Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 22...Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 228 patients with possible coronary heart disease who were examined in this hospital between November 2014 and March 2017 were selected, and the CACS levels as well as the serum contents of inflammatory factors and plaque stability indexes in patients with different lesions were determined. Pearson test was used to assess the correlation between CACS level and disease severity in patients with coronary heart disease. Results: The CACS level of triple vessel disease group was higher than that of double vessel disease group and single vessel disease group, and the CACS level of double vessel disease group was higher than that of single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents were higher than those of double vessel disease group and single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents of double vessel disease group were higher than those of single vessel disease group;serum Cys C content of triple vessel disease group was lower than that of double vessel disease group and single vessel disease group, and serum Cys C content of double vessel disease group was lower than that of single vessel disease group. Pearson test showed that the CACS level in patients with coronary heart disease was directly correlated with serum contents of inflammatory factors and plaque stability indexes. Conclusion: The CACS levels in patients with coronary heart disease increase with the aggravation of disease, and the specific CACS level is directly correlated with the degree of inflammatory response and the stability of the plaques.展开更多
Arterial calcification is a well-recognized complication of advanced atherosclerosis.Chronic kidney disease(CKD) is characterized by significantly more pronounced,dis-seminated and fast-progressing calcification of th...Arterial calcification is a well-recognized complication of advanced atherosclerosis.Chronic kidney disease(CKD) is characterized by significantly more pronounced,dis-seminated and fast-progressing calcification of the vascular system,including the coronary arteries.New computed tomography-based imaging techniques al-low for the noninvasive assessment and monitoring of calcification in different vascular sites.Coronary artery calcification(CAC) develops early in the course of CKD and is tightly associated with mineral and bone disor-ders,which include but are not limited to secondary hyperparathyroidism.In this review,recent data on the pathogenesis of CAC development and progression are discussed,with a special emphasis on fibroblast growth factor 23 and its co-receptor,klotho.The prevalence,progression and prognostic significance of CAC are reviewed separately for patients with end-stage renal disease treated with dialysis,kidney transplant recipi-ents and patients with earlier stages of CKD.In the last section,therapeutic considerations are discussed,with special attention paid to the importance of treatment that addresses mineral and bone disorders of CKD.展开更多
The purpose of the present study was to determine the association between presence and progression of Coronary Artery Calcifications (CAC) quantified with Agatston Score (AS) and inflammatory index as CRP and other pa...The purpose of the present study was to determine the association between presence and progression of Coronary Artery Calcifications (CAC) quantified with Agatston Score (AS) and inflammatory index as CRP and other parameters in unselected renal transplant recipients. Forty-five patients were underwent a baseline Multislice CT (MSCT) at the time of renal transplant and a repeat evaluation 12 - 16 months later. After second MSCT recipients were divided in three groups: Gr1 (26 patients) with absence of CAC at basal and