Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of...Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Fudan University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes.展开更多
In June 2006,a 20.12 m shallow ice core was recovered from an elevation of 5,040 m in the northern branch firn basin of No.12 Glacier,Great Snow Mountain,in the western part of Qilian Mountain,China.Isotopes(δ 18 O),...In June 2006,a 20.12 m shallow ice core was recovered from an elevation of 5,040 m in the northern branch firn basin of No.12 Glacier,Great Snow Mountain,in the western part of Qilian Mountain,China.Isotopes(δ 18 O),major soluble ions,and radionuclide(β-activity) measurements from the ice core revealed a 46-year record(1960-2006).In this paper,the method of sea-salt ion tracer,correlation analysis and trend analysis were used in this research to confirm the source of the chemical composition.The correlation analysis and HYSPLIT backward trajectory analysis suggests that atmospheric soluble dust species dominate the chemical signature.展开更多
The mung bean variety Ji Heilv No.12 was bred by Institute of Characteristic Crop Research, Chongqing Academy of Agricultural Sciences and Institute of Food and Oil Crops, Hebei Academy of Agricultural and Forestry Sc...The mung bean variety Ji Heilv No.12 was bred by Institute of Characteristic Crop Research, Chongqing Academy of Agricultural Sciences and Institute of Food and Oil Crops, Hebei Academy of Agricultural and Forestry Sciences. using Jilv 9and Jilv 7 as female and male parent respectively,with pedigree method. Ji Heilv No.12 is a new variety with features of high and stable yield,broad adaptability and strong resistance in yield trails during 2011-2012; it was approved and released by Chongqing Provincial Committee of Crop Variety Identification in 2012,suitable for cultivating in most area of Chongqing.展开更多
The Laohugou Glacier No. 12 is the largest valley glacier in Qilian Mountains, which is located in northem Qinghai-Tibet Plateau. Movement is the basic characteristic of glaciers, and is also an important distinction ...The Laohugou Glacier No. 12 is the largest valley glacier in Qilian Mountains, which is located in northem Qinghai-Tibet Plateau. Movement is the basic characteristic of glaciers, and is also an important distinction from other terrestrial natural ice. Glacier changes not only reflect climate change, but also play an important role in humanity society. In the arid regions of western China, glaciers are becoming an important water source. We use the GPS receiver （South-Lingrui $82） as data platform with the aid of RTK measurement technology to observe the surface velocity of Laohugou Glacier No. 12. Surface velocity data shows that the maximum value appears at an altitude of 4,750-4,850 m during the period of 2008-2009. During this period, the west branch surface velocity reached 32.6 m per year at an altitude near 4,830 m, the east branch surface velocity reached 32.4 m per year at the altitude near 4,770 m. Comparing the surface velocity data during 2008-2009 with observation results in 1959, the glacier velocity slowed down about 11%.展开更多
BACKGROUND Controversy over the issue that No.12a lymph node involvement is distant or regional metastasis remains,and the possible inclusion of 12a lymph nodes in D2 lymphadenectomy is unclear.As reported,gastric can...BACKGROUND Controversy over the issue that No.12a lymph node involvement is distant or regional metastasis remains,and the possible inclusion of 12a lymph nodes in D2 lymphadenectomy is unclear.As reported,gastric cancer(GC)located in the lower third is highly related to the metastasis of station 12a lymph nodes.AIM To investigate whether the clinicopathological factors and metastasis status of other perigastric nodes can predict station 12a lymph node metastasis and evaluate the prognostic significance of station 12a lymph node dissection in patients with lower-third GC.METHODS A total of 147 patients with lower-third GC who underwent D2 or D2+lymphadenectomy,including station 12a lymph node dissection,were included in this retrospective study from June 2003 to March 2011.Survival prognoses were compared between patients with or without station 12a lymph node metastasis.Logistic regression analyses were used to clarify the association between station 12a lymph node metastasis and clinicopathological factors or metastasis status of other perigastric nodes.The metastasis status of each regional lymph node was evaluated to identify the possible predictors of station 12a lymph node metastasis.RESULTS Metastasis to