目的:探讨血清基质金属蛋白酶-1(matrix metalloproteinase-1,MMP1)和纽约食管鳞状细胞癌抗原-1(New York esophageal squamous cell carcinoma 1,NY-ESO-1)自身抗体联合检测在食管鳞状细胞癌中的诊断意义。方法:应用酶联免疫吸附实验检...目的:探讨血清基质金属蛋白酶-1(matrix metalloproteinase-1,MMP1)和纽约食管鳞状细胞癌抗原-1(New York esophageal squamous cell carcinoma 1,NY-ESO-1)自身抗体联合检测在食管鳞状细胞癌中的诊断意义。方法:应用酶联免疫吸附实验检测120例食管鳞状细胞癌患者和120例正常对照血清中MMP1和NY-ESO-1自身抗体的表达水平,采用受试者工作特征(receiver operating characteristic,ROC)曲线评价诊断效能。结果:血清MMP1和NY-ESO-1自身抗体在食管鳞状细胞癌患者中的表达均明显高于正常对照[(8.070±5.738)ng/mL vs(4.331±3.137)ng/mL,Z=6.214,P<0.001;0.463±0.571 vs 0.156±0.086,Z=5.210,P<0.001]。ROC曲线显示,当血清MMP1为最佳诊断临界值10.586 ng/mL时,其在诊断食管鳞状细胞癌的曲线下面积(area under the ROC curve,AUC)为0.732(95%CI:0.671~0.787),敏感度为24.2%,特异度为95.0%。NY-ESO-1自身抗体诊断食管鳞状细胞癌AUC为0.695(95%CI:0.632~0.752),敏感度为33.0%,特异度为95.0%。MMP1和NY-ESO-1自身抗体联合检测诊断食管鳞状细胞癌的AUC为0.800(95%CI:0.744~0.849),敏感度为47.5%,特异度为95.0%。结论:血清MMP1和NY-ESO-1自身抗体联合检测可能有助于提高食管鳞状细胞癌的诊断效能。展开更多
Pollen morphology of eight species of Saxifraga,i.e.S.cespitosa,S.oppositifolia,S.cernua,S.nivalis,S.aizoides,S.rivularis,S.hieraciifolia,and S.hirculus,collected from Ny-Alesund,Svalbard,Arctic was examined using lig...Pollen morphology of eight species of Saxifraga,i.e.S.cespitosa,S.oppositifolia,S.cernua,S.nivalis,S.aizoides,S.rivularis,S.hieraciifolia,and S.hirculus,collected from Ny-Alesund,Svalbard,Arctic was examined using light and scanning electron microscopy.Pollen grains of Saxifraga species are subprolate or prolate,3-colpate,15.4–44.4μm in the polar axis,11.4–34.6μm in the equatorial axis,and show a P/E ratio 1.19–1.40.On the basis of exine ornamentation,four pollen types,viz.,the S.oppositifolia type(striate without scabrae on the muri),S.cernua type(striate with scabrae on the muri),S.nivalis type(microreticulate and operculum absent),and S.cespitosa type(microechinate and operculum present),were recognized.Hierarchical cluster analysis of the pollen morphological characters indicated that pollen morphology supports the infrageneric classification of the genus Saxifraga.展开更多
The concentrations of organic carbon (OC) and elemental carbon (EC)in total suspended particle (TSP) were investigated at Ny-(A)lesund, Svalbard in a two-week campaign. The levels of OC and EC are 0.86 ±0.27 μgm...The concentrations of organic carbon (OC) and elemental carbon (EC)in total suspended particle (TSP) were investigated at Ny-(A)lesund, Svalbard in a two-week campaign. The levels of OC and EC are 0.86 ±0.27 μgm-3 (mean±standard deviation) and 0. 19±0.10 μgm-3 , respectively. Back trajectory analysis of air masses arriving at Ny-(A)lesund reveals that long-range transport of polluted air play insignificant role in OC and EC levels, to which the potential influence of the local contamination were ascribed. The average OC/EC ratio is 5.41,suggesting the presence of the secondary organic aerosols. The estimated secondary organic carbon (SOC) in TSP is 0.59 μg/m3 , accounting for 64% of the total organic carbon.展开更多
