<strong>Objective:</strong><span style="font-family:Verdana;"> To determine and compare the effect of vitamin D3 supplementation on modifying the disease severity in cystic fibrosis (CF) an...<strong>Objective:</strong><span style="font-family:Verdana;"> To determine and compare the effect of vitamin D3 supplementation on modifying the disease severity in cystic fibrosis (CF) and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis pediatric patients.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A randomized clinical trial evaluating the role of oral vitamin D3 supplementation for six months, was performed in forty patients with CF and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis under the age of 18 years with vitamin D deficiency or insufficiency. The primary outcome was to reach the sufficient Vitamin D level, the secondary outcome was to reevaluate bronchiectasis severity by following up the frequency, severity of pulmonary exacerbations and lung function after vitamin D3 supplementation.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Results:</span></b><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">Forty patients completed the trial. The percentage of improvement of vitamin D level after vitamin D3 supplementation for six months was significantly higher in CF (88.3%) than non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis patients (59.82%)</span><span style="font-family:""> </span><span style="font-family:Verdana;">(P =</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.03).</span><span style="font-family:""> </span><span style="font-family:Verdana;">Additionally, moderate to severe pulmonary exacerbations significantly decreased by more than 60%, 45% (P</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.001,</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.005) and frequent exacerbations decreased by 15%, 10% (P</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.327, 0.490), while the forced expiratory volume in 1 (FEV1) significantly increased by 17% and 15% in non CF bronchiectasis and CF patients respectively (p</span><span style="font-family:""> </span><span style="font-family:Verdana;"><</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.001).</span><b><span style="font-family:Verdana;"> Conclusions: </span></b><span style="font-family:Verdana;">Vitamin D3 therapy was effective in decreasing the frequency and severity of pulmonary exacerbations and preserving lung function. Thereby, improving the disease severity even more in non</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis than CF patients.</span>展开更多
Current studies of a seawater axial piston pump mainly solve the problems of corrosion and wear in a slipper pair by selecting materials with corrosion resistance, self-lubrication, and wear resistance. In addition, a...Current studies of a seawater axial piston pump mainly solve the problems of corrosion and wear in a slipper pair by selecting materials with corrosion resistance, self-lubrication, and wear resistance. In addition, an appropriate biomimetic non-smooth surface design for the slipper pair can further improve the tribological behavior. In this paper, 316 L stainless steel and CF/PEEK were selected to process the upper and bottom specimens, and the biomimetic non-smooth surface was introduced into the interface between the friction pair. The friction and wear tests were performed on a MMD-5 A tester at a rotation speed of 1000 r/min and load of 200 N under seawater lubricated condition. The results indicate that the main friction form of the smooth surface friction pair corresponds to abrasive wear and adhesive wear and that it exhibits a friction coe cient of 0.05–0.07, a specimen temperature of 56 ℃, a high wear rate, and surface roughness. Pits on the non-smooth surface friction pairs produced hydrodynamic lubrication and reduced abrasive wear, and thus the plowing e ect is their main friction form. The non-smooth surface friction pairs exhibit a friction coe cient of 0.03–0.04, a specimen temperature of 48 ℃, a low wear rate, and surface roughness. The study has important theoretical significance for enriching the lubrication, friction, and wear theory of a seawater axial piston pump, and economic significance and military significance for promoting the marine development and the national defense military.展开更多
目的采用非培养法研究成年非CF支气管扩张患者呼吸道菌群特点及与临床指标间的相关性。方法入选23例非CF支气管扩张患者(实验组,n=23)和15例健康志愿者(对照组,n=15),记录所有研究对象的一般临床指标,并收集痰液标本和支气管肺泡灌洗液...目的采用非培养法研究成年非CF支气管扩张患者呼吸道菌群特点及与临床指标间的相关性。方法入选23例非CF支气管扩张患者(实验组,n=23)和15例健康志愿者(对照组,n=15),记录所有研究对象的一般临床指标,并收集痰液标本和支气管肺泡灌洗液标本。对痰液标本进行传统细菌培养和16S r DNA测序,对支气管肺泡灌洗液标本行16S r DNA测序。分析受试者呼吸道菌群特点及其与患者临床指标间的关系。结果痰标本焦磷酸测序检测到铜绿假单胞菌和流感嗜血杆菌的频率要高于标准培养法报告的频率。两组均显示,痰标本比BAL标本提供了更多的测序序列。细菌群落多样性与FEV1呈正的线性相关。Mantel检验显示,菌落组成的相似性和FEV1间有显著相关性,全部菌种与LCS、痰中性粒细胞数和性别间有显著相关性。结论非CF支气管扩张患者下呼吸道菌群的多样性与临床检测指标间有相关性。展开更多
Resistive random access memory (RRAM) has received significant research interest because of its promising potential in terms of down-scaling,high density,high speed and low power. However,its endurance,retention and u...Resistive random access memory (RRAM) has received significant research interest because of its promising potential in terms of down-scaling,high density,high speed and low power. However,its endurance,retention and uniformity are still imperfect. In this article,the physical mechanisms of filament-type RRAM and the approaches for improving the switching performance,including doping,process optimization and interface engineering,are introduced.展开更多
