Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent a...Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment.展开更多
The aim of this study was to evaluate the cost and effectiveness of soft silicone foam dressings （SSFD, Mepilex） on the treatment of pressure ulcers. We searched electronic databases and retrieved articles to make a...The aim of this study was to evaluate the cost and effectiveness of soft silicone foam dressings （SSFD, Mepilex） on the treatment of pressure ulcers. We searched electronic databases and retrieved articles to make a systematic evaluation, and then make a cost-effectiveness analysis by decision tree model combined with data from clinical treatments. The result shows that compared with the common sterile gauze, SSFD possesses an apparent advantage. The effective ratio is 96.3% versus 77.3%, although the cost of SSFD is much higher than that of sterile gauze, Mepilex appears to be more cost-effectiveness for preventive use.展开更多
目的探讨早期应用美皮康联合美清佳预防盐酸胺碘酮(商品名:可达龙)外周静脉输注所致静脉炎的临床效果。方法选取外周静脉输注可达龙的患者100例,在患者知情同意的情况下采用随机数字法将患者分为研究组与对照组,每组各50例。研究组使用...目的探讨早期应用美皮康联合美清佳预防盐酸胺碘酮(商品名:可达龙)外周静脉输注所致静脉炎的临床效果。方法选取外周静脉输注可达龙的患者100例,在患者知情同意的情况下采用随机数字法将患者分为研究组与对照组,每组各50例。研究组使用美皮康及美清佳干预,对照组应用50%葡萄糖水20 m L+地塞米松5 mg浸湿无菌纱布后持续湿敷至输液结束。2组分别于干预后第1、2、3天观察静脉炎发生率及严重程度,评价应用效果。结果预防措施实施3 d后,对照组静脉炎发生率及严重程度明显高于研究组(P=0.032),研究组预防效果优于对照组。结论美皮康联合美清佳预防可达龙外周静脉输注所致静脉炎的效果显著,可明显减少外周静脉炎的发生率,静脉炎严重程度大大降低,可在临床应用推广。展开更多
基金supported by the Yeungnam University research grant in 2017。
文摘Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment.
基金Mlnlycke Health Care for their assistance on this project
文摘The aim of this study was to evaluate the cost and effectiveness of soft silicone foam dressings （SSFD, Mepilex） on the treatment of pressure ulcers. We searched electronic databases and retrieved articles to make a systematic evaluation, and then make a cost-effectiveness analysis by decision tree model combined with data from clinical treatments. The result shows that compared with the common sterile gauze, SSFD possesses an apparent advantage. The effective ratio is 96.3% versus 77.3%, although the cost of SSFD is much higher than that of sterile gauze, Mepilex appears to be more cost-effectiveness for preventive use.
文摘目的探讨早期应用美皮康联合美清佳预防盐酸胺碘酮(商品名:可达龙)外周静脉输注所致静脉炎的临床效果。方法选取外周静脉输注可达龙的患者100例,在患者知情同意的情况下采用随机数字法将患者分为研究组与对照组,每组各50例。研究组使用美皮康及美清佳干预,对照组应用50%葡萄糖水20 m L+地塞米松5 mg浸湿无菌纱布后持续湿敷至输液结束。2组分别于干预后第1、2、3天观察静脉炎发生率及严重程度,评价应用效果。结果预防措施实施3 d后,对照组静脉炎发生率及严重程度明显高于研究组(P=0.032),研究组预防效果优于对照组。结论美皮康联合美清佳预防可达龙外周静脉输注所致静脉炎的效果显著,可明显减少外周静脉炎的发生率,静脉炎严重程度大大降低,可在临床应用推广。
