Shaped beam pattern synthesis with desired nulling level and minimum sidelobe level

For the anti-interference/denoise purpose,it usually requires minimizing the sidelobe level(SLL)of a wide-beam pattern with a desired low nulling level(NL)in the nulling region.To realize such an objective,the shaped-beam pattern synthesis(SBPS)is the most commonly used approach.However,since the SBPS problem focuses on synthesizing a predetermined beam shape,the minimum SLL via this approach cannot ensure to obtain the maximum power gain.Conversely,it cannot obtain the lowest SLL with a certain power gain requirement.Based on such consideration,this paper tries to further minimize SLL of a wide-beam pattern with a desired low NL nulling region,by solving the power gain pattern synthesis(PGPS)problem.The PGPS problem selects the array excitation by directly optimizing the power gain.Hence,it has the potential to reduce SLL,when achieving the equal mainlobe power gain constraint via SBPS.An iterative algorithm which converts the primal optimization problem into convex sub-problems is proposed,resulting in an effective problem-solving scheme.Numerical simulations demonstrate the proposed algorithm can obtain about 10-dB lower SLL than the existing algorithms.

基于Null Importance和Stacking模型的知识追踪研究

为应对基于游戏的学习平台在知识追踪应用方面的不足,本研究利用Field Day Lab提供的教育游戏用户日志进行深入分析。采用方差法和Null Importance方法对数据集进行降维处理,并结合K折交叉验证与LightGBM算法,建立了一个高效的预测模型。此外,通过集成Logistic模型,构建起Stacking模型。研究表明,该模型在验证集上的Macro-F1值显著提升至0.699,同时也在测试集上显示出优异的泛化能力。本研究为教育游戏领域的知识追踪提供了创新方法,并为游戏开发与教育实践提供了宝贵参考,支持教育游戏的开发者为学生创造更有效的学习体验。

The mid-domain effect in flowering phenology

The timing of flowering is an important driver of species distribution and community assembly patterns.However,we still have much to learn about the factors that shape flowering diversity(i.e.,number of species flowering per period) in plant communities.One potential explanation of flowering diversity is the mid-domain effect,which states that geometric constraints on species ranges within a bounded domain(space or time) will yield a mid-domain peak in diversity regardless of ecological factors.Here,we determine whether the mid-domain effect explains peak flowering time(i.e.,when most species of communities are flowering) across China.We used phenological data of 16,267 herbaceous and woody species from the provincial Flora in China and species distribution data from the Chinese Vascular Plant Distribution Database to determine relationships between the observed number of species flowering and the number of species flowering as predicted by the mid-domain effect model,as well as between three climatic variables(mean minimum monthly temperature,mean monthly precipitation,and mean monthly sunshine duration).We found that the mid-domain effect explained a significant proportion of the temporal variation in flowering diversity across all species in China.Further,the mid-domain effect explained a greater proportion of variance in flowering diversity at higher latitudes than at lower latitudes.The patterns of flowering diversity for both herbaceous and woody species were related to both the mid-domain effect and environmental variables.Our findings indicate that including geometric constraints in conjunction with abiotic and biotic predictors will improve predictions of flowering diversity patterns.

Laboratory observation of electron energy distribution near three-dimensional magnetic nulls

The acceleration of electrons near three-dimensional(3D)magnetic nulls is crucial to the energy conversion mechanism in the 3D magnetic reconnection process.To explore electron acceleration in a 3D magnetic null topology,we constructed a pair of 3D magnetic nulls in the PKU Plasma Test(PPT)device and observed acceleration of electrons near magnetic nulls.This study measured the plasma floating potential and ion density profiles around the 3D magnetic null.The potential wells near nulls may be related to the energy variations of electrons,so we measured the electron distribution functions(EDFs)at different spatial positions.The axial variation of EDF shows that the electrons deviate from the Maxwell distribution near magnetic nulls.With scanning probes that can directionally measure and theoretically analyze based on curve fitting,the variations of EDFs are linked to the changes of plasma potential under 3D magnetic null topology.The kinetic energy of electrons accelerated by the electric field is 6 eV(v_(e)~7v_(Alfvén-e))and the scale of the region where accelerating electrons exist is in the order of serval electron skin depths.