文摘<strong>Objective:</strong><span style="font-family:Verdana;"> To determine and compare the effect of vitamin D3 supplementation on modifying the disease severity in cystic fibrosis (CF) and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis pediatric patients.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A randomized clinical trial evaluating the role of oral vitamin D3 supplementation for six months, was performed in forty patients with CF and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis under the age of 18 years with vitamin D deficiency or insufficiency. The primary outcome was to reach the sufficient Vitamin D level, the secondary outcome was to reevaluate bronchiectasis severity by following up the frequency, severity of pulmonary exacerbations and lung function after vitamin D3 supplementation.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Results:</span></b><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">Forty patients completed the trial. The percentage of improvement of vitamin D level after vitamin D3 supplementation for six months was significantly higher in CF (88.3%) than non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis patients (59.82%)</span><span style="font-family:""> </span><span style="font-family:Verdana;">(P =</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.03).</span><span style="font-family:""> </span><span style="font-family:Verdana;">Additionally, moderate to severe pulmonary exacerbations significantly decreased by more than 60%, 45% (P</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.001,</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.005) and frequent exacerbations decreased by 15%, 10% (P</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.327, 0.490), while the forced expiratory volume in 1 (FEV1) significantly increased by 17% and 15% in non CF bronchiectasis and CF patients respectively (p</span><span style="font-family:""> </span><span style="font-family:Verdana;"><</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.001).</span><b><span style="font-family:Verdana;"> Conclusions: </span></b><span style="font-family:Verdana;">Vitamin D3 therapy was effective in decreasing the frequency and severity of pulmonary exacerbations and preserving lung function. Thereby, improving the disease severity even more in non</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">CF bronchiectasis than CF patients.</span>
基金Supported by National Natural Science Foundation of China(Grant No.51375421)Key Project of Science and Technology Plan of Higher Education of Hebei Province of China(Grant No.ZD20131027)Youth Project of Basic Research Project of Yanshan University(Grant No.14LGB032)
文摘Current studies of a seawater axial piston pump mainly solve the problems of corrosion and wear in a slipper pair by selecting materials with corrosion resistance, self-lubrication, and wear resistance. In addition, an appropriate biomimetic non-smooth surface design for the slipper pair can further improve the tribological behavior. In this paper, 316 L stainless steel and CF/PEEK were selected to process the upper and bottom specimens, and the biomimetic non-smooth surface was introduced into the interface between the friction pair. The friction and wear tests were performed on a MMD-5 A tester at a rotation speed of 1000 r/min and load of 200 N under seawater lubricated condition. The results indicate that the main friction form of the smooth surface friction pair corresponds to abrasive wear and adhesive wear and that it exhibits a friction coe cient of 0.05–0.07, a specimen temperature of 56 ℃, a high wear rate, and surface roughness. Pits on the non-smooth surface friction pairs produced hydrodynamic lubrication and reduced abrasive wear, and thus the plowing e ect is their main friction form. The non-smooth surface friction pairs exhibit a friction coe cient of 0.03–0.04, a specimen temperature of 48 ℃, a low wear rate, and surface roughness. The study has important theoretical significance for enriching the lubrication, friction, and wear theory of a seawater axial piston pump, and economic significance and military significance for promoting the marine development and the national defense military.
文摘目的采用非培养法研究成年非CF支气管扩张患者呼吸道菌群特点及与临床指标间的相关性。方法入选23例非CF支气管扩张患者(实验组,n=23)和15例健康志愿者(对照组,n=15),记录所有研究对象的一般临床指标,并收集痰液标本和支气管肺泡灌洗液标本。对痰液标本进行传统细菌培养和16S r DNA测序,对支气管肺泡灌洗液标本行16S r DNA测序。分析受试者呼吸道菌群特点及其与患者临床指标间的关系。结果痰标本焦磷酸测序检测到铜绿假单胞菌和流感嗜血杆菌的频率要高于标准培养法报告的频率。两组均显示,痰标本比BAL标本提供了更多的测序序列。细菌群落多样性与FEV1呈正的线性相关。Mantel检验显示,菌落组成的相似性和FEV1间有显著相关性,全部菌种与LCS、痰中性粒细胞数和性别间有显著相关性。结论非CF支气管扩张患者下呼吸道菌群的多样性与临床检测指标间有相关性。
基金supported by the National Basic Research Program of China (2010CB934200 and 2008CB925002)the National Natural Science Foundation of China (60825403 and 50972160)the National High-Tech Research & Development Program of China (2008AA031403 and 2009AA03Z306)
文摘Resistive random access memory (RRAM) has received significant research interest because of its promising potential in terms of down-scaling,high density,high speed and low power. However,its endurance,retention and uniformity are still imperfect. In this article,the physical mechanisms of filament-type RRAM and the approaches for improving the switching performance,including doping,process optimization and interface engineering,are introduced.
