We used the flow cytometric immunoassay to study the correlation between the tumor-suppressor gene product p53- and the DNA ploidy in 30 de novo cases of acute nonlymphocytic leukemia (ANLL).The results showed that 15...We used the flow cytometric immunoassay to study the correlation between the tumor-suppressor gene product p53- and the DNA ploidy in 30 de novo cases of acute nonlymphocytic leukemia (ANLL).The results showed that 15 cases were negative and the other 15 cases were positive expression for p53. As compared with p53 negative (p53) cases, the patients with positive p53 (p53+) had higher percentage of bone marrow blasts and lower peripheral leukocyte and platelet counts,which had no influence on the complete remission rate. Before treatment, DNA diploidy was seen in 18 cases including 12 p53- cases, and DNA aneuploidy in 12 cases including 9 p53+. After therapy, aneuploidy could be transformed into diploidy.Patients with P53+ or having aneuploidy in complete remission were at risk for early relapse. We believe that p53 may be involved in the process of leukemogenesis and progression of ANLL.展开更多
Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2.The overall incidence of chromosomal abnormality was 70.1% (68 out of 97 cases),which was hig...Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2.The overall incidence of chromosomal abnormality was 70.1% (68 out of 97 cases),which was higher in children(84. 2% )than in edults (61%).The male to female chromosomal abnormality ratio was nearly the same(male 71% and female 68. 4% .P>0.05).Hypodiploidy was the most common numerical abnormality(39%)and t (8;21) was the most common structural abnormality (48.1%) It the patients with t (8;21),64 5%(2) out of 31cases) male lost chromosome Y (-Y) and 33%(5 out of 15 cases)female lost one chromosomeX(-X).展开更多
Bone marrow studies including morphological,morphometrical and ultrastructural aspects were performed in 35 patients with M2/t(8;21)and and 23 patients with M2/NN.It was found that M2/t(8;21)patients had higher cellul...Bone marrow studies including morphological,morphometrical and ultrastructural aspects were performed in 35 patients with M2/t(8;21)and and 23 patients with M2/NN.It was found that M2/t(8;21)patients had higher cellularity in bone marrow.Type(Ⅱ)myeloblast cells were predominant among myeoloblasts.Deformation of nuclei,nucleocytoplasmic asynchronism and dysmegakaryctytopoiesis were more evident n M2/t (8;21) than in M2/NN patients.展开更多
BACKGROUND Myeloid sarcoma(MS) is relatively rare,occurring mainly in the skin and lymph nodes,and MS invasion of the ulnar nerve is particularly unusual.The main aim of this article is to present a case of MS invadin...BACKGROUND Myeloid sarcoma(MS) is relatively rare,occurring mainly in the skin and lymph nodes,and MS invasion of the ulnar nerve is particularly unusual.The main aim of this article is to present a case of MS invading the brachial plexus,causing ulnar nerve entrapment syndrome,and to further clinical understanding of the possibility of MS invasion of peripheral nerves.CASE SUMMARY We present the case of a 46-year-old man with a 13-year history of well-treated acute nonlymphocytic leukaemia who was admitted to the hospital after presenting with numbness and pain in his left little finger.The initial diagnosis was considered a simple case of nerve entrapment disease,with magnetic resonance imaging showing slightly abnormal left brachial plexus nerve alignment with local thickening,entrapment,and high signal on compression lipid images.Due to the severity of the ulnar nerve compression,we surgically investigated and cleared the entrapment and nerve tissue hyperplasia;however,subsequent pathological biopsy results revealed evidence of MS.The patient had significant relief from his neurological symptoms,with no postoperative complications,and was referred to the haemato-oncology department for further consultation about the primary disease.This is the first report of safe treatment of ulnar nerve entrapment from MS.It is intended to inform hand surgeons that nerve entrapment may be associated with extramedullary MS,as a rare presenting feature of the disease.CONCLUSION MS invasion of the brachial plexus and surrounding tissues of the upper arm,resulting in ulnar nerve entrapment and degeneration with significant neurological pain and numbness in the little finger,is uncommon.Surgical treatment significantly relieved the patient’s nerve entrapment symptoms and prevented further neurological impairment.This case is reported to highlight the rare presenting features of MS.展开更多
