This paper studies the conformal invariance by infinitesimal point transformations of non-conservative Lagrange systems. It gives the necessary and sufficient conditions of conformal invariance by the action of infini...This paper studies the conformal invariance by infinitesimal point transformations of non-conservative Lagrange systems. It gives the necessary and sufficient conditions of conformal invariance by the action of infinitesimal point transformations being Lie symmetric simultaneously. Then the Noether conserved quantities of conformal invariance are obtained. Finally an illustrative example is given to verify the results.展开更多
Alkaline phosphatase(ALP) plays an integral role in the metabolism of liver and development of the skeleton in humans. To date, the interactions between different-duration terahertz(THz) radiation and ALP activities, ...Alkaline phosphatase(ALP) plays an integral role in the metabolism of liver and development of the skeleton in humans. To date, the interactions between different-duration terahertz(THz) radiation and ALP activities, as well as the influence mechanism are still unclear. In this study, using the para-nitro-phenyl-phosphate(p NPP) method, we detect changes in ALP activities during 40-minute THz radiation(0.1 THz, 13 m W/cm^2). It is found that the activity of ALP decreases in the first 25 min, and subsequently increases in the later 15 min. Compared with the activity of ALP being heated, the results suggest that short-term terahertz radiation induces a decrease in enzyme activity through the non-thermal mechanism. In order to explore the non-thermal effects of THz radiation on ALP, we focus on the impacts of 0.1 THz radiation for 20 min on the activity of ALP in different concentrations. The results reveal that the activity of ALP decreases significantly after exposure to THz radiation. In addition, it could be deduced from fluorescence, ultraviolet-visible(UV-vis), and THz spectra results that THz radiation has induced changes in ALP structures. Our study unlocks non-thermal interactions between THz radiation and ALP, as well as suggests that THz spectroscopy is a promising technique to distinguish ALP structures.展开更多
In this paper, we present the fractional Hamilton's canonical equations and the fractional non-Noether symmetry of Hamilton systems by the conformable fractional derivative. First/y, the exchanging relationship betwe...In this paper, we present the fractional Hamilton's canonical equations and the fractional non-Noether symmetry of Hamilton systems by the conformable fractional derivative. First/y, the exchanging relationship between isochronous variation and fractional derivatives, and the fractional Hamilton principle of the system under this fractional derivative are proposed. Secondly, the fractional Hamilton's canonical equations of Hamilton systems based on the Hamilton principle are established. Thirdly, the fractional non-Noether symmetries, non-Noether theorem and non-Noether conserved quantities for the Hamilton systems with the conformable fractional derivatives are obtained. Finally, an example is given to illustrate the results.展开更多
This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conf...This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conformal invariance of the system are presented. The conformal factor expression is deduced from conformal invariance and Lie symmetry. The necessary and sufficient condition that conformal invaxiance of the system would have Lie symmetry under single-parameter infinitesimal transformations is obtained. The corresponding conserved quantity of conformal invariance is derived with the aid of a structure equation. Lastly, an example is given to illustrate the application of the results.展开更多
This paper provides an introduction to the topic of water shutoff and conformance improvement. After indicating the volumes of water produced during oilfield operations, a strategy is provided for attacking excess wat...This paper provides an introduction to the topic of water shutoff and conformance improvement. After indicating the volumes of water produced during oilfield operations, a strategy is provided for attacking excess water production problems. Problem types are categorized, typical methods of problem diagnosis are mentioned, and the range of solutions is introduced for each problem type. In the third section of the paper, the concept of disproportionate permeability reduction is introduced—where polymers and gels may reduce permeability to water more than to oil or gas. When and where this property is of value is discussed. The fourth section describes the properties of formed gels as they extrude through fractures and how those properties can be of value when treating conformance problems caused by fractures. Section 5 covers the efficiency with which gels block fractures after gel placement—especially, the impact of fluids injected subsequent to the gel treatment.展开更多