Exact controllability of rational expectations model with multiplicative noise and input delay

This paper considers the rational expectations model with multiplicative noise and input delay,where the system dynamics rely on the conditional expectations of future states.The main contribution is to obtain a sufficient condition for the exact controllability of the rational expectations model.In particular,we derive a sufficient Gramian matrix condition and a rank condition for the delay-free case.The key is the solvability of the backward stochastic difference equations with input delay which is derived from the forward and backward stochastic system.

Simultaneously realizing thermal andelectromagnetic cloaking by multi-physicalnull medium

Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration level,the precise and efficient control of the propagation of electromagnetic waves and heat fluxes simultaneously is particularly important.In this study,we propose a graphical designing method(i.e.,thermal-electromagnetic surface transformation)based on thermal-electromagnetic null medium to simultaneously control the propagation of electromagnetic waves and thermal fields according to the pre-designed paths.A thermal-electromagnetic cloak,which can create a cloaking effect on both electromagnetic waves and thermal fields simultaneously,is designed by thermal-electromagnetic surface transformation and verified by both numerical simulations and experimental measurements.The thermal-electromagnetic surface transformation proposed in this study provides a new methodology for simultaneous controlling on electromagnetic and temperature fields,and may have significant applications in improving thermal-electromagnetic compatibility problem,protecting of thermal-electromagnetic sensitive components,and improving efficiency of energy usage for complex onchip systems.

Principal Equatorial Null Geodesic Congruences in the Kerr Metric, and Their Quantum Propagators

Using the Raychaudhuri equation, we associate quantum probability amplitudes (propagators) to equatorial principal ingoing and outgoing null geodesic congruences in the Kerr metric. The expansion scalars diverge at the ring singularity;however, the propagators remain finite, which is an indication that at the quantum level singularities might disappear or, at least, become softened.

Isometric Immersions of Lightlike Warped Product Manifolds

In this paper, we deal with isommetric immersions of globally null warped product manifolds into Lorentzian manifolds with constant curvature c in codimension k≥3. Under the assumptions that the globally null warped product manifold has no points with the same constant sectional curvature c as the Lorentzian ambient, we show that such isometric immersion splits into warped product of isometric immersions.

基于NSMC方法的某核工程场地裂隙地下水数值模拟不确定分析

裂隙介质渗透结构表现为高度的非均质性与各项异性。为了科学有效地预测某核工程场地裂隙地下水的流动规律,揭示裂隙岩体地下水的渗流特性,笔者等采用Pilot Point调参方法与null space Monte Carlo方法(NSMC),开展了裂隙岩体渗透结构的不确定性分析研究,构建了符合实际水文地质条件的多个渗流数值模型集合。结果表明:该方法获得的各个实现地下水位模拟结果能够与实际观测数据较好吻合,可反映工程场地裂隙地下水动力特征与流动趋势;各个实现的参数化渗透结构在空间上存在一定的差异性,但整体变化趋势是保持一致的,渗透参数的不确定性表现为在实测数据分布区域相对较低,钻孔空白区域相对较高;该方法可以弥补单一、确定性模拟结果在表征裂隙介质渗透结构方面的局限性,有效地降低模型参数的不确定性与随机性。此方法对进一步提升裂隙岩体渗流模拟精度与预测能力,深化裂隙地下水迁移规律的认识具有重要的意义。

