Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomi...Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomiting, burning sensations, dizziness, and edema. We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. A 57-year-old female with T3N2M0 rectal adenocarcinoma received modified FOLFOX-6. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9th and 10th infusions, she developed fever to a maximum of 38.3℃ with stable hemodynamic status despite medications. During 11th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever. On examination, she was pale, cyanotic, with a temperature of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min and O2 saturation of 88%-91%. She was hospitalized for management and recovered in 24 h. Fever alone is not a usual symptom of oxaliplatin HSR. It may be indicative that the patient may develop serious reactions subsequently, as did our patient who developed hypotension with the third challenge. Treatment and prevention consists of slowing the infusion rate, use of steroids and antagonists of Type 1 and 2 histamine receptor antagonists, whereas desensitization could help to provide the small number of patients who experience severe HSR with the ability to further receive an effective therapy for their colorectal cancer.展开更多
Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used ...Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient's fever was of unknown origin, she was hospitalized. All treatment was stopped and an extensive workup to explore the source of fever and chills was performed. Results of chest X-ray, viral, urine, and blood cultures, autoimmune serology, transthoracic and transesophageal echocardiography, and abdominal ultrasound revealed no source of infection. A rechallenge test of azathioprine was performed and the fever and chills returned within a few hours. Azathioprine was established as the definite cause following rechallenge. Fever as an adverse drug reaction is often unrecognized. Azathioprine has been reported to cause druginduced fever in patients with inflammatory bowel disease, rheumatoid arthritis, and sarcoidosis. To the bestof our knowledge there have been no previous reports documenting azathioprine-induced fever in patients with autoimmune hepatitis. The occurrence of fever following the readministration of azathioprine suggests the diagnosis of drug-induced fever, particularly after the exclusion of other causes. A careful rechallenge is recommended to confirm the diagnosis.展开更多
Adverse reactions to mesalamine,a treatment used to induce and maintain remission in inflammatory bowel diseases,particularly ulcerative colitis,have been described in the literature as case reports.This case illustra...Adverse reactions to mesalamine,a treatment used to induce and maintain remission in inflammatory bowel diseases,particularly ulcerative colitis,have been described in the literature as case reports.This case illustrates an unusual adverse reaction.Our patient developed an isolated fever of unexplained etiology,which was found to be related to mesalamine treatment.A 22-year-old patient diagnosed with ulcerative colitis developed a fever with rigors and anorexia 10 d after starting oral mesalamine while his colitis was clinically resolving.Testing revealed no infection.A mesalamineinduced fever was considered,and treatment was stopped,which led to spontaneous resolution of the fever.The diagnosis was confirmed by reintroducing the mesalamine.One year later,this side effect was noticed again in the same patient after he was administered topical mesalamine.This reaction to mesalamine seems to be idiosyncratic,and the mechanism that induces fever remains unclear.Fever encountered in the course of a mesalamine treatment in ulcerative colitis must be considered a mesalamine-induced fever when it cannot be explained by the disease activity,an associated extraintestinal manifestation,or an infectious etiology.展开更多
This work investigated on the presence of African swine fever virus (ASFV) in Nigerian Indigenous pig (NIP), its hybrid and backcross using Polymerase chain reaction (PCR) screening method on the extracted DNA and hae...This work investigated on the presence of African swine fever virus (ASFV) in Nigerian Indigenous pig (NIP), its hybrid and backcross using Polymerase chain reaction (PCR) screening method on the extracted DNA and haematological screening from these pig bloods. Pig populations selected from Southwestern Nigeria were used for this study. ASFV infected blood samples collected from the University of Ibadan were used as positive control. White blood cell count was significantly highest in hybrid (31.27 ± 1.79 × 10<sup>3</sup>/μl) and higher in backcross (27.71 ± 2.01 × 10<sup>3</sup>/μl) compared with NIP (18.16 ± 3.01 × 10<sup>3</sup>/μl) for NIP, and while Lymphocyte count was found to be highest in hybrid (86.17% ± 1.95%) and lowest in backcross (56.23% ± 1.17%). The PAS primers (PAS<sub>1</sub>F: 5’-ATG GAT ACC GAG GGA ATA GC-3’ and PAS<sub>2</sub>R: 5’-CTT ACC GAT GAA AAT GAT AC-3’) amplified the 278 bp of ASFV in the DNA extracted from NIP, its hybrids and backcross. In conclusion, this study has shown that NIP, its hybrid and backcross have ASFV in their genome in an ASF-prone environment and thus confirming the continuous prevalence of ASF in Southwest Nigeria. This is an on-going research where the severity and virulence of the virus has to be measured.展开更多
This work investigated the presence of African Swine Fever Virus (ASFV) in Nigerian Indigenous Pig (NIP) using Polymerase Chain Reaction (PCR) screening method on the extracted DNA from the pig blood. NIP population s...This work investigated the presence of African Swine Fever Virus (ASFV) in Nigerian Indigenous Pig (NIP) using Polymerase Chain Reaction (PCR) screening method on the extracted DNA from the pig blood. NIP population selected from south western Nigeria were used for this study. ASFV infected blood samples collected from the University of Ibadan were used as positive control. Adiscrete and specific band was observed in both NIP and the infected samples show the presence of ASFV in NIP. The bands were of the expected size 278 base pairs (bp). The implication of this finding is that NIPs have domiciled ASFV without showing any clinical symptoms.展开更多
文摘Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomiting, burning sensations, dizziness, and edema. We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. A 57-year-old female with T3N2M0 rectal adenocarcinoma received modified FOLFOX-6. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9th and 10th infusions, she developed fever to a maximum of 38.3℃ with stable hemodynamic status despite medications. During 11th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever. On examination, she was pale, cyanotic, with a temperature of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min and O2 saturation of 88%-91%. She was hospitalized for management and recovered in 24 h. Fever alone is not a usual symptom of oxaliplatin HSR. It may be indicative that the patient may develop serious reactions subsequently, as did our patient who developed hypotension with the third challenge. Treatment and prevention consists of slowing the infusion rate, use of steroids and antagonists of Type 1 and 2 histamine receptor antagonists, whereas desensitization could help to provide the small number of patients who experience severe HSR with the ability to further receive an effective therapy for their colorectal cancer.