Excess water production has become an important issue in the oil and gas extraction process.Preformed particle gels(PPGs),show the capability to control the conformance and reduce excess water cut.However,conventional...Excess water production has become an important issue in the oil and gas extraction process.Preformed particle gels(PPGs),show the capability to control the conformance and reduce excess water cut.However,conventional PPGs have poor mechanical properties and their swollen particles are easily damaged by shearing force when passing through the fractures in formations,meanwhile PPGs can be also degraded into various byproducts,leading to permanent damage to the reservoir permeability after temporary plugging.Herein,a novel type of dual cross-linked PPGs(dPPGs)was designed and synthesized using sodium alginate(SA)and acrylamide(AAm),cross-linked with N,N’-methylenebisacrylamide(MBA)and Fe^(3+).Results show that dPPGs have excellent mechanical properties with a storage modulus up to 86,445 Pa,which is almost 20 times higher than other reported PPGs.Meanwhile,dPPGs can be completely degraded into liquid without any solid residues or byproducts and the viscosity of dPPGs degraded liquid was found to be lower than 5 mPa·s.A laboratory coreflooding test showed that the plugging efficiency of dPPGs was up to 99.83%on open fractures.The obtained results demonstrated that dPPGs could be used as economical and environment-friendly temporary plugging agent with high-strength,self-degradation,thermal stability,and salt stability,thus making it applicable to a wide range of conformance control to enhance oil recovery.展开更多
Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling p...Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling plugging.Finding an effective method for the gas channeling plugging is a critical issue in the CO_(2)EOR process.In this work,an acid-resistance microgel named dispersed particle gel(DPG)was characterized and its stability was tested in the CO_(2)environment.The microgel size selection strategies for the homogeneous and heterogeneous reservoirs were respectively investigated using the single core flooding and three parallel core flooding experiments.Moreover,the comparison of microgel alternate CO_(2)(MAC)injection and water alternate CO_(2)(WAC)injection in the dual core flooding experiments were presented for the investigation of the role of microgel on the conformance control in CO_(2)flooding process.The results have shown that the microgel featured with ANH and CAN groups can keep its morphology after aging 7 days in the CO_(2)environment.Where,the small microgel with unobstructed migration and large microgel with good plugging efficiency for the high permeability zone were respectively featured with the higher recovery factor in homogeneous and heterogeneous conditions,which indicate they are preferred used for the oil displacement and conformance control.Compared to WAC injection,MAC injection had a higher incremental recovery factor of 12.4%.It suggests the acid-resistance microgel would be a good candidate for the conformance control during CO_(2)flooding process.展开更多
Objective: To evaluate the clinical effect of gemcitabine and concurrent three-dimensional conformal radiation therapy (3D-CRT) for locally advanced non-small cell lung cancer (NSCLC). Methods: From April 2002 t...Objective: To evaluate the clinical effect of gemcitabine and concurrent three-dimensional conformal radiation therapy (3D-CRT) for locally advanced non-small cell lung cancer (NSCLC). Methods: From April 2002 to June 2005, 38 patients with inoperable stage Ⅲ NSCLC were treated with gemcitabine and 3D-CRT simultaneously. Chemotherapy consisted of intravenously gemcitabine 350 mg/m^2 on days 1, 8, 15, 22, 29, 36.3D-CRT was delivered up to a total dose of 60-64 Gy with a 2.0 Gy dose fraction per day, 5 days per week. Results: The overall response rates of primary tumor and mediastinum metastatic node were 86.8% (33/38) and 90.6% (29/32) respectively, and 91.7% (22/24) and 78.6% (11/14) for squamous cell carcinoma and adenocarcinoma respectively. The acute side effects of patients were mostly myelosuppression, nausea, vomiting, radiation-induced esophagitis and pneumonitis (RTOG 1/11), however, all of them were cured. Conclusion: Concurrent application of gemcitabine and 3D-CRT can improve the overall response rate for locally advanced NSCLC without aggravating the side effects.展开更多
Polymer gel systems have been widely applied to control excessive water and improve oil recovery(IOR)in petroleum reservoirs.They are usually divided into two main types,in-situ cross-linked polymer gels,and pre-forme...Polymer gel systems have been widely applied to control excessive water and improve oil recovery(IOR)in petroleum reservoirs.They are usually divided into two main types,in-situ cross-linked polymer gels,and pre-formed polymer gels.In recent years,nuclear magnetic resonance(NMR) technology has been gradually applied to the research of polymer gel systems due to its unique analysis advantages.This paper is intent to review these works systematically.For in-situ cross-linked polymer gel systems,NMR can be used to characterize the chemical structure changes of the polymer,the cross-linker,and the auxiliary agent in the formulation of the polymer gel systems.Moreover,the gelation time and the gel strength of the in-situ cross-linked polymer gel systems can also be measured by NMR.For pre-formed polymer gels,NMR can be employed to detect the chemical structure of the designed products.Last,the NMR method can evaluate the plugging,water control,and oil improvement performance of the polymer gels in porous media without using dopants.This review can help readers build a more systematic understanding of the application of NMR technology in polymer gel systems for IOR and help re searchers to more deeply study the performance of polymer gel systems.展开更多
