BACKGROUND Congenital heart disease(CHD)is a cardiovascular malformation caused by abnormal heart and/or vascular development in the fetus.In children with CHD,abnormalities in the development and function of the nerv...BACKGROUND Congenital heart disease(CHD)is a cardiovascular malformation caused by abnormal heart and/or vascular development in the fetus.In children with CHD,abnormalities in the development and function of the nervous system are common.At present,there is a lack of research on the preoperative neurological development and injury in young children with non-cyanotic CHD.AIM To determine the changes in white matter,gray matter,and cerebrospinal fluid(CSF)by magnetic resonance imaging(MRI)in children with non-cyanotic CHD as compared with healthy controls.METHODS Children diagnosed with non-cyanotic CHD on ultrasonography(n=54)and healthy control subjects(n=35)were included in the study.All the subjects were aged 1-3 years.Brain MRI was performed prior to surgery for CHD.The SPM v12 software was used to calculate the volumes of the gray matter,white matter,CSF,and the whole brain(sum of the gray matter,white matter,and CSF volumes).Volume differences between the two groups were analyzed.Voxel-based morphometry was used to compare specific brain regions with statistically significant atrophy.RESULTS Compared with the control group,the study group had significantly reduced whole-brain white matter volume(P<0.05),but similar whole-brain gray matter,CSF,and whole-brain volumes(P>0.05).As compared with the healthy controls,children with non-cyanotic CHD had mild underdevelopment in the white matter of the anterior central gyrus,the posterior central gyrus,and the pulvinar.CONCLUSION Children with non-cyanotic CHD show decreased white matter volume before surgery,and this volume reduction is mainly concentrated in the somatosensory and somatic motor nerve regions.展开更多
Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to ch...Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many patients.Metabolomics is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the targets.In order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).展开更多
文摘BACKGROUND Congenital heart disease(CHD)is a cardiovascular malformation caused by abnormal heart and/or vascular development in the fetus.In children with CHD,abnormalities in the development and function of the nervous system are common.At present,there is a lack of research on the preoperative neurological development and injury in young children with non-cyanotic CHD.AIM To determine the changes in white matter,gray matter,and cerebrospinal fluid(CSF)by magnetic resonance imaging(MRI)in children with non-cyanotic CHD as compared with healthy controls.METHODS Children diagnosed with non-cyanotic CHD on ultrasonography(n=54)and healthy control subjects(n=35)were included in the study.All the subjects were aged 1-3 years.Brain MRI was performed prior to surgery for CHD.The SPM v12 software was used to calculate the volumes of the gray matter,white matter,CSF,and the whole brain(sum of the gray matter,white matter,and CSF volumes).Volume differences between the two groups were analyzed.Voxel-based morphometry was used to compare specific brain regions with statistically significant atrophy.RESULTS Compared with the control group,the study group had significantly reduced whole-brain white matter volume(P<0.05),but similar whole-brain gray matter,CSF,and whole-brain volumes(P>0.05).As compared with the healthy controls,children with non-cyanotic CHD had mild underdevelopment in the white matter of the anterior central gyrus,the posterior central gyrus,and the pulvinar.CONCLUSION Children with non-cyanotic CHD show decreased white matter volume before surgery,and this volume reduction is mainly concentrated in the somatosensory and somatic motor nerve regions.
文摘Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many patients.Metabolomics is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the targets.In order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).
