Microarray Analysis Using Rank Order Statistics for ARCH Residual Empirical Process

Statistical two-group comparisons are widely used to identify the significant differentially expressed (DE) signatures against a therapy response for microarray data analysis. We applied a rank order statistics based on an Autoregressive Conditional Heteroskedasticity (ARCH) residual empirical process to DE analysis. This approach was considered for simulation data and publicly available datasets, and was compared with two-group comparison by original data and Auto-regressive (AR) residual. The significant DE genes by the ARCH and AR residuals were reduced by about 20% - 30% to these genes by the original data. Almost 100% of the genes by ARCH are covered by the genes by the original data unlike the genes by AR residuals. GO enrichment and Pathway analyses indicate the consistent biological characteristics between genes by ARCH residuals and original data. ARCH residuals array data might contribute to refining the number of significant DE genes to detect the biological feature as well as ordinal microarray data.

ESMO2023:恩扎卢胺联合雄激素剥夺治疗对比安慰剂联合雄激素剥夺治疗在中国转移性激素敏感性前列腺癌患者中的疗效和安全性(中国ARCHES)

2019年发表的全球ARCHES试验(NCT02677896)结果显示,与安慰剂(placebo,PBO)+雄激素剥夺治疗(androgen deprivation therapy,ADT)相比,恩扎卢胺+ADT延长了转移性激素敏感性前列腺癌(metastatic hormone-sensitive prostate cancer,mHSPC)患者的总生存期和放射影像学无进展生存期(radiographic progression-free survival,rPFS)^([1])。然而,该试验无中国患者入组。欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)2023年会议报道了中国ARCHES研究(NCT04076059)的初步结果,这是一项评估恩扎卢胺+ADTvs.PBO+ADT在中国m HSPC患者中的疗效和安全性的多中心、随机、双盲、PBO对照的Ⅲ期试验^([2])。

MDCT of right aortic arch with aberrant left subclavian artery associated with kommerell diverticulum and calcified ligamentum arteriosum

We present a case of the right aortic arch with kommerell diverticulum (KD) and aberrant left subclavian artery in a symptomatic 50-year-old patient with a calcification in the presumed attachment site of the ligamentum arteriosum (LA) to the KD. In another 30-year-old male patient, the entire course of a calcified LA was demonstrated using multidetector row computed tomography.

被动桩中土拱形成机理的平面有限元分析

国内外对被动桩中土拱形成机理的研究比较少,尤其针对不同土性土体中这类问题的对比研究更是少见。借助平面有限元数值方法,对粘性土与无粘性土中被动桩间的土拱形成机理作了研究和对比分析,并讨论了土拱形成过程与土拱效应随土体参数如粘聚力、内摩擦角、弹性模量、剪胀角、泊松比、桩土接触特征的变化规律。研究表明:土性不同时,土拱形成过程中桩周土体的受力和破坏形式不同;剪胀角、泊松比、桩土接触特征对桩间土拱形成机理和效应影响明显。

中国绍兴现存古石桥建筑

中国绍兴地区现存民国以前古石桥600多座,连续跨越1600多年,形成一种古桥文化体系,在世界上是无与伦比的。因此应申报世界文化遗产。为了国内外同行对绍兴古桥有所了解,绍兴朋友曾与笔者撰两文首先在国外作初步宣传。在此基础上笔者进一步学习和再次去绍兴实地考察并拍摄照片以增加感性认识。现从12个方面予以综合介绍。这些桥从结构上可分两大类:梁桥和拱桥,其中梁桥含石梁柱桥、石梁墩桥、伸臂支承梁桥、有异形平面的梁桥和梁拱组合桥,拱桥有多种型式,这包括圆弧形拱桥、半圆形拱桥、马蹄形拱桥、折线形拱桥和悬链线形拱桥。为了申遗,笔者谨提出些不成熟想法供有关方面参考,如清理有代表性古桥的环境对周围进行某些拆除,更换桥上风化石块,对古桥年代予以科学鉴定,恢复少数更改过的桥名,因海外侨胞只记得或只知道原桥名……等。

A History of the Urban Underground Tunnel (4000 B.C.E. - 1900 C.E.)