文摘Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient's fever was of unknown origin, she was hospitalized. All treatment was stopped and an extensive workup to explore the source of fever and chills was performed. Results of chest X-ray, viral, urine, and blood cultures, autoimmune serology, transthoracic and transesophageal echocardiography, and abdominal ultrasound revealed no source of infection. A rechallenge test of azathioprine was performed and the fever and chills returned within a few hours. Azathioprine was established as the definite cause following rechallenge. Fever as an adverse drug reaction is often unrecognized. Azathioprine has been reported to cause druginduced fever in patients with inflammatory bowel disease, rheumatoid arthritis, and sarcoidosis. To the bestof our knowledge there have been no previous reports documenting azathioprine-induced fever in patients with autoimmune hepatitis. The occurrence of fever following the readministration of azathioprine suggests the diagnosis of drug-induced fever, particularly after the exclusion of other causes. A careful rechallenge is recommended to confirm the diagnosis.
文摘Adverse reactions to mesalamine,a treatment used to induce and maintain remission in inflammatory bowel diseases,particularly ulcerative colitis,have been described in the literature as case reports.This case illustrates an unusual adverse reaction.Our patient developed an isolated fever of unexplained etiology,which was found to be related to mesalamine treatment.A 22-year-old patient diagnosed with ulcerative colitis developed a fever with rigors and anorexia 10 d after starting oral mesalamine while his colitis was clinically resolving.Testing revealed no infection.A mesalamineinduced fever was considered,and treatment was stopped,which led to spontaneous resolution of the fever.The diagnosis was confirmed by reintroducing the mesalamine.One year later,this side effect was noticed again in the same patient after he was administered topical mesalamine.This reaction to mesalamine seems to be idiosyncratic,and the mechanism that induces fever remains unclear.Fever encountered in the course of a mesalamine treatment in ulcerative colitis must be considered a mesalamine-induced fever when it cannot be explained by the disease activity,an associated extraintestinal manifestation,or an infectious etiology.
文摘This work investigated on the presence of African swine fever virus (ASFV) in Nigerian Indigenous pig (NIP), its hybrid and backcross using Polymerase chain reaction (PCR) screening method on the extracted DNA and haematological screening from these pig bloods. Pig populations selected from Southwestern Nigeria were used for this study. ASFV infected blood samples collected from the University of Ibadan were used as positive control. White blood cell count was significantly highest in hybrid (31.27 ± 1.79 × 10<sup>3</sup>/μl) and higher in backcross (27.71 ± 2.01 × 10<sup>3</sup>/μl) compared with NIP (18.16 ± 3.01 × 10<sup>3</sup>/μl) for NIP, and while Lymphocyte count was found to be highest in hybrid (86.17% ± 1.95%) and lowest in backcross (56.23% ± 1.17%). The PAS primers (PAS<sub>1</sub>F: 5’-ATG GAT ACC GAG GGA ATA GC-3’ and PAS<sub>2</sub>R: 5’-CTT ACC GAT GAA AAT GAT AC-3’) amplified the 278 bp of ASFV in the DNA extracted from NIP, its hybrids and backcross. In conclusion, this study has shown that NIP, its hybrid and backcross have ASFV in their genome in an ASF-prone environment and thus confirming the continuous prevalence of ASF in Southwest Nigeria. This is an on-going research where the severity and virulence of the virus has to be measured.
文摘This work investigated the presence of African Swine Fever Virus (ASFV) in Nigerian Indigenous Pig (NIP) using Polymerase Chain Reaction (PCR) screening method on the extracted DNA from the pig blood. NIP population selected from south western Nigeria were used for this study. ASFV infected blood samples collected from the University of Ibadan were used as positive control. Adiscrete and specific band was observed in both NIP and the infected samples show the presence of ASFV in NIP. The bands were of the expected size 278 base pairs (bp). The implication of this finding is that NIPs have domiciled ASFV without showing any clinical symptoms.