station 12a lymph nodes was observed in 18 patients with lowerthird GC,but not in 129 patients.The incidence of station 12a lymph node involvement was reported as 12.2%in patients with lower-third GC.The overall survival of patients without station 12a lymph node metastasis was significantly better than that of patients with station 12a metastasis(P<0.001),which could also be seen in patients with or without extranodal soft tissue invasion.Station 12a lymph node metastasis and extranodal soft tissue invasion were identified as independent predictors of poor prognosis in patients with lower-third GC.Advanced pN stage was defined as independent risk factor significantly correlated with station 12a lymph node positivity.Station 3 lymph node staus was also proven to be significantly correlated with station 12a lymph node involvement.CONCLUSION Metastasis of station 12a lymph nodes could be considered an independent prognosis factor for patients with lower-third GC.The dissection of station 12a lymph nodes may not be ignored in D2 or D2+lymphadenectomy due to difficulties in predicting station 12a lymph node metastasis.展开更多
Regularity of the Inverse of a Homeomorphism with Finite Inner Distortion Chang Yu GUO Abstract Let f:Ω→f（Ω）R<sup>n</sup> be a W<sup>1,1</sup>-homeomorphism with L<sup>1</sup>...Regularity of the Inverse of a Homeomorphism with Finite Inner Distortion Chang Yu GUO Abstract Let f:Ω→f（Ω）R<sup>n</sup> be a W<sup>1,1</sup>-homeomorphism with L<sup>1</sup>-integrable inner distortion.We show that finiteness of min{lip<sub>f</sub>（x）,k<sub>f</sub>（x）},for every x∈Ω\E,implies that f<sup>-1</sup>∈W<sup>1,n</sup>and has finite distortion,provided that the exceptional set E hasσ-finite H<sup>1</sup>-measure.Moreover,f has finite distortion,differentiable a.e.and the Jacobian J<sub>f</sub>】0 a.e.展开更多
Distances between Elements of a Semigroup and Estimates for Derivatives Zohra BENDOUAD Isabelle CHALENDAR Jean ESTERLE Jonathan R.PARTINGTON Abstract This paper is concerned first with the behaviour of differences T(t...Distances between Elements of a Semigroup and Estimates for Derivatives Zohra BENDOUAD Isabelle CHALENDAR Jean ESTERLE Jonathan R.PARTINGTON Abstract This paper is concerned first with the behaviour of differences T(t) - T(s) near the origin,where(T(t)) is a semigroup of operators on a Banach space,defined either on the positive real line or a sector in the right half-plane(in which case it is assumed analytic).For the non-quasinilpotent case extensions of results in the published literature are provided,with best possible constants;in the case of quasinilpotent semigroups on the half-plane,it is展开更多
With global warming,glaciers in the high mountains of China are retreating rapidly.However,few data have been reported on whether greenhouse gases from these glaciers are released into the atmosphere or absorbed by gl...With global warming,glaciers in the high mountains of China are retreating rapidly.However,few data have been reported on whether greenhouse gases from these glaciers are released into the atmosphere or absorbed by glacial meltwater.In this study,we collected meltwater and ice samples from Laohugou Glacier No.12 in western China and measured CH_(4)and CO_(2)concentrations.Meltwater from the glacier terminus was continually sampled between 3 and 5 August 2020 to measure CH_(4)and CO_(2)concentrations.The results demonstrated that meltwater is a source of CH_(4)because the average saturations are over 100%.It could be con eluded that CH_(4)in the atmosphere can be released by glacial meltwater.However,the CO_(2)saturations are various,and CO_(2)fluxes exhibit positive(released CO_(2))or negative(absorbed CO_(2))values because the water and atmospheric conditions are variable.More importantly,the CH_(4)and CO_(2)concentrations were higher in meltwater samples from the glacier terminus than in samples from the surface ice(including an ice core)and a surface stream.Although the meltwater effect from the upper part of the glacier cannot be excluded,we speculated that subglacial drainage systems with an anaerobic environment may represent the CH_(4)source,but it needs to be further investigated in the future.However,high mountain glaciers are currently ignored in global carbon budgets,and the increased melting of glaciers with global warming may accelerate the absorption of much more CO_(2)and lead to the release of CH_(4).展开更多
基金supported by National Natural Science Fund(No.31842033)。
文摘Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Fudan University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes.
