Objective To show the distribution of facial exposure to non-melanoma biologically effective UV irradiance changes by rotation angles. Methods This study selected the cheek, nose, and forehead as representative facial...Objective To show the distribution of facial exposure to non-melanoma biologically effective UV irradiance changes by rotation angles. Methods This study selected the cheek, nose, and forehead as representative facial sites for UV irradiance measurements, which were performed using a rotating manikin and a spectroradiometer. The measured UV irradiance was weighted using action spectra to calculate the biologically effective UV irradiances that cause non-melanoma （UVBEnon.rnel） skin cancer. The biologically effective UV radiant exposure （HBEnon-mel） was calculated by summing the UVBEnon-mel data collected over the exposure period. Results This study revealed the following： （1） the maximum cheek, nose and forehead exposure UVA and UVB irradiance times and solar elevation angles （SEA） differed from those of the ambient UV irradiance and were influenced by the rotation angles; （2） the UV irradiance exposure increased in the following order： cheek 〈 nose 〈 forehead; （3） the distribution of UVBEnon-mel irradiance differed from that of unweighted UV radiation （UVR） and was influenced by the rotation angles and exposure times; and （4） the maximum percentage decreases in the UVBEnon-melradiant exposure for the cheek, nose and forehead from 0° to 180° were 48.41%, 69.48% and 71.71%, respectively. Conclusion Rotation angles relative to the sun influence the face＇s exposure to non-melanoma biologically effective UV.展开更多
Background: Reviewing and analyzing the Clinico-pathologic aspects of non-melanoma skin cancer of the head and neck (NMSCHN), type of management, prognostic factors, and disease-free survival (DFS) in a period of 5 ye...Background: Reviewing and analyzing the Clinico-pathologic aspects of non-melanoma skin cancer of the head and neck (NMSCHN), type of management, prognostic factors, and disease-free survival (DFS) in a period of 5 years at the National Cancer Institute—Cairo University—Egypt. Materials and Methods: A retrospective study of two hundred patients with NMSCHN was treated at the National Cancer Institute—Cairo University—Egypt from January 2008 to December 2012. The mean follow-up was 6 months (1 - 84 months). Results: 117 males and 83 females with 90% ≥ 50 years old. The scalp (27.5%), the periorbital region (13%), the cheek (12.5%) and the nose (12.5%) are the main anatomical sites affected. BCC represented 71.5% with nodular type (79%) predominance;SCC represented 21% with GII (61.1%) the commonest grade. Surgery was the main modality of treatment (93%) with local flaps only (63.9%) and primary closure (14.7%) were the main surgical options following wide local excision. Positive and close margins were detected in 23.5% of excised specimens. No significant association was found between disease-free survival (DFS) and pathology, treatment modality, the occurrence of complications or safety margin status. Conclusion: NMSCHN lesions should be surgically excised in specialized high volume centers with readily available peripheral margin control and should be operated by senior experienced surgeons.展开更多
The management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic spread.Metastatic non-melanoma skin cancers to the parotid...The management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic spread.Metastatic non-melanoma skin cancers to the parotid and neck often behave aggressively,with a high incidence of local recurrence after treatment and reduced five-year survival outcomes.Patterns of lymphatic spread are different from those seen in mucosal squamous cell carcinoma,with higher prevalence of disease in the parotid and superficial lymphatics.These factors require that treatment is individualized to achieve optimal outcomes.Traditionally,the management of non-melanoma skin cancers metastatic to lymph nodes has involved surgical excision followed by adjuvant radiation therapy.However,novel systemic therapies are showing promising results and their role in the management of these cancers is evolving.展开更多
