<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.&...<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.展开更多
目的:初步探讨不同能量负荷对正常糖耐量人群的GLP-1(glucagon like peptide-1)影响。方法:14例正常糖耐量受试者先后接受75g葡萄糖及混合餐试验,检测空腹及葡萄糖或混合餐后15,30,60,90和120min的血糖、胰岛素及GLP-1。结果:(1)本组人...目的:初步探讨不同能量负荷对正常糖耐量人群的GLP-1(glucagon like peptide-1)影响。方法:14例正常糖耐量受试者先后接受75g葡萄糖及混合餐试验,检测空腹及葡萄糖或混合餐后15,30,60,90和120min的血糖、胰岛素及GLP-1。结果:(1)本组人群的GLP-1在葡萄糖负荷后15min出现第一峰值;第二峰值在60min。(2)混合餐负荷GLP-1分泌无明显峰值。(3)两种能量负荷GLP-1曲线下面积差异无显著性。结论:本研究正常糖耐量人群葡萄糖负荷后GLP-1的分泌呈双时相,混合餐负荷后GLP-1无明显峰值。不同能量负荷对正常糖耐量人群GLP-1影响不同。展开更多
文摘<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.
文摘目的:初步探讨不同能量负荷对正常糖耐量人群的GLP-1(glucagon like peptide-1)影响。方法:14例正常糖耐量受试者先后接受75g葡萄糖及混合餐试验,检测空腹及葡萄糖或混合餐后15,30,60,90和120min的血糖、胰岛素及GLP-1。结果:(1)本组人群的GLP-1在葡萄糖负荷后15min出现第一峰值;第二峰值在60min。(2)混合餐负荷GLP-1分泌无明显峰值。(3)两种能量负荷GLP-1曲线下面积差异无显著性。结论:本研究正常糖耐量人群葡萄糖负荷后GLP-1的分泌呈双时相,混合餐负荷后GLP-1无明显峰值。不同能量负荷对正常糖耐量人群GLP-1影响不同。