Globally, traditional power systems are rapidly transforming towards the adoption of smart grid platforms. Substations which are at the center of the electric power transformation from the power plant are changing to ...Globally, traditional power systems are rapidly transforming towards the adoption of smart grid platforms. Substations which are at the center of the electric power transformation from the power plant are changing to IEC 61850 based digital substations. Therefore, within substation, there is a growing demand for the IEC 61850 based Intelligent Electronic Devices (IEDs). The operation of multiple manufacturers of IEDs in a single digital substation network increases the need for IEC 61850 communications specification conformance diagnosis to ensure interoperability for efficient data exchange between IEDs. The IEC 61850-10 presents test items for diagnosing communication specification conformance. There are many test tools available in the market today to test the compliance of the IEC 61850 communications specifications to the IED. In this paper, we propose a model-based diagnostic method for IED communication conformance testing. The proposed model-based software therefore uses the “drag and drop” technique to select the various IEC 61850 communication services (objects) required to design the test case in a user friendly Graphical User Interface (GUI). This makes the service conformance testing more flexible for test engineers and system integrators especially in situations that require test case modifications. Also, the proposed software tool makes it easy to understand the various IEC 61850 services using the friendly GUI.展开更多
Injecting CO2into hydrocarbon reservoirs can enhance the recovery of hydrocarbon resources,and simultaneously,CO2can be stored in the rese rvoirs,reducing considerable amount of carbon emissions in the atmosphere.Howe...Injecting CO2into hydrocarbon reservoirs can enhance the recovery of hydrocarbon resources,and simultaneously,CO2can be stored in the rese rvoirs,reducing considerable amount of carbon emissions in the atmosphere.However,injected CO_(2)tends to go through fractures,high-permeability channels and streaks present in reservoirs,resulting in inefficient hydrocarbon recovery coupled with low CO_(2)storage performance.Conformance treatments with CO_(2)-resistant crosslinked polymer gels were performed in this study to mitigate the CO_(2)channeling issue and promote the synergy between enhanced oil recovery(EOR) and subsurface sequestration of CO_(2).Based on a typical low-permeability CO_(2)-flooding reservoir in China,studies were performed to investigate the EOR and CO_(2)storage performance with and without conformance treatment.The effect of permeability contrast between the channels and rese rvoir matrices,treatment size,and plugging strength on the efficiency of oil recovery and CO_(2)storage was systematically investigated.The results indicated that after conformance treatments,the CO_(2)channeling problem was mitigated during CO_(2)flooding and storage.The injected CO_(2)was more effectively utilized to recover the hydrocarbons,and entered wider spectrum of pore spaces.Consequently,more CO_(2)was trapped underground.Pronounced factors on the synergy of EOR and CO_(2)storage were figured out.Compared with the treatment size,the CO_(2)storage efficiency was more sensitive to the plugging strength of the conformance treatment materials.This observation was important for conformance treatment design in CCUS-EOR projects.According to this study,the materials should reduce the channel permeability to make the channel/matrix permeability ratio below 30.The results demonstrate the importance of conformance treatment in maximizing the performance of CCUS-EOR process to achieve both oil recovery improvement and efficient carbon storage.This study provides guidelines for successful field applications of CO_(2)transport control in CO_(2)geo-utilization and storage.展开更多
OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV ...OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy (CRT). In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose (DT) of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect (CR + PR) was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.展开更多