糖蛋白非转移性黑色素瘤蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)是一种I型跨膜蛋白,多富集在癌细胞表面,在巨噬细胞和小胶质细胞中呈高表达。GPNMB在肿瘤进展及免疫反应中发挥了重要作用,其胞外结构域与整合素相...糖蛋白非转移性黑色素瘤蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)是一种I型跨膜蛋白,多富集在癌细胞表面,在巨噬细胞和小胶质细胞中呈高表达。GPNMB在肿瘤进展及免疫反应中发挥了重要作用,其胞外结构域与整合素相互作用,能促进免疫抑制,并能促进血管生成细胞募集到肿瘤微环境,从而影响肿瘤的免疫反应,有可能可作为免疫治疗及靶向治疗的潜在靶点。展开更多
基金supported by the National Natural Science Foundation of China(No.81273034)Program for Liaoning Innovative Research Team in University(Grant number LT2015028)
文摘Objective To show the distribution of facial exposure to non-melanoma biologically effective UV irradiance changes by rotation angles. Methods This study selected the cheek, nose, and forehead as representative facial sites for UV irradiance measurements, which were performed using a rotating manikin and a spectroradiometer. The measured UV irradiance was weighted using action spectra to calculate the biologically effective UV irradiances that cause non-melanoma （UVBEnon.rnel） skin cancer. The biologically effective UV radiant exposure （HBEnon-mel） was calculated by summing the UVBEnon-mel data collected over the exposure period. Results This study revealed the following： （1） the maximum cheek, nose and forehead exposure UVA and UVB irradiance times and solar elevation angles （SEA） differed from those of the ambient UV irradiance and were influenced by the rotation angles; （2） the UV irradiance exposure increased in the following order： cheek 〈 nose 〈 forehead; （3） the distribution of UVBEnon-mel irradiance differed from that of unweighted UV radiation （UVR） and was influenced by the rotation angles and exposure times; and （4） the maximum percentage decreases in the UVBEnon-melradiant exposure for the cheek, nose and forehead from 0° to 180° were 48.41%, 69.48% and 71.71%, respectively. Conclusion Rotation angles relative to the sun influence the face＇s exposure to non-melanoma biologically effective UV.
文摘Background: Reviewing and analyzing the Clinico-pathologic aspects of non-melanoma skin cancer of the head and neck (NMSCHN), type of management, prognostic factors, and disease-free survival (DFS) in a period of 5 years at the National Cancer Institute—Cairo University—Egypt. Materials and Methods: A retrospective study of two hundred patients with NMSCHN was treated at the National Cancer Institute—Cairo University—Egypt from January 2008 to December 2012. The mean follow-up was 6 months (1 - 84 months). Results: 117 males and 83 females with 90% ≥ 50 years old. The scalp (27.5%), the periorbital region (13%), the cheek (12.5%) and the nose (12.5%) are the main anatomical sites affected. BCC represented 71.5% with nodular type (79%) predominance;SCC represented 21% with GII (61.1%) the commonest grade. Surgery was the main modality of treatment (93%) with local flaps only (63.9%) and primary closure (14.7%) were the main surgical options following wide local excision. Positive and close margins were detected in 23.5% of excised specimens. No significant association was found between disease-free survival (DFS) and pathology, treatment modality, the occurrence of complications or safety margin status. Conclusion: NMSCHN lesions should be surgically excised in specialized high volume centers with readily available peripheral margin control and should be operated by senior experienced surgeons.
文摘The management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic spread.Metastatic non-melanoma skin cancers to the parotid and neck often behave aggressively,with a high incidence of local recurrence after treatment and reduced five-year survival outcomes.Patterns of lymphatic spread are different from those seen in mucosal squamous cell carcinoma,with higher prevalence of disease in the parotid and superficial lymphatics.These factors require that treatment is individualized to achieve optimal outcomes.Traditionally,the management of non-melanoma skin cancers metastatic to lymph nodes has involved surgical excision followed by adjuvant radiation therapy.However,novel systemic therapies are showing promising results and their role in the management of these cancers is evolving.
文摘糖蛋白非转移性黑色素瘤蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)是一种I型跨膜蛋白,多富集在癌细胞表面,在巨噬细胞和小胶质细胞中呈高表达。GPNMB在肿瘤进展及免疫反应中发挥了重要作用,其胞外结构域与整合素相互作用,能促进免疫抑制,并能促进血管生成细胞募集到肿瘤微环境,从而影响肿瘤的免疫反应,有可能可作为免疫治疗及靶向治疗的潜在靶点。
