Background:We evaluated factors associated with eczema severity in adolescence.Methods:Nottingham Eczema Severity Score(NESS),family and personal history of atopy,skin prick test for common food and aeroallergens,high...Background:We evaluated factors associated with eczema severity in adolescence.Methods:Nottingham Eczema Severity Score(NESS),family and personal history of atopy,skin prick test for common food and aeroallergens,highest serum IgE level and eosinophil count were evaluated.Patients with paired NESSs(childhood-NESS is NESS performed at<10 years of age;adolescence-NESS is NESS performed at age>10 years)were further analyzed.Results:Adolescence-NESS(n=383 patients)was associated with eczema onset in infancy,dust mite and food allergen sensitization,dietary avoidance,use of wet wrap,traditional Chinese medicine,immunomodulant(azathioprine or cyclosporine),high IgE level,eosinophil count,but not with family/personal history of atopy.Eighty-two patients had both childhood-NESS and adolescence-NESS(mean follow-up of 6.8 years)showing that adolescence-NESS was associated with childhood-NESS severity grades(P=0.034).Of these patients,48%remained in the same severity grades,whereas 39%improved,and 13%deteriorated from childhood to adolescence.Conclusions:It is not possible to assure parents that their child can outgrow eczema.In eczema prognosis research,long-term follow-up is warranted.展开更多
文摘Background:We evaluated factors associated with eczema severity in adolescence.Methods:Nottingham Eczema Severity Score(NESS),family and personal history of atopy,skin prick test for common food and aeroallergens,highest serum IgE level and eosinophil count were evaluated.Patients with paired NESSs(childhood-NESS is NESS performed at<10 years of age;adolescence-NESS is NESS performed at age>10 years)were further analyzed.Results:Adolescence-NESS(n=383 patients)was associated with eczema onset in infancy,dust mite and food allergen sensitization,dietary avoidance,use of wet wrap,traditional Chinese medicine,immunomodulant(azathioprine or cyclosporine),high IgE level,eosinophil count,but not with family/personal history of atopy.Eighty-two patients had both childhood-NESS and adolescence-NESS(mean follow-up of 6.8 years)showing that adolescence-NESS was associated with childhood-NESS severity grades(P=0.034).Of these patients,48%remained in the same severity grades,whereas 39%improved,and 13%deteriorated from childhood to adolescence.Conclusions:It is not possible to assure parents that their child can outgrow eczema.In eczema prognosis research,long-term follow-up is warranted.