Objective: To study the toxicities and efficacy of concurrent gemcitabine plus cisplatin combined with three-dimensional conformal radiotherapy for stage Ⅲ non-small cell lung cancer (NSCLC). Methods: Thirty-six ...Objective: To study the toxicities and efficacy of concurrent gemcitabine plus cisplatin combined with three-dimensional conformal radiotherapy for stage Ⅲ non-small cell lung cancer (NSCLC). Methods: Thirty-six patients with pathologically diagnosed NSCLC received radiotherapy and concurrent chemotherapy. There were 22 patients with stage Ilia and 14 patients with IIIb. Radiotherapy was given a total of 60-70 Gy in conventional fractionation. Chemotherapy included gemcitabine (600 mg/m^2) and cisplatin (20 mg/m^2), once per week. Results: Thirty-two patients received a total dose of 60-72 Gy. Two patients received 56 Gy and another two patients received 58 Gy. Thirty-four patients received 4-6 weeks of chemotherapy, while two patients received only 2 weeks of chemotherapy. The overall response rate (CR + PR), complete response rate (CR), partially response rate (PR) were 83.3% (30/36), 11.1% (4/36) and 72.2% (26/36) respectively. The median follow-up duration was 18.4 months. The 1- and 2-year overall survival rates were 77.8% (28/36) and 55.6% (20/36), respectively. Conclusion: Concurrent gemcitabine and cisplatin combined with three-dimensional conformal radiotherapy for stage III non-small cell lung cancer is effective and well tolerated. Lone-term results need further study.展开更多
Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electroni...Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.展开更多
The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst asses...The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence value.Given the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential failures.To address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its output.The proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test dataset.The CP was evaluated on a rockburst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence levels.Significantly,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed decision-making.The proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10472040, 10572021 and 10772025)the Outstanding Young Talents Training Found of Liaoning Province of China (Grant No 3040005)
文摘This paper studies the conformal invariance by infinitesimal point transformations of non-conservative Lagrange systems. It gives the necessary and sufficient conditions of conformal invariance by the action of infinitesimal point transformations being Lie symmetric simultaneously. Then the Noether conserved quantities of conformal invariance are obtained. Finally an illustrative example is given to verify the results.
基金Project supported by the National Natural Science Foundation of China(Grant No.61675151)
文摘Alkaline phosphatase(ALP) plays an integral role in the metabolism of liver and development of the skeleton in humans. To date, the interactions between different-duration terahertz(THz) radiation and ALP activities, as well as the influence mechanism are still unclear. In this study, using the para-nitro-phenyl-phosphate(p NPP) method, we detect changes in ALP activities during 40-minute THz radiation(0.1 THz, 13 m W/cm^2). It is found that the activity of ALP decreases in the first 25 min, and subsequently increases in the later 15 min. Compared with the activity of ALP being heated, the results suggest that short-term terahertz radiation induces a decrease in enzyme activity through the non-thermal mechanism. In order to explore the non-thermal effects of THz radiation on ALP, we focus on the impacts of 0.1 THz radiation for 20 min on the activity of ALP in different concentrations. The results reveal that the activity of ALP decreases significantly after exposure to THz radiation. In addition, it could be deduced from fluorescence, ultraviolet-visible(UV-vis), and THz spectra results that THz radiation has induced changes in ALP structures. Our study unlocks non-thermal interactions between THz radiation and ALP, as well as suggests that THz spectroscopy is a promising technique to distinguish ALP structures.
基金supported by the National Natural Science Foundation of China(Grant Nos.11272287 and 11472247)the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT13097)the Key Science and Technology Innovation Team Project of Zhejiang Province,China(Grant No.2013TD18)
文摘In this paper, we present the fractional Hamilton's canonical equations and the fractional non-Noether symmetry of Hamilton systems by the conformable fractional derivative. First/y, the exchanging relationship between isochronous variation and fractional derivatives, and the fractional Hamilton principle of the system under this fractional derivative are proposed. Secondly, the fractional Hamilton's canonical equations of Hamilton systems based on the Hamilton principle are established. Thirdly, the fractional non-Noether symmetries, non-Noether theorem and non-Noether conserved quantities for the Hamilton systems with the conformable fractional derivatives are obtained. Finally, an example is given to illustrate the results.