基于Null Importance与GS-LGBM的糖尿病视网膜病变因素分析与风险预测

目的:通过机器学习算法分析糖尿病视网膜病变(DR)关键因素,构建DR风险预测模型,为DR的预防和诊断提供参考。方法:采用国家人口健康科学数据中心的《糖尿病并发症预警数据集》,基于Null Importance方法去除噪声特征,筛选出与DR有关的关键因素;基于GridSearch优化LGBM模型参数,构建GS-LGBM DR风险预测模型。以准确率、精确率、召回率、F1分数、AUC值作为评价标准,与XGBoost、随机森林、Logistic以及未调优的LGBM模型进行比较。结果:Null Importance方法筛选出30个关键因素;与XGBoost、随机森林、Logistic以及未调优的LGBM模型相比,本研究所构建的GS-LGBM DR风险预测模型各评价指标均最优,其在测试数据上的AUC值高达0.897。结论:相较传统的DR预测模型,经过超参数优化后的模型具有更好的DR风险预测能力,更有助于DR的临床诊断。

Python语言处理各类空值的方法研究

在各类编程语言中的空值表述都有所不同。对于数据分析而言,筛选出当前表内的空值并对其进行有效填充或进行其他操作,是数据清洗过程中的重要一环。该文对各类编程语言中可能出现的空值表述方法进行了梳理汇总,然后通过Python中的pandas扩展库相关函数操作阐述了Python语言处理这些不同语境中空值的常用方法。

Effect size in papers published by the Journal of Forestry Research:A missing treasure?

P values based on standard hypothesis testing are commonly reported in articles published by the Journal of Forestry Research(JFR).However,effect sizes are barely used and reported,even if they are of direct relevance to the primary questions of many of the published studies.The incorporation of effect sizes in studies published by JFR should be encouraged and promoted.Inclusion of effect sizes as a requirement in the journal guidelines will facilitate a major change in the way data are tested and interpreted,with the ultimate goal to exempt researchers from the custom of drawing conclusions merely based upon a dichotomous statistical result(P value).Such a policy can also lead to more informed decisions of whether identified effects are of practical relevance to the forestry.

Stochastic analysis of load-transfer mechanism of energy piles by random finite difference model

The surge in demand for renewable energy to combat the ever-escalating climate crisis promotes development of the energy-saving,carbon saving and reduction technologies.Shallow ground-source heat pump(GSHP)system is a promising carbon reduction technology that can stably and effectively exploit subsurface geothermal energy by taking advantage of load-bearing structural elements as heat transfer medium.However,the transformation of conventional geo-structures(e.g.piles)into heat exchangers between the ground and superstructures can potentially induce variable thermal axial stresses and displacements in piles.Traditional energy pile analysis methods often rely on deterministic and homogeneous soil parameter profiles for investigating thermo-mechanical soil-structure interaction,without consideration of soil spatial variability,model uncertainty or statistical uncertainty associated with interpolation of soil parameter profiles from limited site-specific measurements.In this study,a random finite difference model(FDM)is proposed to investigate the thermo-mechanical load-transfer mechanism of energy piles in granular soils.Spatially varying soil parameter profile is interpreted from limited site-specific measurements using Bayesian compressive sensing(BCS)with proper considering of soil spatial variability and other uncertainties in the framework of Monte Carlo simulation(MCS).Performance of the proposed method is demonstrated using an illustrative example.Results indicate that the proposed method enables an accurate evaluation of thermally induced axial stress/displacement and variation in null point(NP)location with quantified uncertainty.A series of sensitivity analyses are also carried out to assess effects of the pile-superstructure stiffness and measurement data number on the performance of the proposed method,leading to useful insights.

Spherical and Circular Non-Equatorial Photon Orbits around Kerr Black Holes

By analytically solving the equation of azimuthal null geodesics for spherical photon trajectories, a parametric representation of the corresponding segment of the orbit is obtained. The solution parameter is the latitude coordinate. The dependences of the orbital radius on the black hole spinning parameter and the angle of inclination of its plane with respect to the rotation axis are calculated for flat circular non-equatorial orbits. It is proved that all spherical photon trajectories in the Kerr spacetime are unstable, as well as equatorial ones, and the critical photon orbits in the Schwarzschild metric.

