AIM: To investigate the progression rate of small pancreatic cystic lesions and identify characteristics associated with their progression.METHODS: Patients with pancreatic cystic lesions with at least 1-year of follo...AIM: To investigate the progression rate of small pancreatic cystic lesions and identify characteristics associated with their progression.METHODS: Patients with pancreatic cystic lesions with at least 1-year of follow-up were evaluated retrospectively. We excluded patients with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 patients were evaluated. The interval progression of the cysts was examined. Characteristics were compared between patients with and without progression.RESULTS: The pancreatic cysts ranged from 3 to 29 mm. The mean follow-up period was 4.5 ± 2.3 years and the mean progression rate was 1.0 ± 1.3 mm/year. Ninety patients showed interval progression and were divided into two groups; the minimal-change group(n = 41), who had cyst progression at less than 1 mm/year, and the progression group(n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct(P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular cysts.CONCLUSION: Small pancreatic cysts progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.展开更多
Background Rapid progression of non-culprit coronary artery lesion happens in some patients after percuta- neous coronary intervention （PCI）. However, the incidence and prognostic factors for progression of coronary...Background Rapid progression of non-culprit coronary artery lesion happens in some patients after percuta- neous coronary intervention （PCI）. However, the incidence and prognostic factors for progression of coronary le- sion are not clarified. Methods The patients who underwent two coronary angiography （CAG） from January 2015 to January 2017 in our hospital were selected as objects of this retrospective study. According to the results of the second CAG, they were divided into control group （No restenosis in the stent, no change or improvement of out-stent lesions, n=42） and lesion progression group（Aggravation of out-stent lesions, n = 29）. The clinical data of patients between the two groups were analyzed by statistics. Results The change of Lipopro- tein （a） （ Lp （a））and uric acid （UA） in lesion progression group were significantly different from control group （P=0.004 and P=0.037）. Regression analysis showed that, the change of UA was an independent predictive factor of coronary artery lesion progression in a short time（6 - 12 months）after PCI（odds ratio [OR]： 1.007; 95% confidence interval [CI] ： （1.000, 1.013） ; P=0.042）. Conclusion UA is an independent predictive factor of non-culprit coronary artery lesion after stent implanting.展开更多
文摘AIM: To investigate the progression rate of small pancreatic cystic lesions and identify characteristics associated with their progression.METHODS: Patients with pancreatic cystic lesions with at least 1-year of follow-up were evaluated retrospectively. We excluded patients with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 patients were evaluated. The interval progression of the cysts was examined. Characteristics were compared between patients with and without progression.RESULTS: The pancreatic cysts ranged from 3 to 29 mm. The mean follow-up period was 4.5 ± 2.3 years and the mean progression rate was 1.0 ± 1.3 mm/year. Ninety patients showed interval progression and were divided into two groups; the minimal-change group(n = 41), who had cyst progression at less than 1 mm/year, and the progression group(n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct(P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular cysts.CONCLUSION: Small pancreatic cysts progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.
基金the Key Research and Development Project of Zhejiang Province,China(2022C02044)National Natural Science Foundation of China(32171889 and 32071895)+1 种基金the Natural Science Foundation of Zhejiang Province,China(LQ22C130004)the National Key Research and Development Program of China(2018YFD0700501).
文摘Background Rapid progression of non-culprit coronary artery lesion happens in some patients after percuta- neous coronary intervention （PCI）. However, the incidence and prognostic factors for progression of coronary le- sion are not clarified. Methods The patients who underwent two coronary angiography （CAG） from January 2015 to January 2017 in our hospital were selected as objects of this retrospective study. According to the results of the second CAG, they were divided into control group （No restenosis in the stent, no change or improvement of out-stent lesions, n=42） and lesion progression group（Aggravation of out-stent lesions, n = 29）. The clinical data of patients between the two groups were analyzed by statistics. Results The change of Lipopro- tein （a） （ Lp （a））and uric acid （UA） in lesion progression group were significantly different from control group （P=0.004 and P=0.037）. Regression analysis showed that, the change of UA was an independent predictive factor of coronary artery lesion progression in a short time（6 - 12 months）after PCI（odds ratio [OR]： 1.007; 95% confidence interval [CI] ： （1.000, 1.013） ; P=0.042）. Conclusion UA is an independent predictive factor of non-culprit coronary artery lesion after stent implanting.