文摘目的:探讨血清基质金属蛋白酶-1(matrix metalloproteinase-1,MMP1)和纽约食管鳞状细胞癌抗原-1(New York esophageal squamous cell carcinoma 1,NY-ESO-1)自身抗体联合检测在食管鳞状细胞癌中的诊断意义。方法:应用酶联免疫吸附实验检测120例食管鳞状细胞癌患者和120例正常对照血清中MMP1和NY-ESO-1自身抗体的表达水平,采用受试者工作特征(receiver operating characteristic,ROC)曲线评价诊断效能。结果:血清MMP1和NY-ESO-1自身抗体在食管鳞状细胞癌患者中的表达均明显高于正常对照[(8.070±5.738)ng/mL vs(4.331±3.137)ng/mL,Z=6.214,P<0.001;0.463±0.571 vs 0.156±0.086,Z=5.210,P<0.001]。ROC曲线显示,当血清MMP1为最佳诊断临界值10.586 ng/mL时,其在诊断食管鳞状细胞癌的曲线下面积(area under the ROC curve,AUC)为0.732(95%CI:0.671~0.787),敏感度为24.2%,特异度为95.0%。NY-ESO-1自身抗体诊断食管鳞状细胞癌AUC为0.695(95%CI:0.632~0.752),敏感度为33.0%,特异度为95.0%。MMP1和NY-ESO-1自身抗体联合检测诊断食管鳞状细胞癌的AUC为0.800(95%CI:0.744~0.849),敏感度为47.5%,特异度为95.0%。结论:血清MMP1和NY-ESO-1自身抗体联合检测可能有助于提高食管鳞状细胞癌的诊断效能。
基金financially supported by the National Natural Science Foundation of China(Grant no.41271222)Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences(Grant no.KSCX2-EW-J-1)+3 种基金Projects of the CAA,SOA(Grant nos.2012YR06006 and13/14YR05)SKLSEB-IBCAS(Grant no.56176G1048)Chinese Academy of Sciences Visiting Professorship for Senior International Scientists(Grant no.90004F1005)Visiting Scholarship funded by the China Scholarship Council(Grant no.201204910043)
文摘Pollen morphology of eight species of Saxifraga,i.e.S.cespitosa,S.oppositifolia,S.cernua,S.nivalis,S.aizoides,S.rivularis,S.hieraciifolia,and S.hirculus,collected from Ny-Alesund,Svalbard,Arctic was examined using light and scanning electron microscopy.Pollen grains of Saxifraga species are subprolate or prolate,3-colpate,15.4–44.4μm in the polar axis,11.4–34.6μm in the equatorial axis,and show a P/E ratio 1.19–1.40.On the basis of exine ornamentation,four pollen types,viz.,the S.oppositifolia type(striate without scabrae on the muri),S.cernua type(striate with scabrae on the muri),S.nivalis type(microreticulate and operculum absent),and S.cespitosa type(microechinate and operculum present),were recognized.Hierarchical cluster analysis of the pollen morphological characters indicated that pollen morphology supports the infrageneric classification of the genus Saxifraga.
基金supported by grants from the National Natural Science Foundation of China(Project No.40306001)the Foundation for the Author of Nationa1 Excellent Doctoral Dissertation of P.R.China(Grant No.200354)from Ministry of Education of China and Chinese Academy of Sciencessupported by the Chinese Arctic and Antarctic Administration
文摘The concentrations of organic carbon (OC) and elemental carbon (EC)in total suspended particle (TSP) were investigated at Ny-(A)lesund, Svalbard in a two-week campaign. The levels of OC and EC are 0.86 ±0.27 μgm-3 (mean±standard deviation) and 0. 19±0.10 μgm-3 , respectively. Back trajectory analysis of air masses arriving at Ny-(A)lesund reveals that long-range transport of polluted air play insignificant role in OC and EC levels, to which the potential influence of the local contamination were ascribed. The average OC/EC ratio is 5.41,suggesting the presence of the secondary organic aerosols. The estimated secondary organic carbon (SOC) in TSP is 0.59 μg/m3 , accounting for 64% of the total organic carbon.