外源性Nurr1基因过表达增强SK-N-SH细胞对神经毒素6-OHDA敏感性的研究

目的 通过比较自身不表达Nurrl基因的人神经母细胞瘤细胞SK—N—SH和过表达外源性Null基因的SK—N—SH／Nurrl细胞对神经毒素6-羟多巴胺（6-OHDA）损伤的敏感程度，探讨Null基因与6一OHDA引起的多巴胺（DA）能神经元特异性损伤的相关性。方法①绘制SK—N—SH细胞及SK—N—SH／Nurrl细胞的生长曲线，比较外源性Null基因过表达对细胞增殖率的影响。②用不同浓度的6-OHDA（5—100μmol·L^-1）分别作用两株细胞1—24h，倒置相差显微镜下观察细胞形态变化，MTT测定法比较两株细胞的存活率。③用75μmol·L^-1的6-OHDA作用12h，经Hoechst33342染色，荧光显微镜观察细胞核形态，比较两株细胞的凋亡情况。结果①生长曲线结果显示，SK—N—SH／Null细胞增殖数目低于SK—N—SH细胞一②MTT结果显示，6-OHDA对两株细胞的存活均有抑制作用，但SK—N—SH／Null细胞存活率下降更为明显。③Hoechst33342染色结果显示，用75μmol·L^-1的6-OHDA作用12h后SK—N—SH细胞核没有出现明显的凋亡形态改变，而部分SK—N—SH／Null细胞的细胞核出现了染色质凝聚、碎裂等凋亡形态改变，比例约为22％-24％。结论外源性Null基因过表达抑制SK—N—SH细胞增殖，增强SK—N—SH细胞对6-OHDA的敏感性并有可能促进6-OHDA诱导的细胞凋亡。Null基因可能作为易感因子参与多巴胺能神经元的特异性损伤。

人急性B淋巴细胞白血病-NOD/SCID/IL2rγnull新生小鼠异种移植模型的建立

本研究旨在应用NOD/SCID/IL2rγnull新生小鼠建立人急性B淋巴细胞白血病(B-ALL)的异种移植模型。NOD/SCID/IL2rγnull新生期(出生48 h之内)小鼠经亚致死剂量(100 cGy)137Cs全身照射后,由面静脉输注FACSAria流式细胞仪分选纯化的B-ALL患者骨髓CD3-CD4-CD8-CD34+CD19+细胞,于移植后8-12周用流式细胞术检测受鼠外周血、骨髓和脾脏中人源细胞的植入水平及其免疫表型,并通过HE染色评价人源B-ALL细胞在受鼠各组织器官中的迁移浸润能力。结果表明,在接受B-ALL患者CD34+CD19+细胞移植的受鼠外周血、骨髓和脾脏细胞中,不仅检测到了不同程度的人源B-ALL(huCD45+CD19+)细胞的植入〔(83.36±10.05)%,(93.88±5.05)%,(88.31±5.01)%〕,而且植入细胞具有与B-ALL患者相似的细胞形态和免疫表型特征。此外,人源B-ALL细胞广泛迁移浸润到受鼠的肝脏、肺脏、肾脏和脑等组织器官中。结论:NOD/SCID/IL2rγnull新生小鼠模型能够支持B-ALL患者CD34+CD19+细胞的高水平植入,是对人B-ALL进行体内功能性研究的新型异种移植模型。

Forskolin激活MN9D细胞内源性Nurr1表达的信号机制研究

目的利用具有未成熟多巴胺神经前体细胞特性的杂交瘤细胞系MN9D,探讨Forskolin激活Nurr1表达的分子信号机制。Nurr1是未知配体的核转录因子,对中脑多巴胺神经元的发育至关重要。方法①用Forskolin作用MN9D细胞1～6h,提取细胞蛋白,Westernblot方法检测MN9D细胞内源性Nurr1表达的变化,并利用磷酸化的ERK1/2(pERK1/2)抗体检测Forskolin作用后MN9D细胞内ERK信号转导通路是否被激活。②应用ERK信号转导通路的特异性抑制剂U0126预孵育MN9D细胞,再用Forskolin作用,检测MN9D细胞Nurr1表达的变化。结果①从Forskolin作用1h起,直至6h,MN9D细胞核内Nurr1表达均比未加Forskolin作用组明显增加。同时,MN9D细胞内pERK1/2蛋白含量迅速增加,在1h起即达到差异有显著性(P<0.05),并持续保持在较高水平,直至Forskolin作用6h。而Forskolin作用前后MN9D细胞内ERK1/2总蛋白的表达量基本保持不变。②用MEK1/2的特异性抑制剂U0126预处理,可有效抑制MN9D细胞内ERK信号转导通路的激活,并明显阻断Forskolin引起的MN9D细胞内源性Nurr1表达增加。结论ERK信号通路在Forskolin引起的MN9D细胞内源性Nurr1表达及核转位增加中发挥重要作用。