Generally hidden from public view, out of our daily thoughts, and literally under our feet, are myriad urban underground tunnels that make our modern megacities possible. From their ancient beginnings in antiquity, as a means of supplying fresh water and draining waste water from cities, underground tunnels evolved into a means of providing high capacity rail mass transit in our most densely populated urban centers. This paper provides a broad overview of the evolution of urban tunnels across a 6000 year time span and includes the specific engineering formulas/computations for the earliest 19th century subways/infrastructure projects based on the Roman vaulted arch tunnel.

Evaluation of revascularization after total arch replacement in common carotid artery occlusion

Occlusion of the common carotid artery(CCA) is rare. CCA occlusion(CCAO) can present as drowsiness and right hemiplegia related to emboli after total arch replacement. Although we selected a follow-up at first because color duplex sonography showed retrograde flow from the left external carotid artery to the internal carotid artery, this patient had epilepsy and single-photon emission computed tomography(SPECT) acquired quantitative results of actual brain perfusion and showed insufficient collateral blood flow. To improve brain perfusion, we performed a bypass of the left subclavian artery to left CCA bypass. Postoperatively, the patient did not have epilepsy and drowsiness. Also, right hemiplegia improved enough for him to walk with support. SPECT showed increased left cerebral flow(the asymmetry ratio was 71% to 81%). Evaluation of the carotid artery with color duplex sonography alone was insufficient when CCAO showed retrograde or collateral flow. We should have performed quantitative evaluation with SPECT at the same time.

Numerical Simulation Analysis of Welded Joints in Arch Ribs of Large Span Steel Pipe Arch Bridges

In order to study the residual stress distribution law of welded joints of arch ribs of large-span steel pipe concrete arch bridges,numerical simulation of temperature,stress and strain fields based on ABAQUS for welded joints of arch-ribbed steel tubes using 7-,8-and 9-layer welds is carried out and its accuracy is demonstrated.The steel pipe welding temperature changes,residual stress distribution,different processes residual stress changes in the law,the prediction of post-weld residual stress distribution and deformation are studied in this paper.The results show that the temperature field values and test results are more consistent with the accuracy of numerical simulation of welding,the welding process is mainly in the form of heat transfer;Residual high stresses are predominantly distributed in the Fusion zone(FZ)and Heat-affected zone(HAZ),with residual stress levels tending to decrease from the center of the weld along the axial path,the maximum stress appears in the FZ and HAZ junction;The number of welding layers has an effect on the residual stress distribution,the number of welding layers increases,the residual stress tends to decrease,while the FZ and HAZ high stress area range shrinks;Increasing the number of plies will increase the amount of residual distortion.

Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in China.Safety control is essential to long-term operation of these dams.This study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in China.Subsequently,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect characteristics.These findings revealed the governing mechanism of main factors.Furthermore,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch dams.This model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation differences.Ultimately,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam performance.Additionally,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably interpreted.Validation of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan dam.The findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

大跨度钢桁架拱桥的极限承载力研究

在强地震设防区或桥梁承受铁路荷载且地质条件良好时,钢桁架拱桥是理想的大跨度桥梁选择方案。以朝天门大桥和大宁河大桥为背景,从边界条件、初始状态、荷载要素等几个关键影响参数着手,对大跨度钢桁架拱桥的极限承载能力进行参数研究,指出活载的布置形式、侧向风荷载及不同的约束条件对钢桁架拱桥的极限承载力有较大影响。

高拱坝结构安全的风险源集及主要失效路径研究

基于风险理论开展大坝安全性评估是一种发展趋势,其中风险源辨识是大坝风险分析的重要方面。结合高拱坝的结构特点和所处区域环境条件,对其面临的风险源集进行了分类,从自然灾害风险源、大坝构筑物及坝肩(基)稳定性影响风险源、人为原因影响风险源3个方面,阐述了高拱坝面临的主要风险源集,并根据锦屏一级高拱坝的模型试验研究成果,探讨了高拱坝的主要失效模式和失效路径,可为更详实的高拱坝风险分析提供基础支撑。

ARCH类模型研究及其在沪市A股中的应用

本文主要介绍ARCH(AutoregressiveConditionalHeteroskedasticity)模型、GARCH模型和E GARCH模型 ,分析这些模型的特点和适用范围 ,并在模型中引入t分布取代正态分布假设 ,最后利用这些模型对上证指数进行了实证分析。

