Objective:To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femora...Objective:To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femoral head necrosis from January 2016 to January 2017 were studied by prospective matched and controlled design.60 cases in the treatment group were treated with Tongluo Shenggu Formula.The control group(60 cases)received high energy extracorporeal shock wave therapy.The imaging stability rate,Harris score and SF-36 score were used as clinical efficacy indicators,followed up for 24 months,and the follow-up results were statistically analyzed.Results:Among the 120 patients,5 fell off and the rest were followed up.The imaging stability rate is heavy.The imaging stability rate of the patients in the treatment group is 78.95%,while that in the control group is 72.41%.The two groups have the same stability rate(P>0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p<0.05),and the pain degree,joint function and joint deformity score of the treatment group were better than those of the control group(p<0.05).In the SF-36 score,the scores of physiological function,physiological function,physical pain,overall health,social function and emotional function in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p<0.05).the incidence of adverse events in the treatment period of the two groups was lower and the patients could relieve themselves in the later stage.Conclusion:Tongluo Shenggu prescription has definite curative effect in treating ARCOⅡnon-traumatic femoral head necrosis,especially in improving hip joint function,relieving hip joint pain and improving quality of life.To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femoral head necrosis from January 2016 to January 2017 were studied by prospective matched and controlled design.60 cases in the treatment group were treated with Tongluo Shenggu Formula.The control group(60 cases)received high energy extracorporeal shock wave therapy.The imaging stability rate,Harris score and SF-36 score were used as clinical efficacy indicators,followed up for 24 months,and the follow-up results were statistically analyzed.Results:Among the 120 patients,5 fell off and the rest were followed up.The imaging stability rate is heavy.The imaging stability rate of the patients in the treatment group is 78.95%,while that in the control group is 72.41%.The two groups have the same stability rate(P>0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p<0.05),and the pain degree,joint function and joint deformity score of the treatment group were better than those of the control group(p<0.05).In the SF-36 score,the scores of physiological function,physiological function,physical pain,overall health,social function and emotional function in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p<0.05).the incidence of adverse events in the treatment period of the two groups was lower and the patients could relieve themselves in the later stage.Conclusion:Tongluo Shenggu prescription has definite curative effect in treating ARCOⅡnon-traumatic femoral head necrosis,especially in improving hip joint function,relieving hip joint pain and improving quality of life.展开更多
目的:分析股骨头血供参数和平均坏死面积指数与股骨头坏死国际骨微循环研究学会(Association Research Circulation Osseous,ARCO)分期的相关性,为量化评估股骨头血供和坏死程度提供参考。方法:纳入股骨头坏死患者60例(65髋),其中ARCOⅠ...目的:分析股骨头血供参数和平均坏死面积指数与股骨头坏死国际骨微循环研究学会(Association Research Circulation Osseous,ARCO)分期的相关性,为量化评估股骨头血供和坏死程度提供参考。方法:纳入股骨头坏死患者60例(65髋),其中ARCOⅠ期11髋、Ⅱ期23髋、Ⅲ期16髋、Ⅳ期15髋。于患者股骨头血管造影片上测量并计算跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量等股骨头血供参数,于股骨头轴位MRI T1加权像上测量并计算股骨头平均坏死面积指数。比较不同ARCO分期患髋的股骨头血供参数和平均坏死面积指数,采用Spearman相关分析法分析股骨头血供参数和平均坏死面积指数与股骨头坏死ARCO分期的相关性。结果:不同ARCO分期患髋的跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量及股骨头平均坏死面积指数的组间差异均有统计学意义(H=16.191,P=0.001;H=31.331,P=0.000;H=13.737,P=0.003;H=12.699,P=0.005)。Spearman相关分析显示,跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量与股骨头坏死ARCO分期均呈负相关(r_(s)=-0.489,P=0.000;r_(s)=-0.678,P=0.000;r_(s)=-0.456,P=0.000),股骨头平均坏死面积指数与股骨头坏死ARCO分期呈正相关(r_(s)=0.438,P=0.000)。结论:股骨头血供参数与股骨头坏死ARCO分期呈负相关,股骨头平均坏死面积指数与股骨头坏死ARCO分期呈正相关,这些指标对于量化评估股骨头血供和坏死程度具有一定的参考价值。展开更多