基金supported by the National Basic Research Program of China (2007CB411501)the National Essential Scientific Program of the Ministry of Scienceand Technology of the People’s Republic of China(2006FY110200)
文摘In June 2006,a 20.12 m shallow ice core was recovered from an elevation of 5,040 m in the northern branch firn basin of No.12 Glacier,Great Snow Mountain,in the western part of Qilian Mountain,China.Isotopes(δ 18 O),major soluble ions,and radionuclide(β-activity) measurements from the ice core revealed a 46-year record(1960-2006).In this paper,the method of sea-salt ion tracer,correlation analysis and trend analysis were used in this research to confirm the source of the chemical composition.The correlation analysis and HYSPLIT backward trajectory analysis suggests that atmospheric soluble dust species dominate the chemical signature.
基金Supported by Chongqing Science&Technology Commission(cstc2016shmszx80116csct2012jj A80042+5 种基金cstc2013yykfc800022015cstc-jbky-005072015cstc-jbky-00508)National Modern Agricultural Industry Technology System(CARS-09)Chongqing Finance Program(NKY-2016AB009NKY-2016AA002)
文摘The mung bean variety Ji Heilv No.12 was bred by Institute of Characteristic Crop Research, Chongqing Academy of Agricultural Sciences and Institute of Food and Oil Crops, Hebei Academy of Agricultural and Forestry Sciences. using Jilv 9and Jilv 7 as female and male parent respectively,with pedigree method. Ji Heilv No.12 is a new variety with features of high and stable yield,broad adaptability and strong resistance in yield trails during 2011-2012; it was approved and released by Chongqing Provincial Committee of Crop Variety Identification in 2012,suitable for cultivating in most area of Chongqing.
基金supported by the Chinese Key Basic Research Development Project (973) (Grant Number: 2007CB411501)the National Basic Work Program of Chinese Ministry of Science and Technology "Investigation of glacier resources and their variations in China" (Grant number: 2006FY110200)the Self-determination Project of State Key Laboratory of Cryospheric Sciences (Grant number: SKLCS09-04)
文摘The Laohugou Glacier No. 12 is the largest valley glacier in Qilian Mountains, which is located in northem Qinghai-Tibet Plateau. Movement is the basic characteristic of glaciers, and is also an important distinction from other terrestrial natural ice. Glacier changes not only reflect climate change, but also play an important role in humanity society. In the arid regions of western China, glaciers are becoming an important water source. We use the GPS receiver （South-Lingrui $82） as data platform with the aid of RTK measurement technology to observe the surface velocity of Laohugou Glacier No. 12. Surface velocity data shows that the maximum value appears at an altitude of 4,750-4,850 m during the period of 2008-2009. During this period, the west branch surface velocity reached 32.6 m per year at an altitude near 4,830 m, the east branch surface velocity reached 32.4 m per year at the altitude near 4,770 m. Comparing the surface velocity data during 2008-2009 with observation results in 1959, the glacier velocity slowed down about 11%.