second MSCT, Gr2 (11 patients) with reduction of CAC after one year and Gr3 (8 patients) with increased values of CAC after one year. Mean +/- Standard deviation of basal and after one year values of AS and CRP were respectively: Gr1: 2 +/-3;2 +/- 5 and 0.4 +/- 0.3;0.55 +/- 0.67;Gr2: 317 +/- 288;212 +/- 242 and 0.9 +/- 1.1;0.55 +/- 0.6;Gr3: 854 +/- 1168;1032 +/- 1153 and 0.8 +/- 0.8;1.1 +/-?0.96. We found capacity of renal transplantation to protect against development of new calcium deposits in recipients without CAC at time of transplantation. While we confirmed association in Gr2 between reduction of CAC with reduction of CRP levels and in Gr3 between increased levels of CRP with increasing of CAC. Conclusion: In this preliminary study, renal transplantation appears to slow down or increasing CAC, in strict association with modifications of CRP levels. Long term studies are needed to confirm our preliminary data and to determine the effects of CAC on cardiovascular morbidity and mortality in renal transplant recipients.展开更多
目的探讨老年钙化性心脏瓣膜病患者颈动脉斑块积分(Crouse积分)、内膜中层厚度(intima media thickness,IMT)与瓣膜钙化程度的关系。方法回顾性分析2020年4月至2023年3月收治的106例老年钙化性心脏瓣膜病患者的临床资料(观察组)。另选...目的探讨老年钙化性心脏瓣膜病患者颈动脉斑块积分(Crouse积分)、内膜中层厚度(intima media thickness,IMT)与瓣膜钙化程度的关系。方法回顾性分析2020年4月至2023年3月收治的106例老年钙化性心脏瓣膜病患者的临床资料(观察组)。另选择90例颈动脉粥样硬化的非心脏瓣膜病患者作为对照组1、选取95例非老年钙化性心脏瓣膜病患者作为对照组2。单因素方差分析检验三组Crouse积分、IMT、管腔狭窄程度及老年钙化性心脏瓣膜病不同心瓣膜钙化程度患者Crouse积分、IMT。Pearson分析Crouse积分、IMT与心瓣膜钙化程度的相关性;受试者工作特征(ROC)曲线分析Crouse积分、IMT对老年钙化性心脏瓣膜病患者瓣膜钙化的预测价值。结果观察组Crouse积分、IMT、管腔狭窄程度均明显高于对照组1和对照组2(P<0.05)。老年钙化性心脏瓣膜病不同心瓣膜钙化程度患者Crouse积分、IMT比较:1级<2级<3级(P<0.05)。相关性分析结果显示,Crouse积分、IMT与老年钙化性心脏瓣膜病瓣膜钙化程度均呈明显正相关关系(r=0.585、0.623,P<0.05)。绘制Crouse积分、IMT预测老年钙化性心脏瓣膜病患者瓣膜钙化的ROC曲线示,Crouse积分、IMT联合预测的AUC为0.802(95%CI为0.738~0.867),明显高于各指标单一预测的AUC,最佳诊断敏感度和特异度分别为0.887、0.794(P<0.05)。结论老年钙化性心脏瓣膜病患者Crouse积分、IMT存在异常增高,且与瓣膜钙化程度呈正相关,测量上述指标有助于对心脏瓣膜钙化程度进行评估。展开更多
AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and ...AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.展开更多
文摘Objective: To investigate the correlation of coronary CTA calcification score (CACS) with serum inflammatory factors and plaque stability-related indexes in patients with coronary heart disease. Methods: A total of 228 patients with possible coronary heart disease who were examined in this hospital between November 2014 and March 2017 were selected, and the CACS levels as well as the serum contents of inflammatory factors and plaque stability indexes in patients with different lesions were determined. Pearson test was used to assess the correlation between CACS level and disease severity in patients with coronary heart disease. Results: The CACS level of triple vessel disease group was higher than that of double vessel disease group and single vessel disease group, and the CACS level of double vessel disease group was higher than that of single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents were higher than those of double vessel disease group and single vessel disease group;serum sICAM-1, IL-6, IL-18, CRP, PTX3, Lp-PLA2 and Cat K contents of double vessel disease group were higher than those of single vessel disease group;serum Cys C content of triple vessel disease group was lower than that of double vessel disease group and single vessel disease group, and serum Cys C content of double vessel disease group was lower than that of single vessel disease group. Pearson test showed that the CACS level in patients with coronary heart disease was directly correlated with serum contents of inflammatory factors and plaque stability indexes. Conclusion: The CACS levels in patients with coronary heart disease increase with the aggravation of disease, and the specific CACS level is directly correlated with the degree of inflammatory response and the stability of the plaques.