基金Project supported by the Graduate Students Innovative Foundation of China University of Petroleum (East China) (Grant NoS2009-19)
文摘This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conformal invariance of the system are presented. The conformal factor expression is deduced from conformal invariance and Lie symmetry. The necessary and sufficient condition that conformal invaxiance of the system would have Lie symmetry under single-parameter infinitesimal transformations is obtained. The corresponding conserved quantity of conformal invariance is derived with the aid of a structure equation. Lastly, an example is given to illustrate the application of the results.
文摘This paper provides an introduction to the topic of water shutoff and conformance improvement. After indicating the volumes of water produced during oilfield operations, a strategy is provided for attacking excess water production problems. Problem types are categorized, typical methods of problem diagnosis are mentioned, and the range of solutions is introduced for each problem type. In the third section of the paper, the concept of disproportionate permeability reduction is introduced—where polymers and gels may reduce permeability to water more than to oil or gas. When and where this property is of value is discussed. The fourth section describes the properties of formed gels as they extrude through fractures and how those properties can be of value when treating conformance problems caused by fractures. Section 5 covers the efficiency with which gels block fractures after gel placement—especially, the impact of fluids injected subsequent to the gel treatment.
基金supported by Shanxi Provincial Key Research and Development Project(No.20201102002)the Science Foundation of China University of Petroleum,Beijing(No.2462020BJRC007,2462020YXZZ003)State Key Laboratory of Petroleum Resources and Prospecting,China University of Petroleum(No.PRP/DX-2216)
文摘Excess water production has become an important issue in the oil and gas extraction process.Preformed particle gels(PPGs),show the capability to control the conformance and reduce excess water cut.However,conventional PPGs have poor mechanical properties and their swollen particles are easily damaged by shearing force when passing through the fractures in formations,meanwhile PPGs can be also degraded into various byproducts,leading to permanent damage to the reservoir permeability after temporary plugging.Herein,a novel type of dual cross-linked PPGs(dPPGs)was designed and synthesized using sodium alginate(SA)and acrylamide(AAm),cross-linked with N,N’-methylenebisacrylamide(MBA)and Fe^(3+).Results show that dPPGs have excellent mechanical properties with a storage modulus up to 86,445 Pa,which is almost 20 times higher than other reported PPGs.Meanwhile,dPPGs can be completely degraded into liquid without any solid residues or byproducts and the viscosity of dPPGs degraded liquid was found to be lower than 5 mPa·s.A laboratory coreflooding test showed that the plugging efficiency of dPPGs was up to 99.83%on open fractures.The obtained results demonstrated that dPPGs could be used as economical and environment-friendly temporary plugging agent with high-strength,self-degradation,thermal stability,and salt stability,thus making it applicable to a wide range of conformance control to enhance oil recovery.
基金supported by the National Natural Science Foundation of China(52004305)the Postdoctoral Research Foundation of China(2021M693497)the Science Foundation of China University of Petroleum,Beijing(2462020XKBH006)。
文摘Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling plugging.Finding an effective method for the gas channeling plugging is a critical issue in the CO_(2)EOR process.In this work,an acid-resistance microgel named dispersed particle gel(DPG)was characterized and its stability was tested in the CO_(2)environment.The microgel size selection strategies for the homogeneous and heterogeneous reservoirs were respectively investigated using the single core flooding and three parallel core flooding experiments.Moreover,the comparison of microgel alternate CO_(2)(MAC)injection and water alternate CO_(2)(WAC)injection in the dual core flooding experiments were presented for the investigation of the role of microgel on the conformance control in CO_(2)flooding process.The results have shown that the microgel featured with ANH and CAN groups can keep its morphology after aging 7 days in the CO_(2)environment.Where,the small microgel with unobstructed migration and large microgel with good plugging efficiency for the high permeability zone were respectively featured with the higher recovery factor in homogeneous and heterogeneous conditions,which indicate they are preferred used for the oil displacement and conformance control.Compared to WAC injection,MAC injection had a higher incremental recovery factor of 12.4%.It suggests the acid-resistance microgel would be a good candidate for the conformance control during CO_(2)flooding process.
