The phase relation of harmonics in high-intensity focused ultrasound is investigated numerically and experimen- tally. The nonlinear Westervelt equation is solved to model nonlinear focused sound field by using the fi...The phase relation of harmonics in high-intensity focused ultrasound is investigated numerically and experimen- tally. The nonlinear Westervelt equation is solved to model nonlinear focused sound field by using the finite difference time domain method. Experimental waveforms are measured by a robust needle hydrophone. Then the relative phase quantity is introduced and obtained by using the zero-phase filter. The results show that the nth harmonic relative phase quantity is approximately （n - 1） π/3 at geometric center and increases along the axial direction. Moreover, the relative phase quantity decreases with the increase of source amplitude. This phase relation gives an explanation of some nonlinear phenomena such as the discrepancy of positive and negative pressure.展开更多
Modelling and biomedical applications of ultrasound contrast agent （UCA） microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including （i） ...Modelling and biomedical applications of ultrasound contrast agent （UCA） microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including （i） the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; （ii） a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; （iii） the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and （iv） the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.展开更多
The relationship between ultrasonic nonlinearity and microstructure of the liner was studied during the whole curing process by ultrasonic transmission method and infrared spectroscopy.Nonlinearity of input instrument...The relationship between ultrasonic nonlinearity and microstructure of the liner was studied during the whole curing process by ultrasonic transmission method and infrared spectroscopy.Nonlinearity of input instrumentation was minimized by the natural filtering effect of piezoelectric discs and the maximum excitation energy was acquired simultaneously so as to improve the accuracy of the measuring data.The experimental results indicate that in the liner curing reaction at40℃ultrasonic nonlinearity parameter decreases gradually after a sharp decline,which is consistent with the outcome of infrared spectroscopy as the curing degree increases.The research suggests an effective nondestructive approach to detect the curing properties of the liner in a nonlinear ultrasonic way.展开更多
A novel technique for reducing reverberation artifact in acoustic shadow imaging using nonlinear ultrasound interaction, called nonlinear acoustic shadow method, has been developed and experimentally studied. In this ...A novel technique for reducing reverberation artifact in acoustic shadow imaging using nonlinear ultrasound interaction, called nonlinear acoustic shadow method, has been developed and experimentally studied. In this technique, the conventional acoustic shadow method is modified by using the secondary wave generated by nonlinear interaction of two primary sound waves emitted from parametric array. Either conventional or nonlinear acoustic shadow imaging is carried out for aluminum square cylinder and the size of the shadow is compared. The result shows that the nonlinear acoustic shadow method reduces reverberation artifact inside the square cylinder and has better accuracy in the size measurement than conventional acoustic shadow method.展开更多
Application of the temperature dependence of ultrasound nonlinear parameter B/A can realize noninvasive temperature measurement in biological media. The principle of temperature measurement is described and an experim...Application of the temperature dependence of ultrasound nonlinear parameter B/A can realize noninvasive temperature measurement in biological media. The principle of temperature measurement is described and an experiment system is set up. The experiments for measuring the nonlinear parameter B/A and estimating their temperature dependences in tested media are described. Preliminary experiment results are presented.展开更多
基于信息可视化分析,对非线性超声的研究现状进行分析。检索Web of Science数据库,得到非线性超声相关文献4061篇。对关键词进行可视化分析及聚类分析,非线性超声领域关键词主要涉及6个方面,目前主要侧重于理论研究。对于应用范围,在微...基于信息可视化分析,对非线性超声的研究现状进行分析。检索Web of Science数据库,得到非线性超声相关文献4061篇。对关键词进行可视化分析及聚类分析,非线性超声领域关键词主要涉及6个方面,目前主要侧重于理论研究。对于应用范围,在微裂纹、结构监测等方面具有应用前景。对非线性超声的论文数及专利数进行技术成熟度分析,结果表明其处在技术发展的增长期。展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 41274134 and 81527901the '12th Five-Year Plan' Period for Informatization Project in Supercomputing Key Demonstration of Chinese Academy of Sciences under Grant No XXH12503-02-02-2(07)
文摘The phase relation of harmonics in high-intensity focused ultrasound is investigated numerically and experimen- tally. The nonlinear Westervelt equation is solved to model nonlinear focused sound field by using the finite difference time domain method. Experimental waveforms are measured by a robust needle hydrophone. Then the relative phase quantity is introduced and obtained by using the zero-phase filter. The results show that the nth harmonic relative phase quantity is approximately （n - 1） π/3 at geometric center and increases along the axial direction. Moreover, the relative phase quantity decreases with the increase of source amplitude. This phase relation gives an explanation of some nonlinear phenomena such as the discrepancy of positive and negative pressure.
基金Projects supported by the National Natural Science Foundation of China(Grant Nos.81127901,81227004,11374155,11274170,11274176,11474001,11474161,11474166,and 11674173)the National High-Technology Research and Development Program,China(Grant No.2012AA022702)Qing Lan Project of Jiangsu Province,China
文摘Modelling and biomedical applications of ultrasound contrast agent （UCA） microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including （i） the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; （ii） a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; （iii） the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and （iv） the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.
基金National Natural Science Foundation of China(No.61201412)
文摘The relationship between ultrasonic nonlinearity and microstructure of the liner was studied during the whole curing process by ultrasonic transmission method and infrared spectroscopy.Nonlinearity of input instrumentation was minimized by the natural filtering effect of piezoelectric discs and the maximum excitation energy was acquired simultaneously so as to improve the accuracy of the measuring data.The experimental results indicate that in the liner curing reaction at40℃ultrasonic nonlinearity parameter decreases gradually after a sharp decline,which is consistent with the outcome of infrared spectroscopy as the curing degree increases.The research suggests an effective nondestructive approach to detect the curing properties of the liner in a nonlinear ultrasonic way.
文摘A novel technique for reducing reverberation artifact in acoustic shadow imaging using nonlinear ultrasound interaction, called nonlinear acoustic shadow method, has been developed and experimentally studied. In this technique, the conventional acoustic shadow method is modified by using the secondary wave generated by nonlinear interaction of two primary sound waves emitted from parametric array. Either conventional or nonlinear acoustic shadow imaging is carried out for aluminum square cylinder and the size of the shadow is compared. The result shows that the nonlinear acoustic shadow method reduces reverberation artifact inside the square cylinder and has better accuracy in the size measurement than conventional acoustic shadow method.
基金This work was supported by Natural Science Foundation in China( No:596 76 0 32 ) ,The Yong TrainingFoundation( No:KI2 70 1 2 0 0 1 0 1 ) and Education Foundation( No:KP0 6 0 82 0 0 2 0 1 ) from Beijing Cit
文摘Application of the temperature dependence of ultrasound nonlinear parameter B/A can realize noninvasive temperature measurement in biological media. The principle of temperature measurement is described and an experiment system is set up. The experiments for measuring the nonlinear parameter B/A and estimating their temperature dependences in tested media are described. Preliminary experiment results are presented.
文摘基于信息可视化分析,对非线性超声的研究现状进行分析。检索Web of Science数据库,得到非线性超声相关文献4061篇。对关键词进行可视化分析及聚类分析,非线性超声领域关键词主要涉及6个方面,目前主要侧重于理论研究。对于应用范围,在微裂纹、结构监测等方面具有应用前景。对非线性超声的论文数及专利数进行技术成熟度分析,结果表明其处在技术发展的增长期。