Spontaneous rupture and bleeding from the carotid artery in acute promyelocytic leukemia （APL）patients leading to pseudoaneurysm （PSA） formation has not been reported. We first successfully treated an APL patient ...Spontaneous rupture and bleeding from the carotid artery in acute promyelocytic leukemia （APL）patients leading to pseudoaneurysm （PSA） formation has not been reported. We first successfully treated an APL patient with leli internal carotid artery rupture during chemotherapy leading to PSA using ultrasound-guided thrombin iniection （UGTI）.展开更多
文摘We used the flow cytometric immunoassay to study the correlation between the tumor-suppressor gene product p53- and the DNA ploidy in 30 de novo cases of acute nonlymphocytic leukemia (ANLL).The results showed that 15 cases were negative and the other 15 cases were positive expression for p53. As compared with p53 negative (p53) cases, the patients with positive p53 (p53+) had higher percentage of bone marrow blasts and lower peripheral leukocyte and platelet counts,which had no influence on the complete remission rate. Before treatment, DNA diploidy was seen in 18 cases including 12 p53- cases, and DNA aneuploidy in 12 cases including 9 p53+. After therapy, aneuploidy could be transformed into diploidy.Patients with P53+ or having aneuploidy in complete remission were at risk for early relapse. We believe that p53 may be involved in the process of leukemogenesis and progression of ANLL.
文摘Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2.The overall incidence of chromosomal abnormality was 70.1% (68 out of 97 cases),which was higher in children(84. 2% )than in edults (61%).The male to female chromosomal abnormality ratio was nearly the same(male 71% and female 68. 4% .P>0.05).Hypodiploidy was the most common numerical abnormality(39%)and t (8;21) was the most common structural abnormality (48.1%) It the patients with t (8;21),64 5%(2) out of 31cases) male lost chromosome Y (-Y) and 33%(5 out of 15 cases)female lost one chromosomeX(-X).
文摘Bone marrow studies including morphological,morphometrical and ultrastructural aspects were performed in 35 patients with M2/t(8;21)and and 23 patients with M2/NN.It was found that M2/t(8;21)patients had higher cellularity in bone marrow.Type(Ⅱ)myeloblast cells were predominant among myeoloblasts.Deformation of nuclei,nucleocytoplasmic asynchronism and dysmegakaryctytopoiesis were more evident n M2/t (8;21) than in M2/NN patients.
文摘BACKGROUND Myeloid sarcoma(MS) is relatively rare,occurring mainly in the skin and lymph nodes,and MS invasion of the ulnar nerve is particularly unusual.The main aim of this article is to present a case of MS invading the brachial plexus,causing ulnar nerve entrapment syndrome,and to further clinical understanding of the possibility of MS invasion of peripheral nerves.CASE SUMMARY We present the case of a 46-year-old man with a 13-year history of well-treated acute nonlymphocytic leukaemia who was admitted to the hospital after presenting with numbness and pain in his left little finger.The initial diagnosis was considered a simple case of nerve entrapment disease,with magnetic resonance imaging showing slightly abnormal left brachial plexus nerve alignment with local thickening,entrapment,and high signal on compression lipid images.Due to the severity of the ulnar nerve compression,we surgically investigated and cleared the entrapment and nerve tissue hyperplasia;however,subsequent pathological biopsy results revealed evidence of MS.The patient had significant relief from his neurological symptoms,with no postoperative complications,and was referred to the haemato-oncology department for further consultation about the primary disease.This is the first report of safe treatment of ulnar nerve entrapment from MS.It is intended to inform hand surgeons that nerve entrapment may be associated with extramedullary MS,as a rare presenting feature of the disease.CONCLUSION MS invasion of the brachial plexus and surrounding tissues of the upper arm,resulting in ulnar nerve entrapment and degeneration with significant neurological pain and numbness in the little finger,is uncommon.Surgical treatment significantly relieved the patient’s nerve entrapment symptoms and prevented further neurological impairment.This case is reported to highlight the rare presenting features of MS.
文摘Spontaneous rupture and bleeding from the carotid artery in acute promyelocytic leukemia （APL）patients leading to pseudoaneurysm （PSA） formation has not been reported. We first successfully treated an APL patient with leli internal carotid artery rupture during chemotherapy leading to PSA using ultrasound-guided thrombin iniection （UGTI）.