文摘BACKGROUND Controversy over the issue that No.12a lymph node involvement is distant or regional metastasis remains,and the possible inclusion of 12a lymph nodes in D2 lymphadenectomy is unclear.As reported,gastric cancer(GC)located in the lower third is highly related to the metastasis of station 12a lymph nodes.AIM To investigate whether the clinicopathological factors and metastasis status of other perigastric nodes can predict station 12a lymph node metastasis and evaluate the prognostic significance of station 12a lymph node dissection in patients with lower-third GC.METHODS A total of 147 patients with lower-third GC who underwent D2 or D2+lymphadenectomy,including station 12a lymph node dissection,were included in this retrospective study from June 2003 to March 2011.Survival prognoses were compared between patients with or without station 12a lymph node metastasis.Logistic regression analyses were used to clarify the association between station 12a lymph node metastasis and clinicopathological factors or metastasis status of other perigastric nodes.The metastasis status of each regional lymph node was evaluated to identify the possible predictors of station 12a lymph node metastasis.RESULTS Metastasis to station 12a lymph nodes was observed in 18 patients with lowerthird GC,but not in 129 patients.The incidence of station 12a lymph node involvement was reported as 12.2%in patients with lower-third GC.The overall survival of patients without station 12a lymph node metastasis was significantly better than that of patients with station 12a metastasis(P<0.001),which could also be seen in patients with or without extranodal soft tissue invasion.Station 12a lymph node metastasis and extranodal soft tissue invasion were identified as independent predictors of poor prognosis in patients with lower-third GC.Advanced pN stage was defined as independent risk factor significantly correlated with station 12a lymph node positivity.Station 3 lymph node staus was also proven to be significantly correlated with station 12a lymph node involvement.CONCLUSION Metastasis of station 12a lymph nodes could be considered an independent prognosis factor for patients with lower-third GC.The dissection of station 12a lymph nodes may not be ignored in D2 or D2+lymphadenectomy due to difficulties in predicting station 12a lymph node metastasis.
文摘Regularity of the Inverse of a Homeomorphism with Finite Inner Distortion Chang Yu GUO Abstract Let f:Ω→f（Ω）R<sup>n</sup> be a W<sup>1,1</sup>-homeomorphism with L<sup>1</sup>-integrable inner distortion.We show that finiteness of min{lip<sub>f</sub>（x）,k<sub>f</sub>（x）},for every x∈Ω\E,implies that f<sup>-1</sup>∈W<sup>1,n</sup>and has finite distortion,provided that the exceptional set E hasσ-finite H<sup>1</sup>-measure.Moreover,f has finite distortion,differentiable a.e.and the Jacobian J<sub>f</sub>】0 a.e.
文摘Distances between Elements of a Semigroup and Estimates for Derivatives Zohra BENDOUAD Isabelle CHALENDAR Jean ESTERLE Jonathan R.PARTINGTON Abstract This paper is concerned first with the behaviour of differences T(t) - T(s) near the origin,where(T(t)) is a semigroup of operators on a Banach space,defined either on the positive real line or a sector in the right half-plane(in which case it is assumed analytic).For the non-quasinilpotent case extensions of results in the published literature are provided,with best possible constants;in the case of quasinilpotent semigroups on the half-plane,it is
基金This research has been supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XAD19070103)the National Key Research and Development Program of China(2020YFA0608501)+2 种基金the State Key Laboratory of Cryospheric Science(SKLCS-ZZ-2021)the Youth Innovation Promotion Association,CAS(2020419)the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0605).
文摘With global warming,glaciers in the high mountains of China are retreating rapidly.However,few data have been reported on whether greenhouse gases from these glaciers are released into the atmosphere or absorbed by glacial meltwater.In this study,we collected meltwater and ice samples from Laohugou Glacier No.12 in western China and measured CH_(4)and CO_(2)concentrations.Meltwater from the glacier terminus was continually sampled between 3 and 5 August 2020 to measure CH_(4)and CO_(2)concentrations.The results demonstrated that meltwater is a source of CH_(4)because the average saturations are over 100%.It could be con eluded that CH_(4)in the atmosphere can be released by glacial meltwater.However,the CO_(2)saturations are various,and CO_(2)fluxes exhibit positive(released CO_(2))or negative(absorbed CO_(2))values because the water and atmospheric conditions are variable.More importantly,the CH_(4)and CO_(2)concentrations were higher in meltwater samples from the glacier terminus than in samples from the surface ice(including an ice core)and a surface stream.Although the meltwater effect from the upper part of the glacier cannot be excluded,we speculated that subglacial drainage systems with an anaerobic environment may represent the CH_(4)source,but it needs to be further investigated in the future.However,high mountain glaciers are currently ignored in global carbon budgets,and the increased melting of glaciers with global warming may accelerate the absorption of much more CO_(2)and lead to the release of CH_(4).