The New Arched Bridge over Dnipro in Kyiv

The Podilskyi Arch bridge is crossing the Dnipro River in center of Kiev and is part of a 7.4 km long link which connects the center of Kiev with the “sleeping district” on the left bank of the river. The bridge has a main span of 344 m intended for six lanes of vehicles in the top level and two metro lines in the bottom level plus large diameter water pipes. The bridge is of steel, except of the reinforced concrete bases of the lower parts of the arches. The draft design works began in 1991 and in 2005 parallel design and construction work started. Due to the financial crisis in Ukraine, the work was interrupted for several years but construction recommenced in 2018 and the bridge is now planned to be completed in 2020 and the first stage of the transition in 2022.

小湾水电站工程的挑战与思考

小湾水电站位于我国西南高山峡谷地区,地形地质条件复杂,坝高、库大,泄洪流量及功率大,技术难度高,在许多方面均超越了现行规程规范及以往的认知,极具挑战性。该工程复杂高边坡、拱坝及拱座、坝基岩体开挖卸荷松弛、混凝土骨料料源、拱坝混凝土温控及裂缝、物探检测与安全监测、引水发电系统及临时设施、"数值小湾"等方面积累的经验和教训,必将使我国的高拱坝建设迈上一个新台阶。

基于SARIMA-ARCH的电量预测模型

电量预测是供电单位购电的重要依据,是电力经济稳定运行的根本基础。提出采用SARIMA-ARCH融合模型对某地区售电量进行预测。首先,采用季节时间序列分析方法(SARIMA)对月度电量时间序列进行建模,通过ACF和PACF图筛选确定出最佳模型阶数,得到季节性时间序列模型(SARIMA)基础预测模型;提取模型残差的波动性,建立自回归条件异方差(ARCH)模型;最后,将SARIMA-ARCH模型与常规SRIAM和ARIMA的预测值进行对比分析。结果表明,SARIMAARCH混合模型的预测精度较高。

ARCH族模型对沪市综合指数的实证分析

本文选取沪市股价综合日指数(1999 01 01～2002 12 30)作为样本,根据有效市场理论,利用股指的随机游走过程对上海股市的有效性进行检验,建立ARCH模型验证上海股市的可预测性.实证结果发现,上海股市具有杠杆效应、波动集群性和波动持续性.

拱塔斜拉桥预应力索塔锚固区节段应力分析

某桥为主跨260 m三塔双索面预应力混凝土拱塔斜拉桥,采用空间有限元法对5种荷载工况下索塔锚固区节段应力进行分析。结果表明:空心矩形索塔内布置双向井字形预应力筋能够有效抵消斜拉索水平分力产生的拉应力;索力及预应力分别作用下,距离基准节段中心分别为1.2 m和1.5 m范围内,应力呈现渐进衰减趋势;设计计算中可通过控制侧墙与倒角交界处、斜拉索出口处以及锚块与塔壁交界等处混凝土应力,来控制整个索塔锚固区的应力分布。

Global Comprehensive Sensitivity Analysis of Arch Dam Construction Parameters Based on Orthogonal Experiment

The construction of arch dams exhibits high uncertainty. Sensitivity analysis of construction parameters is important for the design and optimization of dam construction duration. However, current research cannot fully consider the combined influences of multiple parameters on the total construction. To effectively analyze the duration of arch dam construction, this study proposes a global comprehensive sensitivity analysis method in view of the whole process of arch dam construction based on an orthogonal experiment. This method could comprehensively consider the influence of the construction parameters that may lead to the uncertainty of construction duration. In addition, this method is able to identify the key parameters that may have a significant effect on duration uncertainty and sums up the general rules of combined parameters' interaction effect, which provides a scientific basis for reasonable optimization of the duration of dam construction.

ARCH模型对上证指数收益波动性的实证研究

波动性是诸多经济和金融研究的一个重要方面。本文采用ARCH模型及其扩展模型对上证综合指数的波动性进行实证研究,结果显示我国股票市场收益有明显的尖峰厚尾性,波动集簇性以及波动的信息不对称性等特点,从而表明了我国股票市场与发达国家成熟市场有相似之处。