文摘Arterial calcification is a well-recognized complication of advanced atherosclerosis.Chronic kidney disease(CKD) is characterized by significantly more pronounced,dis-seminated and fast-progressing calcification of the vascular system,including the coronary arteries.New computed tomography-based imaging techniques al-low for the noninvasive assessment and monitoring of calcification in different vascular sites.Coronary artery calcification(CAC) develops early in the course of CKD and is tightly associated with mineral and bone disor-ders,which include but are not limited to secondary hyperparathyroidism.In this review,recent data on the pathogenesis of CAC development and progression are discussed,with a special emphasis on fibroblast growth factor 23 and its co-receptor,klotho.The prevalence,progression and prognostic significance of CAC are reviewed separately for patients with end-stage renal disease treated with dialysis,kidney transplant recipi-ents and patients with earlier stages of CKD.In the last section,therapeutic considerations are discussed,with special attention paid to the importance of treatment that addresses mineral and bone disorders of CKD.
文摘The purpose of the present study was to determine the association between presence and progression of Coronary Artery Calcifications (CAC) quantified with Agatston Score (AS) and inflammatory index as CRP and other parameters in unselected renal transplant recipients. Forty-five patients were underwent a baseline Multislice CT (MSCT) at the time of renal transplant and a repeat evaluation 12 - 16 months later. After second MSCT recipients were divided in three groups: Gr1 (26 patients) with absence of CAC at basal and second MSCT, Gr2 (11 patients) with reduction of CAC after one year and Gr3 (8 patients) with increased values of CAC after one year. Mean +/- Standard deviation of basal and after one year values of AS and CRP were respectively: Gr1: 2 +/-3;2 +/- 5 and 0.4 +/- 0.3;0.55 +/- 0.67;Gr2: 317 +/- 288;212 +/- 242 and 0.9 +/- 1.1;0.55 +/- 0.6;Gr3: 854 +/- 1168;1032 +/- 1153 and 0.8 +/- 0.8;1.1 +/-?0.96. We found capacity of renal transplantation to protect against development of new calcium deposits in recipients without CAC at time of transplantation. While we confirmed association in Gr2 between reduction of CAC with reduction of CRP levels and in Gr3 between increased levels of CRP with increasing of CAC. Conclusion: In this preliminary study, renal transplantation appears to slow down or increasing CAC, in strict association with modifications of CRP levels. Long term studies are needed to confirm our preliminary data and to determine the effects of CAC on cardiovascular morbidity and mortality in renal transplant recipients.
文摘目的探讨老年钙化性心脏瓣膜病患者颈动脉斑块积分(Crouse积分)、内膜中层厚度(intima media thickness,IMT)与瓣膜钙化程度的关系。方法回顾性分析2020年4月至2023年3月收治的106例老年钙化性心脏瓣膜病患者的临床资料(观察组)。另选择90例颈动脉粥样硬化的非心脏瓣膜病患者作为对照组1、选取95例非老年钙化性心脏瓣膜病患者作为对照组2。单因素方差分析检验三组Crouse积分、IMT、管腔狭窄程度及老年钙化性心脏瓣膜病不同心瓣膜钙化程度患者Crouse积分、IMT。Pearson分析Crouse积分、IMT与心瓣膜钙化程度的相关性;受试者工作特征(ROC)曲线分析Crouse积分、IMT对老年钙化性心脏瓣膜病患者瓣膜钙化的预测价值。结果观察组Crouse积分、IMT、管腔狭窄程度均明显高于对照组1和对照组2(P<0.05)。老年钙化性心脏瓣膜病不同心瓣膜钙化程度患者Crouse积分、IMT比较:1级<2级<3级(P<0.05)。相关性分析结果显示,Crouse积分、IMT与老年钙化性心脏瓣膜病瓣膜钙化程度均呈明显正相关关系(r=0.585、0.623,P<0.05)。绘制Crouse积分、IMT预测老年钙化性心脏瓣膜病患者瓣膜钙化的ROC曲线示,Crouse积分、IMT联合预测的AUC为0.802(95%CI为0.738~0.867),明显高于各指标单一预测的AUC,最佳诊断敏感度和特异度分别为0.887、0.794(P<0.05)。结论老年钙化性心脏瓣膜病患者Crouse积分、IMT存在异常增高,且与瓣膜钙化程度呈正相关,测量上述指标有助于对心脏瓣膜钙化程度进行评估。
文摘AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.
