Study on VEGF, bFGF and TGF-β_1 in the Endometrium of Norplant Users

To investigate the relationship between abnormal uterus bleeding and endometrium vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) as well as transforming growth factor β 1 (TGF β 1) expressions among Norplant users. Materials & Methods Thirty six endometrium samples from Norplant users with normal and abnormal bleeding were studied morphologically and immunohistochemically for VEGF, bFGF and TGF β 1 expression. Six normal samples of proliferate endometria were studied as control. Results In the Norplant users, the characteristics of endometrium changed and glands decreased in numbers. The VEGF expression in epithelium and vascular endothelium was lower in those with abnormal uterine bleeding. However, no difference was detected on bFGF and TGF β 1 expression. Conclusion The decline of VEGF expression may relate to the abnormal uterine bleeding in Norplant users.

Norplant使用者子宫内膜血管内皮生长因子、碱性成纤维细胞生长因子及转移生长因子β_1的研究

为探讨Norplant使用者子宫不规则出血的相关因素,对使用Norplant月经规律和有不规则子宫出血者的子宫内膜与正常子宫内膜的形态、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)及转移生长因子β1(TGFβ1)进行比较观察。结果显示:Norplant使用者子宫内膜无典型的周期特点,子宫内膜VEGF比正常子宫内膜减少,尤其是不规则出血组减少更为明显,但bFGF及GFβ1无明显差异。提示Norplant使用者子宫异常出血与子宫内膜VEGF的减少有关。