基金Science foundation for postdoctoral researches in China(2017 M613179)Studio construction project of Traumatology and orthopedics of traditional Chinese medicine Guo family genre([2018]40)
文摘Objective:To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femoral head necrosis from January 2016 to January 2017 were studied by prospective matched and controlled design.60 cases in the treatment group were treated with Tongluo Shenggu Formula.The control group(60 cases)received high energy extracorporeal shock wave therapy.The imaging stability rate,Harris score and SF-36 score were used as clinical efficacy indicators,followed up for 24 months,and the follow-up results were statistically analyzed.Results:Among the 120 patients,5 fell off and the rest were followed up.The imaging stability rate is heavy.The imaging stability rate of the patients in the treatment group is 78.95%,while that in the control group is 72.41%.The two groups have the same stability rate(P>0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p<0.05),and the pain degree,joint function and joint deformity score of the treatment group were better than those of the control group(p<0.05).In the SF-36 score,the scores of physiological function,physiological function,physical pain,overall health,social function and emotional function in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p<0.05).the incidence of adverse events in the treatment period of the two groups was lower and the patients could relieve themselves in the later stage.Conclusion:Tongluo Shenggu prescription has definite curative effect in treating ARCOⅡnon-traumatic femoral head necrosis,especially in improving hip joint function,relieving hip joint pain and improving quality of life.To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femoral head necrosis from January 2016 to January 2017 were studied by prospective matched and controlled design.60 cases in the treatment group were treated with Tongluo Shenggu Formula.The control group(60 cases)received high energy extracorporeal shock wave therapy.The imaging stability rate,Harris score and SF-36 score were used as clinical efficacy indicators,followed up for 24 months,and the follow-up results were statistically analyzed.Results:Among the 120 patients,5 fell off and the rest were followed up.The imaging stability rate is heavy.The imaging stability rate of the patients in the treatment group is 78.95%,while that in the control group is 72.41%.The two groups have the same stability rate(P>0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p<0.05),and the pain degree,joint function and joint deformity score of the treatment group were better than those of the control group(p<0.05).In the SF-36 score,the scores of physiological function,physiological function,physical pain,overall health,social function and emotional function in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p<0.05).the incidence of adverse events in the treatment period of the two groups was lower and the patients could relieve themselves in the later stage.Conclusion:Tongluo Shenggu prescription has definite curative effect in treating ARCOⅡnon-traumatic femoral head necrosis,especially in improving hip joint function,relieving hip joint pain and improving quality of life.
文摘目的:分析股骨头血供参数和平均坏死面积指数与股骨头坏死国际骨微循环研究学会(Association Research Circulation Osseous,ARCO)分期的相关性,为量化评估股骨头血供和坏死程度提供参考。方法:纳入股骨头坏死患者60例(65髋),其中ARCOⅠ期11髋、Ⅱ期23髋、Ⅲ期16髋、Ⅳ期15髋。于患者股骨头血管造影片上测量并计算跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量等股骨头血供参数,于股骨头轴位MRI T1加权像上测量并计算股骨头平均坏死面积指数。比较不同ARCO分期患髋的股骨头血供参数和平均坏死面积指数,采用Spearman相关分析法分析股骨头血供参数和平均坏死面积指数与股骨头坏死ARCO分期的相关性。结果:不同ARCO分期患髋的跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量及股骨头平均坏死面积指数的组间差异均有统计学意义(H=16.191,P=0.001;H=31.331,P=0.000;H=13.737,P=0.003;H=12.699,P=0.005)。Spearman相关分析显示,跨股骨颈的旋股内侧动脉长度与股骨颈直径的比值、后上支持带动脉数量、后下支持带动脉数量与股骨头坏死ARCO分期均呈负相关(r_(s)=-0.489,P=0.000;r_(s)=-0.678,P=0.000;r_(s)=-0.456,P=0.000),股骨头平均坏死面积指数与股骨头坏死ARCO分期呈正相关(r_(s)=0.438,P=0.000)。结论:股骨头血供参数与股骨头坏死ARCO分期呈负相关,股骨头平均坏死面积指数与股骨头坏死ARCO分期呈正相关,这些指标对于量化评估股骨头血供和坏死程度具有一定的参考价值。