文摘Objective: To evaluate the clinical effect of gemcitabine and concurrent three-dimensional conformal radiation therapy (3D-CRT) for locally advanced non-small cell lung cancer (NSCLC). Methods: From April 2002 to June 2005, 38 patients with inoperable stage Ⅲ NSCLC were treated with gemcitabine and 3D-CRT simultaneously. Chemotherapy consisted of intravenously gemcitabine 350 mg/m^2 on days 1, 8, 15, 22, 29, 36.3D-CRT was delivered up to a total dose of 60-64 Gy with a 2.0 Gy dose fraction per day, 5 days per week. Results: The overall response rates of primary tumor and mediastinum metastatic node were 86.8% (33/38) and 90.6% (29/32) respectively, and 91.7% (22/24) and 78.6% (11/14) for squamous cell carcinoma and adenocarcinoma respectively. The acute side effects of patients were mostly myelosuppression, nausea, vomiting, radiation-induced esophagitis and pneumonitis (RTOG 1/11), however, all of them were cured. Conclusion: Concurrent application of gemcitabine and 3D-CRT can improve the overall response rate for locally advanced NSCLC without aggravating the side effects.
基金supported by the Research Foundation of China University of Petroleum-Beijing at Karamay (No. XQZX20200010)the Natural Science Foundation of Xinjiang Uygur Autonomous Region (No. 2019D01B57)+3 种基金the Tianshan Talent Project (No. 2019Q025)the Sichuan Province Regional Innovation Cooperation Project (No. 2020YFQ0036)the Science and Technology Department of Shaanxi Province (No. 2021JQ-836)the CNPC Strategic Cooperation Science and Technology Project (ZLZX2020-01-04-04)。
文摘Polymer gel systems have been widely applied to control excessive water and improve oil recovery(IOR)in petroleum reservoirs.They are usually divided into two main types,in-situ cross-linked polymer gels,and pre-formed polymer gels.In recent years,nuclear magnetic resonance(NMR) technology has been gradually applied to the research of polymer gel systems due to its unique analysis advantages.This paper is intent to review these works systematically.For in-situ cross-linked polymer gel systems,NMR can be used to characterize the chemical structure changes of the polymer,the cross-linker,and the auxiliary agent in the formulation of the polymer gel systems.Moreover,the gelation time and the gel strength of the in-situ cross-linked polymer gel systems can also be measured by NMR.For pre-formed polymer gels,NMR can be employed to detect the chemical structure of the designed products.Last,the NMR method can evaluate the plugging,water control,and oil improvement performance of the polymer gels in porous media without using dopants.This review can help readers build a more systematic understanding of the application of NMR technology in polymer gel systems for IOR and help re searchers to more deeply study the performance of polymer gel systems.
文摘Globally, traditional power systems are rapidly transforming towards the adoption of smart grid platforms. Substations which are at the center of the electric power transformation from the power plant are changing to IEC 61850 based digital substations. Therefore, within substation, there is a growing demand for the IEC 61850 based Intelligent Electronic Devices (IEDs). The operation of multiple manufacturers of IEDs in a single digital substation network increases the need for IEC 61850 communications specification conformance diagnosis to ensure interoperability for efficient data exchange between IEDs. The IEC 61850-10 presents test items for diagnosing communication specification conformance. There are many test tools available in the market today to test the compliance of the IEC 61850 communications specifications to the IED. In this paper, we propose a model-based diagnostic method for IED communication conformance testing. The proposed model-based software therefore uses the “drag and drop” technique to select the various IEC 61850 communication services (objects) required to design the test case in a user friendly Graphical User Interface (GUI). This makes the service conformance testing more flexible for test engineers and system integrators especially in situations that require test case modifications. Also, the proposed software tool makes it easy to understand the various IEC 61850 services using the friendly GUI.
