science Foundation of China(No.40874050)
文摘Marine controlled source electromagnetic signal could be used in mineral resource exploration,reservoir appraisal and communicative technique in ocean. It's necessary to study the electromagnetic generated by MCSEM. The propagation of the electromagnetic fields from a controlled source in the marine environment was studied with virtual interface method combined with discrete complex image method. Transmitter of finite length current source is approximated by dipole (HED) . A three-layered model is accepted,with sea water as intermediate conductive layer under air and a relatively high resistive seabed as basement,possibly containing a hydrogen layer of higher resistivity. The electromagnetic fields in whole space thus computed show that: (1) the spatial distribution of field component depends on its type; (2) inline Ex component is more sensitive to reservoir layer than that in broadside; (3) The airwave affects marine electromagnetic (MEM) exploration when sea water is relatively shallow; in the case of deep water MEM exploration,the airwave influence could be neglected; and (4) an appropriate frequency should be selected in order to balance the signal strength and electromagnetic induction effect.
基金supported by the Guangdong Grant Key Technologies for Treatment of Brain Disorders,China,No. 2018B030332001 (to GC)the Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No. 20200730009 (to YX)the Guangdong Basic and Applied Basic Research Foundation,No. 2020A1515110898 (to WYC)。
文摘The onset of retinal degenerative disease is often associated with neuronal loss. Therefore, how to regenerate new neurons to restore vision is an important issue. NeuroD1 is a neural transcription factor with the ability to reprogram brain astrocytes into neurons in vivo. Here, we demonstrate that in adult mice, NeuroD1 can reprogram Müller cells, the principal glial cell type in the retina, to become retinal neurons. Most strikingly, ectopic expression of NeuroD1 using two different viral vectors converted Müller cells into different cell types. Specifically, AAV7 m8 GFAP681::GFP-ND1 converted Müller cells into inner retinal neurons, including amacrine cells and ganglion cells. In contrast, AAV9 GFAP104::ND1-GFP converted Müller cells into outer retinal neurons such as photoreceptors and horizontal cells, with higher conversion efficiency. Furthermore, we demonstrate that Müller cell conversion induced by AAV9 GFAP104::ND1-GFP displayed clear dose-and time-dependence. These results indicate that Müller cells in adult mice are highly plastic and can be reprogrammed into various subtypes of retinal neurons.