信号转导子与转录活化子6(STAT6)在人结肠癌细胞株HT29(STAT6^(high))、Caco2(STAT6^(null))细胞凋亡中的作用

目的通过分析信号转导子与转录活化子6(signal transducer and activator of transcription 6,STAT6)活化状态时不同的人结肠癌细胞株HT29(STAT6high)和Caco2(STAT6null)凋亡情况来研究STAT6与细胞凋亡之间的关系,并从分子水平探讨其可能的机制。方法采用流式细胞仪检测人结肠癌细胞株HT29(STAT6high)和Caco2(STAT6null)细胞凋亡的情况,比较其差异;同时采用RT-PCR检测人结肠癌细胞株HT29(STAT6high)和Caco2(STAT6null)中凋亡相关基因(Caspase家族蛋白Caspase3 mRNA、Caspase7 mRNA和Bcl-2家族蛋白凋亡抑制蛋白Bcl-2 mRNA、Bcl-xl mRNA、促凋亡蛋白Hrk mRNA)的表达水平,比较其差异。结果人结肠癌细胞株Caco2(STAT6null)细胞早期凋亡率为(13.30±0.73)%,明显高于HT29(STAT6high)的(2.00±0.43)%(P<0.01)。RT-PCR显示,人结肠癌细胞株Caco2(STAT6null)中Caspase3 mRNA和Caspase7 mRNA表达水平均明显高于HT29(STAT6high)(均P<0.01)。人结肠癌细胞株Caco2(STAT6null)中凋亡抑制蛋白Bcl-2 mRNA、Bcl-xl mR-NA、促凋亡蛋白Hrk mRNA表达水平均明显高于HT29(STAT6high)(均P<0.01)。人结肠癌细胞株Caco2(STAT6null)、HT29(STAT6high)中STAT6活性水平与Caspase7、Caspase3、Bcl-2、Bcl-xl、Hrk mRNA表达水平均呈负相关(r=-0.514、-0.562、-0.518、-0.512、-0.426,均P<0.05)。结论 STAT6可能参与结肠癌细胞凋亡,其机制可能与凋亡相关基因的表达有关。

中国稀有Lu_(null)血型筛查及其LU基因检测

目的随着我国医疗技术的发展,对于人群中出现频率小于千分之一的稀有血型的临床输配血及其应用,日益得到人们的关注。血站对献血者的血型常规检测未包含稀有血型项目,如何发掘和利用献血者中的稀有血型资源,为临床稀有血型患者输配血服务,值得我们关注和探讨。本研究以上海地区随机献血者中稀有Lunull血型为例,针对性研究该血型在中国人群随机献血者中的频率,检测其血清学及分子学特征,建立该稀有血型献血者数据库,探索该稀有血型资源在临床输配血服务中的应用前景。方法采用单克隆抗-Lub,使用96孔U型板IAT试验方法对上海地区共39897位献血者的Lutheran血型进行筛选。

关于数据表中字段属性“NULL”的理解与使用

本文针对关系数据库表中字段属性“NULL”的设置、赋值及其有关编程处理方法进行了讨论和分析 ,并给出了一些明确的结论和使用建议。这些结论和建议对于数据库维护及有关软件开发的编程和测试人员 ,具有较高的使用和参考价值。