基金supported by Science Foundation of China University of Petroleum,Beijing(No.2462022BJRC001,2462021YJRC012)the funding from State Key Laboratory of Petroleum Resources and Prospecting(No.PRP/indep-1-2103)
文摘Injecting CO2into hydrocarbon reservoirs can enhance the recovery of hydrocarbon resources,and simultaneously,CO2can be stored in the rese rvoirs,reducing considerable amount of carbon emissions in the atmosphere.However,injected CO_(2)tends to go through fractures,high-permeability channels and streaks present in reservoirs,resulting in inefficient hydrocarbon recovery coupled with low CO_(2)storage performance.Conformance treatments with CO_(2)-resistant crosslinked polymer gels were performed in this study to mitigate the CO_(2)channeling issue and promote the synergy between enhanced oil recovery(EOR) and subsurface sequestration of CO_(2).Based on a typical low-permeability CO_(2)-flooding reservoir in China,studies were performed to investigate the EOR and CO_(2)storage performance with and without conformance treatment.The effect of permeability contrast between the channels and rese rvoir matrices,treatment size,and plugging strength on the efficiency of oil recovery and CO_(2)storage was systematically investigated.The results indicated that after conformance treatments,the CO_(2)channeling problem was mitigated during CO_(2)flooding and storage.The injected CO_(2)was more effectively utilized to recover the hydrocarbons,and entered wider spectrum of pore spaces.Consequently,more CO_(2)was trapped underground.Pronounced factors on the synergy of EOR and CO_(2)storage were figured out.Compared with the treatment size,the CO_(2)storage efficiency was more sensitive to the plugging strength of the conformance treatment materials.This observation was important for conformance treatment design in CCUS-EOR projects.According to this study,the materials should reduce the channel permeability to make the channel/matrix permeability ratio below 30.The results demonstrate the importance of conformance treatment in maximizing the performance of CCUS-EOR process to achieve both oil recovery improvement and efficient carbon storage.This study provides guidelines for successful field applications of CO_(2)transport control in CO_(2)geo-utilization and storage.
基金supported by a grant from the Natural Science Foundation of Ningxia Hui Autonomous Region,China(No.NZ0680)
文摘OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy (CRT). In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose (DT) of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect (CR + PR) was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.
文摘Objective: To study the toxicities and efficacy of concurrent gemcitabine plus cisplatin combined with three-dimensional conformal radiotherapy for stage Ⅲ non-small cell lung cancer (NSCLC). Methods: Thirty-six patients with pathologically diagnosed NSCLC received radiotherapy and concurrent chemotherapy. There were 22 patients with stage Ilia and 14 patients with IIIb. Radiotherapy was given a total of 60-70 Gy in conventional fractionation. Chemotherapy included gemcitabine (600 mg/m^2) and cisplatin (20 mg/m^2), once per week. Results: Thirty-two patients received a total dose of 60-72 Gy. Two patients received 56 Gy and another two patients received 58 Gy. Thirty-four patients received 4-6 weeks of chemotherapy, while two patients received only 2 weeks of chemotherapy. The overall response rate (CR + PR), complete response rate (CR), partially response rate (PR) were 83.3% (30/36), 11.1% (4/36) and 72.2% (26/36) respectively. The median follow-up duration was 18.4 months. The 1- and 2-year overall survival rates were 77.8% (28/36) and 55.6% (20/36), respectively. Conclusion: Concurrent gemcitabine and cisplatin combined with three-dimensional conformal radiotherapy for stage III non-small cell lung cancer is effective and well tolerated. Lone-term results need further study.
基金This work is financially supported by the National Natural Science Foundation of China(52303036)the Natural Science Foundation of Guangxi Province(2020GXNSFAA297028)+4 种基金the Guangxi Science and Technology Base and Talent Special Project(GUIKE AD23026179)the International Science&Technology Cooperation Project of Chengdu(2021-GH03-00009-HZ)the Program of Innovative Research Team for Young Scientists of Sichuan Province(22CXTD0019)the Natural Science Foundation of Sichuan Province(2023NSFSC0986)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(Sklpme2023-3-18).
文摘Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.
文摘The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence value.Given the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential failures.To address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its output.The proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test dataset.The CP was evaluated on a rockburst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence levels.Significantly,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed decision-making.The proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.